Un article de Wikipédia, l'encyclopédie libre.
l'intelectine 1 (ou omentine ) est une lectine de type adiponectine dont le gène est ITLN situé sur le chromosome 1 humain .
Il s'agit d'une protéine de 313 acides aminés, essentiellement exprimé au niveau du tissu adipeux viscéral, essentiellement par les cellules vasculaires. Il augmente la phosphorylation de l'akt [ 5] endothéliale et diminue l'apoptose de ces cellules[ 6] inflammation provoquée par le TNF [ 7] cellules musculaires lisses [ 8] athérome en diminuant la réponse inflammatoire[ 9]
On expression est diminuée en cas d'obésité [ 10] maladie coronarienne [ 11] artériopathie oblitérante des membres inférieurs [ 12] athérome carotidien [ 13]
↑ a b et c GRCh38: Ensembl release 89: ENSG00000179914 - Ensembl , May 2017↑ a b et c GRCm38: Ensembl release 89: ENSMUSG00000038209 - Ensembl , May 2017↑ « Publications PubMed pour l'Homme National Center for Biotechnology Information, U.S. National Library of Medicine ↑ « Publications PubMed pour la Souris National Center for Biotechnology Information, U.S. National Library of Medicine ↑ Yang RZ, Lee MJ, Hu H et al. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action
↑ Maruyama S, Shibata R, Kikuchi R et al. Fat-derived factor omentin stimulates endothelial cell function and ischemia-induced revascularization via endothelial nitric oxide synthase-dependent mechanism
↑ Yamawaki H, Kuramoto J, Kameshima S et al. Omentin, a novel adipocytokine inhibits TNF-induced vascular inflammation in human endothelial cells
↑ Uemura Y, Shibata R, Kanemura N et al. Adipose-derived protein omentin prevents neointimal formation after arterial injury
↑ Watanabe K, Watanabe R, Konii H et al. Counteractive effects of omentin-1 against atherogenesis
↑ de Souza Batista CM, Yang RZ, Lee MJ et al. Omentin plasma levels and gene expression are decreased in obesity
↑ Shibata R, Ouchi N, Takahashi R et al. Omentin as a novel biomarker of metabolic risk factors
↑ Onur I, Oz F, Yildiz S et al. A decreased serum omentin-1 level may be an independent risk factor for peripheral arterial disease
↑ Shibata R, Takahashi R, Kataoka Y et al. Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men
