ADRO

Drug Doses
DRUG DOSES
The drug doses in the following pages are reproduced from the 15 th edion (2010)
of Drug Doses, courtesy of Professor Frank Shann, from the Intensive Care Unit,
Royal Childrens Hospital, Parkville, Victoria 3052, Australia
DRUGS ARE LISTED BY GENERIC NAME
1/100=1%=10mg/ml, 1/1000=1mg/ml, 1/10000=0.1mg/ml
Abacavir. 8mg/kg (adult 300mg) 12H oral. Aciclovir. Neonate - 12wk: 20mg/kg IV over 1hr
Abacavir + lamivudine. 600mg/300mg tab, daily (<30wk gest), 18H (30-32wk), 12H (1st wk
>12yr (NOT/kg): 1tab daily oral. life), 8H (2-12wk) for 2wk (3wk and CSF PCR -ve if
Abacavir + lamivudine + zidovudine. herp enceph). age >12wk: EBV, herpes enceph,
300mg/150mg/300mg tab, 18yr (NOT/kg): immunodef, varicella: 500mg/m2 (12wk-12 yr)
1tab 12H oral. 10mg/kg (>12yr) 8H IV over 1hr. Cutaneous
Abarelix. Adult (NOT/kg): 1 vial (delivers 100mg) herpes 250 mg/m2 (12wk-12yr) 5mg/kg (>12yr)
IM on day 1, 15 and 29, and then every 28 days. 8H IV over 1hr. Genital herpes (>12yr NOT/kg):
200mg oral x5/day for 10 days, then 200mg
Abatacept. NOT/kg: 500mg (40-60kg) 750mg
x2-3/day for 6mo if reqd. Zoster (>12yr NOT/kg):
(60-100 kg) 1g (>100kg) IV over 30min day 1, 400 mg (<2yr) or 800mg (>=2yr) oral x5/day for
2wk, 4wk, then every 4wk. 7 days. Cold sores: 5% cream x5/day.
Abciximab. 0.25mg/kg IV stat 10min before Eye: 3% oint x5/day.
angioplasty, then 0.2mcg/kg/min (max Acipimox. 5mg/kg (adult 250mg) 8-12H oral.
10mcg/min) IV for 12hr.
Acitre n. 0.5-1mg/kg (adult 25-50mg) daily oral.
Acamprosate calcium. Adult (NOT/kg). <60kg:
Acriflavine hydrochloride. 0.1% soltn: apply
666mg mane, 333mg noon and nocte oral.
12-24H.
>60kg: 666mg 8H.
Acrivas ne. 0.15mg/kg (adult 8mg) 8H oral.
Acarbose. 1-4mg/kg (adult 50-200mg) 8H oral.
Ac nomycin D. See dac nomycin.
Acebutolol. 4-8mg/kg (adult 200-400mg)
Ac vated charcoal. See charcoal, ac vated.
8-24H oral.
Adalimumab. Adult (NOT/kg): 40mg every 1-2wk SC.
Aceclofenac. 2mg/kg (adult 100mg) 12H oral.
Adapalene. 0.1% gel: apply once/day before bed
Acemetacin. 1.2mg/kg (adult 60mg) 8-12H oral.
Adefovir. Adult (NOT/kg): 10mg daily oral.
Acenocoumarol. See nicoumalone.
Adenosine. Arrhythmia: 0.1mg/kg (adult 3mg)
Acetaminophen. See paracetamol.
stat by rapid IV push, incr by 0.1mg/kg (adult
Acetazolamide. 5-10mg/kg (adult 100-250mg) 3mg) every 2min to max 0.5 mg/kg (adult 18mg).
6-8H (daily for epilepsy) oral. Pul hypertension: 50mcg/kg/min (3 mg/ml at
Acetohydroxamic acid. 5mg/kg (adult 250mg) 1ml/kg/hr) into central vein.
6-8H oral. Adrenaline. Croup: 1% 0.05 ml/kg diluted to 4ml,
Acetylcholine chloride. Adult (NOT/kg): 1% ins l or 1/1000 0.5ml/kg (max 6ml) by inhaltn. Cardiac
0.5-2ml into anterior chamber of the eye. arrest (repeat if reqd): 0.1ml/kg of 1/10,000 IV or
Acetylcysteine. Paracetamol poisoning (regardless intracardiac; via ETT 0.1 ml/kg of 1/1000.
of delay): 150mg/kg in 5%D IV over 1hr; then Anaphylaxis: IV 0.05-0.1ml/kg of 1/10,000, rpt
10mg/kg/hr for 20hr (delay <10hr), 32hr (delay if reqd; IM into thigh: 0.01mg/kg (0.01ml/kg of
10-16hr), 72hr (delay >16hr) and longer if s ll 1/1000) up to 0.1mg/kg, x3 doses 20min apart
encephalopathic; oral 140mg/kg stat, then 70 if reqd. IV infsn 0.3 mg/kg in 50ml 5%D-hep at
mg/kg 4H for 72hr. Monitor serum K+. 0.5-10ml/hr (0.05-1mcg/kg/min).
Give if paracetamol >1000umol/L (150mg/L) Adrenaline 0.1% + fluorouracil 3.33%.
at 4hr, >500umol/L 8hr, >250umol/L 12hr. Gel: inject into each wart x1/wk for up to 6wk.
Lung disease: 10% soltn 0.1ml/kg (adult 5ml) Adrenocor cotrophic hormone (ACTH). See
6-12H nebulised or intratracheal. cor co-trophin.
Meconium ileus equivalent: 5ml (NOT/kg) of 20%
Agalsidase beta. 0.2-1mg/kg every 2wk IV over 40min
soltn 8H oral; 60-100ml of 50mg/ml for 45 min PR.
CF:4-8mg/kg 8H oral. Eye drop 5% + hypro- Agar + paran 65%. NOT/kg: 6mo-2yr 5ml,
mellose 0.35%: 1 drop/eye 6-8H. 3-5yr 5-10ml, >5yr 10ml 8-24H oral.
Acetylsalicylic acid. See aspirin. Agar + paran + phenolphthalein (Agarol).NOT/kg:
Acetyl sulfisoxazole. 1.16g = 1.0g sulphafurazole (qv). 6mo-2yr 2.5ml, 3-5yr 2.5-5ml, >5yr 5ml 8-24H oral.

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Drug Doses
Alatrofloxacin. 4mg/kg (adult 200mg) daily IV Alpha tocopheryl acetate. One alpha-tocopheryl
over 60min. Severe in n: 6mg/kg (adult (at) equivalent = 1mg d-at = 1.1mg d-at acetate =
300mg) daily IV over 90min. 1.5mg dl-at acetate = 1.5u vit E. Abetalipoprotein-
Albendazole. Pinworm, threadworm, roundworm, aemia: 100mg/kg (max 4g) daily oral. Cys c
hook-worm, whipworm: 20mg/kg (adult 400mg) fibrosis: 45-200mg (NOT/kg) daily oral. Newborn
oral once (may repeat a er 2wk). Strongyloides, (high dose, toxicity reported): 10-25mg/kg daily
cutaneous larva migrans, Taenia, H.nana,O.viverrini, IM or IV, 10-100mg/kg daily oral.
