Spirulina Book PDF
Spirulina Book PDF
Spirulina Book PDF
iii
Publishers Note
Disclaimer. The information in this book is for educational purposes only; it is not
intended to be taken as medical advice or as an attempt to sell a particular product, nor is it
intended to diagnose, treat, cure, or prevent any disease. The opinions expressed are those of
the author. People with medical problems or questions should consult a health professional.
Animal Research is never conducted by the publisher. Animal Research
Policy: Cyanotech Corporation, the publisher of this book, does not condone animal
experimentation. As a service to the reader, animal studies conducted by others are reported
in this book so readers may fully understand the ongoing medical research and the potential
benefits of spirulina in human nutrition.
Reproduction of Contents. This book may not be reproduced in whole or in part,
by any means, without written permission from Cyanotech Corporation, 73-4460 Queen
Kaahumanu Highway, Suite 102, Kailua-Kona, HI 96740 USA or email info@cyanotech.
com.
iv
Table of Contents
Publishers Note . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ii
Introduction by William Sears, M.D. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vi
Chapter 1
Spirulina: The Blue-Green Superfood . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
What Is Spirulina? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Where Does Spirulina Come From? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2
Who Should Take Spirulina? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Why Take Spirulina? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4
How Much Spirulina Should Be Taken and When? . . . . . . . . . . . . . . . . . . . . . . . . . . 9
Chapter 2
The Synergy of Nine Potent Nutrients . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10
Chapter 3
Superfood for Super Health . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16
Sustained Energy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16
Year-Round Immune Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18
Heavy Metal and Radiation Reduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
Antioxidant Benefits . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20
Essential Iron Source . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20
Brain Cell Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22
Liver and Kidney Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23
Cardiovascular Health Benefits . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23
Table of Contents
Chapter 4
High-Quality Spirulina Production and Environmental Stewardship . . . . . . . 25
25
26
26
26
26
26
27
27
27
Chapter 5
Better Than Organic . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29
Chapter 6
Top Considerations When Choosing a Spirulina Brand . . . . . . . . . . . . . . . . . . . . 32
Chapter 7
Recipes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34
Chapter 8
Frequently Asked Questions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57
vi
Introduction
Nearly 20 years ago, after suffering a life-threatening illness and needing to transform
my health, I discovered that some of the healthiest superfoods come from the sea. So, I went
fishing for these superfoods.
My first catch was omega-3 fats found in oily fish, especially wild Pacific salmon.
This discovery led to my first book about that nutrient: The Omega-3 Effect, published in 2012.
The next healthy catch came while fishing in Alaska with Randy Hartnell, former
Alaskan fisherman and owner of an online provider of sustainable seafood. One day while
watching a salmon run, I asked Randy, Why are wild salmon so pink?
The answer led to my next book: Natural Astaxanthin: Hawaiis Supernutrient published
in 2015. The pink color that you see in salmon comes from a nutrient called astaxanthin that
is present in the marine food chain. Microalgae produce astaxanthin to withstand the intense
conditions theyre subjected to in the marine environment. Its one of the most protective
substances in the world, which is why its so healthful for us to ingest in our bodies.
In my never-ending quest for seafood superfoods, I decided to visit a farm in Hawaii
where astaxanthin is grown commercially, and thats where I discovered spirulina. Spirulina
is another species of microalgae, the super seaplant that has many very attractive health
benefits. Ive always advocated getting your nutrients from healthy food, not supplement
pills. But I realize that many people dont get the nutrients they need from food, so
supplements solve a problem in many peoples diets. For example, if youre not eating three
to four servings of wild salmon each week, youre probably not getting enough omega-3s or
astaxanthin, and should consider supplementing your diet with them each day.
But thats one of the beautiful things about spirulinaits not a supplement. Spirulina
is a super-healthy food. In fact, spirulina has been referred to as a superfood for many years
because its so packed with nutrients that just one teaspoon of the leading brand, Hawaiian
Spirulina, delivers a variety of vitamins, minerals, calcium, iron, and protein. Hawaiian
Spirulina is especially high in antioxidants, which are nutrients that support longevity and
a healthy immune system. And as a show-me-the-science doctor, I was extremely pleased
to find out that there are hundreds of medical research studies showing a wide range of
health benefits from Hawaiian Spirulinafrom supporting cardiovascular health to simply
boosting peoples everyday energy levels.
Ive been back to the microalgae farm in Hawaii multiple times since my original visit
there a few years ago. Ive had the pleasure of meeting the founder of the spirulina farm,
Dr. Gerry Cysewski. I am extremely impressed with the quality his company puts into its
products and its focus on research. Hawaiian Spirulina grows on the only farm in the world
that adds deep seawater to its spirulina ponds. The water comes from 2,000 feet below the
Introduction
vii
surface of the Pacific Ocean, and so it hasnt been exposed to the surface for thousands of
years. Its the purest water you can find anywhere, full of rich minerals. Dr. Cysewski and his
staff really care about health and the quality of the product that bears the Hawaiian Spirulina
name.
In just a few years, Ive gone from spirulina novice to spirulina enthusiast. In fact,
Im so enthusiastic about Hawaiian Spirulina that not only do I add it to my smoothies
each morning, but Ive also written a book about spirulina for children, called My Big Green
Smoothie. Spirulinas not just good for adults like me, its a wonderful food for people of all
ages who need to eat what Dr. Mother Nature prescribes: superfood for super health.
Chapter
Most people are familiar with the large green or red algae growing in lakes and the
ocean. These are commonly known as seaweed. By contrast, microalgae are tiny, one-celled
organisms that come in different species depending on their phytopigment and phytonutrient content. These microalgae are extensively researched for their health-giving benefits.
Of the more than 30,000 species of
microalgae, blue-green microalgae, such as spirulina, are the most primitive. They contain no
nucleus and their cell walls are soft and easily
digested, unlike those of other plants that contain hard cellulose walls. Of all the microalgae,
spirulina has emerged as the most potent and
nutritious.
Commercial production of spirulina
began over 45 years ago from a single lake
on the outskirts of Mexico City. The Mexican
Spirulina cells
company skimmed the spirulina from the surface of the lake, air-dried it, then sold it to supplement brands, primarily in the United States and Europe. Unfortunately, the lake suffered
from being too close to Mexico City, and the spirulina soaked up all the heavy metals and
lead in the air and water from the nearby polluted metropolis, destroying spirulinas most
fragile and health-giving nutrients.
To fill the void in the marketplace for safe and nutritious spirulina, the microalgae
company Cyanotech began an exhaustive search lasting two years to find the ideal conditions in which to cultivate high-quality spirulina. The Kona coast of Hawaiis pristine Big
Island was selected for its size, low population density, pure water access, state protection
and temperate climate.
