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HLA-DPB1

From Wikipedia, the free encyclopedia

HLA-DPB1
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesHLA-DPB1, DPB1, HLA-DP, HLA-DP1B, HLA-DPB, major histocompatibility complex, class II, DP beta 1
External IDsOMIM: 142858; HomoloGene: 129927; GeneCards: HLA-DPB1; OMA:HLA-DPB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002121

n/a

RefSeq (protein)

NP_002112

n/a

Location (UCSC)Chr 6: 33.08 – 33.09 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

HLA class II histocompatibility antigen, DP(W2) beta chain is a protein that in humans is encoded by the HLA-DPB1 gene.

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.[3]

See also

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References

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  1. ^ a b c ENSG00000230708, ENSG00000229295, ENSG00000226826, ENSG00000215048, ENSG00000223865, ENSG00000230763, ENSG00000237710 GRCh38: Ensembl release 89: ENSG00000236693, ENSG00000230708, ENSG00000229295, ENSG00000226826, ENSG00000215048, ENSG00000223865, ENSG00000230763, ENSG00000237710Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Entrez Gene: HLA-DPB1 major histocompatibility complex, class II, DP beta 1".

Further reading

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