Cationic amino acid transporter 4

SLC7A4
Identifiers
Aliases	SLC7A4, CAT-4, CAT4, HCAT3, VH, solute carrier family 7 member 4
External IDs	OMIM: 603752; MGI: 2146512; HomoloGene: 20883; GeneCards: SLC7A4; OMA:SLC7A4 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	21,032,840 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	17,401,078 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; prefrontal cortex; ; right hemisphere of cerebellum; ; right adrenal gland; ; right adrenal cortex; ; gonad; ; right frontal lobe; ; left adrenal cortex; ; Hypothalamus;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; seminal vesicula; ; superior frontal gyrus; ; primary visual cortex; ; parotid gland; ; right ventricle; ; hippocampus proper; ; lacrimal gland; ; Region I of hippocampus proper; ; prefrontal cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	basic amino acid transmembrane transporter activity; transmembrane transporter activity; amino acid transmembrane transporter activity;
Cellular component	integral component of membrane; membrane;
Biological process	cellular amino acid metabolic process; amino acid transport; basic amino acid transmembrane transport; transmembrane transport; amino acid transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	6545
	224022
	ENSG00000099960
	ENSMUSG00000022756
	O43246
	Q8BLQ7
	NM_004173
	NM_144852; NM_001359891; NM_001359892; NM_001359893
	NP_004164
	NP_659101; NP_001346820; NP_001346821; NP_001346822
	Wikidata
View/Edit Human	View/Edit Mouse

Cationic amino acid transporter 4 is a protein that in humans is encoded by the SLC7A4 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000099960 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022756 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sperandeo MP, Borsani G, Incerti B, Zollo M, Rossi E, Zuffardi O, Castaldo P, Taglialatela M, Andria G, Sebastio G (Aug 1998). "The gene encoding a cationic amino acid transporter (SLC7A4) maps to the region deleted in the velocardiofacial syndrome". Genomics. 49 (2): 230–6. doi:10.1006/geno.1998.5252. hdl:11566/82078. PMID 9598310.
^ Hammermann R, Brunn G, Racke K (Oct 2001). "Analysis of the genomic organization of the human cationic amino acid transporters CAT-1, CAT-2 and CAT-4". Amino Acids. 21 (2): 211–9. doi:10.1007/s007260170029. PMID 11665818. S2CID 30892800.
^ "Entrez Gene: SLC7A4 solute carrier family 7 (cationic amino acid transporter, y+ system), member 4".

Muñoz L, Lasa A, Carricondo MT, et al. (2007). "Comparative analysis of ZAP-70 expression and Ig VH mutational status in B-cell chronic lymphocytic leukemia". Cytometry Part B. 72 (2): 96–102. doi:10.1002/cyto.b.20149. PMID 17051526.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wolf S, Janzen A, Vékony N, et al. (2002). "Expression of solute carrier 7A4 (SLC7A4) in the plasma membrane is not sufficient to mediate amino acid transport activity". Biochem. J. 364 (Pt 3): 767–75. doi:10.1042/BJ20020084. PMC 1222626. PMID 12049641.
Neshat MN, Goodglick L, Lim K, Braun J (2000). "Mapping the B cell superantigen binding site for HIV-1 gp120 on a V(H)3 Ig". Int. Immunol. 12 (3): 305–12. doi:10.1093/intimm/12.3.305. PMID 10700465.
Fischer M, Küppers R (1998). "Human IgA- and IgM-secreting intestinal plasma cells carry heavily mutated VH region genes". Eur. J. Immunol. 28 (9): 2971–7. doi:10.1002/(SICI)1521-4141(199809)28:09<2971::AID-IMMU2971>3.0.CO;2-3. PMID 9754584.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000099960 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022756 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9598310-5] Sperandeo MP, Borsani G, Incerti B, Zollo M, Rossi E, Zuffardi O, Castaldo P, Taglialatela M, Andria G, Sebastio G (Aug 1998). "The gene encoding a cationic amino acid transporter (SLC7A4) maps to the region deleted in the velocardiofacial syndrome". Genomics. 49 (2): 230–6. doi:10.1006/geno.1998.5252. hdl:11566/82078. PMID 9598310.

[pmid11665818-6] Hammermann R, Brunn G, Racke K (Oct 2001). "Analysis of the genomic organization of the human cationic amino acid transporters CAT-1, CAT-2 and CAT-4". Amino Acids. 21 (2): 211–9. doi:10.1007/s007260170029. PMID 11665818. S2CID 30892800.

[entrez-7] "Entrez Gene: SLC7A4 solute carrier family 7 (cationic amino acid transporter, y+ system), member 4".

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Cationic amino acid transporter 4

See also

References

Further reading