Drug Study (Imdur)
Drug Study (Imdur)
Drug Study (Imdur)
Classification: Imdur is in a group of drugs called nitrates. Isosorbide mononitrate dilates (widens) blood
vessels, making it easier for blood to flow through them and easier for the heart to pump.Imdur is used to
prevent angina attacks (chest pain).Imdur will not treat an angina attack that has already begun.
Mechanism of Action: The Imdur product is an oral extended-release formulation of ISMN, the major active
metabolite of isosorbide dinitrate; most of the clinical activity of the dinitrate is attributable to the mononitrate.
The principal pharmacological action of ISMN and all organic nitrates in general is relaxation of vascular smooth
muscle, producing dilatation of peripheral arteries and veins, especially the latter. Dilatation of the veins
promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular
end-diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic
vascular resistance, and systolic arterial pressure and mean arterial pressure (afterload). Dilatation of the
coronary arteries also occurs. The relative importance of preload reduction, afterload reduction, and coronary
dilatation remains undefined.
Indications and Usage for Imdur: Imdur Tablets are indicated for the prevention of angina pectoris due to
coronary artery disease. The onset of action of oral isosorbide mononitrate is not sufficiently rapid for this
product to be useful in aborting an acute anginal episode
Contraindications: Imdur Tablets are contraindicated in patients who have shown hypersensitivity or
idiosyncratic reactions to other nitrates or nitrites.