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Self-adaptive Biosystems Through Tunable Genetic Parts and Circuits

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Vittorio Bartoli,Mario di Bernardo,

Thomas E. Gorochowski^*

Vittorio Bartoli,Mario di Bernardo,

Thomas E. Gorochowski^*

This version is not peer-reviewed

Submitted:

06 October 2020

Posted:

06 October 2020

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Abstract

Biological systems often need to operate in complex environments where conditions can rapidly change. This is possible due to their inherent ability to sense changes and adapt their behavior in response. Here, we detail recent advances in the creation of synthetic genetic parts and circuits whose behaviors can be dynamically tuned through a variety of intra- and extra-cellular signals. We show how this capability lays the foundation for implementing control engineering schemes in living cells and allows for the creation of biological systems that are able to self-adapt, ensuring their functionality is maintained in the face of varying environmental and physiological conditions. We end by discussing some of the broader implications of this technology for the safe deployment of synthetic biology.

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Subject: Biology and Life Sciences - Biochemistry and Molecular Biology

Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.