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Predisposing Factor Precipitating Factor

This document outlines the pathophysiology of preeclampsia. It begins with predisposing and precipitating factors such as family history, age, diet, and previous preeclampsia. Decreased placental perfusion leads to endothelial cell damage and vasospasms. This causes fluid shifts, intravascular coagulation, and increased sensitivity to angiotensin II. Symptoms develop including liver and kidney damage, neurological symptoms, edema, and eventually seizures, coma and death if left untreated.

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41 views2 pages

Predisposing Factor Precipitating Factor

This document outlines the pathophysiology of preeclampsia. It begins with predisposing and precipitating factors such as family history, age, diet, and previous preeclampsia. Decreased placental perfusion leads to endothelial cell damage and vasospasms. This causes fluid shifts, intravascular coagulation, and increased sensitivity to angiotensin II. Symptoms develop including liver and kidney damage, neurological symptoms, edema, and eventually seizures, coma and death if left untreated.

Uploaded by

kamotenikimi
Copyright
© Attribution Non-Commercial (BY-NC)
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
Download as docx, pdf, or txt
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Predisposing factor Precipitating factor

family history Diet and nutrition


age Multiple gestation
Previous pre-eclampsia
Pre- existing hypertension
Decreased placental perfusion.
Placental production
ofendothelin

Endothelial cell damage Vasospasms

Intravascular Fluid shifts feom increased


intravascular to sensitivity to
coagulation
intracellular angiotensin II
space (decreased
plasma volume)
(increased
hematocrit)

Hepatic-microemboli; liver damage


Retinal arteriolar spasms Pulmonary edema Cortical brain spasms Generalized edema Glomerular damage Uteroplacental arteriole lesions Generalized vasocontriction

-elevated liver -blurred vision -dyspnea -headaches -proteinuria -intrauterine Chronic


enzymes (AST and -scotoma -hyperreflexia -increased growth restriction Hypertension
LDH) -visible edema of plasma uricacid -abruptio placentae
-seizure activity
-Nausea/ face, hands, and and creatinine -increased uterine
Vomiting abdomen -otiguria contractility
-epigastric pain -pitting edema -increased
after 12 hours of sodium retention
Indications of increasing intaracranial pressure bed rest
s/sx: Increase Intracranial Pressure
Tissue Necrosis >headache
>drowsiness
>loss of
concsiousness

Neuronal death Seizure activity

Regional Paralysis
(left Hemisphere)

Coma

Death

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