The Big Island, as Hawaii Island has come to be known, has the largest area of all the
Hawaiian Islands, but also one of the lowest population densities. There is no agricultural
runoff of fertilizers or pesticides, nor are there golf courses in the area that could affect the
quality of the ponds. Furthermore, the Big Island has an almost constant on-shore breeze
that knocks back any potential manmade air pollution.
Not only does the Kona coast have clean air, it also has pure water. Cyanotechs water
supply begins with rainwater that gets naturally filtered through lava rock. It is this pure
drinking water that fills the ponds in which spirulina grows.
The Kona coast has also been designated as a BioSecure zone, which prohibits any
genetically modified organisms or other unnatural substances. This ensures that the 90-acre
Hawaiian Spirulina farm is a pure and natural environment for growing microalgae.
Spirulina needs mild temperatures and plenty of sunshine. Kona is the sunniest
coastal location in the United States, making it the only spirulina farm in the world that is
able to grow spirulina year-round.
Not only do people enjoy the benefits of spirulina, but animals and plants can thrive
on it, too. Veterinarians recommend spirulina for animal stamina and for general toning.
Prize-winning koi carp are fed spirulina to enhance their color and health. Bird
breeders add spirulina to bird food to enhance plumage color and luster. Spirulina is used
extensively by aquaculture companies to increase disease resistance among various fish and
shellfish and to improve their overall quality and coloration.2
Gardeners can use spirulina as a complete, effective plant food. Homeowners can
sprinkle a little spirulina in the soil around their favorite houseplant and see what a difference
it makes. Organic farmers can use spirulina as a natural fertilizer.
The protein in spirulina is complete, meaning that it contains all the essential amino
acids. Spirulina also supplies non-essential amino acids. Non-essential does not mean that
these amino acids are not needed by the body, but only that the body can produce them by
itself. Still, the body is better served if they are readily available in dietary sources.
While most animal proteins are high in fat, calories, and cholesterol, a three-gram
daily serving of spirulina has only five percent fat, most of which is unsaturated. There are
fewer than four calories in each gram and practically no cholesterol.
Spirulinas protein is easily digested and assimilated. Other plants have cell walls of
hard, indigestible cellulose, whereas spirulinas cell walls consist of soft mucopolysaccharides, making it easy for the body to digest. Digestibility and absorption are very important
factors, especially for undernourished people, convalescents and the elderly.
To determine the percentage of usable protein in a food, the amount of protein present is measured along with its digestibility and biological value. As shown in Table 1.1, the
only food with more usable protein than spirulina is eggs.
Spirulina supplies several of the vitamins that all living beings need to carry on metabolic processes. These include all the B vitamins, including vitamin B12, the most difficult of
all vitamins to obtain from vegetable sources. Hawaiian Spirulina contains 250 percent more
of this rare vitamin than beef liver, previously thought to be the vitamins richest source.
It also includes a substantial amount of vitamin A in the form of beta carotene. Vitamin A comes from two sources: animal sources and plants. Vitamin A from animal sources,
called retinoids, can lead to toxicity levels. When it comes from plants it is called a carotenoid, which includes beta carotene. This is the form found in Hawaiian Spirulina. The body
converts beta carotene to vitamin A as needed, without the concern of excess levels.
Vitamins K1 and K2 are found in spirulina, both of which play important roles in
blood formation and circulation.
Few other microalgae contain the abundance of trace minerals, such as iron and zinc,
Food
Protein (%)
NPU (%)*
Dried eggs
Spirulina
Dried skimmed milk
Soy flour
Fish
Chicken
Beef
Peanuts
47
65
36
37
22
24
22
26
94
57
82
61
80
67
67
38
Usable
Protein (%)
44
37
30
23
18
16
16
10
and major minerals, such as potassium and magnesium, that Hawaiian Spirulina does.
Powerful Antioxidants
The potent trio of phytopigments found in spirulina can be found only in abundant
quantities of fruits and vegetables. The yellow-orange carotenoids, the green chlorophyll,
and the blue phycocyanin also make up the bulk of spirulinas antioxidant strength. Hawaiian Spirulina also contains superoxide dismutase (S.O.D.), one of the most powerful antioxidant enzymes. The importance of carotenoids, phycocyanin, and S.O.D. will be discussed in
further detail in Chapter 2.
Essential fatty acids, which include omega-6 and omega-3, are fats that the body
cannot produce on its own, so they need to come from food sources. Omega-6s and
omega-3s play a crucial role in supporting healthy brain function, as well as normal growth
and development of cells. Spirulina is made up of about five percent lipids. These fats are
absolutely vital to health.4, 5
Figure 1.1
Based on periodic analysis. Typical analysis per three grams one teaspoon
General Composition
Protein
Carbohydrates
Lipids
Minerals
Moisture
Calories
Minerals
Boron
Calcium
Chromium
Copper
Iodine
Iron
Magnesium
Manganese
Phosphorus
Potassium
Selenium
Sodium
Zinc
>60%
<30%
4-6%
8-13%
3-6%
10
Vitamins
22 mcg
11 mg
65 mcg
50 mcg
15 mcg
5 mg
15 mg
200 mcg
30 mg
43 mg
0.9 mcg
35 mg
90 mcg
Biotin
0.5 mcg - < 1 mcg
Folic Acid
5 mcg
Inositol
1.7 mcg
Pantothenic Acid
5 mcg
Vitamin A (Beta Carotene)
9,500 IU
Vitamin B1 Thiamine
3 mcg
Vitamin B2 Riboflavin
179 mcg
Vitamin B3 Niacin
465 mcg
Vitamin B6 Pyridoxine
21 mcg
Vitamin B12 Cobalamin
8.0 mcg
Vitamin K1, K2
40 mcg
Phytonutrients
Chlorophyll
Phycocyanin (c, allo)
Zeaxanthin
Total Carotenoids
21 mg
270 mg
3.0 mg
13 mg
Omega 3 Family
Alpha Linolenic
Docosahexaenoic (DHA)
Omega 6 Family
Gamma Linolenic (GLA)
Essential Linoleic
Dihomogamma Linolenic
Monoenoic Family
Palmitoleic
Oleic
Palmitic Acid
Myristic Acid
Stearic Acid
Arachidonic Acid
0.10 mg
0.0435 mg
32 mg
13.2 mg
0.53 mg
24.2 mg
0.10 mg
0.70 mg
0.10 mg
4.1 mg
1.6 mg
Protein
Spirulina is a superior source of dietary protein about 60 percent highly
digestible protein, containing all essential amino acids.