C.sinesis: 20mg/kg (adult 400mg) daily for 3 days, Alprazolam. 0.005-0.02mg/kg (adult 0.25-1mg)
repeated in 3wk. 7.5mg/kg (adult 400mg) 12H for 8H oral. Slow rel: 0.5-1mg daily, incr to 3-6mg
8-30 days (neurocys cercosis); 12H for three 28 (max 10mg) daily oral.
day courses 14 days apart (hyda d). Alprenolol. 1-4mg/kg (max 200mg) 6-12H oral.
Albumin. 20%: 2-5ml/kg IV. 4%: 10-20ml/kg. Alprostadil (prostaglandin E1, PGE1). Maintain
If no loss from plasma: dose (ml/kg) = PDA: 60 mcg/kg in 50ml 0.9% saline 0.5-3ml/hr
5 x (increase g/L) / (% albumin). (10-60ng/kg/min).
Alclometasone. 0.05% cream/ointment: apply 8-12H. Alteplase ( ssue plasminogen ac vator).
Aldesleukin (synthe c IL-2). Malignancy: 0.1-0.6mg/kg/hr IV for 6-12hr (longer if no response);
constant IV infsn less toxic than bolus injtn: keep fibrinogen >100mg/dL (give cryoprecipitate
3,000,000-5,000,000u/m2/day for 5 days, if 1bag/5kg), give heparin 10u/kg/hr IV, give fresh
tolerated repeat x1-2 with 5 day interval. frozen plasma (FFP) 10ml/kg IV daily in infants.
Alefacept. Adult (NOT/kg): 7.5mg IV, 15mg IM Local IA infsn: 0.05mg/kg/hr, give FFP 10ml/kg IV
weekly for 12wk. daily. Blocked central line: 0.5mg/2ml (<10kg)
Alemtuzumab. Adult (NOT/kg): 3mg daily IV 2mg/2ml (>10kg) per lumen le for 2-4hr, with-
over 2hr for 2-3 days, 10mg daily 2-3 days, draw drug, flush with saline; rpt once in 24hr if reqd.
then 30mg x3/wk for up to 12wk. Altretamine. 150-300mg/m2 daily oral.
Alendronate. 0.5mg/kg (adult 40mg) daily oral. Aluminium acetate. 13% soltn (Burrows lotion): for
Alendronate 70mg + vitamin D3 2800u. 1 tab wet compresses, or daily to molluscum contagiosum.
each wk oral. Aluminium chloride hexahydrate. 20% lo on:
Alfacalcidol. 0.05mcg/kg (max 1mcg) daily oral x 1-2/wk.
or IV, adjusted according to response. Aluminium hydroxide. 25mg/kg (adult 0.5-1g)
Alfentanil. 10mcg/kg IV, IM stat, then 5mcg/kg prn. 4-6H oral. Gel (64mg/ml) 0.1ml/kg 6H oral.
Theatre (ven lated): 30-50mcg/kg IV over 5min, Aluminium hydroxide 40mg/ml, Mg hydroxide
then 15mcg/kg prn or 0.5-1mcg/kg/min. ICU: 50- 40mg/ml, simethicone 4mg/ml (Mylanta, Gelusil).
100mcg/kg IV over 10min, then 0.5-4mcg/kg/min. 0.5-1ml/kg (adult 10-20ml) 6-8H oral. ICU:
Alfuzosin. Adult (NOT/kg): 10mg daily oral. 0.5ml/kg 3H oral if gastric pH <5.
Alginic acid (Gaviscon single strength). <1yr: Aluminium sulphate. 20% soltn: apply promptly
liquid 2ml with feed 4H. 1-12yr: liquid 5-10ml, to s ng
or 1 tab a er meals. >12yr: liquid 10-20ml, or Alverine. 1-2mg/kg (adult 60-120mg) 8-12H oral.
1-2 tab a er meals. Amantadine hydrochloride. 2mg/kg (adult
100mg) 12-24H oral. Flu A prophylaxis (NOT/
Alglucerase. Usual ini al dose is 60u/kg every
kg): 100mg daily (5-9yr), 100mg 12H (>9yr).
2wk IV over 2hr, adjusted according to
response; reduce every 3-6mo. Ambrisentan. Adult (NOT/kg): 5mg (max 10mg) dly oral
Alimemazine. See trimeprazine. Amcinonide. 0.1% lo on, cream, ointment:
apply 8-12H.
Aliskiren. Adult (NOT/kg): 150mg (max 300mg)
daily oral. Amethocaine. Gel 4% in methylcellulose: 0.5g
to skin, apply occlusive dressing, wait 30-60min,
Alitre noin. 0.1% gel: apply 6-12H.
remove gel. 0.5%, 1%: 1 drop/eye.
Allopurinol. 10mg/kg (adult 300mg) 12-24H oral.
Amifos ne. 910mg/m IV over 15min daily 30min
Chemotherapy: 50-100mg/m2 6H IV, oral.
before chemotherapy; reduce to 740mg/m if
Almotriptan. Adult (NOT/kg): 6.25-12.5mg oral, severe side eects.
repeat in 2hr if reqd (max 2 doses in 24hr).
Amikacin. Single daily dose IV or IM. Neonate:
Alosetron. Adult (NOT/kg): 1mg daily oral, incr if 15mg/kg stat, then 7.5mg/kg (<30wk) 10mg/kg
reqd a er 4wk to 1mg 12H (stop if no response (30-35wk) 15mg/kg (term <1wk) daily. 1wk-10yr:
a er 4wk). 25mg/kg day 1, then 18mg/kg daily. >10yr:
Alpha proteinase inhibitor. See alpha an trypsin. 20mg/kg day 1, then 15mg/kg (max 1.5g) daily.
Alpha an trypsin. 60mg/kg once wkly IV over 30min Trough level <5.0mg/L.

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 Drug Doses
Amiloride. 0.2mg/kg (adult 5mg) 12-24H oral. Amoxycillin + clavulanic acid. Dose as amoxycillin.
Aminoacridine hydrochloride. See aminacrine. 4:1 (non-Duo products) 8H, 7:1 (Duo) 12H, 16:1
Aminacrine hydrochloride. 0.02% 1 drop/eye 2-4H. (XR) 12H oral.
