Spatial omics technologies at multimodal and single cell/subcellular level
Spatial omics technologies enable a deeper understanding of cellular organizations and
interactions within a tissue of interest. These assays can identify specific compartments or …
interactions within a tissue of interest. These assays can identify specific compartments or …
AI on a chip
Artificial intelligence (AI) has dramatically changed the landscape of science, industry,
defence, and medicine in the last several years. Supported by considerably enhanced …
defence, and medicine in the last several years. Supported by considerably enhanced …
Characterization of pre-existing and induced SARS-CoV-2-specific CD8+ T cells
I Schulien, J Kemming, V Oberhardt, K Wild… - Nature medicine, 2021 - nature.com
Emerging data indicate that SARS-CoV-2-specific CD8+ T cells targeting different viral
proteins are detectable in up to 70% of convalescent individuals,,,–. However, very little …
proteins are detectable in up to 70% of convalescent individuals,,,–. However, very little …
Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19
Our understanding of protective versus pathological immune responses to SARS-CoV-2, the
virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of …
virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of …
[HTML][HTML] Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines
J Liu, J Wang, J Xu, H Xia, Y Wang, C Zhang, W Chen… - Cell Discovery, 2021 - nature.com
Large-scale COVID-19 vaccinations are currently underway in many countries in response
to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies …
to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies …
Unsupervised discovery of tissue architecture in multiplexed imaging
J Kim, S Rustam, JM Mosquera, SH Randell… - Nature …, 2022 - nature.com
Multiplexed imaging and spatial transcriptomics enable highly resolved spatial
characterization of cellular phenotypes, but still largely depend on laborious manual …
characterization of cellular phenotypes, but still largely depend on laborious manual …
Single-cell RNA-seq methods to interrogate virus-host interactions
The twenty-first century has seen the emergence of many epidemic and pandemic viruses,
with the most recent being the SARS-CoV-2-driven COVID-19 pandemic. As obligate …
with the most recent being the SARS-CoV-2-driven COVID-19 pandemic. As obligate …
Universal antigen encoding of T cell activation from high-dimensional cytokine dynamics
Systems immunology lacks a framework with which to derive theoretical understanding from
high-dimensional datasets. We combined a robotic platform with machine learning to …
high-dimensional datasets. We combined a robotic platform with machine learning to …
Generalized and scalable trajectory inference in single-cell omics data with VIA
Inferring cellular trajectories using a variety of omic data is a critical task in single-cell data
science. However, accurate prediction of cell fates, and thereby biologically meaningful …
science. However, accurate prediction of cell fates, and thereby biologically meaningful …
The early neutrophil-committed progenitors aberrantly differentiate into immunoregulatory monocytes during emergency myelopoiesis
N Ikeda, H Kubota, R Suzuki, M Morita, A Yoshimura… - Cell Reports, 2023 - cell.com
Inflammatory stimuli cause a state of emergency myelopoiesis leading to neutrophil-like
monocyte expansion. However, their function, the committed precursors, or growth factors …
monocyte expansion. However, their function, the committed precursors, or growth factors …