Typical Amino Acid Analysis
Essential Amino Acids
Isoleucine
Leucine
Lysine
Methionine
Phenylalanine
Threonine
Tryptophan
Valine
Percent of Total
Mg per Gram
5.98
8.91
4.99
2.47
4.98
5.25
1.80
6.00
34.6
51.6
28.9
14.3
28.8
30.4
10.4
34.7
7.90
7.31
10.14
0.97
13.94
5.44
1.77
4.01
4.89
4.74
45.7
42.3
58.7
5.6
80.7
31.5
10.4
23.6
28.8
28.2
100.0
589.0
Total
Please Note: This is only a partial list of the variety of health-giving nutrients
found in Hawaiian Spirulina.
10
Chapter
Phycocyanin
Beta carotene
Zeaxanthin
Iron
Vitamin B12
Vitamin K
GLA (gamma linolenic acid)
Trace minerals
S.O.D. (superoxidase dismutase)
11
Phycocyanin ( phyco meaning algae and cyanin meaning blue-green) is a powerful molecule only found in spirulina and some other blue-green algae. It is a water-soluble
antioxidant and gives spirulina its rich blue-green pigment. Spirulina is the only whole food
that contains this blue antioxidant. Wheat grass and chlorella are green from chlorophyll, but
only spirulina has both the blue and green antioxidants.
Phycocyanin, a water-soluble protein, works with the chlorophyll in Hawaiian Spirulina to become a powerful antioxidant. Scientists have labeled phycocyanin a wonder
molecule for its many health benefits.6 Phycocyanin has been shown to:
Beta carotene: The Antioxidant for Skin, Eyes, and Immune System
Beta carotene is one of the most important antioxidants for skin, eyes, and immune
function. It belongs to the family of fat-soluble antioxidants called carotenoids, the nutrients
responsible for the bright orange and yellow color of pumpkins, carrots, and sweet potatoes.
Beta carotene is a precursor of vitamin A. The body converts the carotenoid to vitamin
A to protect cells from oxidization. Vitamin A behaves like a scavenger of oxidized cells
in the body. When sunlight, for example, causes skin cells to oxidize, vitamin A, working
in tandem with other vitamins and minerals in Hawaiian Spirulina, can latch onto those
cells, protecting them from further breakdown. It also contributes to skin health and radiant
appearance and works with other antioxidants to protect the cornea of the eye and boost the
immune system.
Table 2.1 Beta carotene in Food Comparison 7
Food
Amount of Beta Carotene
Hawaiian Spirulina (three grams)
9,500 IU
Carrot, small (50 grams)
8,353 IU
7,420 IU
Papaya, large (781 grams)
Pumpkin, 1 cup raw (116 grams)
9,875 IU
Chlorella (three grams)
845 IU
12
Zeaxanthin: The Antioxidant for the Retina, Lens, and Brain Tissue
Zeaxanthin is also part of the carotenoid family of antioxidants. Like beta carotene, it
is found in brightly colored fruits and vegetables. Zeaxanthin specifically works on the retina
and lens of the eyes. Zeaxanthin protects the eyes by
absorbing damaging blue light and reducing glare. Over
time, blue light can cause oxidative stress in the eyes.8
Zeaxanthins antioxidant properties naturally reduce
these harmful effects
In the side-by-side antioxidant test shown in Figure
2.1, zeaxanthin came out almost 500 times stronger than
vitamin E. The only antioxidant that was more powerful
in quenching singlet oxygen, the highly unstable form of
oxygen responsible for oxidation damage, was astaxanthin.
The ability of zeaxanthin to cross the blood-brain
barrier to fight the oxidative degeneration of brain tissue
is another reason to consume zeaxanthin.
Food and dietary supplements are the only way to get zeaxanthin in the bloodstream,
because it is not made naturally in the body.9 Receiving adequate amounts of zeaxanthin
through food can be particularly difficult, as it requires many servings a day of certain fruits
and vegetables. A three-gram serving of Hawaiian Spirulina has more zeaxanthin than a
bowl of spinach, one of natures richest sources of zeaxanthin.
Figure. 2.1 Singlet Oxygen Quenching Rates 10
Antioxidant Strength
600
500
400
300
200
100
0
Antioxidant
13
Hawaiian Spirulina has by far the highest levels of iron of any brand of spirulina. Iron
is an essential element for life on earth, primarily for its role in producing blood. About 70
percent of the bodys iron is found in red blood cells and muscle cells. Red blood cells transfer oxygen from the lungs to all the cells in the body. The immune system especially depends
on available iron stores. 11
Iron is also involved in the conversion of blood sugar to energy. Metabolic energy is
crucial for athletes since it allows muscles to work at their optimum levels during exercise or
when competing.
Vegetarians, especially, are prone to iron deficiency, since iron is most commonly
found in meats. Because the body recognizes spirulina as a food and spirulina's cell walls are
perfectly digestible, the iron in spirulina is easily absorbed. This makes Hawaiian Spirulina
an ideal source of iron: five milligrams of iron in a three-gram serving of Hawaiian Spirulina
make up 30 percent of the U.S. Food and Drug Administration recommended daily value
(see Figure 2.2).
Figure 2.2 Iron Content of Spirulina
Quality Competor #2
14
Vitamin B12 has a key role in the normal functioning of the nervous system and the
formation of blood. Vegetarians and vegans are susceptible to being vitamin B12 deficient,
because the vitamin is mostly found in animals and animal products. The foods with the
highest amounts of vitamin B12 are cooked clams, beef liver, and mackerel. Vegetarians and
vegans have to find a way to get this essential vitamin into their diets. Fortunately, one daily
serving of three grams of Hawaiian Spirulina gives 150 percent of the recommended daily
value of vitamin B12.
There are two different kinds of vitamin B12: human-active, which the body can
absorb and use; and analog which is not absorbed by the body. Both forms are found in
Hawaiian Spirulina. The amount of human-active B12 represents 54 percent of the U.S.
FDA recommended daily intake of B12. (The analog B12 does not interfere with the absorption of human-active B12, and neither form has side effects or toxicity.)
While the health benefits of vitamins A, B, C, D, and E are widely known, the benefits
of vitamin K are still emerging, and there are many. Most important, this fat-soluble vitamin
plays a role in blood clotting. In fact, the K comes from the German word koagulation. Its
particular chemistry also promotes decalcification of the arteries. Vitamin K has also been
studied for its role in preserving bone mineral density, especially in the elderly. 12, 13
Vitamin K has two main forms, K1 and K2. K2 is suggested to be the form of vitamin K most responsible for maintaining healthy cardiovascular function. A three-gram daily
serving of Hawaiian Spirulina provides 50 percent of the U.S. FDA recommended daily dose
of vitamin K. A tremendous amount of leafy green vegetables would have to be consumed
to get the same dose.
Gamma-linolenic acid (GLA) is an omega-6 fatty acid that is found mostly in hard-tofind plant oils, like evening primrose oil. The oils in Hawaiian Spirulina contain three times
more GLA than what is found in evening primrose oil. Omega-6 fatty acids are considered
essential fatty acids: While they are necessary for human health, the body must supply them
from food. Along with omega-3 fatty acids, omega-6 fatty acids have a powerful antioxidant
effect on brain tissue, protecting the brain from cognitive decline due to oxidative deterioration. These antioxidants are also known for their protection of the arteries, skin, and bones,
as well as their role in metabolism and reproduction.
