In recent years, our understanding of protein structure and function has advanced rapidly,
providing a mechanistic understanding of a wide variety of biological processes. As an …

Background Venoarterial extracorporeal membrane oxygenation (ECMO) has been used
successfully for treatment of cardiogenic shock or cardiac arrest. The exact complication rate is …

Reinforcement Learning (RL) algorithms have found limited success beyond simulated
applications, and one main reason is the absence of safety guarantees during the learning …

The systemic amyloidoses are a broad spectrum of diseases that result from misfolding of
proteins that aggregate into b-sheet amyloid fibrils. Over 35 amyloidogenic precursor proteins …

The COVID-19 (SARS-2-Cov) pandemic, first reported in Wuhan, China, is now spreading
to many continents and countries, causing a severe public health burden. Currently, there is …

This present paper shows different levels of electroacupuncture analgesia (antinociceptive
effect) induced by three different frequencies of stimulation (ie 0.2, 4 and 200 Hz); highest …

Background Studies on outcomes among patients with heart failure (HF) with preserved left
ventricular ejection fraction (HFpEF), borderline left ventricular ejection fraction (HFbEF), and …

The incorporation of fluorescently labeled dideoxynucleotides by T7 DNA polymerase is
optimized by the use of Mn 2+ , fluorescein analogs and four 2′-deoxyribonucleoside 5′-O-(1-…

Small proteins or protein domains generally require disulfide bridges or metal sites for their
stabilization. Here it is shown that the ββα architecture of zinc fingers can be reproduced in a …

Mammalian myocardial infarction is typically followed by scar formation with eventual
ventricular dilation and heart failure. Here we present a novel model system in which mice …