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Greco-Buddhism is the cultural syncretism between Hellenistic culture and Buddhism, which developed over a period of close to 800 years in Central Asia in the area corresponding to modern-day Afghanistan and Pakistan, between the 4th century BCE and the 5th century CE. Greco-Buddhism influenced the artistic (and, possibly, conceptual) development of Buddhism, and in particular Mahayana Buddhism, before it was adopted by Central and Northeastern Asia from the 1st century CE, ultimately spreading to China, Korea and Japan.

The interaction between Hellenistic Greece and Buddhism started when Alexander the Great conquered Asia Minor and Central Asia in 334 BCE, crossing the Indus and Jhelum rivers, and going as far as the Beas, thus establishing direct contact with India, the birthplace of Buddhism. Alexander founded several cities in his new territories in the areas of the Oxus and Bactria, and Greek settlements further extended to the Khyber Pass, Gandhara and the Punjab. These regions correspond to a unique geographical passageway between the Himalayas and the Hindu Kush mountains, through which most of the interaction between India and Central Asia took place, generating intense cultural exchange and trade.