Every second of every day, the body relies on trace minerals to conduct and generate
15
billions of tiny electrical impulses. Without these impulses, not a single muscle, including the
heart, would be able to function. The brain would not function and the cells would not be
able to use osmosis to balance water pressure and absorb nutrients. Traditionally, eating fresh
grains, fruits, and vegetables grown in nutrient-rich soil has been the primary supply for a
full spectrum of minerals. Unfortunately, in todays world, naturally occurring, nutrient-rich
soil is becoming increasingly rare. Eons of vegetation growth and aggressive modern farming techniques have brought many of the earths minerals to the surface where they have
been washed away into the ocean.
Hawaiian Spirulina is grown in ponds that are enriched with a small percentage of
deep sea water pumped from 2,000 feet below the oceans surface. This is where the trace
minerals such as iron, zinc, copper, iodine, selenium, manganese, chromium, fluoride, and
molybdenum have settled. Spirulina absorbs these minerals into its delicate filaments and
makes them available in the human body, where they work to create and restore health.
The enzyme superoxide dismutase, or S.O.D, has been called the antioxidant catalyst, because it speeds up the breakdown of superoxide radicals produced as a byproduct
of energy metabolism. If not regulated, superoxide radicals cause many types of cellular
damage.
The benefits of S.O.D. in normalizing aging have been widely demonstrated. A University of California, San Diego, study reported that [S.O.D.] protects cells from toxic, reactive oxygen species and may be involved in age-related degeneration. 14 In Finland, scientists
concluded compounds with S.O.D. and catalase activities have shown promising results
in animal models against a variety of oxidant exposures. 15 At the University of Colorado
School of Medicine, researchers found that the space between individual cells is protected
from oxidative stress by S.O.D. and that this activity is more highly pronounced in blood
vessels, the heart, lungs, kidneys, and the placenta. 16
Although S.O.D. is one the more important antioxidants the body relies on, the
enzyme is susceptible to the harsh acids present in the human stomach. As a result of a
patented ocean chill drying method, the S.O.D. in Hawaiian Spirulina tablets is not highly
destroyed by stomach acids, which can be a potential problem when taking S.O.D. in some
supplement forms.
But what about Hawaiian Spirulina powder? Will stomach acids destroy the S.O.D.
before it can get into the bloodstream if spirulina is taken in powder form? Research suggests
that even powder sources of S.O.D. elevate S.O.D. levels in the body. 17
Not many foods qualify as a complete source of nutrition. The label of superfood is
reserved for only an elite few. The antioxidants, vitamins, and minerals found in Hawaiian
Spirulina can each stand alone in their importance to human health. But when one food can
deliver all of them in rich supply and with a synergy that empowers them to greater effectiveness, their impact is multiplied and their contributions to health unparalleled.
16
Chapter
Sustained energy
Year-round immune support
Heavy metal and radiation reduction
Antioxidant benefits
Essential iron source
Brain cell support
Liver and kidney support
Cardiovascular health maintenance
Sustained Energy
People consume staggering amounts of coffee and other caffeinated drinks for one
main purpose to give themselves an artificial energy boost to get through the day. The
body is perfectly capable of supplying its own energy so long as it stays in optimal working
order. Overeating processed foods, sitting too long at a desk, lack of sleep, and other detriments to health deplete the bodys natural energy reserves.
Assuming lifestyle changes are on most people's to-do list, supplementing with
Hawaiian Spirulina offers a kind of shortcut to health. With the synergy of its beta carotene,
iron, vitamins, phycocyanin, and other nutrients, Hawaiian Spirulina can provide sustained
energy without the crash. And because it is a natural food, there are no chemicals to counteract the health benefits.
In 2006, a small double-blind, placebo-controlled study was conducted on non-athletic
17
18
ately athletic mens endurance increased by 32 percent versus only seven percent in the first
study (see Figure 3.1).
19
ers used to measure immune strength white blood cell count and certain liver enzymes
increased in the majority of subjects, 22 demonstrating spirulinas positive role in bolstering
the immune system.
In 2002, researchers in Mexico and Russia independently observed spirulinas reinforcing effect on immune cells compromised by infection in a laboratory setting. 23, 24 They
found that spirulina demonstrated antiviral activity by inhibiting cells from becoming
infected by certain viruses and by slowing the reproduction of certain viruses.
20
Antioxidant Benefits
Antioxidants have a tough job. Like the Greek myth of Sisyphus, who repeatedly
pushed a boulder uphill only to have it roll down again, antioxidants must stay strong enough
to keep the free radicals from rolling through the body, breaking down tissue in their wake.
The outward signs of free radical damage are lines, wrinkles, and dry skin, for example. Internally, free radicals impair muscle tissue, cardiovascular tissue, brain tissue, and
other organ tissues. On a cellular level, free radicals can damage DNA, leading to a faster
than normal rate of aging.
Although spirulina looks primarily green, it actually contains four distinct pigments,
each of which is known for its antioxidant power on different parts of the body, though they
often overlap.
An essential mineral means that the body cant manufacture it on its own and must get
it from food. One of the most essential minerals in the body is iron. Without it, blood cells
(hemoglobin) and muscle cells would be unable to deliver oxygen. Spirulina is a naturally
rich source of iron. The body is able to absorb more iron from spirulina than from other
mineral-rich foods such as beef. Researchers in Montpellier, France, found that consumption of spirulina led to iron bioavailability that was 6.5 times higher than from consumption
of beef. 34
A study in Calcutta, India, compared two randomly divided groups of women: one that
received only a supplement of iron, folic acid, and B12, and another that received spirulina
21
along with that supplement. The study found that the addition of spirulina to the supplement
resulted in the women having higher hemoglobin levels than without the spirulina.35
Healthy stores of iron and the resulting increased hemoglobin are particularly important to women who are pregnant or breastfeeding. In an animal study, researchers found
that spirulina improved the amount of hemoglobin and iron storage in rats that were either
pregnant or lactating. The improvement was compared to diets of fortified plant sources of
iron, namely casein and wheat gluten. 36
Ascorbic acid, or vitamin C, plays a key role in enhancing iron absorption in the body.
Even with the rich source of iron in spirulina, it is important to also consume oranges, strawberries, broccoli, and other foods with vitamin C. Hawaiian Spirulina has a healthy amount
of vitamin B12 and folic acid, both of which help the body absorb iron.
