Prerpints.org logo
Preprint
Review

Fueling the Heart: What Are the Optimal Dietary Strategies in Heart Failure?

Altmetrics

Downloads

142

Views

82

Comments

0

A peer-reviewed article of this preprint also exists.

Submitted:

02 August 2024

Posted:

05 August 2024

You are already at the latest version

Alerts
Abstract
Heart failure (HF) is a global health concern with rising incidence and poor prognosis. While the essential role of nutritional and dietary strategies in HF patients is acknowledged in the existing scientific guidelines and clinical practice, there are no comprehensive nutritional recommendations for optimal dietary management of HF. In this review, we discuss results from recent studies on the obesity paradox and the effects of calorie restriction and weight loss, intermittent fasting, the Western diet, the Mediterranean diet, the ketogenic diet, and the DASH diet on HF progression. Many of these strategies remain under clinical and basic investigation for their safety and efficacy, and there is considerable heterogeneity in the observed response, presumably because of heterogeneity in the pathogenesis of different types of HF. In addition, while specific aspects of cardiac metabolism, such as changes in ketone body utilization, might underlie the effects of certain dietary strategies on the heart, there is a critical divide between supplement strategies (i.e. with ketones) and dietary strategies that impact ketogenesis. This review aims to highlight this gap by exploring emerging evidence supporting the importance of personalized dietary strategies to prevent progression and improve outcomes in the context of HF.
Keywords: 
Subject: Medicine and Pharmacology  -   Dietetics and Nutrition
Anahita Ataran 1, Alexander Pompian 1, Hamidreza Hajirezaei 1, Rehman Lodhi 1 and Ali Javaheri 1,2,*
1 Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO, USA; [email protected] (A.A.); [email protected] (A.P.); [email protected] (H.H.); [email protected] (R.L.)
2 John Cochran VA Hospital, St Louis, MO, USA

Epidemiology and Metabolic Alteration in Heart Failure

A simple definition of heart failure (HF) is that the heart fails to pump efficiently, either with lower than normal output or under increased filling pressures. In the case of end-stage disease, left ventricular dysfunction leads to insufficient cardiac output, failure to supply the metabolic demands of the body, and volume overload with multi-organ congestion [1]. In developed countries, HF affects 1% to 3% of the general population [2], with a 5-year mortality rate of approximately 50% [3]. HF is the leading cause of hospitalization among older adults, with increasing prevalence in the elderly [4], ranging from 20 per 1000 in individuals aged 65 to 69 to over 80 per 1000 in those aged 85 and more [5,6]. Other major risk factors for HF include obesity, socioeconomic status, hypertension, coronary heart disease (CHD), diabetes, chronic kidney disease, smoking, chronic obstructive pulmonary disease (COPD), and rheumatic heart disease [1,6,7]. Additionally, HF can develop after myocarditis secondary to viral infections including parvovirus, enteroviruses, adenovirus, coxsackievirus B, human herpesvirus 6, COVID-19, and others [8,9]. Though age is categorized as a non-modifiable risk factor, different studies have been conducted to explore methods aimed at decelerating the pace of cardiovascular aging [1,10,11]. In this context, cardiovascular aging encompasses a variety of biological changes, such as cellular senescence, telomere shortening, altered intercellular communication, chronic inflammation, and genomic instability. [1,12]. The convergence of these conditions, coupled with the prevalent chief complaint of anorexia and malnutrition experienced by many HF patients, can disrupt metabolic homeostasis [13]. Consequently, as HF progresses to more advanced stages, patients can develop cachexia and sarcopenia, further exacerbating HF debility [14,15,16].
Metabolic disruption is central to the pathology of HF. Under normal conditions, myocardial tissue dynamically utilizes diverse substrates to fulfill its considerable energy demands and can generate adenosine triphosphate (ATP) via two primary means: glycolysis and mitochondrial oxidative phosphorylation. Of these, mitochondrial oxidative phosphorylation predominates in ATP production [17,18], with fatty acid oxidation contributing to 70-90% of ATP production [19]. In a healthy heart, metabolic flexibility allows for the seamless transition between different energy substrates, depending on factors such as substrate availability, cardiac workload, and hormonal status [20]. However, due to impaired crucial cellular processes including impaired mitochondrial function and diminished biogenesis, metabolic adaptability is compromised in HF, and insufficient metabolism can be a major underlying mechanism of cardiac dysfunction in heart failure [17,21].
Given these complex metabolic challenges, HF is classified into three main subtypes: i) heart failure with reduced ejection fraction (HFrEF), defined as left ventricular EF <40%; ii) heart failure with preserved ejection fraction (HFpEF), with EF >50%, and iii) heart failure with midrange ejection fraction (HFmrEF), with EF ranging between >40% and <50% [5,22,23,24,25], with HFrEF and HFpEF being better studied than HFmrEF. Despite the distinct classifications of HF subtypes, there are still limited human clinical trials addressing the optimal dietary regimen for each specific subtype. Herein, we delve into different dietary interventions that mitigate or aggravate energy metabolism in the cardiac tissue, and how they could be tailored to the evolving stages of HF to improve duration and quality of life and mitigate disease progression, noting that further research is essential to elucidate the most effective approaches.

Dietary Strategies to Prevent and Treat Heart Failure

Although research continues to explore how modulating nutrient intake can mitigate metabolic imbalances associated with HF, there are currently no detailed dietary guidelines customized specifically for this condition [14]. Preventive dietary strategies in the context of HF mainly include early interventions to prevent development of HF-associated risk factors including hypertension, obesity, and the onset of disease [26]. To date, several dietary regimens have been shown to mitigate HF risk factors, with some even implicated as therapeutic with respect to pre-existing HF.

Dietary Approach to Stop Hypertension (DASH) Diet

The Dietary Approaches to Stop Hypertension (DASH) diet is a well-established diet for preventing hypertension and consequent heart failure. The original diet, developed in the early 90s, emphasized “fruits, vegetables, and low-fat dairy,” and was found to be effective at lowering both systolic and diastolic blood pressure in the original clinical trial [27,28]. Following this, a second trial was carried out testing the diet in combination with varying sodium intake. In the trial, across three levels of sodium intake (high: ~3.3g/2100kcal, intermediate: ~2.5g/2100kcal, and low: ~1.5g/2100kcal), the DASH diet in tandem with lower sodium decreased blood pressure more than either variable individually [29]. Given the average American’s sodium intake (~3.5g/day), DASH guidelines were updated to recommend 2300mg sodium daily, noting that 1500mg/day lowers blood pressure even more [30,31,32,33].
In the context of HF, increased sodium intake is associated with a 19% increase in incident HF (after adjusting for demographic and lifestyle variables) [34,35]. However, it should be noted that there are arguments advocating against sodium restriction alone in patients with HF. Especially at levels <1500mg per day, patients may find adherence to sodium restriction “difficult or impossible” [36]. Additionally, animal studies have shown extremely low-sodium diets can exacerbate HF through renin-angiotensin-aldosterone system (RAAS) activation, which causes salt and water retention to increase preload and afterload [37]. Thus, a lack of evidence makes it difficult to recommend a “lower limit” on sodium intake that patients should adopt to attenuate existing HF. Nonetheless, adherence to the standard DASH diet as a whole has been inversely associated with the incidence of heart failure, mainly through lowering blood pressure and increasing insulin sensitivity, especially among individuals less than 75 years old [38,39,40]. Additionally, though more sparse, data also suggests adherence to the DASH diet is associated with a modest reduction in HF mortality [41]. Therefore, wholistic implementation of the DASH diet can be reasonably recommended as a dietary strategy for HF patients. Although the diet has been clearly shown to improve cardiovascular disease risk factors, the pros and cons of long-term adherence to this diet should be further investigated [42,43].

