1-methyl-4-phenylpyridinium

English

Noun

1-methyl-4-phenylpyridinium (uncountable)

1. (organic chemistry) MPP+, the active metabolite of MPTP.
   • 2006, Zhang et al, Investigative Opthamological and Visual Science [1]

     Apical uptake was higher than basolateral uptake at 37 degrees C and was decreased to 70% in the presence of NaN(3) or in the absence of extracellular Na(+). Besides alpha2-agonists, apical uptake was inhibited by verapamil, desipramine, and quinidine, but not by MPP(+) (1-methyl-4-phenylpyridinium), TEA (tetraethylammonium), decynium-22, carnitine, PHA (p-aminohippurate), alanine, or inosine.

2. (neurotoxicology) A neurotoxin that cannot cross the blood-brain barrier but which, once in contact, can destroy the dopaminergic neurons of the substantia nigra.