In a roomful of fruits and vegetables, why do blueberries consistently get all the attention? The answer, of course, is because of its rich antioxidant content. But this knowledge
wasnt widely known until Dr. Paula Bickford, a professor in the Department of Neurosurgery at the University of South Florida College of Medicine, conducted extensive research on
the health benefits of eating blueberries. Her findings were so well publicized that she was
able to establish blueberries as a superfood.
After this work, she turned her attention to
spirulina. Specifically, she studied spirulinas effects
on the brain. In a comparison study of the effects
of spirulina, blueberries, and spinach on the brain
health of laboratory rats, in which some rats were fed
spirulina, some rats blueberries, some rats spinach,
and some rats a control food that contained none
of the above, she found that the rats that were fed a
daily diet of either of the three antioxidant-rich foods
for four weeks showed sustained levels of heightened
cognition. Spirulina, especially, had significant positive outcomes on the brain scans of rats. 37
She also studied spirulinas effect on stem
cell proliferation. A daily dose of spirulina was administered to laboratory rats for 30 days.
Stem cells are important for learning and memory, essentially a repair system in the human
body. They can divide in unlimited numbers to replenish other cells. She found that a diet
enriched with spirulina and other nutraceuticals may help protect the stem/progenitor cells
from insults. 38 This means that Hawaiian Spirulina may support the brains ability to withstand deterioration.
Although these results have yet to be demonstrated in human clinical trials, the
animal trials have consistently found several potential neurological benefits from taking spi-
22
23
rulina. Simply put, all signs point to spirulina being a neuroprotective supplement.
Many other scientists continue to study how exactly spirulina supports the brain.
They have found in laboratories that spirulina promotes lead detoxification,39 improves
motor functioning,40 and protects the brain from oxidative stress. 41-45
The liver and kidneys are responsible for turning food into energy and safely ridding
unwanted by-products. The bodys own antioxidants enable the cells of the liver and kidneys
to do their job without breaking down from exposure to free radicals.
Free radicals are the name of unstable oxygen molecules that are formed during
normal metabolism and exposure to environmental stressors, such as strenuous exercise,
air and water pollution, chemicals in foods, and multiple sources of radiation, including
sunlight.
When the bodys antioxidants cant keep up with the number of free radicals, the liver
and kidneys are unable to perform at necessary rates.
This is where spirulina comes in. The antioxidant array of vitamins, minerals, and
phytonutrients in spirulina is immediately recruited to the areas of the body that are losing
the battle against free radicals. In several studies around the world, scientists tested spirulinas antioxidant effect on the liver and kidneys by exposing rats to a known oxidant and
observing whether spirulina can bolster the liver and kidney cells ability to withstand oxidation. The results unilaterally showed a positive correlation between spirulina and the function of liver and kidney cells.46-52
When a food is said to be good for the heart, it usually means its good for the cardiovascular system. The heart might be the hardest-working organ in the body, but it doesnt
work alone. To do its job, it depends on the arteries to carry nutrient-rich blood to all the
areas of the body. And it depends on veins to return the depleted blood back to the heart.
The antioxidant concentration in Hawaiian Spirulina, especially that in phycocyanin, is
designed to cooperate alongside this system. Phycocyanin is known for its protective activity on heart cells and the cells lining the blood vessels.53 Its presence helps prevent the cells
from oxidizing.
In a human clinical trial in Mexico, scientists administered 4.5 grams a day of spirulina to 36 subjects and measured several cardiovascular indicators before and after the
spirulina intake.54 The group was a diverse mix of men and women ages 18 to 65. They were
told to go about their lives without any dietary restrictions. After six weeks of consuming
spirulina, scientists discovered that their systolic and diastolic blood pressure had lowered.
In another human clinical trial, conducted in Korea on 78 healthy, elderly men and
women ages 60 to 87, scientists wanted to test spirulinas nutritive effects on the cardiovascular system. The men and women were given either eight grams of spirulina a day or a placebo,
24
25
Chapter
Cyanotech has developed a proprietary drying method called Ocean Chill Drying
that uses cold ocean water pumped from 2,000 feet below the surface of the Pacific Ocean.
The ocean water cools and dehumidifies the warm moist air exiting the dryer. The dehumidified air is then recycled back into the dryer. As air recycles through the dryer, the oxygen
level drops to less than one percent and carbon dioxide increases and gets recycled into the
spirulina ponds. Not only is this an environmentally responsible drying method, but it is
a way to keep oxygen to a minimum in the
Figure 4.1 Ocean Chill Drying Process
drying process. If the antioxidants in spirulina are exposed to oxygen, they will oxidize
and become ineffective. The harvesting process of Hawaiian Spirulina is so efficient that
the spirulina goes from pond culture to finished product in less than 30 minutes, which
reduces its exposure to oxygen and preserves
its nutrients.
Tests have been run with and without
Ocean Chill Drying. Without it, as much as 50
to 60 percent of the antioxidants in spirulina
Source: Cyanotech
26
are neutralized. Data from independent laboratories, in fact, show antioxidants present in
Hawaiian Spirulina that are not present in other brands.56
Hawaiian Spirulina is rinsed at least three times before being dried. In addition, the
facility shuts down every day for four to five hours for an intense cleaning. Cyanotechs
dedication to hygienic production not only removes contaminants that might oxidize S.O.D.
and other fragile nutrients, but also leaves Hawaiian Spirulina with a fresher taste than could
otherwise be achieved.
S.O.D. Preservation
Hawaiian Spirulina is grown using 100 percent pure drinking water from the Big
Islands pristine aquifer, which collects water that has been filtered through lava rock to
maximize its purity. The majority of the fresh water is recycled back to the spirulina pond
for the next growing cycle to reduce water waste. The potable-water ponds are infused with
a very small percentage of deep ocean water to expose the absorptive microalgae to the deep
oceans abundant mineral content.
A continuous culture system means that only about 70 percent of the Hawaiian Spirulina culture is harvested at a time, with the remaining microalgae left behind to re-seed
the next batch. This allows for a continuous infusion of nutrients from harvest to harvest.
Because Hawaiian Spirulina has been cultivated in this way for over 30 years, it has evolved
into a superior strain. The continuous culture depends on Hawaiis year-round ideal climate
to ensure that there are no interruptions in the growing cycle.
BioSecure Zone
27
Cold-Pressed Tableting
Cyanotech reviews and measures every stage of Hawaiian Spirulina production from cultivation to harvest. Seventeen
separate quality tests are conducted to ensure that the spirulina
meets strict specifications, including measuring the levels of each
nutrient and testing for heavy metal contamination. The facility
regularly undergoes third-party Good Manufacturing Practices
(GMP) inspections, processing inspections, and other qualitycontrol tests.
Once the spirulina has passed the rigorous testing, the bulk product is packaged and
distributed worldwide. The raw spirulina is contained in a foil bag that serves as an oxygen
barrier. An oxygen absorber is placed in each
bag, the air is vacuumed out, and the bag is
heat-sealed and placed in a sturdy cardboard
box. The great care to remove all oxygen and
prevent exposure to light during shipping and
storage protects spirulinas fragile nutrients.
