Scribd Logo
Upload

Welcome to Scribd!

  • 21 views

    Spread Thru Olfactory Bulb

    Uploaded by

    leo
    1. Herpes viruses are double-stranded DNA viruses that infect humans and animals. They include herpes simplex virus types 1 and 2, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, and recently detected HHV-6, 7, and 8. 2. Herpes viruses have a virion structure that contains DNA surrounded by a protein capsid and lipid envelope. Upon host cell entry, tegument proteins initiate viral replication. Herpes viruses establish lifelong latent infections in host cells. 3. Laboratory diagnosis of herpes viruses can be done through cell culture, which detects a characteristic cytopathic effect, or through techniques like PCR, antigen

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd

    Spread Thru Olfactory Bulb

    Uploaded by

    leo
    21 views2 pages
    1. Herpes viruses are double-stranded DNA viruses that infect humans and animals. They include herpes simplex virus types 1 and 2, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, and recently detected HHV-6, 7, and 8. 2. Herpes viruses have a virion structure that contains DNA surrounded by a protein capsid and lipid envelope. Upon host cell entry, tegument proteins initiate viral replication. Herpes viruses establish lifelong latent infections in host cells. 3. Laboratory diagnosis of herpes viruses can be done through cell culture, which detects a characteristic cytopathic effect, or through techniques like PCR, antigen

    Original Description:

    hepa hsv

    Original Title

    hepa hsv

    Copyright

    © © All Rights Reserved

    Available Formats

    DOCX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    1. Herpes viruses are double-stranded DNA viruses that infect humans and animals. They include herpes simplex virus types 1 and 2, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, and recently detected HHV-6, 7, and 8. 2. Herpes viruses have a virion structure that contains DNA surrounded by a protein capsid and lipid envelope. Upon host cell entry, tegument proteins initiate viral replication. Herpes viruses establish lifelong latent infections in host cells. 3. Laboratory diagnosis of herpes viruses can be done through cell culture, which detects a characteristic cytopathic effect, or through techniques like PCR, antigen

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    21 views2 pages

    Spread Thru Olfactory Bulb

    Uploaded by

    leo
    1. Herpes viruses are double-stranded DNA viruses that infect humans and animals. They include herpes simplex virus types 1 and 2, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, and recently detected HHV-6, 7, and 8. 2. Herpes viruses have a virion structure that contains DNA surrounded by a protein capsid and lipid envelope. Upon host cell entry, tegument proteins initiate viral replication. Herpes viruses establish lifelong latent infections in host cells. 3. Laboratory diagnosis of herpes viruses can be done through cell culture, which detects a characteristic cytopathic effect, or through techniques like PCR, antigen

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 2

    Mendiola. Leomill O.

    January 31, 2017


    BMLS 3B

    HERPES AND HEPATITIS VIRUS

    1. Herpes Virus
    A double-stranded DNA, enveloped viruses.
    The virion consists of four components, additionally the tegument.
    o tegument, an asymmetric structure made of a fibrous-like material, surrounds the
    capsid and contains 20 different proteins.
    o These proteins enter the host cell upon fusion of the envelope and cell membrane and
    initiate the viral replication cycle.
    Only Herpes B Virus known to cause infection in humans and the rest infects animals
    o It includes HSV types 1 and 2 (HSV-1 and HSV-2),
    o varicella-zoster virus (VZV)
    o Epstein-Barr virus (EBV)
    o Cytomegalovirus (CMV).
    o (HHV-6), 7 (HHV-7), and 8 (HHV-8) - More recently detected
    o HHV-6 and HHV-7 are lymphotropic viruses acquired early in life.
    Also associated with the childhood disease roseola.
    o Aforementioned above known to cause Acute Encephalitis
    o Kaposis sarcomaassociated herpes virus (KSHV)
    o HSV 1 and 2 have a shorter replication cycle and the ability to establish latency in the
    sensory ganglia
    o HSV 1 infection occurs at the oropharyngeal mucosa and cause viral neurotropic
    spread thru olfactory bulb.
    o HSV-2 infection occurs at genital sites (Women more easily infected).
    o Except for neonates, infections are more severe in adults than in children.
    o All herpesviruses produce latent infections.
    o Sites of latency include leukocytes and peripheral nerves.
    o Reactivation may result from physiological stress. The symptoms are
    milder than primary infection. The exception is shingles, which is a
    reactivation of VZV
    LAB DIAGNOSIS
    o Cell culture (gold standard)
    The herpes lesion may be punctured and the vesicular fluid absorbed with
    a swab and must be inoculated for the span of an hour. Froze at -70C for
    preservation.
    A-549 or MRC-5 is suitable cell lines- produces a rounding, refractile CPE
    within 1 to 2 days after inoculation of the cell culture.
    o Others (PCR, Direct antigen assay using IF or IP stain, ELISA, Nucleic acid T.)

    Varicella Zoster
    o as a classic childhood disease, chicken pox, characterized by the appearance of a
    maculopapular rash.
    o VZV infects the conjunctiva or mucosa of the upper respiratory tract and then travels to
    the lymph nodes.
    o Primary viremia: After 4 to 6 days infected T cells enter the bloodstream and
    o 2ndary viremia: infected T cells invade the liver, spleen, and other organs,
    o When the 2dary viremia ensue, it infects cells in the skin, causing the characteristic
    vesicular rash (varicella).
    The lesions usually crust over in 1 to 2 days but do not resolve for
    approximately 3 weeks.
    After the acute viral replication in the skin, VZV hides in the Ganglia of CNS and
    if its reactivated it is known as Shingles (commonly infects immunocompetent
    >45 yo individual)

    You might also like