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Neuro-Oncology News
FDA approves Gomekli for neurofibromatosis type 1 with plexiform neurofibromas
The FDA has approved an oral, small molecule MEK inhibitor for adult and pediatric patients 2 years of age and older with neurofibromatosis type 1 who have symptomatic plexiform neurofibromas not amenable to complete resection.
Exposure to CT radiation increases risk for childhood brain tumors
Exposure to radiation from head or neck CT imaging increased risk for childhood brain tumors, according to results of a nationwide population-based study conducted in Finland.
Temozolomide regimen extends survival for people with grade 2 gliomas
The addition of temozolomide to radiation therapy prolonged OS for patients with both co-deleted and non-co-deleted grade 2 gliomas, according to study results.
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Malignant glioma diagnosed earlier in men
An analysis of adults with malignant glioma revealed that men were diagnosed at a younger age and women had worse preoperative status, but researchers found no other sex-related differences or clinical advantage.
CAR T-cell therapy produces ‘jaw dropping’ results for deadly pediatric brain tumors
Chimeric antigen receptor T-cell therapy can reduce tumor burden and improve neurologic function for patients with certain brain and spinal cord cancers, a first-in-human clinical trial showed.
De-escalated adjuvant chemotherapy effective for high-risk retinoblastoma
A shortened adjuvant chemotherapy regimen improved outcomes for infants with unilateral pathologic high-risk retinoblastoma, according to study results.
Addition of veliparib to temozolomide fails to extend survival in glioblastoma
The addition of veliparib to adjuvant temozolomide failed to improve OS for patients with newly diagnosed, MGMT-hypermethylated glioblastoma, according to randomized phase 2/phase3 study results.
MS linked to greater risk for certain cancers
People with MS had an increased risk for bladder, brain and cervical cancers compared with people without MS, according to a new study in Neurology, the medical journal of the American Academy of Neurology.
Trial to assess personalized vaccine for aggressive brain tumors
A first-in-human clinical trial will assess the safety of a personalized vaccine to treat diffuse hemispheric glioma, an aggressive brain tumor.
Young children treated for brain tumors less ready for school than their peers
Young children who underwent treatment for brain tumors had lower academic readiness scores than their peers, according to results of a prospective longitudinal trial.
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