Mediterranean Diet

Like the DASH diet, the Mediterranean diet emphasizes plant-derived foods (fruits, vegetables, nuts, and legumes), whole grains, moderate intake of fish/poultry, and is generally low in saturated fats, red meat, alcohol, and processed foods [44,45,46,47]. However, it should be noted that moderate consumption of wine (preferably red wine) with meals has also been suggested as an essential element of Mediterranean diet [47]. In contrast to the DASH diet, which limits total fat (especially saturated fatty acids), the Mediterranean diet suggests increasing unsaturated fatty acid intake, especially though consumption of olive oil [35]. The diet has been shown to reduce the risk of cardiovascular diseases, including HF, in both healthy individuals and people with prior cardiovascular diseases [48]. A review by Oppedisano et al. highlights that dietary supplementation with n-3 polyunsaturated fatty acid (PUFAs) has anti-inflammatory and cardioprotective effects, with benefits linked to dosage and treatment duration [49]. However, the exact underlying mechanisms of the protective effects of this dietary regimen have yet to be determined [44]. Olive oil/unsaturated fat consumption (especially as a substitute for saturated fats) has been associated with decreased risk of cardiovascular disease and all-cause mortality, though HF-specific trials have yet to be carried out [50,51,52]. Importantly, like the DASH diet, no singular aspect of the Mediterranean diet has been found to be as beneficial as the overall diet [46]. A similar diet to Mediterranean diet is the plant-based EAT-Lancet diet, but with a greater emphasis on legumes and cereals [53]. This diet has been found to lower the risk of heart failure with higher adherence, identifying eight plasma proteins that may mediate this relationship (Apolipoprotein-M, Growth Differentiation Factor-15, Interleukin-6, TIM, Cathepsin D, CCL20, FS, and FUR). This study by Zhang, et al. proposes that these plasma proteins are inversely associated with the risk of HF and might mediate the protective effects of this diet [54].

Weight Loss Strategies and Heart Failure

Obesity, defined as a body mass index (BMI) of 30 kg/m2 or higher, is a well-known risk factor for HF [55,56]. For example, in patients with type 2 diabetes, weight loss (average 15%) as a result of glucagon-like peptide 1 receptor agonists (GLP-1 RAs) was found to lower the risk of HF hospitalization by 9% (HR: 0·91, 95%CI: 0·83–0·99; p=0·028) according to a meta-analysis of 7 randomized controlled trials [57]. Moreover, an analysis of HF incidence following bariatric surgery (15-25% weight loss) found incidence to be reduced by half (HR: 0.50, 95% CI 0.38–0.66, p=<0.001) [58]. Interestingly, however, once individuals have developed HF, a higher BMI is associated with improved outcomes [59,60,61,62]. This “obesity paradox" raises an important conundrum: specifically, how obesity should be treated clinically in the context of HF. Though more evidence is needed, current recommendations do not purport GLP-1 RAs as protective in overweight/obese patients (BMI >25kg/m2) with pre-existing advanced HFrEF where GLP-1 RA treatment may increase the risk of HF-rehospitalization (HR 1.33, 95% CI 0.83-2.12) [63], although evolving evidence suggests GLP-1 RA could certainly benefit those with HFpEF [64]. On the other hand, HF patients with a BMI >35 kg/m2 who underwent bariatric surgery experienced a lower risk of all-cause mortality (HR, 0.55 [95% CI, 0.49–0.63]; P<0.001) and a greater reduction in HF hospitalization (rate ratio, 0.72 [95% CI, 0.67–0.77]; P<0.001) [65]. Therefore, further investigation into the merit of weight-loss oriented dietary strategies in the context of HF is warranted.

Intermittent Fasting and Caloric Restriction

Various dietary approaches such as the 16/8 method, the 5:2 diet, and the 12/12 method, have been developed to address cardiometabolic benefits and drawbacks of intermittent fasting (IF) [66]. Various clinical trials have also explored the effects of fasting on body weight, insulin sensitivity and overall metabolic health [66,67,68]. A recent human clinical trial from patients with ST-elevation myocardial infarction (STEMI) showed that IF significantly improved left ventricular ejection fraction and reduced diastolic blood pressure compared to regular diet, with improvement occurring up to 6 months after STEMI [69]. However, to date, no randomized controlled trials in humans have specifically investigated the effects of fasting on HF progression. In contrast, animal studies suggested that alternate day fasting (ADF), a commonly used form IF in rodent models, potentiates cardiotoxic effects of doxorubicin chemotherapy, which causes HF in humans, highlighting the need for cautious exploration of IF in this context [70]. Mechanistically, ADF increases myocardial nuclear transcription factor EB (TFEB), which drives HF progression after doxorubicin [70]. However, other rodent studies do corroborate potential beneficial effects of IF in the cardiometabolic disease setting suggesting that the role of IF may be context dependent [71,72,73]. Numerous other studies have reviewed both continuous energy restriction and intermittent energy restriction for their other effects on reducing body fat mass, promoting weight loss, and improving cardiovascular health [74,75,76]. In a randomized controlled trial involving geriatric obese patients with HFpEF, caloric restriction alone led to a significant reduction in serum Interleukin-6, TNF-α-receptor-I, growth differentiation factor-15, cystatin C, and N-terminal pro-b-type natriuretic peptide) (Table 1.), resulting in improved physical performance and exercise tolerance compared to the group that combined caloric restriction with aerobic exercise [77]. In a separate randomized controlled trial, no significant impact on patients’ quality of life was found when they underwent caloric restriction, aerobic exercise, or a combination of both, as assessed through a questionnaire-based evaluation (Table 1.) [78]. On the other hand, insufficient caloric intake is known to worsen post-discharge quality of life and increase burden of readmission in HF patients [79]. Therefore, the potential benefits of calorie restriction must be determined on a case-by-case basis [76]. Although a sustained, 5-10% weight loss is recommended in HF patients with a BMI >35 kg/m2, weight loss puts lower-BMI groups at greater risk of mortality, likely reflective of cachexia [80]. Without the addition of resistance training, weight lost across all groups as a result of calorie restriction can be, in part, due to a loss of skeletal muscle mass [81]. Thus, calorie restriction alone cannot be universally recommended as an HF treatment, but rather a strategy to mitigate one of its main risk factors: obesity [80].

Alternative Dietary Strategies for Heart Failure

High Fat. Western, and Ketogenic Diet

In Western nations, the most common diets are high in calories, fats, and sugars such as fructose and sucrose, contributing to chronic conditions such as hypertension and type 2 diabetes, which are other common risk factors for HF [82,83,84]. Generally, high fat and Western-type diets are used to induce obesity, metabolic syndrome, and diabetes in mouse models and are associated with cardiac dysfunction [85,86,87,88]. In such models, long term adherence to the Western diet specifically leads to impaired glucose tolerance and changes in lipid storage dynamics (higher triglyceride levels with reduced turnover), resulting in the development of a unique phenotype of metabolic stress.
While a prior study suggested that a high fat diet (60% fat, 20% carb, and 20% protein, compared to a 17% fat, 54% carb, 29% protein chow diet) causes systolic dysfunction in mice by reducing sirtuin 3 [87], these results have been called into question by other models that suggest a high fat diet can improve cardiac function [85,86]. Interestingly, in a model of mitochondrial pyruvate carrier deficiency that caused reduced EF in mice, high-fat diet feeding with either a ketogenic or non-ketogenic diet reversed cardiac dysfunction [89]. Ketones may have protective effects on cardiac metabolism due to effective energy production compared to FAs [90]. In essence, the ketogenic diet -high in fat and low in carbohydrates- aims to induce ketosis by decreasing carbohydrates leading to increased myocardial fatty acid oxidation and ketone utilization. Given that ketones are considered an efficient and increasingly utilized source of fuel in a failing heart [91], the ketogenic diet, along with beta-hydroxybutyrate (BHB, a key byproduct of ketosis) supplementation has been increasingly studied in recent years [92,93,94,95,96]. One mechanism by which the ketogenic diet may improve myocardial health is through BHB-mediated inhibition of NLRP3 inflammasome and consequent improvement of chronic inflammation [97]. However, in the context of HF, animal studies incorporating the ketogenic diet have yielded mixed results as recent studies suggest that it induces cellular senescence in multiple organs, including the heart [98,99]. Additionally, in humans, how the ketogenic diet is implemented may influence the extent of its therapeutic effects. For example, carbohydrate restricted diets are often associated with increased mortality -- but only when carbs are replaced with animal-derived protein and fat. When replaced with equivalent plant-based counterparts, Seidelmann et al. found that mortality decreased [100]. In comparison to a high carbohydrate diet, a low carbohydrate diet has been shown to lead to a greater weight loss due to the enhanced loss of water weight and fat loss with beneficial effects on glycemic control [101]. Additionally, one model comparing the continuous ketogenic diet versus the alternate-day ketogenic diet showed that the continued ketogenic diet failed to protect against HF, whereas alternate-day ketogenic diet exerted significant cardioprotective effects against HF and did not impair the capacity of hepatic ketogenesis [102]. Thus, the evidence suggests that our understanding of the mechanisms behind the ketogenic diet and its role in treating HF requires much further study.

