Dinoksilin

Dinoksilin
(IUPAC) ime
	8,9-dihidroksi-1,2,3,11b-tetrahidrochromeno[4,3,2,-de]isoquinoline
Klinički podaci
Identifikatori
ATC kod	nije dodeljen
PubChem	9819126
Hemijski podaci
Formula	C15H13NO3
Mol. masa	255,268
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C15H13NO3/c17-11-5-4-9-10-7-16-6-8-2-1-3-12(13(8)10)19-15(9)14(11)18/h1-5,10,16-18H,6-7H2 ; Key: QOHSTVKJXZTEOL-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Dinoksilin je sintetičko jedinjenje koje je razvijeno za primenu u naučnim istraživanjima. Dinoksilin deluje kao potentan pun agonist na svih pet podtipova dopaminskog receptora.^[3]^[4]^[5]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Grubbs RA, Lewis MM, Owens-Vance C, Gay EA, Jassen AK, Mailman RB, Nichols DE (March 2004). „8,9-dihydroxy-1,2,3,11b-tetrahydrochromeno[4,3,2,-de]isoquinoline (dinoxyline), a high affinity and potent agonist at all dopamine receptor isoforms”. Bioorganic & Medicinal Chemistry 12 (6): 1403–12. DOI:10.1016/j.bmc.2004.01.008. PMID 15018913.
↑ Ryman-Rasmussen JP, Nichols DE, Mailman RB (October 2005). „Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists”. Molecular Pharmacology 68 (4): 1039–48. DOI:10.1124/mol.105.012153. PMID 15985612.
↑ Zhang J, Xiong B, Zhen X, Zhang A (March 2009). „Dopamine D1 receptor ligands: where are we now and where are we going”. Medicinal Research Reviews 29 (2): 272–94. DOI:10.1002/med.20130. PMID 18642350.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[pmid15018913-3] Grubbs RA, Lewis MM, Owens-Vance C, Gay EA, Jassen AK, Mailman RB, Nichols DE (March 2004). „8,9-dihydroxy-1,2,3,11b-tetrahydrochromeno[4,3,2,-de]isoquinoline (dinoxyline), a high affinity and potent agonist at all dopamine receptor isoforms”. Bioorganic & Medicinal Chemistry 12 (6): 1403–12. DOI:10.1016/j.bmc.2004.01.008. PMID 15018913.

[pmid15985612-4] Ryman-Rasmussen JP, Nichols DE, Mailman RB (October 2005). „Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists”. Molecular Pharmacology 68 (4): 1039–48. DOI:10.1124/mol.105.012153. PMID 15985612.

[pmid18642350-5] Zhang J, Xiong B, Zhen X, Zhang A (March 2009). „Dopamine D1 receptor ligands: where are we now and where are we going”. Medicinal Research Reviews 29 (2): 272–94. DOI:10.1002/med.20130. PMID 18642350.

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