To ensure that the quality packaging is continued from bulk to finished consumer goods,
Cyanotech launched Nutrex Hawaii in 1990 to
oversee all areas of consumer marketing and
packaging.
28
Source: Cyanotech
Cyanotech also uses cold deep seawater to save energy. The company utilizes water
that is pumped up from 2,000 feet below the surface of the Pacific Ocean to cool its ponds
and run its Ocean Chill Drying process as explained earlier in this chapter. The cold seawater is also as a source of air conditioning for Cyanotechs offices. By running pipes through
its buildings, the company is able to bring in the cold water, efficiently and effectively cooling
its offices with low energy usage.
To further reduce its carbon footprint, Cyanotech recently added 2,280 solar array
panels, which produce1,147,000 kilowatt-hours of electricity each year.The energy production is sufficient to power the farms during daylight hours, with projected greenhouse gas
emissions reduced by 791 metric tons of carbon dioxide per yearthats equivalent to the
annual greenhouse gas emissions of 167 passenger vehicles.
29
Chapter
30
To be absolutely certain that it was making the right choice in giving up its organic
certification, Cyanotech conducted independent research on these alternative sources of
nitrogen. A reputable spirulina producer in California, called Earthrise, had also been faced
with the decision on whether to keep its organic label and begin using animal manure or
compost teas. Earthrise also conducted independent research.
After analyzing the results, both companies came to the same conclusion. Organic
sources of nitrogen would compromise the quality and safety of spirulina. The highly
absorptive microalgae could potentially soak up the bacteria and heavy metals that could be
present in animal manure and compost teas. This exposure to cow manure or decomposed
organic matter would also spoil spirulinas taste and smell. Finally, spirulina grown in these
conditions would be depleted of some of its most prized, but fragile, nutrients.
Table 5.1 Natural vs. Organic Spirulina
Comparison
Organic Spirulina
Produced Under
the New Standard
Pesticide Free
Herbicide Free
Environmentally Friendly
Purified Nutrients
Non-Animal Fertilizers
Minimally Processed
Source: Cyanotech
Both Cyanotech and Earthrise chose the health and safety of its consumers over the
much more lucrative organic label. Despite the fear that consumers preference for organic
food would cut Cyanotech from the market, the company went forward with is all-natural
labels. Cyanotech was rewarded for its economic bravery. No loss of market share or sales has
occurred as a result of the new labeling. In fact, in the U.S. market, Hawaiian Spirulina has
nearly 50 percent of all spirulina sales.
Because Hawaiian Spirulina continues to use natural nitrogen mined from the earth,
31
it is not eligible for organic certification. But it does meet these rigorous aquaculture farming
standards:
Hawaiian Spirulina is grown in a BioSecure zone free from pesticides, herbicides, genetically modified organisms (GMOs), and other unnatural substances.
Hawaiian Spirulina is cultured in lined ponds. The microalgae are grown in
self-contained ecosystems. This ensures no runoff from the cultured ponds
into the environment, nor even the remote possibility of unwanted chemical
seepage into the ponds.
Hawaiian Spirulina regularly undergoes third-party inspections, processing
inspections, and other extensive quality-control tests.
Hawaiian Spirulina uses the same nitrogen source that wild-growing spirulina
has used for billions of years.
Cyanotech was the first company to receive the Non-GMO Project Verified
seal on its spirulina from the Non-GMO Project non-profit organization.
If purity, freshness, and safety are the goals of farmers and consumers alike, then
when it comes to spirulina, organic is not always best.
32
Chapter
The quality of water used to grow spirulina has a major influence on the quality of the
spirulina produced. Cyanotech is the only producer of spirulina that uses certified potable
(drinking) water. Other spirulina producers use non-potable river or irrigation water that
might contain contaminates that spirulina can absorb. And as previously stated, Cyanotechs
spirulina production is in a biosecure zone and uses Ocean Chill drying to protect sensitive
nutrients in spirulina.
The freshest sources of spirulina have a mild sea vegetable aroma and flavor. This is
perhaps the easiest way to identify the quality of the spirulina. If the spirulina smells like
rancid oil or tastes fishy, theres a good chance the producers used an organic source of nitrogen to feed their crops. Recall that organic nitrogen comes from either animal manure or
decomposing plant life, both highly susceptible to bacterial infestation. Hawaiian Spirulinas
clean, fresh smell and taste result from both its inorganic fertilizer mined right from the
earth as well as its state-of-the-art production methods.
While people take spirulina to increase their energy and improve their health, not
just any spirulina will accomplish these goals. When it says Hawaiian Spirulina on a product
label, buyers know that no shortcut has been taken in the growing, harvesting and processing of the spirulinaall nutrients have been preserved from pond to package.
Excipients
Spirulina is a very fine powder and thus very difficult to tablet. It requires what are
known as excipients, inert ingredients that make the raw material easier to make tablets. The
amount and type of excipients used in tableting are crucial for quality control. Hawaiian
33
Spirulina contains only 1.5 percent of the highest-quality excipients. The other 98.5 percent
is pure Hawaiian Spirulina. The amount and quality of the excipients can reduce not only the
nutritional quality of the spirulina, but also the tablets bioavailability in the body.
Hawaiian Spirulina is regulated by the U.S. Food and Drug Administration (FDA)
under the Dietary Supplement Health and Education Act, the State of Hawaii Department
of Health, the U.S. Department of Agriculture, and the Federal Trade
Commission. In addition, the company is subjected to frequent independent audits and rigorous Quality Assurance and Supplier Approval
programs. The inspections consist of an intensive audit of processes and
practices, including manufacturing, packaging, and labeling of Hawaiian Spirulina products according to Current Good Manufacturing Practices. The FDA has awarded Hawaiian Spirulina the GRAS (Generally
Recognized as Safe) certification for its ingredients and Hawaiian Spirulina has been given the Non-GMO Project Verification seal, validating that the product
contains no genetically modified organisms. Hawaiian Spirulina is also Kosher, certified
gluten-free, and 100 percent vegan.
In some locations, high pollution levels in the air or runoff by nearby factories contains high amounts of heavy metals. Just as spirulina absorbs harmful metals from the body,
it also does the same from its environment. Grown on the Big Islands sparsely populated
Kona coast, and inside Hawaiis BioSecure zone, Hawaiian Spirulina is in no danger of toxic
heavy metal contamination.
Recipes
34
Chapter
Recipes
A note from the Author: I like to eat spirulina, but while Im a scientist
who is very good at growing microalgae, Im not very skilled in a kitchen.
Fortunately, I have many people around me who do a good job of incorporating
spirulina into food. Ive turned this section of the book over to them to share
some delicious spirulina recipes.
