Physio B 1.2 Renal Physiology Pt. 4 (Dr. Vila) : Because of Increase Water Reabsorption
Physio B 1.2 Renal Physiology Pt. 4 (Dr. Vila) : Because of Increase Water Reabsorption
Physio B 1.2 Renal Physiology Pt. 4 (Dr. Vila) : Because of Increase Water Reabsorption
Increase ADH
Supposedly.
Because of increase water reabsorption:
Increase BV
Increase BF
Increase GFR
Urine is hyperosmotic
P a g e |2
Edema
Clinical Findings:
o Swelling in most dependent parts of the body due
to effects of gravity and increase hydrostatic
pressure in the capillaries
Edema vs. Effusion
Principle of osmosis
Fluid INFLUX
Isotonic
Influx (2L
NSS)
Hypotonic
Influx (Water
loading)
Hypertonic
Influx (Drink
sea water)
ECF
Vol.
ECF
OP
H2O
Shift
ICF
Vol.
ICF
OP
Compensatory
Mechanism
SA
ME
NONE
SA
ME
SA
ME
NONE
Extra
to
intrace
llular
Intra
to
extrac
ellular
-Decrease ECF
tonicity
-Activate ADH
-Water
reabsorbed
-Decrease
urine volume
-Increase
urine tonicity
-Increase ECF
tonicity
-Inhibit ADH
-Increase
urine volume
-Decrease
urine tonicity
P a g e |3
Fluid EFFLUX
Isotonic
Efflux
(Burns)
Hypotonic
Efflux
(Profuse
Sweating)
Hypertonic
Efflux
(SIADH)
ECF
Vol.
ECF
OP
H2O
Shift
ICF
Vol.
ICF
OP
Compensatory
Mechanism
SA
ME
NONE
SA
ME
SA
ME
NONE
Intra
to
extrac
ellular
Extra
to
intrace
llular
-High ECF
tonicity
-Activate ADH
-Water
reabsorption
-Decrease
urine volume
-Increase
urine tonicity
-Low ECF
tonicity
-Inhibit ADH
-Increase
urine volume
-Decrease
urine tonicity
Acid-Base Balance
Rules:
pH
(35 45
mmHg)
(7.35 7.45)
pCO3(22 -26mmHg)
7.29
Acidic
48
Acidic
24
Normal
7.29
Acidic
37
Normal
19
Acidic
7.47
Basic
32
Basic
24
Normal
7.47
Basic
37
Normal
29
Basic
7.29
Acidic
36
Normal
19
Acidic
7.47
Basic
32
Basic
19
Acidic
7.47
Basic
48
Acidic
29
Basic
7.29
Acidic
30
Basic
28
Basic
7.47
Basic
30
Basic
19
Acidic
7.44
Normal
48
Acidic
30
Basic
7.38
Normal
48
Acidic
30
Basic
Disorder
Respiratory
Acidosis
Metabolic
Acidosis
Respiratory
Alkalosis
Metabolic
Alkalosis
Metabolic
Acidosis
Respiratory
Alkalosis,
partially
compensated
by the
kidneys
Metabolic
Alkalosis,
partially
compensated
by lungs
Mixed
Acidosis,
partially
compensated
Respiratory
Alkalosis,
partially
compensated
Metabolic
Alkalosis,
fully
compensated
Respiratory
Acidosis, fully
compensated
P a g e |4
Kidneys
o Third line of defense
o Remove excess H+ from the body in combination
with urinary buffers
Henderson-Hasselbach Equation
pH Units
Respiratory system
o Second line of defense
o Large loads of acid stimulate breathing which
removes CO2 from the body
P a g e |5
H+,K+-ATPase
o HCO3- exits across the basolateral membrane in
exchange for Cl-, via a Cl-HCO3- antiporter
o Active during metabolic acidosis
NH3: ammonia
Please refer to Guyton for the Phosphate Buffer System and Proteins
as ICF buffers, and Guyton Chp. 36 Acid-Base Balance (Hindi na
diniscuss ni doc, pero kasama daw sa shifting )
Reading assignments:
Renal Failure
Sources:
Lecture: Dr. Vila
Berne&Levy, 6th Edition
Guyton and Hall, 12th Edition
Read Berne & Levy or Guyton, guys! Mas specific at complete mga
explanations dun. Good luck and God bless! Labyu all <3