Supplemental Strategies in Heart Failure

Alongside dietary and lifestyle modifications for heart failure patients, there is great investment and interest in supplements (nutriceuticals) to enhance heart failure management. For example, a clinical trial testing BHB supplementation in 24 HFrEF patients showed significant increases in cardiac output, stroke volume, and LVEF vs placebo. The patients underwent 11C-Acetate PET examinations to assess myocardial energy expenditure (MEE) and myocardial oxygen consumption (MVO2) and it was found that BHB infusion led to increases in MVO2 while MEE remained the same, suggesting that BHB may improve cardiac function without impairing the energy expenditure of the heart. Further clinical trials are currently underway [103,104,105,106]. Beetroot juice is also under investigation, having been shown to reduce infarct size and improve heart function in mice in addition to its antihypertensive properties and ability to increase exercise capacity in humans with HFpEF [107,108]. Mechanistically, inorganic nitrate/nitrite content in beetroot is thought to be responsible for its ameliorative effects, however randomized trials on nitrites have yet to show a benefit [109]. Ongoing randomized clinical trials have yet to be concluded on inorganic nitrates [110]. In HF patients with vitamin deficiency, vitamin supplementation can also exert significant therapeutic effects. For example, Vitamin B1 (thiamine) deficiency is known to cause HF, and its repletion has been shown to significantly improve LVEF in B1-deficient patients with HFrEF, along with improvements in the 6-minute walking test [111,112,113]. Vitamin C deficiency is also common in HF patients, and relative plasma levels thereof can predict the risk of HF across men and women aged 39-79. Although there has been investigation into several other supplementation strategies in HF (e.g taurine, vitamin D, etc.; see Dragan et al. for review), treating various nutrient deficiencies with supplementation can be avoided altogether by adhering to dietary strategies like the aforementioned Med and DASH diets, making them a more well-rounded approach to treating and preventing HF [114].

