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    Brochure Soothex

    Uploaded by

    Rojas Evert Alonso
    información científica inhibidor de la 5 lipo oxigenaza

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Brochure Soothex

    Uploaded by

    Rojas Evert Alonso
    278 views2 pages
    información científica inhibidor de la 5 lipo oxigenaza

    Original Title

    Brochure Soothex (002)

    Copyright

    © © All Rights Reserved

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    PDF, TXT or read online from Scribd

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    información científica inhibidor de la 5 lipo oxigenaza

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    278 views2 pages

    Brochure Soothex

    Uploaded by

    Rojas Evert Alonso
    información científica inhibidor de la 5 lipo oxigenaza

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 2

    natural soothing

    Proven soothing action


    Reduce irritation
    For sensitive skin formulations
    Soothex is a natural extract of Indian Frankincense, widely
    used in Ayurvedic medecine. It has in-vitro demonstrated anti-
    inflammatory properties similar to 18-b-glycyrrhetinic acid, a natural
    anti-inflammatory, with inhibitory effects on the 5-lipoxygenase
    enzyme involved in the inflammatory pathway. Soothex is also more
    b-boswellic acid
    One of the 7 boswellic acids identified in Soothex effective than other anti-irritants as it does not block production of
    prostaglandins and thromboxanes. It can be used both in potentially
    irritant formulations or in post-shaving skincare.
    Inflammation pathway

    Different Stress Factors Skin Cells Consumer claims Contains a natural active to reduce irritation (e.g. from
    air pollution anti-acne, whitening or depilatory cream)
    UV irradiation Arachidonic acid Formulated for sensitive and reactive skin
    micro-organisms (in the cell membrane)
    chemicals in everyday Formulated for sensitive body areas
    products
    INCI Dipropylene Glycol, Boswellia Serrata Gum (Soothex)
    Soothex inhibits Isostearyl Alcohol, Boswellia Serrata Gum (Soothex ISA)
    5 - lipoxygenase 5 - lipoxygenase
    Ecocert variant Soothex ISA
    Leukotrienes Appearance Slight hazy brown liquid with light medicated odour
    Pro-inflammatory
    factors causing Dosage 0.5-2.5%
    redness
    pain Formulation Incorporate into oil phase of emulsions
    irritation

    www.givaudan.com/cosmetic-actives
    in-vivo efficacy
    Soothex shows Depilatory cream instrumental test Depilatory cream applied for 20 minutes on
    significant (p<0.001) 19 volunteers, skin redness measured with
    a Chromameter up to 1 hour after cream
    reduction of skin
    removal, measure of a value.
    reddening effect
    coming from a 1.5
    depilatory cream
    Change in skin redness (a value)

    0.5

    -0.5

    -1
    Soothex 2.5%
    -1.5 Placebo
    20 30 40 50 60 70 80 minutes

    Soothex reduces AHA panel test 22 volunteers selected amongst the


    irritation from mild most sensitive on a panel of 44 people,
    application of a cream in the nasogenial
    AHA formulations
    furrows, no Lactic Acid in Placebo, 7%
    Mean difference in stinging score

    3 Lactic Acid in others formulas, self-


    2.5 assessment and scoring from 0 (no
    perceived stinging) to 4 (extreme stinging).
    2
    vs. placebo

    1.5

    0.5

    0
    control control + 0.4%
    (7% Lactic Acid) Bisabool
    control + 2% Soothex
    (0.2% Boswellia Serrata Gum)

    Soothex reduces SLS patch test Surfactant gel formulation containing 0.3%
    significantly skin Up to 30% reduction of skin reddening SLS and 2.5% Soothex, occlusive applied
    (p<0.001) during 8 days on 30 volunteers, visual
    redness due to
    assessment by trained technicians on a 0
    surfactants to 1 scale.
    Visual change from the baseline

    0.6
    0.5
    0.4
    0.3
    0.2
    0.1 Control + Soothex 2.5%
    0 Control 0.3% SLS gel
    day 3 day 5 day 8

    IMPORTANT FOR YOUR PROTECTION


    The information and recommendations contained herein are to the best of our knowledge reliable. However, nothing herein is to be construed as a warranty or representation in
    respect of safety in use, suitability, efficacy or otherwise, including freedom from patent infringement. Users should make their own tests for their particular purpose. We cannot accept
    any liability for any loss, damage or infringement arising from the use of the information and recommendation contained herein.

    www.givaudan.com/cosmetic-actives

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