Aminobenzoic acid. 60mg/kg (max 3g) 6H oral. Amphotericin B (Fungizone). Usually 1.5mg/
Aminocaproic acid. 3g/m2 (adult 5g) over 1hr kg/day (up to 2mg/kg/day) by con nuous infsn IV.
IV, then 1g/m2/hr (adult 1-1.25g/hr). Central line: 1.5mg/kg in 50ml 5%dex-hep at 2ml/
Prophylaxis: 70mg/kg 6H IV, oral. hr (up to 46kg); 1.5 mg/kg in 1.2 ml/kg 5%dex-hep
(1.25mg/ml) at 0.05ml/kg/hr (over 46kg).
Aminoglutethimide. Adult (NOT/kg): 250mg
Peripheral IV: usually 1.5mg/kg in 12ml/kg 5% dex
daily oral, incr over 4wk to 250mg 6H.
-hep at 0.5ml/kg/hr (higher concentra ons may
Aminohippuric acid (PAHA). 6-10mg/kg stat, then cause thrombophlebi s). Oral (NOT/kg): 100mg
0.2-0.5 mg/kg/min IV gives 2mg/100ml in plasma. 6H, 50mg 6H prophylaxis. Bladder washout:
Aminolevulinic acid. 20% soltn: apply to lesions, 25 mcg/ml. Cream, oint 3%: apply 6-12H.
expose to 400-450nm blue light for 1000sec Amphotericin, colloidal dispersion (Amphocil,
(10 J/cm) next day; repeat a er 8wk if reqd. Amphotec). Usually 3-4mg/kg (up to 6mg/kg for
Aminophylline (100mg = 80mg theophylline). aspergillus) daily IV at 2.5mg/kg/hr.
Load: 10 mg/kg (max 500mg) IV over 1hr. Amphotericin, lipid complex (Abelcet).
Maintenance: 1st wk life 2.5mg/kg IV over 1hr 2.5-5mg/kg daily over 2hr IV, typically for 2-4wk.
12H; 2nd wk life 3mg/kg 12H; 3wk-12 mo Amphotericin, liposomal (AmBisome).
((0.12 x age in wk) + 3) mg/kg 8H; >12mo and 3-6mg/kg (up to 15 mg/kg if severe in n) daily
<35kg, 55 mg/kg in 50ml 5%dex-hep at 1ml/hr over 1-2hr IV, typically for 2-4wk.
(1.1mg/kg/hr) or 6mg/kg IV over 1hr 6H; >35kg Ampicillin. 10-25mg/kg (adult 0.25-1g) 6H IV, IM or
and <17yr, or >17yr and smoker, 25 mg/ml at oral. Severe in n: 50mg/kg (max 2g) IV 12H (1st
0.028ml/kg/hr (0.7mg/kg/hr) or 4mg/kg IV over wk life), 6H (2-4 wk), 3-6H or constant infsn (4+wk).
1hr 6H; >17yr non-smoker 25mg/ml at 0.02ml/
Ampicillin + flucloxacillin. NOT/kg. 125mg/
kg/hr (0.5mg/kg/hr) or 3mg/kg IV over 1hr 6H;
125mg or 250/ 250 (child), 250/250 or
Level 60-80umol/L (neonate), 60-110 (asthma)
500/500 (adult) 6H oral, IM or IV.
(x0.18=mcg/ml).
Ampicillin 1g + sulbactam 0.5g. 25-50mg/kg
Aminosalicylic acid (4-Aminosalicylic acid, ASA, 4
(adult 1-2g) of ampicillin 6H IM or IV over 30min.
- ASA, para-ASA, PAS). 50-100mg/kg (adult 4g) 8H oral.
Amprenavir. Age 4yr. Soltn (max 2.8g/day):
5-Aminosalicylic acid. See mesalazine.
22.5 mg/kg 12H, or 17mg/kg 8H oral. Caps (max
Amiodarone. IV: 15mg/kg in 50ml 5% dex (no 2.4g/day): 20mg/kg 12H, or 15mg/kg 8H oral.
heparin) at 5ml/hr (25mcg/kg/min) for 4hr, then
Amrinone. <4wk old: 4mg/kg IV over 1hr, then
1-3ml/hr (5-15mcg/kg /min, max 1.2g/24hr).
3-5mcg/kg /min. >4wk: 1-3mg/kg IV over 1hr,
Oral: 4mg/kg (adult 200mg) 8H 1 wk, 12H 1 wk,
then 5-15mcg/kg/min.
then 12-24H. A er star ng tablets, taper IV infsn
over 5 days. Reduce dose of digoxin and warfarin. Amsacrine. 450-600mg/m IV over 2hr dly x 3 - 5 days
Pulseless VF or VT: 5mg/kg IV over 3-5 min. Amylase. See pancrea c enzymes.
Amisulpride. 1-6mg/kg (adult 50-300mg) daily oral; Amylobarbitone. 0.3-1mg/kg (adult 15-50mg) 8-
acute psychosis 5-15mg/kg (adult 300-800mg) 12H. 12H, or 2-4mg/kg (adult 200-400mg) at night, oral.
Amitriptyline. Usually 0.5-1mg/kg (adult 25-50mg) Anagrelide. Adult (NOT/kg): 0.5mg 12H, incr
8H oral. Enuresis: 1-1.5mg/kg nocte. slowly if reqd to max 2.5mg 6H oral.
Amlodipine. 0.05-0.2mg/kg (adult 2.5-10mg) daily oral. Anakinra. Adult (NOT/kg): 100mg daily SC.
Amlodipine + olmesartan (5mg/20mg, 5/40, Anastrozole. Adult (NOT/kg): 1mg daily oral.
10/20, 10/40). Adult (NOT/kg): 1 tablet daily oral. Ances m (human stem cell factor). 20mcg/kg/d SC
Amlodipine + valsartan (5mg/160mg, 5/320, Aneurine. See thiamine.
10/160, 10/320). Adult (NOT/kg): 1 tablet daily oral. Anidulafungin. 2-4mg/kg (adult 100-200mg) oral
Amodiaquine. Treatment: 10mg/kg daily for 3 day 1, then 1-2mg/kg (adult 50-100mg) daily.
days oral. Prophylaxis: 5mg/kg once a wk. Anistreplase. Adult (NOT/kg): 30u IV over 5min.
Amorolfine. Nail lacquer 5%: apply x1-2/wk. Anthraquinone. See sennoside.
Amoxapine. 0.5-2mg/kg (adult 25-100mg) 8H oral. An haemophilic factor. See factor 8.
Amoxycillin. 10-25mg/kg (adult 0.25-1g) 8H IV, IM An -inhibitor coagulant complex. See factor 8
or oral; or 20mg/kg 12H oral. Severe in n: inhibitor bypassing frac on.
50mg/kg (adult 2g) IV 12H (1st wk life), 6H An lymphocyte globulin. See immunoglobulin,
(2-4 wk), 4-6H or constant infsn (4+ wk). an lymphocyte.

