Diagnostic Problems in Tumors of Female Genital Tract: Selected Topics: DIAGNOSTIC PROBLEMS IN TUMOR PATHOLOGY SERIES, #3
By Kedar Deodhar and Arun Chitale
()
About this ebook
Histopathological evaluation is the gold standard in the diagnosis of malignant tumors and chronic diseases of visceral organs like liver, kidney and lungs. Histopathological analysis provides information that helps the clinician to choose the most appropriate treatment modality and assists in prognostication. Notwithstanding the current and future advances in the imaging technology and other innovations, the status of Histopathology will remain unchanged for decades to come.
Whereas Histopathology is the most objective form of investigation, there are many gray areas in arriving at a definitive diagnosis. On many occasions total lack of clinical information leads to avoidable errors in the diagnosis. The surgical pathologist is advised to keep the cases pending until adequate information is available. On the other hand there are numerous problems in histological interpretation even if the entire clinical information is at hand. This occurs because some lesions have inherent morphological ambiguities and no two surgical pathologists may agree on the correct histological diagnosis. One such lesion, for example, is verrucous squamous cell carcinoma of the oro-pharyngeal region or other organs with squamous epithelial lining. The most controversial problem in thyroid disorders is a lesion called follicular variant of papillary carcinoma. In every organ and system, there are sporadic entities, which have debatable criteria of morphological diagnosis. The object of this book is to adequately address problems of uncommon morphologic variations of common lesions and rare difficult lesions with the help of extensive illustrations. There are excellent frequently updated textbooks of surgical pathology, in which all lesions occurring in various sites are described, illustrated and backed by references. However, due to constraints of space, these problematic entities are not extensively illustrated or explained at length. This deficiency is admirably handled in exclusively individual organ pathology monograms. However, this requires the facility of a well-stocked library; most practicing surgical pathologists do not have access to these.
The proposed book is an attempt to address these lesions with multiple illustrations and detailed pertinent text. It is envisaged that the book should be a companion to a standard surgical pathology textbook and this should be accessible just at the fingertips via power of electronic media using internet. The targeted audience includes residents in Anatomic Pathology; young recently qualified pathologists and a large contingent of pathologists attached to medical institutions, in which the volume of surgical specimens is low.
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Diagnostic Problems in Tumors of Female Genital Tract - Kedar Deodhar
DIAGNOSTIC PROBLEMS IN TUMOR PATHOLOGY SERIES
Diagnostic Problems in Tumors of Female Genital Tract: Selected Topics
Authors
Kedar Deodhar, MD (Path), FRCpath
Professor & Pathologist
Tata Memorial Hospital, Mumbai, India
Arun Chitale, MD (Path), DABP
Diplomate American Board of Pathology (1969)
Surgical Pathologist
Sir HN Hospital, Jaslok Hospital, Surgical Pathology Center
Formerly Professor & Head Department of Pathology Bombay Hospital Institute of Medical Sciences, Mumbai, India
Published by Arun Chitale & Dhananjay Chitale at Smashwords
Copyright 2014 Chitale publications
Smashwords Edition, License Notes
This ebook is licensed for your personal reading only. This ebook may not be re-sold or given away to other people. If you would like to share this book with another person, please purchase an additional copy for each recipient. If you’re reading this book and did not purchase it, or it was not purchased for your use only, then please return to Smashwords.com and purchase your own copy. Thank you for respecting the hard work of the authors.
Series Editors
Arun Chitale, MD (Path), DABP
Diplomate American Board of Pathology (1969)
Surgical Pathologist
Sir HN Hospital, Jaslok Hospital, Surgical Pathology Center
Formerly Professor & Head Department of Pathology Bombay Hospital Institute of Medical Sciences, Mumbai, India
Dhananjay Chitale, MD (Path), DNB, DABP
Diplomate American Board of Pathology
Director, Molecular Pathology & Genomic Medicine,
Senior Staff Surgical Pathologist
Director, Tissue Biorepostiroy
Clinical Assistant Professor, Wayne State University School of Medicine
Henry Ford Hospital, Detroit, Michigan, USA
Diagnostic Problems in Tumors of Head and Neck: Selected Topics, 1/e
Arun Chitale, Dhananjay Chitale, 2014
Diagnostic Problems in Tumors of Gastrointestinal Tract Topics, 1/e
Arun Chitale, Dhananjay Chitale, 2014
Diagnostic Problems in Tumors of Female Genital Tract: Selected Topics, 1/e
Kedar Deodhar, Arun Chitale, 2014
Table of Content
Endometrioid Adenocarcinoma of Endometrium & variants
Cellular classification of Endometrial Carcinoma
Endometrial Hyperplasia
WHO Classification of Endometrial hyperplasia
Endometrioid Adenocarcinoma with Squamous Differentiation
Serous adenocarcinoma of endometrium
Serous Endometrial Cancers (SC) That Mimic Endometrioid Carcinomas (EC)
Endometrial Intraepithelial Carcinoma (EIC)
Serous carcinoma arising in endometrial polyp
Clear Cell Carcinoma of Endometrium (CCC)
Endometrial Adenocarcinoma in Women under 40 years of Age
Malignant Mixed Mullerian Tumors (MMMT)
Mullerian Adenosarcoma (MA)
Endometrial Stromal Tumor (EST)
Low Grade Endometrial Stroma Sarcoma
Endometrial Stromal Nodule
Uterine smooth muscle tumors
Leiomyosarcoma (LMS)
Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP)
Atypical leiomyoma
Epithelioid Smooth Muscle Tumors
Tumors of the uterine cervix
Minimal Deviation Adenocarcinoma of Cervix
Glandular Lesions of Cervix Mimicking Adenocarcinoma
Deep cervical glands and cysts
Tuboendometrioid Metaplasia (TEM) and Endometriosis
Microglandular Adenosis (MGA) or hyperplasia
Mesonephric remnants
Endocervical Glandular Dysplasia
Malignant Melanoma of Female Genital Tract
Mucosal Melanoma
Vulvar Melanoma
Paget’s disease of Vulva
Vaginal Melanoma
Cervical Melanoma
Sarcoma Botryoides (Embryonal Rhabdomyosarcoma)
Gestational Trophoblastic diseases
WHO Classification of Gestational Trophoblastic diseases
Placental site trophoblastic tumor (PSTT)
Exaggerated placental site reaction(synonymous with Syncitial endometritis
)
Placental Site Nodule/Plaque (PSN-P)
Tumors of the Ovary
Surface Epithelial Tumors
Serous borderline tumors (SBT) Synonyms
Serous borderline tumors with microinvasion
‘SBT with micropapillary pattern’ or is it micropapillary carcinoma?