Conclusion and Future Perspectives

Taken together, while some popular dietary strategies offer limited benefits and require further research, one principle remains consistent: dietary strategies in patients with HF are most effective when aligned with the principles of the DASH or Mediterranean diets, which emphasize plant-based foods and low saturated fats [98]. For patients who may benefit from sodium restriction, the DASH diet, which implements many aspects of the Med diet, also shows promise (Figure 1.).
It should be noted, as previously stated, that a change in one’s dietary pattern does not unilaterally prevent HF, but rather mitigates its risk factors, such as obesity and hypotension [34,46]. Thus, lifestyle changes with the goal of preventing HF should target these risk factors, rather than one specific dietary pattern. In addition to traditional dietary approaches, further research should also explore the role of personalized nutrition. Given individual differences in genetics, lifestyle, and metabolic responses, personalized nutrition has the potential to tailor dietary recommendations more effectively. A significant challenge in dietary studies is understanding the metabolic changes and adaptations that occur with different diets. Assessing the physiological response to various nutrient signaling pathways in a single organ is complex and may seem unrealistic. However, elucidating the underlying mechanisms of different nutrients could significantly impact the identification of most effective diet for conditions such as heart failure. Looking ahead, more basic research and randomized trials of various scales and durations are needed to enhance our understanding of metabolic shifts under different diets and evaluate the long-term outcomes of different dietary regimens.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Goyal, P.; Maurer, M.S.; Roh, J. Aging in Heart Failure. JACC: Heart Failure 2024, 12, 795–809. [Google Scholar] [CrossRef] [PubMed]
  2. Lam, C.S.P.; Docherty, K.F.; Ho, J.E.; McMurray, J.J.V.; Myhre, P.L.; Omland, T. Recent Successes in Heart Failure Treatment. Nat Med 2023, 29, 2424–2437. [Google Scholar] [CrossRef] [PubMed]
  3. DeBerge, M.; Shah, S.J.; Wilsbacher, L.; Thorp, E.B. Macrophages in Heart Failure with Reduced versus Preserved Ejection Fraction. Trends in Molecular Medicine 2019, 25, 328–340. [Google Scholar] [CrossRef] [PubMed]
  4. Mahajan, R.; Stokes, M.; Elliott, A.; Munawar, D.A.; Khokhar, K.B.; Thiyagarajah, A.; Hendriks, J.; Linz, D.; Gallagher, C.; Kaye, D.; et al. Complex Interaction of Obesity, Intentional Weight Loss and Heart Failure: A Systematic Review and Meta-Analysis. Heart 2020, 106, 58–68. [Google Scholar] [CrossRef] [PubMed]
  5. Snipelisky, D.; Chaudhry, S.-P.; Stewart, G.C. The Many Faces of Heart Failure. Cardiac Electrophysiology Clinics 2019, 11, 11–20. [Google Scholar] [CrossRef] [PubMed]
  6. Zhang, H.; Huetteman, A.T.; Reyes, E.A.; Appelbaum, J.S. Effects of Sacubitril–Valsartan in Patients With Various Types of Heart Failure: A Meta-Analysis. Journal of Cardiovascular Pharmacology 2023, 81, 434–444. [Google Scholar] [CrossRef] [PubMed]
  7. Zhao, L.; Zierath, R.; John, J.E.; Claggett, B.L.; Hall, M.E.; Clark, D.; Butler, K.R.; Correa, A.; Shah, A.M. Subclinical Risk Factors for Heart Failure With Preserved and Reduced Ejection Fraction Among Black Adults. JAMA Netw Open 2022, 5, e2231878. [Google Scholar] [CrossRef]
  8. Salavati, E.; Hajirezaee, H.; Niazkar, H.R.; Ramezani, M.S.; Sargazi, A. COVID-19 Patients May Present with Myocarditis: A Case Report Emphasizing the Cardiac Involvement of SARS-CoV-2. Med. J. Islam. Republ. Iran 2021. [Google Scholar] [CrossRef]
  9. Verma, A.K.; Olagoke, O.; Moreno, J.D.; Rezaee, N.; Ma, P.; Liu, J.; Javaheri, A.; Lavine, K.; Masood, M.F.; Lin, C.-Y. SARS-CoV-2–Associated Myocarditis: A Case of Direct Myocardial Injury. Circ: Heart Failure 2022, 15, e008273. [Google Scholar] [CrossRef]
  10. Liberale, L.; Kraler, S.; Camici, G.G.; Lüscher, T.F. Ageing and Longevity Genes in Cardiovascular Diseases. Basic Clin Pharma Tox 2020, 127, 120–131. [Google Scholar] [CrossRef]
  11. The Dynamic Interplay between Cardiac Mitochondrial Health and Myocardial Structural Remodeling in Metabolic Heart Disease, Aging, and Heart Failure. J Cardiovasc Aging 2023, 3, 9. [CrossRef] [PubMed]
  12. Pietri, P.; Stefanadis, C. Cardiovascular Aging and Longevity. Journal of the American College of Cardiology 2021, 77, 189–204. [Google Scholar] [CrossRef] [PubMed]
  13. Bahls, M.; Felix, S.B. Cachexia and Right Ventricular Dysfunction in Chronic Heart Failure: What Is the Chicken and What the Egg? Eur Heart J 2016, 37, 1692–1694. [Google Scholar] [CrossRef] [PubMed]
  14. Vest, A.R.; Chan, M.; Deswal, A.; Givertz, M.M.; Lekavich, C.; Lennie, T.; Litwin, S.E.; Parsly, L.; Rodgers, J.E.; Rich, M.W.; et al. Nutrition, Obesity, and Cachexia in Patients With Heart Failure: A Consensus Statement from the Heart Failure Society of America Scientific Statements Committee. Journal of Cardiac Failure 2019, 25, 380–400. [Google Scholar] [CrossRef] [PubMed]
  15. Von Haehling, S. The Wasting Continuum in Heart Failure: From Sarcopenia to Cachexia. Proc. Nutr. Soc. 2015, 74, 367–377. [Google Scholar] [CrossRef] [PubMed]
  16. Krysztofiak, H.; Wleklik, M.; Migaj, J.; Dudek, M.; Uchmanowicz, I.; Lisiak, M.; Kubielas, G.; Straburzyńska-Migaj, E.; Lesiak, M.; Kałużna-Oleksy, M. Cardiac Cachexia: A Well-Known but Challenging Complication of Heart Failure. CIA 2020, Volume 15, 2041–2051. [Google Scholar] [CrossRef]
  17. Lopaschuk, G.D.; Karwi, Q.G.; Tian, R.; Wende, A.R.; Abel, E.D. Cardiac Energy Metabolism in Heart Failure. Circulation Research 2021, 128, 1487–1513. [Google Scholar] [CrossRef] [PubMed]
  18. Finck, B.N.; Lehman, J.J.; Leone, T.C.; Welch, M.J.; Bennett, M.J.; Kovacs, A.; Han, X.; Gross, R.W.; Kozak, R.; Lopaschuk, G.D.; et al. The Cardiac Phenotype Induced by PPARα Overexpression Mimics That Caused by Diabetes Mellitus. J. Clin. Invest. 2002, 109, 121–130. [Google Scholar] [CrossRef] [PubMed]
  19. Doenst, T.; Nguyen, T.D.; Abel, E.D. Cardiac Metabolism in Heart Failure: Implications Beyond ATP Production. Circulation Research 2013, 113, 709–724. [Google Scholar] [CrossRef]
  20. Capone, F.; Sotomayor-Flores, C.; Bode, D.; Wang, R.; Rodolico, D.; Strocchi, S.; Schiattarella, G.G. Cardiac Metabolism in HFpEF: From Fuel to Signalling. Cardiovascular Research 2023, 118, 3556–3575. [Google Scholar] [CrossRef]
  21. Karwi, Q.G.; Uddin, G.M.; Ho, K.L.; Lopaschuk, G.D. Loss of Metabolic Flexibility in the Failing Heart. Front. Cardiovasc. Med. 2018, 5, 68. [Google Scholar] [CrossRef] [PubMed]