371
Drug Doses
An thrombin III. No. IU = (desired - actual level) Artemisinin. 25mg/kg oral day 1; then 12.5mg/kg
x Wt / 2.2. dly for 2 days (with mefloquine 15-25mg/kg on
An thymocyte globulin. See immunoglobulin, day 2), or for 4-6 days if mefloquine resistance.
an lymphocyte. Artesunate. Oral: 5mg/kg day 1; then 2.5mg/kg
An venom to Australian box jellyfish, snakes dly for 2 days (with mefloquine 15-25mg/kg on
(black, brown, death adder, sea, taipan, ger). day 2), or for 4-6 days if mefloquine resistance.
Dose depends on amount of venom injected, IM, or IV over 1-2min: 2mg/kg stat, then 1mg/kg
not size of pa ent. Higher doses for mul ple bites, in 6hr if hyperparasi c, then 1mg/kg daily un l
severe symptoms or delayed administra on. Give oral therapy possible.
adrenaline 0.005mg/kg (0.005ml/kg of 1 in 1000) Ar cane 40mg/ml + adrenaline 1:100,000.
SC. Ini al dose usually 1-2 amp diluted 1/10 in Adult (NOT/kg) avge dose 1.7ml (max 7mg/kg
Hartmanns soltn IV over 30min. Monitor PT, PTT, = 0.175ml/kg) by injec on.
fibrinogen, platelets; give repeatedly if symptoms Ascorbic acid.
or coagulopathy persist. Burn (NOT/kg): 200-500mg daily IV, IM, SC,
An venom to coral snake (USA). 3-6 vials IV oral. Metabolic dis (NOT/kg): 250mg (<7yr)
over 1-2hr, repeat if signs progress. 500mg (>7yr) daily oral. Scurvy (NOT/kg):
Premedicate with diphenhydramine 5mg/kg 100mg 8H oral for 10 days. Urine acidifica on:
(adult 300mg) IV, have adrenaline available. 10-30mg/kg 6H.
An venom to Crotalidae (pit vipers - USA). Asparaginase. See colaspase.
4-6 vials, with higher dose for more severe Aspirin. 10-15mg/kg (adult 300-600mg) 4-6H
envenoma on, diluted 1/10 in saline IV over 1hr, oral. An platelet: 3-5mg/kg (max 100mg) daily.
rptd 1hr later if reqd; then 2 vials 6H for 3 doses. Kawasaki: 10mg/kg 6H (low dose) or 25mg/kg 6H
Apomorphine. Adult (NOT/kg): usually 2.4-3.6mg/ (high dose) for 2wk, then 3-5 mg/kg daily.
dose (max 6mg) prn to max 50mg/day SC. Infsn: Arthri s: 25mg/kg (max 2g) 6H for 3 days,
0.02-0.08 mg/kg/hr (max 200mg/day) SC. then 15-20mg/kg 6H. Salicylate level (arthri s)
Apraclonidine. 1 drop/eye 8H (0.5%), 12H (1%). midway between doses 0.7-2.0 mmol/L (x13.81
= mg/100ml).
Aprepitant. Adult (NOT/kg): 125mg oral 1hr
before chemo, then 80mg on days 2 and 3. Aspirin 25mg + dipyridamole 200mg.
Adult (NOT/kg) 1 sustained rel cap 12H oral.
Apro nin (1kiu = 140ng = 0.00056epu, 1mg =
7143kiu). 1,200,000 kiu/m IV over 1hr (plus Astemizole. 0.2mg/kg (adult 10mg) daily oral.
1,200,000 kiu/m in prime), then 300,000 kiu/m/hr; Atazanavir. >16yr (NOT/kg): 400mg daily oral.
half for low dose. Adult (NOT/kg): 2,000,000kiu Atenolol. Oral: 1-2mg/kg (adult 50-100mg)
IV over 1hr (plus 2,000,000 kiu in prime), then 12- 24H. IV: 0.05 mg/kg (adult 2.5mg) every 5 min
500,000 kiu/hr; half for low dose. Prophylaxis: if reqd (max 4 doses), then 0.1-0.2mg/kg (adult
4000 kiu/kg, then 2000 kiu/kg 6H IV. 5-10mg) over 10min 12-24H.
Arachis oil. 130ml enema as required. Atomoxe ne. 0.5mg/kg (>70kg 40mg) daily oral,
Arachis oil 57% + chlorbutol 5% + dichlorobenzene incr a er at least 3 days to max 1.2mg/kg (>70kg
16% (Cerumol). 5 drops to ear 15-30min before 100mg) as single daily dose or divided 12H.
syringing. Atorvasta n. 0.2mg/kg (adult 10mg) dly, incr if
Arformoterol. reqd every 4wk to max 1.6mg/kg (adult 80mg) dly.
NOT/kg: 15mcg in 2ml 12H by nebulisa on. Atosiban. Adult (NOT/kg): 6.75mg IV over 1min,
Argatroban. then 300 mcg/min for 3hr, then 100mcg/min for
2mcg/kg/min; adjust to maintain APTT x1.5-3. max 45hr.
Arginine hydrochloride. Dose (mg) = BE x Wt(kg) Atovaquone, micronised. Pneumocys s: 3-24mo
x 70; give half this IV over 1hr, then rpt if reqd. 45mg/kg, >24mo 30mg/kg (max 1500mg) dlyoral.
Atovaquone 250mg + proguanil 100mg (Malarone).
Arginine vasopressin. See vasopressin.
Malaria treatment: 20mg/kg of atovaquone (adult
Aripiprazole. Adult (NOT/kg): 10-15mg daily oral, 1g) daily for 3 days oral; prophylaxis: 5mg/kg of
incr if reqd a er 2wk to max 30mg daily. atovaquone (adult 250mg) daily.
Artemether, oily soltn. 3.2mg/kg IM stat, then Atovaquone 62.5mg + proguanil 25mg (Malarone
1.6mg/kg daily unitl oral therapy possible. paediatric). Malaria prophylaxis: 5mg/kg (adult
Artemether 20mg + lumefantrine 120mg. 250mg) daily oral.
NOT/kg: 1 tab (10-14kg), 2 tab (15-24kg), 3 tab Atracurium besylate. 0.3-0.6mg/kg stat, then
(25-34kg), 4 tab (>34kg) at 0hr, 8hr, 24hr, 36hr,
0.1-0.2mg/kg when reqd or 5-10mcg/kg/min IV.
48hr, 60hr. Rpt dose if vomits within 1hr of ingestion.

372
 Drug Doses
Atropine. 0.02mg/kg (max 0.6mg) IV or IM, then Baclofen. 0.2mg/kg (adult 5mg) 8H oral, incr every
0.01mg/kg 4-6H. Organophosphate poisoning: 3 days to 1mg/kg (adult 25mg, max 50mg) 8H.
