Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently
mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH, ROBO/…

Natural killer T (NKT) cells are distinct glycolipid reactive innate lymphocytes that are
implicated in the resistance to pathogens and tumors. Earlier attempts to mobilize NKT cells, …

Background In a phase 1 trial, axicabtagene ciloleucel (axi-cel), an autologous anti-CD19
chimeric antigen receptor (CAR) T-cell therapy, showed efficacy in patients with refractory …

The foreign body reaction composed of macrophages and foreign body giant cells is the end-stage
response of the inflammatory and wound healing responses following implantation of …

Purpose Panitumumab, a fully human antibody against the epidermal growth factor receptor
(EGFR), has activity in a subset of patients with metastatic colorectal cancer (mCRC). …

Pancreatic cancer remains one of the most lethal of malignancies and a major health burden.
We performed whole-genome sequencing and copy number variation (CNV) analysis of …

Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed
exome sequencing and copy number analysis to define genomic aberrations in a …

The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to
more sensitive detection methods, and this increase is creating challenges for clinical …

The ability of the Rev protein of HIV to regulate the cytoplasmic level of unspliced RNA from
a P-globin gene containing the Rev response element was dependent on the integrity of the …

Pancreaticoduodenectomy (PD) with the possible addition of neoadjuvant or adjuvant
therapy is the standard of care in the United States for adenocarcinoma originating in the …