  22. Lam, C.S.P.; Donal, E.; Kraigher-Krainer, E.; Vasan, R.S. Epidemiology and Clinical Course of Heart Failure with Preserved Ejection Fraction. European J of Heart Fail 2011, 13, 18–28. [Google Scholar] [CrossRef] [PubMed]
  23. Solomon, S.D.; McMurray, J.J.V.; Anand, I.S.; Ge, J.; Lam, C.S.P.; Maggioni, A.P.; Martinez, F.; Packer, M.; Pfeffer, M.A.; Pieske, B.; et al. Angiotensin–Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction. N Engl J Med 2019, 381, 1609–1620. [Google Scholar] [CrossRef] [PubMed]
  24. Nie, D.; Xiong, B.; Qian, J.; Rong, S.; Yao, Y.; Huang, J. The Effect of Sacubitril-Valsartan in Heart Failure Patients With Mid-Range and Preserved Ejection Fraction: A Meta-Analysis. Heart, Lung and Circulation 2021, 30, 683–691. [Google Scholar] [CrossRef] [PubMed]
  25. Golla, M.S.G.; Hajouli, S.; Ludhwani, D. Heart Failure and Ejection Fraction. In StatPearls; StatPearls Publishing: Treasure Island (FL), 2024. [Google Scholar]
  26. Patel, R.; Peesay, T.; Krishnan, V.; Wilcox, J.; Wilsbacher, L.; Khan, S.S. Prioritizing the Primary Prevention of Heart Failure: Measuring, Modifying and Monitoring Risk. Progress in Cardiovascular Diseases 2024, 82, 2–14. [Google Scholar] [CrossRef] [PubMed]
  27. Appel, L.J.; Moore, T.J.; Obarzanek, E.; Vollmer, W.M.; Svetkey, L.P.; Sacks, F.M.; Bray, G.A.; Vogt, T.M.; Cutler, J.A.; Windhauser, M.M.; et al. A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure. N Engl J Med 1997, 336, 1117–1124. [Google Scholar] [CrossRef] [PubMed]
  28. Conlin, P.R. The Dietary Approaches to Stop Hypertension (DASH) Clinical Trial Implications for Lifestyle Modifications in the Treatment of Hypertensive Patients: Cardiology in Review 1999, 7, 284–288. [CrossRef]
  29. Sacks, F.M.; Svetkey, L.P.; Vollmer, W.M.; Appel, L.J.; Bray, G.A.; Harsha, D.; Obarzanek, E.; Conlin, P.R.; Miller, E.R.; Simons-Morton, D.G.; et al. Effects on Blood Pressure of Reduced Dietary Sodium and the Dietary Approaches to Stop Hypertension (DASH) Diet. N Engl J Med 2001, 344, 3–10. [Google Scholar] [CrossRef] [PubMed]
  30. Hinderliter, A.L.; Babyak, M.A.; Sherwood, A.; Blumenthal, J.A. The DASH Diet and Insulin Sensitivity. Curr Hypertens Rep 2011, 13, 67–73. [Google Scholar] [CrossRef] [PubMed]
  31. Morales-Alvarez, M.C.; Nissaisorakarn, V.; Appel, L.J.; Miller, E.R.; Christenson, R.H.; Rebuck, H.; Rosas, S.E.; William, J.H.; Juraschek, S.P. Effects of Reduced Dietary Sodium and the DASH Diet on GFR: The DASH-Sodium Trial. Kidney360 2024, 5, 569–576. [Google Scholar] [CrossRef]
  32. Wallace, T.C.; Cowan, A.E.; Bailey, R.L. Current Sodium Intakes in the United States and the Modelling of Glutamate’s Incorporation into Select Savory Products. Nutrients 2019, 11, 2691. [Google Scholar] [CrossRef]
  33. National Heart, Lung, and Blood Institute. Available Online: Https://Www.Nhlbi.Nih.Gov/Education/Dash-Eating-Plan (Accessed on 27.06.2024).
  34. Del Gobbo, L.C.; Kalantarian, S.; Imamura, F.; Lemaitre, R.; Siscovick, D.S.; Psaty, B.M.; Mozaffarian, D. Contribution of Major Lifestyle Risk Factors for Incident Heart Failure in Older Adults. JACC: Heart Failure 2015, 3, 520–528. [Google Scholar] [CrossRef] [PubMed]
  35. Billingsley, H.E.; Hummel, S.L.; Carbone, S. The Role of Diet and Nutrition in Heart Failure: A State-of-the-Art Narrative Review. Progress in Cardiovascular Diseases 2020, 63, 538–551. [Google Scholar] [CrossRef]
  36. Khan, M.S.; Jones, D.W.; Butler, J. Salt, No Salt, or Less Salt for Patients With Heart Failure? The American Journal of Medicine 2020, 133, 32–38. [Google Scholar] [CrossRef] [PubMed]
  37. Shao, W.; Seth, D.M.; Prieto, M.C.; Kobori, H.; Navar, L.G. Activation of the Renin-Angiotensin System by a Low-Salt Diet Does Not Augment Intratubular Angiotensinogen and Angiotensin II in Rats. American Journal of Physiology-Renal Physiology 2013, 304, F505–F514. [Google Scholar] [CrossRef]
  38. Ishikawa, Y.; Laing, E.M.; Anderson, A.K.; Zhang, D.; Kindler, J.M.; Trivedi-Kapoor, R.; Sattler, E.L.P. Adherence to the Dietary Approaches to Stop Hypertension (DASH) Diet Is Associated with Low Levels of Insulin Resistance among Heart Failure Patients. Nutrition, Metabolism and Cardiovascular Diseases 2022, 32, 1841–1850. [Google Scholar] [CrossRef] [PubMed]
  39. Goyal, P.; Balkan, L.; Ringel, J.B.; Hummel, S.L.; Sterling, M.R.; Kim, S.; Arora, P.; Jackson, E.A.; Brown, T.M.; Shikany, J.M.; et al. The Dietary Approaches to Stop Hypertension (DASH) Diet Pattern and Incident Heart Failure. Journal of Cardiac Failure 2021, 27, 512–521. [Google Scholar] [CrossRef]
  40. Ibsen, D.B.; Levitan, E.B.; Åkesson, A.; Gigante, B.; Wolk, A. The DASH Diet Is Associated with a Lower Risk of Heart Failure: A Cohort Study. European Journal of Preventive Cardiology 2022, 29, 1114–1123. [Google Scholar] [CrossRef]
  41. Levitan, E.B.; Lewis, C.E.; Tinker, L.F.; Eaton, C.B.; Ahmed, A.; Manson, J.E.; Snetselaar, L.G.; Martin, L.W.; Trevisan, M.; Howard, B.V.; et al. Mediterranean and DASH Diet Scores and Mortality in Women With Heart Failure: The Women’s Health Initiative. Circ: Heart Failure 2013, 6, 1116–1123. [Google Scholar] [CrossRef]
  42. Choi, Y.; Larson, N.; Steffen, L.M.; Schreiner, P.J.; Gallaher, D.D.; Duprez, D.A.; Shikany, J.M.; Rana, J.S.; Jacobs, D.R. Plant-Centered Diet and Risk of Incident Cardiovascular Disease During Young to Middle Adulthood. JAHA 2021, 10, e020718. [Google Scholar] [CrossRef]
  43. Glenn, A.J.; Guasch-Ferré, M.; Malik, V.S.; Kendall, C.W.C.; Manson, J.E.; Rimm, E.B.; Willett, W.C.; Sun, Q.; Jenkins, D.J.A.; Hu, F.B.; et al. Portfolio Diet Score and Risk of Cardiovascular Disease: Findings From 3 Prospective Cohort Studies. Circulation 2023, 148, 1750–1763. [Google Scholar] [CrossRef]
  44. Laffond, A.; Rivera-Picón, C.; Rodríguez-Muñoz, P.M.; Juárez-Vela, R.; Ruiz De Viñaspre-Hernández, R.; Navas-Echazarreta, N.; Sánchez-González, J.L. Mediterranean Diet for Primary and Secondary Prevention of Cardiovascular Disease and Mortality: An Updated Systematic Review. Nutrients 2023, 15, 3356. [Google Scholar] [CrossRef] [PubMed]
  45. Martínez-González, M.A.; Gea, A.; Ruiz-Canela, M. The Mediterranean Diet and Cardiovascular Health: A Critical Review. Circulation Research 2019, 124, 779–798. [Google Scholar] [CrossRef] [PubMed]
  46. Widmer, R.J.; Flammer, A.J.; Lerman, L.O.; Lerman, A. The Mediterranean Diet, Its Components, and Cardiovascular Disease. The American Journal of Medicine 2015, 128, 229–238. [Google Scholar] [CrossRef] [PubMed]
  47. Martínez-González, M.Á.; Hernández Hernández, A. Effect of the Mediterranean Diet in Cardiovascular Prevention. Revista Española de Cardiología (English Edition) 2024, S1885585724000434. [CrossRef]