Incorporating spirulina into ones diet is the first step toward a healthier lifestyle.
Adding high quality spirulina powder can turn a basic fruit smoothie into a superfood
smoothie, with all the associated health benefits. It can turn a snack food like popcorn
into an antioxidant mouthful. A dash of Hawaiian Spirulina adds sustained energy and
wellness to every bite.
This mix of recipes filled with superfood goodness will become a favorite way to
prepare foods.
Smoothies/Drinks: Adding spirulina to smoothies is one of the easiest
ways to incorporate spirulina daily. Just add a teaspoon to any smoothie
recipe. Spirulina can also be added to other beverages.
Snacks: These snack recipes are potent nutrient powerhouses. They
combine whole food ingredients to create tasty, filling and satisfying
snacks that can be consumed any time of day.
Sides: These savory and sweet dishes pack a real superfood punch that
work well on their own or with an entre.
Treats: An occasional treat fits with any healthy eating plan and when
theyre made with superfoods, its a win-win.
SMOOTHIES/DRINKS
35
1/2 cup yogurt
1 cup of fruit juice
1 or more of the
following: papaya,
peach or mango
1/2 cup of boysenberries
1 teaspoon Hawaiian
Spirulina powder
SMOOTHIES/DRINKS
36
4 leaves of romaine
lettuce
1 kiwi, peeled
1/2 banana (fresh or
frozen)
1-2 tablespoons of frozen
apple-juice
concentrate
1 teaspoonHawaiian
Spirulina powder
1/4 lemon, peeled (leave
pithy part on)
1/8 teaspoon ground
cinnamon
3 fresh mintleaves
5-6 ice cubes
SMOOTHIES/DRINKS
37
2 tablespoons dried
shredded coconut
(unsweetened)
1 frozen banana
38
SMOOTHIES/DRINKS
39
SNACKS
40
Toast bread in toaster or oven. While bread is toasting, mash avocado and mix in the Hawaiian Spirulina powder. Divide the avocado mash between the
four pieces of toast and spread. Sprinkle with blueberries and goat cheese.
SNACKS
41
SPIRULINA POPCORN
This common snack gets supercharged with the addition of Hawaiian Spirulina and seasonings.
42
SNACKS
43
Place walnuts, dates, hemp seeds, Hawaiian Spirulina, and 1/4 cup of coconut into food processor and
mix until it becomes sticky and starts to form a ball
(around two minutes). Take dough from food processor and form one inch balls. Roll the balls into the
remaining coconut to coat them. Serve immediately
or refrigerate in an airtight container for up to five
days.
SNACKS
44
SPIRULINA GUACAMOLE
When spirulina is added to guacamole, it gives it a rich color and skyrockets the nutritional value.
2 large avocados
Cayenne pepper
2 medium tomatoes
1 tablespoon finely
chopped onion
1/2 tablespoon minced
garlic
2 teaspoons Hawaiian
Spirulina powder
Fresh lime juice to taste
2 tablespoons salsa
Salt to taste
SNACKS
45
SIDES
46
MAKES 2 SERVINGS
SIDES
47
TOFU SALAD
This protein and nutrient rich salad is a great lunch option.
MAKES 1-2 SERVINGS
48
SIDES
49
SIDES
50
SUPERFOOD GRAINS
This grains recipe is sweetened with natural fruit and peppers and Hawaiian Spirulina boosts its
nutrient power.
MAKES 4 SERVINGS
SIDES
51
1 large organic
cucumber
1 ripe avocado
Pinch of Kosher salt
1/2 ripe organic roma
tomato, diced
1 teaspoon fresh lime
juice
1/2 teaspoon Hawaiian
Spirulina powder
organic grape tomatoes
for garnish
SIDES
52
SIDES
53
TREATS
54
2 tablespoons agave
nectar
1/4 cup mixed finely
minced toppings
(such as goji berries,
dried dragonfruit, and
culinary gold foil)
TREATS
55
1 cup + 2 tablespoons
freeze-dried
blueberries, divided
56
57
Chapter
ponds and lakes in warm, sunny environments. Spirulina has been used as a food source for
centuries.It is considered the most complete naturally cultivated nutrient in the world, and
Hawaiian Spirulina has approximately double the levels of key nutrients compared to other
brands.Hawaiian Spirulina provides:
Approximately 60 percent complete digestible protein - it contains every essential
amino acid;
Contains more carotenoids than any other whole food and is an excellent source of
vitamins A, K, B12 and iron, manganese and chromium;
Best wholefood source of gamma linoleic acid (GLA) an essential fatty acid, necessary for human health. It plays a crucial role in brain function as well as normal
growth and development;
Rich in vitamins, minerals, trace elements, chlorophyll and enzymes.
wonderful source of protein, spirulina contains more carotenoids than any other whole food.
It is also rich in antioxidants and phytonutrients. There is overwhelming clinical evidence to
show that Hawaiian Spirulina also supports cardiovascular, eye, brain and skin health.
58
including:
Beta Carotene: Necessary for healthy skin, good vision, and a healthy immune
system.
Vitamin B12: An essential vitamin required for proper red blood cell formation,
neurological function, and DNA synthesis.
Vitamin K1 & Vitamin K2: Essential vitamins known to promote blood clotting
and support bone health. Recent studies have confirmed that vitamin K2 may
help osteoporosis and cardiovascular diseases.
Superoxide Dismutase (SOD): An enzyme that acts as both an antioxidant and
anti-inflammatory in the body, neutralizing free radicals and helping to repair
cells, for age related degeneration.
Zeaxanthin: A carotenoid and powerful antioxidant that fights free radical
damage with specific benefits for eye and cellular health.
Phycocyanin: The blue pigment color in nature, only found in spirulina.Supports
kidney, liver and brain health.
Iron: Essential in the formation of red blood cells and transportation of oxygen
throughout the body. Iron assists the memory and helps build resistance to
infection, stress and disease.
Tablet bottles
500 mg - six tablets a day
1,000 mg - three tablets a day
Powder bottles
One teaspoon mixed with liquid
59
actually be a good thing. There are many enzymes in Hawaiian Spirulina (for example super
oxide dismutase is an outstanding antioxidant the human body actually produces itself as a
defense mechanism against harmful reactive oxygen species).Enzymes are often destroyed
by stomach acids during digestion, however spirulina tablets are only partially digested in
the stomach. Their digestion is completed in the intestines. In the intestines there are no
stomach acids present, so you can get the full benefit of these vital enzymes.
is to refrigerate it. If kept cold (or even frozen) there should be a negligible loss of nutrients.
the bioavailability of all the nutrition. Pregnant women should consult their health care
professional.
