Cholinergic receptor muscarinic 5 (Q12746120)

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mammalian protein found in Homo sapiens

• muscarinic acetylcholine receptor M5
• CHRM5
• acetylcholine receptor, muscarinic 5

edit

Language	Label	Description	Also known as
English	Cholinergic receptor muscarinic 5	mammalian protein found in Homo sapiens	muscarinic acetylcholine receptor M5 CHRM5 acetylcholine receptor, muscarinic 5

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P08912

part of

Muscarinic acetylcholine receptor M5

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P08912

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P08912

encoded by

CHRM5

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P08912

molecular function

G protein-coupled receptor activity

determination method or standard

IEA

2 references

retrieved

5 June 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P08912

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08912&geneProductId=UniProtKB:P08912

determination method or standard

IEA

retrieved

5 June 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08912&geneProductId=UniProtKB:P08912

determination method or standard

IEA

signal transducer activity

determination method or standard

IEA

1 reference

retrieved

31 October 2017

stated in

GOA

curator

UniProt

UniProt protein ID

P08912

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08912&geneProductId=UniProtKB:P08912

determination method or standard

IEA

phosphatidylinositol phospholipase C activity

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

TAS

G protein-coupled acetylcholine receptor activity

determination method or standard

IBA

IEA

TAS

4 references

retrieved

8 April 2019

stated in

Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IBA

G protein-coupled receptor activity

determination method or standard

IBA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08912

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IBA

G protein-coupled serotonin receptor activity

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IBA

neurotransmitter receptor activity

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IBA

cell component

integral component of membrane

determination method or standard

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08912

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IEA

postsynaptic membrane

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08912

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IEA

membrane

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08912

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IEA

plasma membrane

determination method or standard

TAS

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

TAS

retrieved

8 April 2019

stated in

Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08912

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IEA

synapse

determination method or standard

IBA

IEA

2 references

retrieved

5 June 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P08912

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08912&geneProductId=UniProtKB:P08912

determination method or standard

IEA

retrieved

5 June 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08912&geneProductId=UniProtKB:P08912

determination method or standard

IBA

integral component of plasma membrane

determination method or standard

IEA

TAS

2 references

retrieved

5 June 2018

stated in

Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08912&geneProductId=UniProtKB:P08912

determination method or standard

TAS

retrieved

5 June 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08912&geneProductId=UniProtKB:P08912

determination method or standard

IEA

cell junction

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08912

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IEA

integral component of plasma membrane

determination method or standard

IBA

IEA

TAS

3 references

retrieved

8 April 2019

stated in

Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IBA

dendrite

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IBA

synapse

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08912

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IEA

biological process

G protein-coupled acetylcholine receptor signaling pathway

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

TAS

regulation of phosphatidylinositol dephosphorylation

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IEA

gastric acid secretion

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IEA

transmission of nerve impulse

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IEA

synaptic transmission, cholinergic

determination method or standard

IBA

1 reference

retrieved

5 June 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08912&geneProductId=UniProtKB:P08912

determination method or standard

IBA

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

determination method or standard

TAS

1 reference

retrieved

5 June 2018

stated in

Identification and molecular characterization of a m5 muscarinic receptor in A2058 human melanoma cells. Coupling to inhibition of adenylyl cyclase and stimulation of phospholipase A2

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08912&geneProductId=UniProtKB:P08912

determination method or standard

TAS

dopamine transport

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IEA

phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway

determination method or standard

IBA

1 reference

retrieved

5 June 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08912&geneProductId=UniProtKB:P08912

determination method or standard

IBA

cell population proliferation

determination method or standard

TAS

1 reference

retrieved

1 January 2018

stated in

Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

TAS

signal transduction

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08912

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IEA

G protein-coupled receptor signaling pathway

determination method or standard

IEA

TAS

3 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08912

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IEA

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IBA

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

determination method or standard

IBA

TAS

2 references

retrieved

8 April 2019

stated in

Identification and molecular characterization of a m5 muscarinic receptor in A2058 human melanoma cells. Coupling to inhibition of adenylyl cyclase and stimulation of phospholipase A2

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

TAS

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IBA

chemical synaptic transmission

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IBA

G protein-coupled serotonin receptor signaling pathway

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08912

determination method or standard

IEA

physically interacts with

acetylcholine

has use

agonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

294

language of work or name

English

retrieved

17 August 2016

milameline

has use

agonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

301

language of work or name

English

retrieved

17 August 2016

pilocarpine

has use

agonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

305

language of work or name

English

retrieved

17 August 2016

sabcomeline

has use

agonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

306

language of work or name

English

retrieved

17 August 2016

xanomeline

has use

agonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

57

language of work or name

English

retrieved

17 August 2016

brucine

has use

allosteric modulator

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

342

language of work or name

English

retrieved

17 August 2016

VU0238429

has use

allosteric modulator

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

3257

language of work or name

English

retrieved

17 August 2016

AFDX384

has use

antagonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

3264

language of work or name

English

retrieved

17 August 2016

amitriptyline

has use

antagonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

200

language of work or name

English

retrieved

17 August 2016

biperiden

has use

antagonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7128

language of work or name

English

retrieved

17 August 2016

darifenacin

has use

antagonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

321

language of work or name

English

retrieved

17 August 2016

glycopyrrolate

has use

antagonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7459

language of work or name

English

retrieved

17 August 2016

hexocyclium

has use

antagonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

323

language of work or name

English

retrieved

17 August 2016

himbacine

has use

antagonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

324

language of work or name

English

retrieved

17 August 2016

methoctramine free base

has use

antagonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

327

language of work or name

English

retrieved

17 August 2016

(RS)-oxybutynin

has use

antagonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

359

language of work or name

English

retrieved

17 August 2016

pirenzepine

has use

antagonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

328

language of work or name

English

retrieved

17 August 2016

3-quinuclidinyl-benzilate

has use

antagonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

318

language of work or name

English

retrieved

17 August 2016

tolterodine

has use

antagonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

360

language of work or name

English

retrieved

17 August 2016

umeclidinium

has use

antagonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7354

language of work or name

English

retrieved

17 August 2016

Gene Atlas image

PBB GE CHRM5 221347 at fs.png
732 × 530; 12 KB

0 references

has part(s)

GPCR, rhodopsin-like, 7TM

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P08912

Identifiers

RefSeq protein ID

NP_001307846

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1133

NP_036257

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1133

UniProt protein ID

P08912

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P08912

Ensembl protein ID

ENSP00000372750

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000372750

ENSP00000453745

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000453745

ENSP00000452742

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000452742

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q12746120&oldid=2114461336"