0.05-1mg/kg (adult 2mg) IV, then 0.02-0.05mg/kg Intrathecal infsn: 2-20mcg/kg (max 1000mcg)/24hr.
(adult 2mg) every 15-60min un l atropinised, then Balsalazide. Adult (NOT/kg): 2.25g 8H oral (=
0.02-0.08mg/kg/hr for several days. 2.34g -mesalazine daily).
Atropine 25mcg + diphenoxylate 2.5mg tab Bambuterol. 0.2-0.4mg/kg (adult 10-20mg) nocte oral
(Lomo l). Adult (NOT/kg): 1-2 tab 6-8H oral. Basiliximab. 12mg/m2 (max 20mg) IV 2hr
A apulgite. Adult (NOT/kg): 0.6-1.2g 3-6H oral. preop, repeated 4 days later.
Auranofin. 0.1mg/kg (adult 6mg) daily oral, incr BCG vaccine. See Bacillus Calme e-Guerin vaccine.
if reqd to max 0.05mg/kg (adult 3mg) 8H. Beclomethasone dipropionate. Rotacap or
Aurothioglucose. 0.25mg/kg weekly IM, incr aerosol (NOT /kg): 100-200mcg (<8yr), 150-
to 1mg/kg (max 40mg) weekly for 20wk, then 400mcg (>8yr) x2/day (rarely x4/day). Nasal
every 1-4wk. (NOT/kg): aerosol or pump (50mcg /spray): 1spray
Azaci dine. 75mg/m SC dly for 7 days, rptd every 12H (<12yr), 2spray 12H (>12yr).
4wk; incr if reqd a er 2 cycles to 100mg/m daily. Bemiparin. Surgery (adult, NOT/kg): 2500u
Azapropazone. 10mg/kg (max 600mg) 12H oral. (orthopaedics 3500u) SC 2hr pre-op or 6hr
Acute gout: 6H (day 1), 8H (day 2), then 12H. post-op, then daily for 7-10 days. DVT: 115u/kg
Azatadine. NOT/kg: 0.5-1mg (child >6yr), 1-2mg daily 5-9 days (or un l oral an coag).
(adult) 12-24H oral. Benazepril. 0.2-0.4mg/kg (adult 10-20mg)
Azathioprine. 25-75mg/m2 (approx 1-3mg/kg) 12-24H oral.
daily oral, IV. Bendroflumethiazide. See bendrofluazide.
Azelaic acid. 20% cream, 15% gel: apply 12H. Bendrofluazide. 0.1-0.2mg/kg (adult 5-10mg) dly oral.
Azelas ne. 0.1% spray, >5yr: 0.15ml to each Benflumetol (lumefantrine). See artemether.
nostril 12H. Benorylate. 30mg/kg (adult 1.5g) 8H oral.
Azidothymidine (AZT). See zidovudine. Benperidol. 5-15mcg/kg (adult 0.25-1.5mg)
Azithromycin. Oral (only 40% bioavailable): 12-24H oral.
15mg/kg (adult 500mg) on day 1 then 7.5mg/kg Benserazide. See levodopa + benserazide.
(adult 250mg) days 2-5, or 15mg/kg (adult 500mg) Benzathine penicillin. See penicillin, benzathine.
dly for 3 days; trachoma 20 mg/kg (adult 1g) wkly Benzbromarone. Adult (NOT/kg): 50-300mg
x3; MAC prophylaxis (adult) 1.2g wkly; Gp A strep daily oral, or 20-25mg with allopurinol.
20mg/kg dly x3. IV: 15mg/kg (adult 500mg) day 1,
Benzhexol. >3yr: 0.02mg/kg (adult 1mg) 8H, incr
then 5mg/kg (adult 200mg) dly. 1% eye drops: 1
to 0.1-0.3 mg/kg (adult 1.5-5mg) 8H oral.
drop 12H for 2 days, then dly for 5 days.
Benzocaine. 1%-20% topical: usually applied 4-6H.
Aztreonam. 30mg/kg (adult 1g) 8H IV. Severe
in n: 50mg/kg (adult 2g) 12H (1st wk life), 8H Benzoczine + cetylpyridinium. Mouth wash
(2-4 wk), 6H or infsn (4+ wk). (Cepacaine): apply 3H prn, do not swallow.
Bacampicillin. 15-25mg/kg (adult 400-800mg) Benzocane + phenazone 5.4% (Auralgin).
12H oral. 3 drops per ear 3 mes a day for 2-3 days.
Bacillus Calme e-Guerin (BCG) vaccine (CSL). Benzoic acid 6% + salicylic acid 3%.
Live. Intradermal (1mg/ml): 0.075ml (<3mo) Whi ields ointment: apply 12H.
or 0.1ml (>3mo) once. Percutaneous (60mg/ml Benzonatate. 2-4mg/kg (adult 100-200mg) 8H oral.
suspension): 1 drop on skin, inoculated with Benzoyl peroxide. Liq, gel 2.5%-10%: apply x 1-3/d
Heaf apparatus, once. Benzquinamide. IM: 0.5-1mg/kg (adult 50mg) stat
Bacillus Calme e-Guerin (BCG) suspension, and repeat in 1hr if needed, then 3-4H prn. IV over
about 5 x 10^8 cfu/vial. Adult: 1 vial (OncoTICE) 1-5min: 0.2-0.4mg/kg (adult 25mg) once.
or 3 vials (ImmuCyst) le in bladder for 2hr each Benzthiazide 25mg + triamterene 50mg.
wk for 6wks, then at 3, 6, 12, 18 and 24mo. Adult (NOT/kg): 1-2 tab on alternate days, oral.
Bacitracin 500u/g + polymyxin B 10,000u/g. Benztropine. >3yr: 0.02mg/kg (adult 1mg) stat
Eye ointment: apply x2-5/day. IM or IV, may repeat in 15min. 0.02-0.06mg/kg
Bacitracin 400u/g + polymyxin B 5000u/g + (adult 1-3mg) 12-24H oral.
neomycin 5mg/g (Neosporin). Ointment or eye Benzyl benzoate. 25% lo on. Scabies: apply from
ointment: apply x2-5/day. Powder: apply 6-12H neck down a er hot bath, wash o a er 24hr;
(skin in n), every few days (burns). Eye drops: see repeat in 5days. Lice: apply to infected region,
gramicidin. wash o a er 24hr; repeat in 7days.

373
Drug Doses
Benzylpenicillin. See penicillin G. Bisacodyl. NOT/kg: <12mo 2.5mg PR, 1-5yr 5mg
Bepridil. 4-8mg/kg (adult 200-400mg) daily oral. PR or 5-10mg oral, >5yr 10mg PR or 10-20mg oral.
