Penicillin
Penicillin is a group of common antibiotics, used to treat bacterial infections. It was one of the first antibiotics to be discovered, and worked well against staphylococci and streptococci. Many strains of bacteria are now resistant. Chemists keep changing part of its structure in the effort to keep it working against the bacteria. Penicillin is sometimes used to treat syphilis, tonsillitis, meningitis, and pneumonia as well as other diseases.
Mechanism
[change | change source]Penicillin can be used to enter and kill two types of bacteria, Gram-positive and Gram-negative bacteria. Gram-positive bacteria have no outer cell membrane (protective layer around the bacteria cell) and have large pores (holes) which allows penicillin to enter easily and kill the cell from the inside.[1] Gram-negative bacteria are harder for penicillin to enter as they have smaller pores and an outer cell membrane so penicillin has to enter through smaller aqueous pores (holes in the membrane where water enters and leaves the cell). This means that killing Gram-negative bacteria takes a longer amount of time and some penicillin drugs may not work against them.[2]
Once the Penicillin is inside the bacteria, it destroys the bacterial cell wall by stopping new chains in the outer membrane from forming and so the structure of the membrane collapses. This means that there is no longer a structure to support the cell and control how much of substances can enter and leave so a large amount of water from the surroundings enters the cell until it can no longer function and so the cell dies.[3]
History
[change | change source]Penicillin was discovered by Scottish scientist Sir Alexander Fleming in 1928, but it was not mass-produced until 1940[4] when it was first used widely during World War II.
Penicillin was discovered when Fleming noticed a mold that was stopping bacteria from growing in a petri dish. Australian scientist Howard Walter Florey made the penicillin mold into a medicine. Together with another scientist Ernst Boris Chain, Fleming and Florey were given the Nobel Prize for Medicine in 1945. The first time penicillin was used in medicine to treat a bacterial infection was in 1930.
Modern day use
[change | change source]The antibiotic penicillin is naturally produced by fungi of the genus Penicillium.[5] There is now a whole group of antibiotics derived from Penicillium including penicillin G, procaine penicillin, benzathine penicillin, and penicillin V which are effective against different bacterial diseases.
Some people are allergic to penicillin. Side effects of taking antibiotics may include nausea, diarrhea, or a rash. Rarely, patients who are allergic to penicillin get a fever, vomit, or have serious skin irritation. Because it is such a popular antibiotic, penicillin is the most common cause of serious allergic reactions to a drug. They are now used regularly in hospitals but because it is so common in modern medicine, strains of bacteria have developed resistance against the antibiotic (the antibiotic can no longer kill the bacteria).
Total synthesis
[change | change source]Chemist John C. Sheehan at the Massachusetts Institute of Technology (MIT) did the first chemical synthesis of penicillin in 1957.[6][7][8]
References
[change | change source]- ↑ Lambert, P.A. (2002-05-01). "Cellular impermeability and uptake of biocides and antibiotics in Gram-positive bacteria and mycobacteria". Journal of Applied Microbiology. 92: 46S–54S. doi:10.1046/j.1365-2672.92.5s1.7.x. ISSN 1364-5072. PMID 12000612. S2CID 24067247.
- ↑ Masi, Muriel; Winterhalter, Mathias; Pagès, Jean-Marie (2019), "Outer Membrane Porins", Subcellular Biochemistry, Cham: Springer International Publishing, pp. 79–123, doi:10.1007/978-3-030-18768-2_4, ISBN 978-3-030-18767-5, PMID 31214985, S2CID 195066847, retrieved 2023-06-30
- ↑ Yocum, R.R.; Rasmussen, J.R.; Strominger, J.L. (May 1980). "The mechanism of action of penicillin. Penicillin acylates the active site of Bacillus stearothermophilus D-alanine carboxypeptidase". Journal of Biological Chemistry. 255 (9): 3977–3986. doi:10.1016/s0021-9258(19)85621-1. ISSN 0021-9258. PMID 7372662.
- ↑ Wainwright M. & Swan H.T. 1986. C.G. Paine and the earliest surviving clinical records of penicillin therapy. Medical History 30 (1): 42–56. [1]
- ↑ Kosalková, Katarina; Sánchez-Orejas, Isabel-Clara; Cueto, Laura; García-Estrada, Carlos (2021), "Penicillium chrysogenum Fermentation and Analysis of Benzylpenicillin by Bioassay and HPLC", Methods in Molecular Biology, New York, NY: Springer US, pp. 195–207, doi:10.1007/978-1-0716-1358-0_11, ISBN 978-1-0716-1357-3, PMID 33977449, retrieved 2023-06-30
- ↑ Sheehan, John C.; Henery-Logan, Kenneth R. (1957). "The total synthesis of Penicillin V". Journal of the American Chemical Society. 79 (5): 1262–1263. doi:10.1021/ja01562a063.
- ↑ Sheehan, John C.; Henery-Logan, Kenneth R. (1959). "The total synthesis of Penicillin V". Journal of the American Chemical Society. 81 (12): 3089–3094. doi:10.1021/ja01521a044.
- ↑ Corey E.J. & John D. Roberts 2013. "Biographical memoirs: John Clark Sheehan". The National Academy Press.
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