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    Preparation of Sodium Bicarbonate Ear Drops Students

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    luisynon
    Sodium bicarbonate, 5 g Glycerol, 30 cm3 Purified water, freshly boiled and cooled, sufficient to produce 100 cm3

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    © All Rights Reserved
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    Preparation of Sodium Bicarbonate Ear Drops Students

    Uploaded by

    luisynon
    3K views2 pages
    Sodium bicarbonate, 5 g Glycerol, 30 cm3 Purified water, freshly boiled and cooled, sufficient to produce 100 cm3

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    © © All Rights Reserved

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    PDF, TXT or read online from Scribd

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    Sodium bicarbonate, 5 g Glycerol, 30 cm3 Purified water, freshly boiled and cooled, sufficient to produce 100 cm3

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    3K views2 pages

    Preparation of Sodium Bicarbonate Ear Drops Students

    Uploaded by

    luisynon
    Sodium bicarbonate, 5 g Glycerol, 30 cm3 Purified water, freshly boiled and cooled, sufficient to produce 100 cm3

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 2

    1

    Preparation of sodium bicarbonate ear drops


    Student worksheet

    Health and safety note
    Wear eye protection.

    Background
    The British Pharmacopoeia (BP) contains information about a pharmaceutical preparation called
    Sodium Bicarbonate Ear Drops.
    The agreed IUPAC name for sodium bicarbonate is sodium hydrogencarbonate. It is commonly
    used in health and hygiene products and in food products, can usually be found on labels under its
    older name.
    Medicines are usually supplied to the pharmacist already prepared. Occasionally, a pharmacist
    formulates one or two medicines on the premises. These are called extemporaneous preparations.
    Instructions are given in pharmacopoeias such as the British Pharmacopoeia (BP). Here are the
    instructions in the British Pharmacopoeia for Sodium Bicarbonate Ear Drops.

    Sodium Bicarbonate Ear Drops
    Definition
    Sodium bicarbonate, 5 g
    Glycerol, 30 cm
    3

    Purified water, freshly boiled and cooled, sufficient to produce 100 cm
    3

    Content of sodium bicarbonate, 4.75 to 5.25% w/w
    Weight per cm
    3
    , 1.10 to 1.12 g
    Extemporaneous preparation
    Dissolve the sodium bicarbonate in about 60 cm
    3
    of purified water; add the glycerol and sufficient
    Purified Water to produce 100 cm
    3
    and mix.
    Assay
    To 5 cm
    3
    add 20 cm
    3
    of water and titrate with 0.10 mol dm
    3
    hydrochloric acid using screened
    methyl orange as indicator. Each cm
    3
    of 0.10 mol dm
    3
    hydrochloric acid is equivalent to 8.401 mg
    of sodium bicarbonate.


    In this activity you will:
    prepare a 100 cm
    3
    of Sodium Bicarbonate Ear Drops;
    determine the density of the prepared Sodium Bicarbonate Ear Drops;
    assay the prepared Sodium Bicarbonate Ear Drops.







    2
    Preparation of Sodium Bicarbonate Ear Drops
    Equipment and materials
    250 cm
    3
    beaker
    100 cm
    3
    measuring cylinder
    Glass rod
    Spatula
    Storage bottle
    Sodium hydrogencarbonate
    Glycerol
    Deionised water
    Balance

    Method
    1. Weigh between 4.9 and 5.1 g of sodium hydrogencarbonate into a 250 cm
    3
    beaker.
    2. Using a 100 cm
    3
    measuring cylinder, add 60 cm
    3
    of deionised water and stir with a glass rod
    until the solid has dissolved.
    3. Pour the mixture back into the measuring cylinder and add enough glycerol to make the
    solution up to 100 cm
    3
    .
    4. Pour the mixture into the beaker again and stir with the glass rod until it is thoroughly mixed.
    5. Store the solution in a labelled bottle.

    Density of Sodium Bicarbonate Ear Drops
    Equipment and materials
    10 cm
    3
    measuring cylinder 100 cm
    3
    beaker

    Method
    1. Weigh a 100 cm
    3
    beaker.
    2. Measure 10 cm
    3
    of Sodium Bicarbonate Ear Drops into the beaker.
    3. Weigh the beaker and its contents.
    4. Repeat steps 1-3 three more times.

    Calculations
    For each measurement, calculate the density of the ear drops.
    Comment on the repeatability of the measurements.
    Does the preparation meet the British Pharmacopoeia standards?

    Sodium Bicarbonate Ear Drops assay
    You are provided with 0.10 mol dm
    3
    hydrochloric acid and screened methyl orange indicator.
    Read the British Pharmacopoeia assay and rewrite it as a series of steps that other students could
    follow. List the equipment and materials needed.
    Carry out a risk assessment and check with your teacher before carrying out the assay.
    Once it has been checked, use the method to assay your preparation.

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