MOET Algorithm

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3013 MOET (new edition)

15/2/07

9:25 AM

Page 150

Algorithm 16.1 Pre-eclampsia/eclampsia

Place in semi-prone position


Call for HELP duty obstetric and
anaesthetic SpRs; senior midwife
Inform consultants obstetrician and
anaesthetist

Do not leave
patient alone

Airway
Assess
Protect airway
Ventilate as required
Loading dose MgSO4:
4 g MgSO4 in 20% solution IV over
1015 minutes. Add 8 ml of 50%
MgSO4 solution to 12 ml
physiological saline
Maintenance dose MgSO4: 1 g per
hour infusion. Add 25 g MgSO4
(50 ml) to 250 ml physiological saline
1 g MgSO4 = 12 ml per hour IV
If seizures continue or recur: MgSO4
2 g 70 kg; 4 g 70 kg IV as per
loading dose over 510 minutes. If this
fails: diazepam 10 ml IV or
thiopentone 50 mg IV paralyse and
intubate
Monitor: Hourly urine output,
respiratory rate, O2 saturation &
patellar reflexes every 10 minutes for
first 2 hours and then every 30
minutes
Check serum magnesium if toxicity is
suspected on clinical grounds
Stop infusion: Check magnesium
levels and review management with
consultant if:
Urine output < 100 ml in 4 hours
or if Patellar reflexes are absent
or if Respiratory rate < 16/minute
or if Oxygen saturation < 90%
Always get suppression of reflexes
before respiratory depression
Antidote: 10% calcium gluconate
10 ml IV over 10 minutes
OBSERVATIONS
Pulse oximeter
BP
Respirations
Temperature
ECG
Test urine for protein
Hourly urine output
Fluid balance charts
FHR monitor continuously

150

Breathing

Circulation

Control seizures

Control
hypertension

Assess
Maintain patency
Apply oxygen
Evaluate pulse and BP
If absent, initiate CPR and call the
arrest team
Secure IV access as soon as safely
possible
Treat hypertension if systolic BP
> 170 mmHg or diastolic BP
> 110 mmHg or MAP >125 mmHg
Aim to reduce BP to around
130140/90100 mmHg Beware
maternal hypotension and FHR
abnormalities monitor FHR with
continuous CTG
HYDRALAZINE 10 mg IV slowly
Repeated doses of HYDRALAZINE
5 mg IV 20 minutes apart may be
given if necessary
Close liaison with anaesthetists: may
require plasma expansion
LABETALOL 50 mg IV slowly if BP
still uncontrolled
If necessary repeat after 20 minutes or
start IV infusion: 200 mg in 200 ml
physiological saline at 40 mg/hour,
increasing dose at half-hourly
intervals as required to a maximum of
160 mg/hour

If not
postpartum . . .
Deliver

INVESTIGATIONS
FBC & platelets
U&Es
Urate
LFT
Coagulation screen
Group & hold serum
MSSU
24-hour urine
collections for:
total protein &
creatinine clearance
catecholamines

The continuation of pregnancy is not


an option if eclampsia occurs
STABILISE THE MOTHER BEFORE
DELIVERY
DELIVERY
IS A TEAM EFFORT

involving obstetricians, midwives,


anaesthetists and paediatricians
Ergometrine should not be used in
severe pre-eclampsia and eclampsia
Consider prophylaxis against
thromboembolism
Maintain vigilance as the majority of
eclamptic seizures occur after
delivery

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