Beractant (bovine surfactant, Survanta). Enema: half daily (6mo-3yr), 1 enema daily (>3yr).
25mg/ml soltn. 4ml/kg intratracheal 2-4 doses in Bisacodyl 10mg + docusate sodium 100mg.
48hr, each dose in 4 parts: body inclined down <2yr half suppos, 1-11yr half to 1 suppos,
with head to right, body down head le , body up >11yr 1 suppos daily.
head right, body up head le . Bismuth subsalicylte. 5mg/kg (adult 240mg) 12H
Beta carotene. Porphyria: 1-5mg/kg (adult oral 30min before meal. H.pylori (adult, NOT/kg):
30-300mg) daily. 107.7mg x4/day with meals and nocte for 2wk +
Betahis ne. 0.15-0.3mg/kg (adult 8-16mg) 8H oral. tetracycline 500mg x4/day + metronidazole
Betaine hydrochloride. Usually 60mg/kg (adult 200mg with meals and 400mg nocte; see also
omeprazole + bismuth.
3g) 12H oral, max 100mg/kg (adult 5g) 12H.
Bisoprolol. 0.2-0.4mg/kg (adult 10-20mg) dly oral.
Betamethasone. 0.01-0.2mg/kg daily oral. Beta-
Bitolterol. Resp soltn (0.2%): 1ml diluted to 4ml
methasone has no mineralocor coid ac on, 1mg
3-6H (mild), 2ml diluted to 4ml 1-2H
= 25mg hydrocor sone in glucocor coid ac on.
(moderate), undiltd con-stant (severe, in ICU).
Gel 0.05%; cream, lo on, ointment, 0.02%, 0.05%,
Aerosol 370mcg/pu: 1-2 pu 4-6H.
0.1%: apply sparingly 8-24H. Eye 0.1%: ini ally 1
drop/eye 1-2H, then 6H; or 0.6cm oint 8-12H. Bivalirudin. 0.75-1mg/kg IV stat, then
1.75-2.5mg/kg/hr for 4hr, then stop or give
Betamethasone 0.1% + neomycin 0.5%.
1.75-2mg/kg/hr for 14-20hr.
1 drop/eye 4-8H. Bleomycin sulfate. 10-20u/m2 IM, SC or IV over
Betamethasone acetate 3mg/ml + betametha- 15min x1-2/wk. Max total dose 250u/m.
sone sodium phosphate 3.9mg/ml (Celestone
Bortezomib. 1.3mg/m on days 1, 4, 8, 11; then
Chronodose). Adult: 0.25-2ml (NOT/kg) IM,
10 day rest (21 day cycle, average 6 cycles).
intra-ar cular, or intralesional injec on.
Stop if toxicity, then use 1 mg/m/dose; stop if
Betamethasone dipropionate 0.064% + calcipo- toxicity recurs, then use 0.7mg/m/dose.
triol 0.005% (Dovonex). Ointment: apply daily to Bosentan. 1mg/kg (adult 62.5mg) 12H oral for
no more than 30% of body for up to 4wk (max 1-4wk, then 2mg/kg (adult 125mg) 12H.
100g/wk in adult). IV: half oral dose.
Betaxolol. 0.4-0.8mg/kg (adult 20-40mg) daily Botulinum toxin type A. NOT/kg: 1.25-2.5u/site
oral. Eye drops 0.25%-0.5%: 1 drop/eye 12H. (max 5u/site) IM, max total 200u in 30 days.
Bethanecol. Oral: 0.2-1mg/kg (adult 10-50mg) Oesoph achalasia: 100u per session divided
6-8H. SC: 0.05-0.1mg/kg (adult 2.5-5mg) 6-8H. between 4-6 sites. Hyperhidrosis: 50u/2ml
Bevacizumab. 5mg/kg IV every 14 days. intradermal per axilla (given in 10-15 sites).
Bexarotene. 300mg/m (range 100-400mg/m) Botulinum toxin type B. NOT/kg: usual total
daily oral. dose 2,500-10,000u, rptd every 3-4 mo if reqd.
Bezafibrate. 4mg/kg (adult 200mg) 8H oral with food. Bretylium tosylate. 5mg/kg IV in 1hr, then 5-30
Bicalutamide. Adult (NOT/kg): 50-150mg daily oral. mcg/kg/min.
Bicalutamide + goserelin. Adult (NOT/kg): Brimonidine. 0.2%: 1 drop/eye 12H.
50mcg daily oral, + goserelin 10.8mg implant Brimonidine 0.2% + molol 0.5%. 1 drop/eye 12H.
4 wkly or 10.8mg SC every 3mo. Brinzolamide. 1%: 1 drop/eye 8-12H.
Bicarbonate. Slow IV: dose (mmol) = BE x Wt/4 Bromazepam. 0.02-0.1mg/kg (adult 1-3mg) 8H oral
(<5kg), BE x Wt/6 (child), BE x Wt/10 (adult). Bromhexine. 0.3mg/kg (adult 16mg) 8H oral for
These doses correct half the base deficit. 7 days, then 0.15mg/kg (adult 8mg) 8H.
Alkalinise urine: 0.25mmol/kg 6-12H oral. Bromocrip ne. 0.025mg/kg (adult 1.25mg) 8-12H,
Bifonazole. 1% cream: apply daily for 2-4wk. incr wkly to 0.05-0.2mg/kg (adult 2.5-10mg)6-12H
Bimatoprost. 0.03% drops: 1 drop/eye /evening. oral. Inhibit lacta on, NOT/kg: 2.5mg 12H for 2wk.
Bimatoprost 0.3mg/ml + molol 5mg/ml. Brompheniramine. 0.1-0.2mg/kg (adult
1 drop/eye daily. 5-10 mg) 6-8H oral, SC, IM or slow IV.
Bio n (coenzyme R, vitamin H). Buclizine. 0.25-1mg/kg (adult 12.5-50mg) 8-24H oral
NOT/kg: 5-20mg daily IV, IM, SC or oral. Budesonide. Metered dose inhaler (NOT/kg):
Biperiden hydrochloride. 0.02-0.04mg/kg (adult <12yr 50-200 mcg 6-12H, reducing to 100-200mcg
1-2mg) 8-12H oral. IM or slow IV: 0.05-0.1mg/kg 12H; >12yr 100-600 mcg 6-12H, reducing to 100-
(adult 2.5-5mg), max x4/day. 400mcg 12H.

