Drug Name Mecahnism of Action Indication Side Effects Generic Name

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DRUG NAME MECAHNISM OF ACTION INDICATION SIDE EFFECTS

GENERIC NAME: Increases osmotic pressure of plasma in  Test dose for marked oliguria or CNS: dizziness, headache
mannitol glomerular filtrate, inhibiting tubular suspected inadequate renal function EENT: blurred vision, rhinitis GI: nausea,
reabsorption of water and electrolytes  To prevent oliguria during vomiting, diarrhea, dry mouth GU: polyuria,
(including sodium and potassium). These cardiovascular and other surgeries urinary retention,
BRAND NAME: actions enhance water flow from various  To reduce intracranial pressure and Metabolic: dehydration, water intoxication,
Osmitro tissues and ultimately decrease intracranial brain mass hypernatremia, hyponatremia,
and intraocular pressures; serum sodium  Irrigation during hypovolemia, hypokalemia,
CLASSIFICATION: level rises while potassium and blood urea Skin: rash, urticaria Other: chills, fever,
Osmotic diuretic levels fall. Also protects kidneys by thirst, edema, extravasation with edema
preventing toxins from forming and blocking and tissue necrosis
tubules.
DOSAGE:
75 cc

CONTRAINDICATION ADVERSE EFFECTS


ROUTES:
Parenteral  Active intracranial bleeding (except CNS: seizures
during craniotomy) Anuria CV: chest pain, hypotension, hypertension,
secondary to severe renal disease tachycardia, thrombophlebitis, heart failure,
 Progressive heart failure, pulmonary vascular overload
FREQUENCY: Metabolic: , hyperkalemia, metabolic
congestion, renal damage, or renal
Q4h dysfunction after mannitol therapy acidosis
 Severe dehydration
TIMING:
8am-12pm-4pm-8pm-12-am-4am

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