  48. Tektonidis, T.G.; Åkesson, A.; Gigante, B.; Wolk, A.; Larsson, S.C. A Mediterranean Diet and Risk of Myocardial Infarction, Heart Failure and Stroke: A Population-Based Cohort Study. Atherosclerosis 2015, 243, 93–98. [Google Scholar] [CrossRef] [PubMed]
  49. Oppedisano, F.; Mollace, R.; Tavernese, A.; Gliozzi, M.; Musolino, V.; Macrì, R.; Carresi, C.; Maiuolo, J.; Serra, M.; Cardamone, A.; et al. PUFA Supplementation and Heart Failure: Effects on Fibrosis and Cardiac Remodeling. Nutrients 2021, 13, 2965. [Google Scholar] [CrossRef] [PubMed]
  50. Xia, M.; Zhong, Y.; Peng, Y.; Qian, C. Olive Oil Consumption and Risk of Cardiovascular Disease and All-Cause Mortality: A Meta-Analysis of Prospective Cohort Studies. Front. Nutr. 2022, 9, 1041203. [Google Scholar] [CrossRef] [PubMed]
  51. Sacks, F.M.; Lichtenstein, A.H.; Wu, J.H.Y.; Appel, L.J.; Creager, M.A.; Kris-Etherton, P.M.; Miller, M.; Rimm, E.B.; Rudel, L.L.; Robinson, J.G.; et al. Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association. Circulation 2017, 136. [Google Scholar] [CrossRef] [PubMed]
  52. Li, Y.; Hruby, A.; Bernstein, A.M.; Ley, S.H.; Wang, D.D.; Chiuve, S.E.; Sampson, L.; Rexrode, K.M.; Rimm, E.B.; Willett, W.C.; et al. Saturated Fats Compared With Unsaturated Fats and Sources of Carbohydrates in Relation to Risk of Coronary Heart Disease. Journal of the American College of Cardiology 2015, 66, 1538–1548. [Google Scholar] [CrossRef] [PubMed]
  53. Carcel, C.; Bushnell, C. Can Dietary Patterns That Support Planetary Health Benefit Population Health? Stroke 2022, 53, 164–166. [Google Scholar] [CrossRef]
  54. Zhang, S.; Marken, I.; Stubbendorff, A.; Ericson, U.; Qi, L.; Sonestedt, E.; Borné, Y. The EAT-Lancet Diet Index, Plasma Proteins, and Risk of Heart Failure in a Population-Based Cohort. JACC: Heart Failure 2024, S2213177924001811. [CrossRef]
  55. Ebong, I.A.; Goff, D.C.; Rodriguez, C.J.; Chen, H.; Bertoni, A.G. Mechanisms of Heart Failure in Obesity. Obesity Research & Clinical Practice 2014, 8, e540–e548. [Google Scholar] [CrossRef]
  56. Kenchaiah, S.; Evans, J.C.; Levy, D.; Wilson, P.W.F.; Benjamin, E.J.; Larson, M.G.; Kannel, W.B.; Vasan, R.S. Obesity and the Risk of Heart Failure. N Engl J Med 2002, 347, 305–313. [Google Scholar] [CrossRef] [PubMed]
  57. Kristensen, S.L.; Rørth, R.; Jhund, P.S.; Docherty, K.F.; Sattar, N.; Preiss, D.; Køber, L.; Petrie, M.C.; McMurray, J.J.V. Cardiovascular, Mortality, and Kidney Outcomes with GLP-1 Receptor Agonists in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Cardiovascular Outcome Trials. The Lancet Diabetes & Endocrinology 2019, 7, 776–785. [Google Scholar] [CrossRef]
  58. Van Veldhuisen, S.L.; Gorter, T.M.; Van Woerden, G.; De Boer, R.A.; Rienstra, M.; Hazebroek, E.J.; Van Veldhuisen, D.J. Bariatric Surgery and Cardiovascular Disease: A Systematic Review and Meta-Analysis. European Heart Journal 2022, 43, 1955–1969. [Google Scholar] [CrossRef] [PubMed]
  59. Carbone, S.; Canada, J.M.; Billingsley, H.E.; Siddiqui, M.S.; Elagizi, A.; Lavie, C.J. Obesity Paradox in Cardiovascular Disease: Where Do We Stand? VHRM 2019, Volume 15, 89–100. [Google Scholar] [CrossRef]
  60. Carbone, S.; Lavie, C.J.; Elagizi, A.; Arena, R.; Ventura, H.O. The Impact of Obesity in Heart Failure. Heart Failure Clinics 2020, 16, 71–80. [Google Scholar] [CrossRef] [PubMed]
  61. Lavie, C.J.; McAuley, P.A.; Church, T.S.; Milani, R.V.; Blair, S.N. Obesity and Cardiovascular Diseases. Journal of the American College of Cardiology 2014, 63, 1345–1354. [Google Scholar] [CrossRef] [PubMed]
  62. Mohsin, S.; Khan, M.; Toko, H.; Bailey, B.; Cottage, C.T.; Wallach, K.; Nag, D.; Lee, A.; Siddiqi, S.; Lan, F.; et al. Human Cardiac Progenitor Cells Engineered With Pim-I Kinase Enhance Myocardial Repair. Journal of the American College of Cardiology 2012, 60, 1278–1287. [Google Scholar] [CrossRef] [PubMed]
  63. Ferreira, J.P.; Sharma, A.; Butler, J.; Packer, M.; Zannad, F.; Vasques-Nóvoa, F.; Leite-Moreira, A.; Neves, J.S. Glucagon-Like Peptide-1 Receptor Agonists Across the Spectrum of Heart Failure. The Journal of Clinical Endocrinology & Metabolism 2023, 109, 4–9. [Google Scholar] [CrossRef]
  64. Kosiborod, M.N.; Abildstrøm, S.Z.; Borlaug, B.A.; Butler, J.; Rasmussen, S.; Davies, M.; Hovingh, G.K.; Kitzman, D.W.; Lindegaard, M.L.; Møller, D.V.; et al. Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity. N Engl J Med 2023, 389, 1069–1084. [Google Scholar] [CrossRef]
  65. Mentias, A.; Desai, M.Y.; Aminian, A.; Patel, K.V.; Keshvani, N.; Verma, S.; Cho, L.; Jacob, M.; Alvarez, P.; Lincoff, A.M.; et al. Trends and Outcomes Associated With Bariatric Surgery and Pharmacotherapies With Weight Loss Effects Among Patients With Heart Failure and Obesity. Circ: Heart Failure 2024, 17. [Google Scholar] [CrossRef]
  66. Nye, K.; Cherrin, C.; Meires, J. Intermittent Fasting: Exploring Approaches, Benefits, and Implications for Health and Weight Management. The Journal for Nurse Practitioners 2024, 20, 104893. [Google Scholar] [CrossRef]
  67. Ozcan, M.; Abdellatif, M.; Javaheri, A.; Sedej, S. Risks and Benefits of Intermittent Fasting for the Aging Cardiovascular System. Canadian Journal of Cardiology 2024, S0828282X24000928. [Google Scholar] [CrossRef] [PubMed]
  68. Duregon, E.; Pomatto-Watson, L.C.D.D.; Bernier, M.; Price, N.L.; De Cabo, R. Intermittent Fasting: From Calories to Time Restriction. GeroScience 2021, 43, 1083–1092. [Google Scholar] [CrossRef] [PubMed]
  69. Dutzmann, J.; Kefalianakis, Z.; Kahles, F.; Daniel, J.-M.; Gufler, H.; Wohlgemuth, W.A.; Knöpp, K.; Sedding, D.G. Intermittent Fasting After ST-Segment–Elevation Myocardial Infarction Improves Left Ventricular Function: The Randomized Controlled INTERFAST-MI Trial. Circ: Heart Failure 2024, e010936. [CrossRef]
  70. Ozcan, M.; Guo, Z.; Valenzuela Ripoll, C.; Diab, A.; Picataggi, A.; Rawnsley, D.; Lotfinaghsh, A.; Bergom, C.; Szymanski, J.; Hwang, D.; et al. Sustained Alternate-Day Fasting Potentiates Doxorubicin Cardiotoxicity. Cell Metabolism 2023, 35, 928–942.e4. [Google Scholar] [CrossRef] [PubMed]
  71. Liu, H.; Javaheri, A.; Godar, R.J.; Murphy, J.; Ma, X.; Rohatgi, N.; Mahadevan, J.; Hyrc, K.; Saftig, P.; Marshall, C.; et al. Intermittent Fasting Preserves Beta-Cell Mass in Obesity-Induced Diabetes via the Autophagy-Lysosome Pathway. Autophagy 2017, 13, 1952–1968. [Google Scholar] [CrossRef] [PubMed]
  72. Ma, X.; Mani, K.; Liu, H.; Kovacs, A.; Murphy, J.T.; Foroughi, L.; French, B.A.; Weinheimer, C.J.; Kraja, A.; Benjamin, I.J.; et al. Transcription Factor EB Activation Rescues Advanced αB-Crystallin Mutation-Induced Cardiomyopathy by Normalizing Desmin Localization. JAHA 2019, 8, e010866. [Google Scholar] [CrossRef] [PubMed]