374
 Drug Doses
Nebuliser (NOT/kg): <12yr 0.5-1mg 12H, reducing Calciferol (Vitamin D2). See ergocalciferol.
to 0.25-0.5mg 12H; >12yr 1-2mg 12H, reducing to Calcipotriol. 50mcg/g (0.005%) ointment: apply
0.5-1mg 12H. Croup: 2mg (NOT/kg) nebulised. 12-24H. See also betamethasone + calcipotriol
Nasal spray, aerosol (NOT/kg): 64-128 mcg/ ointment.
nostril 12-24H. Crohns dis, adult (NOT/kg): 9mg Calcitonin. Hypercalcaemia: 4u/kg 12-24H IM
daily for 8wk, then reduce over 4wk. or SC, may incr up to 8u/kg 6-12H. Pagets:
Budesonide + formoterol. NOT/kg: 80mcg / 1.5-3u/kg (max 160u) x3/wk IM or SC. Nasal
4.5mcg or 160mcg/4.5mcg, two inhala ons 12H. spray: 200u daily.
Bumetanide. 25mcg/kg (adult 1mg) daily oral, Calcitriol (1,25-OH vitamin D3). Renal failure,
may incr to max 50mcg/kg (adult 3mg) 8-12H. vit D resistant rickets: 0.02mcg/kg daily oral,
Bupivacaine. Max dose: 2-3mg/kg (0.4-0.6ml/kg of incr by 0.02mcg/kg every 4-8wk according to
0.5%). With adrenaline: max dose: 3-4mg/kg (0.6- serum Ca (adult usually 0.25mcg 12H).
0.8ml/kg of 0.5%). Intrathecal: 1mgkg (0.2ml/kg Calcium (as carbonate, lactate or phosphate).
of 0.5%). Epidural: 2mg/kg (0.4ml/kg of 0.5%) NOT/kg. Neonate: 50mg x4-6/day; 1mo-3yr:
stat intraop, then 0.25mg/kg/hr (0.2ml/kg/hr of 100mg x2-5/day oral; 4-12yr: 300mg x2-3/day;
0.125%) postop. Intrapleural: 0.5% 0.5ml/kg (max >12yr: 1000mg x1-2/day.
20ml) 8-12H, or 0.5ml/kg (max 10ml) stat then Calcium carbimide. 1-2mg/kg (adult 50-100mg)
0.1-0.25 ml/kg/hr (max 10ml/hr). Epidural in ICU: 12H oral.
25ml 0.5% + 1000 mcg (20ml) fentanyl + saline to Calcium carbonate. Adult NOT/kg: 1250-1500mg
100ml at 2-8ml/hr in adult. (500-600 mg calcium) 8H oral with meals for
Buprenorphine. Adult (NOT/kg): 200-800mcg hyperphosphataemia.
6-8H sublingual, IM or slow IV. Calcium chloride. 10% soltn (0.7mmol/ml Ca):
Bupropion. 2-3mg/kg (adult 100-150mg) 8-12H oral 0.2ml/kg (max 10ml) slow IV stat.
Burrows solu on. See aluminium acetate soltn. Requirement <16yr 2ml/kg/day IV. Inotrope: 0.03-
Buserelin. Adult, NOT/kg. Intranasal: 100mcg 0.12 ml/kg/hr (0.5-2mmol/kg/day) via CVC.
4H, or 150 mcg each nostril 8H. Calcium edetate (EDTA). See sodium calciumedetate
Buspirone. 0.1mg/kg (adult 5mg) 8-12H oral, Calcium folinate. NOT/kg: 5-15mg oral, or 1mg
incr to max 0.3mg/kg (adult 15mg) 8-12H. IM or IV daily. Rescue star ng up to 24hr a er
Busulfan. Induc on: 0.06mg/kg (max 4mg) daily methotrexate: 10-15 mg/m 6H for 36-48hr
oral if leucocytes >20,000/mm and platelets IV. Methotrexate toxicity: 100-1000mg/m
>100,000/mm. Maintenance: 0.01-0.03mg/kg 6H IV. Before a fluorouracil dose of 370 mg/m:
(max 2mg) daily. 200mg/m IV daily x5, repeat every 3-4wk.
Butalbital. 1-2mg/kg (adult 50-100mg) 8-24H oral. Calcium gluconate. 10% soltn (0.22mmol/ml
Butenafine. 1% cream: apply 12-24H for 1-4wk. Ca): 0.5ml/kg (max 20ml) slow IV stat.
Butobarbitone. 2-4mg/kg (adult 100-200mg) Requirement <16yr 5ml/kg/day IV. Inotrope:
nocte oral. 0.5-2mmol/kg/day (0.1-0.4ml/kg/hr) via CVC.
Butoconazole nitrate. 2% vaginal cream: 5g Calcium levofolinate. / the dose of calcium folinate.
(NOT/kg) nocte. Calcium leucovorin. See calcium folinate.
Butorphanol. IM: 0.02-0.1mg/kg (adult 1-4mg) Calcium polystyrene sulfonate (Calcium
3-4H. IV: 0.01-0.05mg/kg (adult 0.5-2mg) 3-4H. Resonium). 0.3-0.6g/kg (adult 15-30g) 6H NG
C1 esterase inhibitor. 1u = ac vity 1ml plasma. (+ lactulose), PR.
10-50u/kg IV over 1hr once (prophylaxis), 12-24H Calfactant. 35mg/ml phosphlipids, 0.65mg/ml
(treatment). proteins: 1.5 ml/kg intratracheal gradually over
Cabergoline. 10mcg/kg/wk (adult 0.5mg) in 20-30 breaths during inspira on with infant lying
1-2 doses, incr if reqd mthly by 10mcg/kg/wk to on one side, then another 1.5 ml/kg with infant
usu. 20mcg/kg/wk (adult 1mg) in 1-4 doses, lying on other side.
max 90mcg/kg/wk (adult 4.5mg). Candesartan. 0.1-0.3mg/kg (adult 4-16mg) dly oral.
Inhibit lacta on: 1 mg oral stat. Canrenoate. 3-8mg/kg (adult 150-400mg) daily IV.
Caeine citrate. 2mg citrate = 1mg base. Capecitabine. 1250mg/m 12H oral for 2wk
1-5mg/kg (adult 50-250mg) of citrate 4-8H oral,PR. then 1wk o, in 3wk cycles.
Neonate: 20mg/kg stat of citrate, then 5mg/kg Capreomycin sulphate. 20mg/kg (adult 1g) IM
daily oral or IV over 30min; weekly level 5-30mg/L daily, decr a er 2-4mo to 2-3 mes per wk.
midway between doses. Capsaicin. Cream 0.025%, 0.075%. Apply 6-8H.
Calcifediol (25-OH D3). Deficiency: 1-2mcg/kg wash o a er 24hr; repeat in 7days.
daily oral.

375
Drug Doses
Captopril. Beware hypotension. 0.1mg/kg (adult Cefepime hydrochloride. 25mg/kg (adult 1g)
2.5-5mg) 8H oral, incr if reqd to max 2mg/kg 12H IM or IV. Severe in n: 50mg/kg (adult 2g)
(adult 50mg) 8H. Less hypotension if mixed IV 8-12H or constant infsn.
with NG feeds given con nuously (or 1-2H). Cefixime. 5mg/kg (adult 200mg) 12-24H oral.
