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    Penicillin G

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    Penicillin G is a broad-spectrum beta-lactam antibiotic that works by binding to penicillin-binding proteins in bacterial cell walls and inhibiting cell wall synthesis. It has antibacterial activity and is a solid, white powder that is slightly soluble in water. Penicillin G is commonly used to treat bacterial infections and can be administered via intramuscular injection. Probenecid may increase penicillin concentrations in the cerebrospinal fluid by inhibiting organic acid excretion from the CSF. Women who are pregnant should consult a physician before using penicillin G due to potential risks.

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    Penicillin G

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    api-295691235
    487 views2 pages
    Penicillin G is a broad-spectrum beta-lactam antibiotic that works by binding to penicillin-binding proteins in bacterial cell walls and inhibiting cell wall synthesis. It has antibacterial activity and is a solid, white powder that is slightly soluble in water. Penicillin G is commonly used to treat bacterial infections and can be administered via intramuscular injection. Probenecid may increase penicillin concentrations in the cerebrospinal fluid by inhibiting organic acid excretion from the CSF. Women who are pregnant should consult a physician before using penicillin G due to potential risks.

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    Penicillin G is a broad-spectrum beta-lactam antibiotic that works by binding to penicillin-binding proteins in bacterial cell walls and inhibiting cell wall synthesis. It has antibacterial activity and is a solid, white powder that is slightly soluble in water. Penicillin G is commonly used to treat bacterial infections and can be administered via intramuscular injection. Probenecid may increase penicillin concentrations in the cerebrospinal fluid by inhibiting organic acid excretion from the CSF. Women who are pregnant should consult a physician before using penicillin G due to potential risks.

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    © All Rights Reserved
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    487 views2 pages

    Penicillin G

    Uploaded by

    api-295691235
    Penicillin G is a broad-spectrum beta-lactam antibiotic that works by binding to penicillin-binding proteins in bacterial cell walls and inhibiting cell wall synthesis. It has antibacterial activity and is a solid, white powder that is slightly soluble in water. Penicillin G is commonly used to treat bacterial infections and can be administered via intramuscular injection. Probenecid may increase penicillin concentrations in the cerebrospinal fluid by inhibiting organic acid excretion from the CSF. Women who are pregnant should consult a physician before using penicillin G due to potential risks.

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    © All Rights Reserved
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    of 2

    Pattaranun Hanwongpaiboon

    Inging 1102

    Penicillin G

    Chemical Name: Benzylpenicillin


    Molecular Formula: C16H18N2O4S

    Penicillin G is a broad-spectrum, beta-lactam normally happening penicillin antibiotic


    with antibacterial activity. Penicillin G binds to and inactivates the penicillin-binding proteins
    (PBPs) situated inside the bacterial cell wall. Inactivation of PBPs interferes with the cross-
    linkage of peptidoglycan chains vital for bacterial cell wall strength and inflexibility. This
    interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall
    and finally causing cell lysis. (1)

    Physical Properties:
    The state of matter is solid. Its color is amorphous white powder. The melting point of
    Penicillin G is at 214-217 C, and it is slightly soluble in water (210 mg/L). The molecular
    weight is 334.39 g/mol. (2)
    Chemical Properties:
    Penicillin usually inactivated in the presence of heat, alkaline or acid pH, oxidising
    agents, alcohols, glycols, and metal ions such as copper, mercury, or zinc. In presently
    available penicillin, cleavage at any time in the penicillin nucleus, including the beta-lactam
    ring, results in total loss of antibacterial activity. The main reason of inactivation of penicillin
    is hydrolysis of the beta-lactam ring. The course of hydrolysis and nature of the degradation
    products can vary and most affected by pH: saturated aqueous solution in 5-7.5 (2)
    Purpose to use:
    Penicillin G benzathine is used to treat a wide variety of bacterial infections. It might
    also be used to prevent specific bacterial infections (such as rheumatic fever).
    This medication is a long-acting penicillin antibiotic. It works by stopping the development
    of bacteria. Penicillin g potassium is a penicillin antibiotic. It works by disturbing with the
    Pattaranun Hanwongpaiboon
    Inging 1102

    formation of the bacteria's cell wall while it is developing. Therefore, it weakens the cell wall
    and destroys the bacteria. (3)
    How to use:
    Penicillin g sodium is common as an injection at the office of specialist, healing
    facility, or health center. Before using penicillin g sodium, the specialist will show the
    instructions. Make sure to know how to use penicillin g sodium and follow the techniques
    when using this medicine. If there is any problem, contacting to the health center. Penicillin g
    sodium is injected into a muscle. It should not be injected into or close to a vein. Also, it has
    the best performance if it is given at the same time every day. Use it as quick as possible,
    when missing this medicine in some day. If it is almost the time for next medicine, skip the
    missed one and turn to the usual medicine schedule. However, do not use two of this
    medicine at once. (3)
    Effect of Probenecid on Cerebrospinal Fluid Concentrations of Penicillin and
    Cephalosporin Derivatives
    Probenecid may elevate the cerebrospinal fluid (CSF) concentration of penicillin G by
    inhibiting the excretion of organic acids from CSF. Penicillin concentrations were determined
    in rabbits under steady-state conditions before and after intravenous probenecid
    administration. Probenecid may demonstrate useful in specific bacterial infections where high
    CSF antibiotic levels are important. (4)
    Important safety information:
    The women who become pregnant should contact to a specialist before using
    penicillin g sodium. They should understand the advantages and dangers for the safety of
    their infants because it is usually found in breast milk. (5)

    References
    1.) Penicillin g (Code C61883). (n.d.). Retrieved May 15, 2017, from
    https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?
    dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C61883
    2.) Penicillin g. (n.d.). Retrieved May 15, 2017, from
    https://pubchem.ncbi.nlm.nih.gov/compound/5904#section=Top
    3.) Penicillin-g-benzathine-syringe : Uses, Side Effects, Interactions, Pictures, Warnings &
    Dosing. (n.d.). Retrieved May 15, 2017, from
    http://www.webmd.com/drugs/2/drug-3781-2240/penicillin-g-benzathine-
    syringe/details
    4.) Giunti, C., & Laveder, M. (2011). Implications of 3 1 short-baseline neutrino oscillations.
    Physics Letters B, 706(2-3), 200-207. doi:10.1016/j.physletb.2011.11.015.
    Retrieved May 22, 2017, from http://aac.asm.org/content/6/4/437.short
    5.) Penicillin g sodium: Indications, Side Effects, Warnings. (n.d.). Retrieved May 15, 2017,
    from https://www.drugs.com/cdi/penicillin-g-sodium.html

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