  73. Ahmet, I.; Wan, R.; Mattson, M.P.; Lakatta, E.G.; Talan, M. Cardioprotection by Intermittent Fasting in Rats. Circulation 2005, 112, 3115–3121. [Google Scholar] [CrossRef] [PubMed]
  74. Antoni, R.; Johnston, K.L.; Collins, A.L.; Robertson, M.D. Intermittent v. Continuous Energy Restriction: Differential Effects on Postprandial Glucose and Lipid Metabolism Following Matched Weight Loss in Overweight/Obese Participants. Br J Nutr 2018, 119, 507–516. [Google Scholar] [CrossRef] [PubMed]
  75. Wang, J.; Wang, F.; Chen, H.; Liu, L.; Zhang, S.; Luo, W.; Wang, G.; Hu, X. Comparison of the Effects of Intermittent Energy Restriction and Continuous Energy Restriction among Adults with Overweight or Obesity: An Overview of Systematic Reviews and Meta-Analyses. Nutrients 2022, 14, 2315. [Google Scholar] [CrossRef]
  76. Templeman, I.; Smith, H.A.; Chowdhury, E.; Chen, Y.-C.; Carroll, H.; Johnson-Bonson, D.; Hengist, A.; Smith, R.; Creighton, J.; Clayton, D.; et al. A Randomized Controlled Trial to Isolate the Effects of Fasting and Energy Restriction on Weight Loss and Metabolic Health in Lean Adults. Sci. Transl. Med. 2021, 13, eabd8034. [Google Scholar] [CrossRef]
  77. Justice, J.N.; Pajewski, N.M.; Espeland, M.A.; Brubaker, P.; Houston, D.K.; Marcovina, S.; Nicklas, B.J.; Kritchevsky, S.B.; Kitzman, D.W. Evaluation of a Blood-Based Geroscience Biomarker Index in a Randomized Trial of Caloric Restriction and Exercise in Older Adults with Heart Failure with Preserved Ejection Fraction. GeroScience 2022, 44, 983–995. [Google Scholar] [CrossRef] [PubMed]
  78. Kitzman, D.W.; Brubaker, P.; Morgan, T.; Haykowsky, M.; Hundley, G.; Kraus, W.E.; Eggebeen, J.; Nicklas, B.J. Effect of Caloric Restriction or Aerobic Exercise Training on Peak Oxygen Consumption and Quality of Life in Obese Older Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial. JAMA 2016, 315, 36. [Google Scholar] [CrossRef] [PubMed]
  79. Bilgen, F.; Chen, P.; Poggi, A.; Wells, J.; Trumble, E.; Helmke, S.; Teruya, S.; Catalan, T.; Rosenblum, H.R.; Cornellier, M.L.; et al. Insufficient Calorie Intake Worsens Post-Discharge Quality of Life and Increases Readmission Burden in Heart Failure. JACC: Heart Failure 2020, 8, 756–764. [Google Scholar] [CrossRef] [PubMed]
  80. Pocock, S.J.; McMurray, J.J.V.; Dobson, J.; Yusuf, S.; Granger, C.B.; Michelson, E.L.; Ostergren, J.; Pfeffer, M.A.; Solomon, S.D.; Anker, S.D.; et al. Weight Loss and Mortality Risk in Patients with Chronic Heart Failure in the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) Programme. European Heart Journal 2008, 29, 2641–2650. [Google Scholar] [CrossRef] [PubMed]
  81. Brubaker, P.H.; Nicklas, B.J.; Houston, D.K.; Hundley, W.G.; Chen, H.; Molina, A.J.A.; Lyles, W.M.; Nelson, B.; Upadhya, B.; Newland, R.; et al. A Randomized, Controlled Trial of Resistance Training Added to Caloric Restriction Plus Aerobic Exercise Training in Obese Heart Failure With Preserved Ejection Fraction. Circ: Heart Failure 2023, 16. [Google Scholar] [CrossRef] [PubMed]
  82. Maurya, S.K.; Carley, A.N.; Maurya, C.K.; Lewandowski, E.D. Western Diet Causes Heart Failure With Reduced Ejection Fraction and Metabolic Shifts After Diastolic Dysfunction and Novel Cardiac Lipid Derangements. JACC: Basic to Translational Science 2023, 8, 422–435. [Google Scholar] [CrossRef] [PubMed]
  83. Clemente-Suárez, V.J.; Beltrán-Velasco, A.I.; Redondo-Flórez, L.; Martín-Rodríguez, A.; Tornero-Aguilera, J.F. Global Impacts of Western Diet and Its Effects on Metabolism and Health: A Narrative Review. Nutrients 2023, 15, 2749. [Google Scholar] [CrossRef] [PubMed]
  84. Kopp, W. How Western Diet And Lifestyle Drive The Pandemic Of Obesity And Civilization Diseases. DMSO 2019, Volume 12, 2221–2236. [Google Scholar] [CrossRef]
  85. Wali, J.A.; Jarzebska, N.; Raubenheimer, D.; Simpson, S.J.; Rodionov, R.N.; O’Sullivan, J.F. Cardio-Metabolic Effects of High-Fat Diets and Their Underlying Mechanisms—A Narrative Review. Nutrients 2020, 12, 1505. [Google Scholar] [CrossRef]
  86. Stanley, W.C.; Dabkowski, E.R.; Ribeiro, R.F.; O’Connell, K.A. Dietary Fat and Heart Failure: Moving From Lipotoxicity to Lipoprotection. Circulation Research 2012, 110, 764–776. [Google Scholar] [CrossRef]
  87. Zeng, H.; Vaka, V.R.; He, X.; Booz, G.W.; Chen, J. High-fat Diet Induces Cardiac Remodelling and Dysfunction: Assessment of the Role Played by SIRT 3 Loss. J Cellular Molecular Medi 2015, 19, 1847–1856. [Google Scholar] [CrossRef] [PubMed]
  88. Arnett, D.K.; Blumenthal, R.S.; Albert, M.A.; Buroker, A.B.; Goldberger, Z.D.; Hahn, E.J.; Himmelfarb, C.D.; Khera, A.; Lloyd-Jones, D.; McEvoy, J.W.; et al. 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation 2019, 140. [Google Scholar] [CrossRef] [PubMed]
  89. McCommis, K.S.; Kovacs, A.; Weinheimer, C.J.; Shew, T.M.; Koves, T.R.; Ilkayeva, O.R.; Kamm, D.R.; Pyles, K.D.; King, M.T.; Veech, R.L.; et al. Nutritional Modulation of Heart Failure in Mitochondrial Pyruvate Carrier–Deficient Mice. Nat Metab 2020, 2, 1232–1247. [Google Scholar] [CrossRef]
  90. Javaheri, A.; Mittendorfer, B. Ketones with a Twist: Tipping the Heart’s Hat to Fat. Obesity 2024, 32, 452–453. [Google Scholar] [CrossRef] [PubMed]
  91. Bedi, K.C.; Snyder, N.W.; Brandimarto, J.; Aziz, M.; Mesaros, C.; Worth, A.J.; Wang, L.L.; Javaheri, A.; Blair, I.A.; Margulies, K.B.; et al. Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure. Circulation 2016, 133, 706–716. [Google Scholar] [CrossRef] [PubMed]
  92. Nielsen, R.; Møller, N.; Gormsen, L.C.; Tolbod, L.P.; Hansson, N.H.; Sorensen, J.; Harms, H.J.; Frøkiær, J.; Eiskjaer, H.; Jespersen, N.R.; et al. Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients. Circulation 2019, 139, 2129–2141. [Google Scholar] [CrossRef] [PubMed]
  93. Puchalska, P.; Crawford, P.A. Multi-Dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics. Cell Metabolism 2017, 25, 262–284. [Google Scholar] [CrossRef] [PubMed]
  94. Yurista, S.R.; Eder, R.A.; Welsh, A.; Jiang, W.; Chen, S.; Foster, A.N.; Mauskapf, A.; Tang, W.H.W.; Hucker, W.J.; Coll-Font, J.; et al. Ketone Ester Supplementation Suppresses Cardiac Inflammation and Improves Cardiac Energetics in a Swine Model of Acute Myocardial Infarction. Metabolism 2023, 145, 155608. [Google Scholar] [CrossRef]
  95. Cox, P.J.; Kirk, T.; Ashmore, T.; Willerton, K.; Evans, R.; Smith, A.; Murray, A.J.; Stubbs, B.; West, J.; McLure, S.W.; et al. Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes. Cell Metabolism 2016, 24, 256–268. [Google Scholar] [CrossRef]