60
61
Endnotes
1 How Many Fruits and Vegetables Do You Need? Centers for Disease Control and Prevention
website. As of April 3, 2015: http://www.fruitsandveggiesmorematters.org/wp-content/uploads/
UserFiles/File/pdf/resources/cdc/HowMany_Brochure.pdf
2 Ronald H. Henson (Nov.-Dec. 1990). Spirulina Algae Improves Japanese Fish Feeds, Aquaculture
Magazine, pp. 38-43.
3 Larry Switzer (1982). Spirulina: The Whole Food Revolution, New York: Bantam Books.
4 Spirulinas Nutritional Analysis, Natural Ways website. As of March 15, 2015: http://www.
naturalways.com/spirulina-analysis.htm
5 Supplements, University of Maryland Medical Center website. As of March 15, 2015: http://umm.
edu/health/medical/altmed/supplement/omega6-fatty-acids
6 Praneel Datla (July 2011). The Wonder Molecule Called Phycocyanin, India: Parry Nutraceuticals.
7 USDA National Nutrient Database for Standard Reference, United States Department of Agriculture
website. As of September 2015: http://ndb.nal.usda.gov/
8 Zeaxanthin Facts. As of February 26, 2015: http://www.ezeyes.info/ezeyes_Zeaxanthin.aspx
9 Zeaxanthin Facts. As of February 26, 2015: http://www.ezeyes.info/ezeyes_Zeaxanthin.aspx
10 N. Shimidzu, M. Goto, and W. Miki (1996). Carotenoids as singlet oxygen quenchers in marine
organisms, Fisheries Science, Vol. 62, No. 1, pp. 134-137.
11 Hemoglobin and Functions of Iron, UCSF Medical Center website. As of February 26, 2015:
http://www.ucsfhealth.org/education/hemoglobin_and_functions_of_iron/
12 Vitamin K2: The Missing Nutrient. As of February 26, 2015: http://chriskresser.com/vitamin-k2the-missing-nutrient
13 Vitamin K1 or K2 Effective for Bone Boosting Potential: Study. As of February 26, 2015: http://
www.nutraingredients-usa.com/Research/Vitamin-K1-or-K2-effective-for-bone-boosting-potentialStudy.
14 E.M. Keithley, C. Canto, Q.Y. Zheng, X. Wang, N. Fischel-Ghodsian, and K.R. Johnson (July 28,
2005). Cu/Zn superoxide dismutase and age-related hearing loss, Hearing Research, Vol. 209, No.
1-2, pp. 76-85.
62
15 V.L. Kinnula (August 2005). Focus on antioxidant enzymes and antioxidant strategies in smoking
related airway diseases, Thorax, Vol. 60, No. 8, pp. 693-700.
16 E. Nozik-Grayck, H.B. Suliman, and C.A. Piantadosi (December 2005). Extracellular superoxide
dismutase, International Journal of Biochemistry & Cell Biology, Vol. 37, No. 12, pp. 2466-71.
17 H.J. Park, Y.J. Lee, H.K. Ryu, M.H. Kim, H.W. Chung, and W.Y. Kim (August 2008). A
randomized double-blind, placebo-controlled study to establish the effects of spirulina in elderly
Koreans, Annals of Nutrition Metabolism, Vol. 52, No. 4, pp. 322-328.
18 H. K. Lu, C.C., Hsieh, J.J., Hsu, Y.K., Yang, and H.N. Chou (September 2006). Preventive
effects of Spirulina platensis on skeletal muscle damage under exercise-induced oxidative stress,
European Journal of Applied Physiology, Vol. 98, No. 2, pp. 220-226.
19 M. Kalafati, A.Z. Jamuartas, M.G. Nikolaidis, V. Paschalis, A.A. Theodorou, G.K. Sakellariou,
Y. Koutedakis, and D. Kouretas (January 2010). Ergogenic and antioxidant effects of spirulina
supplementation in humans, Medicine & Science in Sports & Exercise, Vol. 42, No. 1, pp. 142-151.
20 H. K. Lu, C.C., Hsieh, J.J., Hsu, Y.K., Yang, and H.N. Chou (September 2006). Preventive
effects of Spirulina platensis on skeletal muscle damage under exercise-induced oxidative stress,
European Journal of Applied Physiology, Vol. 98, No. 2, pp. 220-226.
21 Hawaiian Spirulina Survey (May-July 2011). SurveyMonkey, Inc., website. As of April 26, 2015:
https://www.surveymonkey.com/results/SM-BYNSG9W9/
22 C. Selmi, P.S. Leung, L. Fischer, B. German, C.Y. Yang, T.P. Kenny, G.R. Cysewski, and M.E.
Gershwin (May 2011). The effects of Spirulina on anemia and immune function in senior citizens,
Cellular & Molecular Immunology, Vol. 8, pp. 248-254.
23 A. Hernandez-Corona, I. Nieves, M. Meckes, G. Chamorro, and B.L. Barron (December 2002).
Antiviral activity of Spirulina maxima against herpes simplex virus type 2, Antiviral Research, Vol. 56,
No. 3, pp. 379-385.
24 O.B. Gorobets, L.P. Blinkova, and A.P. Baturo (November-December 2002). Action of spirulina
platensis on bacterial viruses, Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii, No. 6, pp. 18-21.
25 M. Misbahuddin, A.Z. Islam, S. Khandker, Islam Ifthaker-Al-Mahmud, and N. Anjumanara
(2006). Efficacy of spirulina extract plus zinc in patients of chronic arsenic poisoning: A randomized
placebo-controlled study, Clinical Toxicology, Vol. 44, No. 2, pp. 135-141.
26 C.D. Upasan and R. Balaraman (April 2003). Protective effect of spirulina on lead induced
deleterious changes in the lipid peroxidation and endogenous antioxidants in rats, Phytotherapy
Research, Vol. 17, No. 4, pp. 330-334.
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27 C.D. Upasan and R. Balaraman (April 2003). Protective effect of spirulina on lead induced
deleterious changes in the lipid peroxidation and endogenous antioxidants in rats, Phytotherapy
Research, Vol. 17, No. 4, pp. 330-334.
28 N. Simsek, A. Karadeniz, Y. Kalkan, O.N. Keles, and B. Unal (May 2009). Spirulina platensis
feeding inhibited the anemia- and leucopenia-induced lead and cadmium in rats, Journal of Hazardous
Materials, Vol. 164, No. 2-3, pp. 1304-09.
29 N. Paniagua-Castro, G. Escalona-Cardoso, D. Hernandez-Navarro, R. Perez-Pasten, and G.
Chamorro-Cevallos (April 2011). Spirulina (Arthrospira) protects against cadmium-induced
teratogenic damage in mice, Journal of Medicinal Food, Vol. 14, No. 4, pp. 398-404.
30 S. K. Saha, M. Misbahuddin, and A.U. Ahmed (January 2010). Comparison between the effects
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