Serous borderline tumors with lymph node involvement
Serous Carcinomas of Ovary
Mucinous borderline tumors
Mucinous Borderline Tumors
MBT of intestinal type
Intraepithelial carcinoma and microinvasion in intestinal MBT
MBT: ovarian primary or metastatic mucinous carcinoma
Pseudomyxoma Peritonei (PMP)
Clear cell carcinoma of the ovary
Gonadoblastoma (Germ cell-sex cord-stromal tumor)
Metastatic Tumors in ovaries (Krukenberg tumors
)
Distinction between Primary and Metastatic Mucinous Carcinomas of the Ovary
Aggressive Angiomyxoma (AAM)
PEComa of the Female Genital Tract
Fallopian Tube Serous Carcinoma &Molecular Pathogenesis of Ovarian Carcinoma
References
PREFACE:
DIAGNOSTIC PROBLEMS IN SURGICAL PATHOLOGY:
Uncommon presentation of common lesions and rare lesions
Histopathological evaluation is the gold standard in the diagnosis of malignant tumors and chronic diseases of visceral organs like liver, kidney and lungs. Histopathological analysis provides information that helps the clinician to choose the most appropriate treatment modality and assists in prognostication. Notwithstanding the current and future advances in the imaging technology and other innovations, the status of Histopathology will remain unchanged for decades to come.
Whereas Histopathology is the most objective form of investigation, there are many gray areas in arriving at a definitive diagnosis. On many occasions total lack of clinical information leads to avoidable errors in the diagnosis. The surgical pathologist is advised to keep the cases pending until adequate information is available. On the other hand there are numerous problems in histological interpretation even if the entire clinical information is at hand. This occurs because some lesions have inherent morphological ambiguities and no two surgical pathologists may agree on the correct histological diagnosis. One such lesion, for example, is verrucous squamous cell carcinoma of the oro-pharyngeal region or other organs with squamous epithelial lining. The most controversial problem in thyroid disorders is a lesion called follicular variant of papillary carcinoma. In every organ and system, there are sporadic entities, which have debatable criteria of morphological diagnosis. The object of this book is to adequately address problems of uncommon morphologic variations of common lesions and rare difficult lesions with the help of extensive illustrations. There are excellent frequently updated textbooks of surgical pathology, in which all lesions occurring in various sites are described, illustrated and backed by references. However, due to constraints of space, these problematic entities are not extensively illustrated or explained at length. This deficiency is admirably handled in exclusively individual organ pathology monograms. However, this requires the facility of a well-stocked library; most practicing surgical pathologists do not have access to these.
The proposed book is an attempt to address these lesions with multiple illustrations and detailed pertinent text. It is envisaged that the book should be a companion to a standard surgical pathology textbook and this should be accessible just at the fingertips via power of electronic media using internet. The targeted audience includes residents in Anatomic Pathology; young recently qualified pathologists and a large contingent of pathologists attached to medical institutions, in which the volume of surgical specimens is low.
Note on statistical data presented in this eBook:
The senior author (ARC) has been a practicing consultant surgical pathologist for the last 44 years (1969-2013). As a surgical pathologist, he has been associated with ‘surgical pathology center’ (his own lab). He is also attached to the following hospitals in Mumbai (Bombay): Sir H N Hospital, Bombay Hospital and Jaslok Hospital (all corporate institutions), Bone Registry, Grant Medical College; Cytology department of KEM Hospital.
He has gathered vast amount of neoplastic cases of different organ-systems and the data has been in the form of Tables for different organ systems. The statistical tabulation of tumors has been based on classification of anatomical site and behavior (benign or malignant). This is not purported to be a population based epidemiological data. However, the data likely represents a fair cross sectional distribution and representation of various neoplasms in the population served in Metropolitan Mumbai (Bombay), India.
DISCLAIMER:
This Book titled Diagnostic Problems in tumors of Female Genital tract: selected topics, is made available by the Authors solely for trained and licensed physician for personal, non-commercial teaching and educational use. No two individual patients with neoplasms are identical and therefore diagnosis and treatment varies greatly depending on the medical and surgical history. The information contained in this Book is not medical advice. It is the professional responsibility of the practitioner to apply the information provided in a specific situation. Attention has been taken for accuracy of the information presented to describe generally accepted practices; however, knowledge and best practice in the field constantly change with new research. Readers are advised to check the most current information. The authors, editors and publishers are not responsible for errors or omissions or for