  96. Yurista, S.; Welsh, A.; Jiang, W.; Eder, R.; Chen, S.; Bonner, B.; Foster, A.; Coll-Font, J.; Rosenzweig, A.; Nguyen, C. KETONE ESTER TREATMENT INCREASES CARDIAC KETONE UTILIZATION AND REDUCES CARDIAC INFLAMMATION IN A PORCINE MODEL OF ACUTE MYOCARDIAL INFARCTION. Journal of the American College of Cardiology 2022, 79, 1039. [Google Scholar] [CrossRef]
  97. Neudorf, H.; Little, J.P. Impact of Fasting & Ketogenic Interventions on the NLRP3 Inflammasome: A Narrative Review. Biomedical Journal 2024, 47, 100677. [Google Scholar] [CrossRef]
  98. Kodur, N.; Yurista, S.; Province, V.; Rueth, E.; Nguyen, C.; Tang, W.H.W. Ketogenic Diet in Heart Failure. JACC: Heart Failure 2023, 11, 838–844. [Google Scholar] [CrossRef] [PubMed]
  99. Wei, S.-J.; Schell, J.R.; Chocron, E.S.; Varmazyad, M.; Xu, G.; Chen, W.H.; Martinez, G.M.; Dong, F.F.; Sreenivas, P.; Trevino, R.; et al. Ketogenic Diet Induces P53-Dependent Cellular Senescence in Multiple Organs. Sci. Adv. 2024, 10, eado1463. [Google Scholar] [CrossRef] [PubMed]
  100. Seidelmann, S.B.; Claggett, B.; Cheng, S.; Henglin, M.; Shah, A.; Steffen, L.M.; Folsom, A.R.; Rimm, E.B.; Willett, W.C.; Solomon, S.D. Dietary Carbohydrate Intake and Mortality: A Prospective Cohort Study and Meta-Analysis. The Lancet Public Health 2018, 3, e419–e428. [Google Scholar] [CrossRef] [PubMed]
  101. Magkos, F.; Ataran, A.; Javaheri, A.; Mittendorfer, B. Effect of Dietary Carbohydrate Restriction on Cardiometabolic Function in Type 2 Diabetes: Weight Loss and Beyond. Current Opinion in Clinical Nutrition & Metabolic Care 2023, 26, 330–333. [Google Scholar] [CrossRef]
  102. Guo, Y.; Liu, X.; Li, T.; Zhao, J.; Yang, Y.; Yao, Y.; Wang, L.; Yang, B.; Ren, G.; Tan, Y.; et al. Alternate-Day Ketogenic Diet Feeding Protects against Heart Failure through Preservation of Ketogenesis in the Liver. Oxidative Medicine and Cellular Longevity 2022, 2022, 1–13. [Google Scholar] [CrossRef] [PubMed]
  103. National Heart, Lung, and Blood Institute. Available Online: Https://Clinicaltrials.Gov/Study/NCT04442555 (Accessed on 28.06.2024).
  104. National Heart, Lung, and Blood Institute. Available Online: Https://Clinicaltrials.Gov/Study/NCT04370600 (Accessed on 28.06.2024).
  105. National Heart, Lung, and Blood Institute. Available Online: Https://Clinicaltrials.Gov/Study/NCT04443426 (Accessed on 28.06.2024).
  106. National Heart, Lung, and Blood Institute. Available Online: Https://Clinicaltrials.Gov/Study/NCT04633460 (Accessed on 28.06.2024).
  107. Salloum, F.N.; Sturz, G.R.; Yin, C.; Rehman, S.; Hoke, N.N.; Kukreja, R.C.; Xi, L. Beetroot Juice Reduces Infarct Size and Improves Cardiac Function Following Ischemia–Reperfusion Injury: Possible Involvement of Endogenous H 2 S. Exp Biol Med (Maywood) 2015, 240, 669–681. [Google Scholar] [CrossRef] [PubMed]
  108. Eggebeen, J.; Kim-Shapiro, D.B.; Haykowsky, M.; Morgan, T.M.; Basu, S.; Brubaker, P.; Rejeski, J.; Kitzman, D.W. One Week of Daily Dosing With Beetroot Juice Improves Submaximal Endurance and Blood Pressure in Older Patients With Heart Failure and Preserved Ejection Fraction. JACC: Heart Failure 2016, 4, 428–437. [Google Scholar] [CrossRef] [PubMed]
  109. Borlaug, B.A.; Anstrom, K.J.; Lewis, G.D.; Shah, S.J.; Levine, J.A.; Koepp, G.A.; Givertz, M.M.; Felker, G.M.; LeWinter, M.M.; Mann, D.L.; et al. Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction: The INDIE-HFpEF Randomized Clinical Trial. JAMA 2018, 320, 1764. [Google Scholar] [CrossRef]
  110. National Heart, Lung, and Blood Institute. Available Online: Https://Clinicaltrials.Gov/Study/NCT03511248 (Accessed on 28.06.2024).
  111. Morimoto, J.; Satogami, K.; Naraoka, T.; Taruya, A.; Tanaka, A. Long-Term Maintenance of Normal Serum Vitamin B1 Levels Is Associated with Better Outcomes in Patients with Heart Failure. Int. Heart J. 2024, 65, 458–465. [Google Scholar] [CrossRef]
  112. Shimon, H.; Almog, S.; Vered, Z.; Seligmann, H.; Shefi, M.; Peleg, E.; Rosenthal, T.; Motro, M.; Halkin, H.; Ezra, D. Improved Left Ventricular Function after Thiamine Supplementation in Patients with Congestive Heart Failure Receiving Long-Term Furosemide Therapy. The American Journal of Medicine 1995, 98, 485–490. [Google Scholar] [CrossRef] [PubMed]
  113. Schoenenberger, A.W.; Schoenenberger-Berzins, R.; Der Maur, C.A.; Suter, P.M.; Vergopoulos, A.; Erne, P. Thiamine Supplementation in Symptomatic Chronic Heart Failure: A Randomized, Double-Blind, Placebo-Controlled, Cross-over Pilot Study. Clin Res Cardiol 2012, 101, 159–164. [Google Scholar] [CrossRef] [PubMed]
  114. Dragan, S.; Buleu, F.; Christodorescu, R.; Cobzariu, F.; Iurciuc, S.; Velimirovici, D.; Xiao, J.; Luca, C.T. Benefits of Multiple Micronutrient Supplementation in Heart Failure: A Comprehensive Review. Critical Reviews in Food Science and Nutrition 2019, 59, 965–981. [Google Scholar] [CrossRef] [PubMed]
Preprints 114204 g001
Figure 1. Graphical abstract for general dietary recommendations compared to the most frequent symptoms and physical activity limitation in different stages of heart failure. Illustration created using BioRender (Biorender.com).
Figure 1. Graphical abstract for general dietary recommendations compared to the most frequent symptoms and physical activity limitation in different stages of heart failure. Illustration created using BioRender (Biorender.com).
Preprints 114204 g001
Table 1. Clinical randomized trials using caloric restriction interventions in patients with HF.
Table 1. Clinical randomized trials using caloric restriction interventions in patients with HF.
Parameter/Study Justice et al. Kitzman et al.
Target group Obese HFpEF Obese HFpEF
Intervention CR* vs CR and/or EX* CR vs CR and/or EX
Intervention duration 20 weeks 20 weeks
Number of participants 88 100
Age (years), mean ± SD 66.6 ± 5.3 67 ± 5
Sex 81% female 81% female
BMI in kg/m2, mean ± SD 39.3 ± 6.3 39.3 ± 5.6
Biomarker index improvement with CR − 0.82 ± 0.58 points, p = 0.05 Not applicable
Biomarker index improvement with EX − 0.28 ± 0.59 points, p = 0.50 Not applicable
*Caloric restriction. *Aerobic exercise training.
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.
Nutritional Supplementation and Exercise – Essential Allies in the Treatment of Chronic Heart Failure: The Metabolic and Molecular Bases.

Evasio Pasini

et al.

,

2023

The Effects of Short-Term Caloric Restriction on Cardiometabolic Health in Overweight/Obese Men and Women

Justin A. DeBlauw

et al.

,

2023

Prevalence and Risk Factors of Metabolic Syndrome: A Prospective Study on Cardiovascular Health

Marius Rus

et al.

,

2023

Prerpints.org logo

Preprints.org is a free preprint server supported by MDPI in Basel, Switzerland.

facebook logotwitter logolinkedin logo
MDPI Initiatives
Important Links
Subscribe

Disclaimer

Terms of Use

Privacy Policy

© 2024 MDPI (Basel, Switzerland) unless otherwise stated