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Use of Drug-level Testing and Single-genome Sequencing to Unravel a Case of Human Immunodeficiency Virus Seroconversion on Pre-exposure Prophylaxis
- Spinelli, Matthew A;
- Lowery, Brentton;
- Shuford, Jennifer A;
- Spindler, Jon;
- Kearney, Mary F;
- McFarlane, Jenny R;
- McDonald, Cheryl;
- Okochi, Hideaki;
- Phung, Nhi;
- Kuncze, Karen;
- Jee, Kathryn;
- Johannessen, DeeJay;
- Anderson, Peter L;
- Smith, Dawn K;
- Defechereux, Patricia;
- Grant, Robert M;
- Gandhi, Monica
- et al.
Published Web Location
https://doi.org/10.1093/cid/ciaa1011Abstract
Cases of seroconversion on pre-exposure prophylaxis (PrEP) should be carefully investigated, given their public health implications and rarity. We report a case of transmitted drug resistance causing seroconversion on PrEP in spite of high adherence, confirmed with dried blood spot and segmental hair drug-level testing and single-genome sequencing.
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