This paper examines multiple machine learning models to find the model that best indicates anomalous activity in an industrial control system that is under a software-based attack. The researched machine learning models are Random Forest, Gradient Boosting Machine, Artificial Neural Network, and Recurrent Neural Network classifiers built-in Python and tested against the HIL-based Augmented ICS dataset. Although the results showed that Random Forest, Gradient Boosting Machine, Artificial Neural Network, and Long Short-Term Memory classification models have great potential for anomaly detection in industrial control systems, we found that Random Forest with tuned hyperparameters slightly outperformed the other models.