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    Pathophysiology of AML

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    jake251996
    Predisposing factors for developing leukemia include being male, over 65 years old, or having genetic abnormalities like Down syndrome. There is generally no single causative agent, but precipitating factors include exposure to radiation, alcohol, smoking, industrial chemicals, chemotherapy drugs, obesity, and a diet high in processed or red meat. Acute myelogenous leukemia results from disrupted genes causing an immature clone of cells to rapidly proliferate and circulate abnormally in the bloodstream, infiltrating organs and bones while suppressing normal blood cell production.

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    Pathophysiology of AML

    Uploaded by

    jake251996
    698 views1 page
    Predisposing factors for developing leukemia include being male, over 65 years old, or having genetic abnormalities like Down syndrome. There is generally no single causative agent, but precipitating factors include exposure to radiation, alcohol, smoking, industrial chemicals, chemotherapy drugs, obesity, and a diet high in processed or red meat. Acute myelogenous leukemia results from disrupted genes causing an immature clone of cells to rapidly proliferate and circulate abnormally in the bloodstream, infiltrating organs and bones while suppressing normal blood cell production.

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    Pathophysiology of AML

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    Predisposing factors for developing leukemia include being male, over 65 years old, or having genetic abnormalities like Down syndrome. There is generally no single causative agent, but precipitating factors include exposure to radiation, alcohol, smoking, industrial chemicals, chemotherapy drugs, obesity, and a diet high in processed or red meat. Acute myelogenous leukemia results from disrupted genes causing an immature clone of cells to rapidly proliferate and circulate abnormally in the bloodstream, infiltrating organs and bones while suppressing normal blood cell production.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    698 views1 page

    Pathophysiology of AML

    Uploaded by

    jake251996
    Predisposing factors for developing leukemia include being male, over 65 years old, or having genetic abnormalities like Down syndrome. There is generally no single causative agent, but precipitating factors include exposure to radiation, alcohol, smoking, industrial chemicals, chemotherapy drugs, obesity, and a diet high in processed or red meat. Acute myelogenous leukemia results from disrupted genes causing an immature clone of cells to rapidly proliferate and circulate abnormally in the bloodstream, infiltrating organs and bones while suppressing normal blood cell production.

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    of 1

    Predisposing Factors

    -Male Sex
    -People over 65 years
    old
    -Genetic abnormalities,
    such as Down syndrome

    Regardless of what type of leukemia,


    there is generally no single causative
    agent in the development of leukemia.

    Precipitating Factors
    -Exposure to Radiation (X-ray)
    -Alcohol intake (4 drinks/wk or more)
    -Smoking
    -Long-term exposure to industrial chemicals like benzene
    --Chemotherapy Drugs
    -Obesity (BMI 30 kg/m2 and above)
    -Large intake of processed and/or red meat (7 servings/wk or
    more)

    Acute Myelogenous Leukemia

    Bruises

    Disrupted genes

    Petechiae
    Ecchymoses

    Immature clone of cells

    Nose bleeding
    Increased Bleeding Tendencies

    Rapid proliferation
    of Abnormal Cells

    Reduced clotting factors


    Abnormal immature leukocytes
    circulate the bloodstream

    Increased WBC infiltrates the


    organs & other parts of the body

    Enlargement of the bloodforming organs


    (liver, spleen)

    Bones
    Lungs

    Bone marrow failure

    Suppressed production
    of normal cells

    Decreased RBC
    count, platelet count
    & immature
    leukocytes

    Pneumonia

    Decreased Oxygen
    concentration and
    distribution in the
    blood

    High numbers of
    immature & abnormal
    leukocytes are unable
    to fight & destroy
    microorganisms.

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