Carbachol. 0.01%: max 0.5ml in ant. chamber (eye) Cefodizime. 25mg/kg (max 1g) 12H IV or IM.
Carbamazepine. 2mg/kg (adult 100mg) 8H Cefonicid. 15-50mg/kg (adult 0.5-2g) IV or IM dly
oral, may incr over 2-4wk to 5-10mg/kg (adult Cefoperazone. 25-60mg/kg (max 1-3g) 6-12H IV
250-500mg) 8H. Bipolar disorder (adult, NOT/kg): in 1hr or IM.
200mg as slow-rel cap 12H oral, incr if reqd to max Cefotaxime. 25mg/kg (adult 1g) 12H (<4wk), 8H
800mg 12H. Level 20-40umol/L (x0.24=mg/l). (4+wk) IV. Severe in n: 50mg/kg (adult 2-3g) IV
Carbaryl. 0.5% lo on: rub into hair, leave 12hr, wash 12H (preterm), 8H (1st wk life), 6H (2-4 wk), 4-6H
Carbenicillin. 382mg tab, adult (NOT/kg): 1-2 or constant infsn (4+ wk).
tab 4H oral. Cefotetan. 25mg/kg (adult 1g) 12H IM, IV.
Carbenoxolone sodium. Adult (NOT/kg): 20- Severe in n: 50mg/kg (max 2-3g) 12H or
50mg 6H oral. Mouth gel 2%, or 2g granules in constant infsn.
40ml water, apply 6H. Cefoxi n. 25-60mg/kg (adult 1-3g) 12H (1st wk
Carbetocin. Adult (NOT/kg): 100mcg IV over 1 min; IM life), 8H (1-4wk), 6-8H (>4wk) IV.
Carbidopa. See levodopa + carbidopa. Cefpirome. 25-50mg/kg (adult 1-2g) 12H IV.
Carbimazole. 0.4mg/kg (adult 20mg) 8-12H oral Cefpodoxime. 5mg/kg (adult 100-200mg) 12H oral.
for 2wk, then 0.1mg/kg (adult 5-10mg) 8-24H. Cefprozil. 15mg/kg (adult 500mg) 12-24H oral.
Carbinoxamine. NOT/kg: 2mg (1-3yr), 2-4mg Ce azidime. 15-25mg/kg (adult 0.5-1g) 8H IV or IM.
(3-6yr), 4-8mg (>6yr) 6-8H oral. Severe inftn, cystic fibrosis: 50mg/kg (max 2g) 12H (1st
Carbocisteine. 10-15mg/kg (adult 500-750mg) 8H oral wk life), 8H (2-4 wk), 6H or constant infsn (4+ wk).
Carbopla n. 300-400mg/m IV over 60min every 4wk Ce ibuten. 10mg/kg (adult 400mg) daily oral.
Carglumic acid. 50mg/kg 12H oral, incr to 6H if reqd Ce izoxime. 25-60mg/kg (adult 1-3g) 6-8H IV.
Carisoprodol. 7mg/kg (adult 350mg) 6H oral. Ce riaxone sodium. 25mg/kg (adult 1g) 12-24H IV,
Carmus ne (BCNU). 200mg/m IV over 2hr every or IM (in 1% lignocaine). Severe in n: 50mg/kg
6wk ( if wbc <3000/mm or plt <75,000mm). (max 2g) dly (1st wk life), 12H (2+ wk). Epiglo s:
Carni ne, L form. IV: 5-15mg/kg (max 1g) 6H. 100mg/kg (max 2g) stat, then 50mg/kg (max2g)
Oral: 25mg/kg 6-12H (max 3g/day). a er 24hr. Meningococ proph (NOT/kg): child
Carob bean gum. NOT/kg: 1 scoop (1.8g) in 100ml 125mg, >12yr 250mg IM in 1% lignocaine once.
water, give 10-20ml by spoon; or add / scoop to Cefuroxime. Oral (as cefuroxime axe l): 10-15mg/
every 100-200ml of milk. kg (adult 250-500mg) 12H. IV: 25mg/kg (adult 1g)
Carteolol. 0.05-0.2mg/kg (adult 2.5-10mg) daily 8H. Severe in n: 50mg/kg (max 2g) IV 12H (1st wk
oral. 1%, 2%: 1drop/eye 12H. life), 8H (2nd wk), 6H or constant infsn (>2wk).
Carvedilol. 0.08mg/kg (adult 3.125mg) 12H oral; if Celecoxib. Usually 2mg/kg (adult 100mg) 12H,
tolerated incr by 0.08mg/kg (adult 3.125mg) every or 4mg/kg (adult 200mg) daily oral.
1-2wk to max 0.5-0.75mg/kg (adult 25mg) 12H. Celiprolol. 5-10mg/kg (adult 200-400mg) daily oral.
Casanthranol + docusate sodium. Cap 30mg/ Cephalexin. 7.5mg/kg (adult 250mg) 6H, or
100mg (NOT/kg): adult 1-2cap 12-24H oral. Syrup 15mg/kg (adult 500mg) 12H oral.
2mg/4mg per ml (NOT/kg): child 5-15ml bed me, Cephalothin. 15-25mg/kg (adult 0.5-1g) 6H IV
adult 15-30ml 12-24H. or IM. Severe in n: 50mg/kg (max 2g) IV 4H or
Caspofungin. 70mg/m (max 70mg) day 1, then 50 constant infsn. Irriga on fluid: 2g/L (2mg/ml).
mg/m (usu. max 50mg, up to 70mg) dly IV over 1h Cephamandole. 15-25mg/kg (adult 0.5-1g) 6-8H
Cefaclor. 10-15mg/kg (adult 250-500mg) 8H IV over 10min or IM. Severe in n: 40mg/kg (adult
oral. Slow release tab 375mg (adult, NOT/kg): 2g) IV over 20min 4-6H or constant infsn.
1-2 tab 12H oral. Cephazolin. 10-15mg/kg (adult 0.5g) 6H IV or IM.
Cefadroxil. 15-25mg/kg (adult 0.5-1g) 12H oral. Severe in n: 50mg/kg (adult 2g) IV 4-6H or con-
Cefamandole. See cephamandole. stant infsn. Surgical proph: 50mg/kg IV at induction.
Cefazolin. See cephazolin. Cephradine. Oral: 10-25mg/kg (adult 0.25-1g)
6H. IM or IV: 25-50mg/kg (adult 1-2g) 6H.
Cefdinir. 14mg/kg (adult 600mg) daily (or in
2 divided doses) oral. Certoparin. Prophylaxis: 60u/kg (adult 3000u)
1-2hr preop, then daily SC.
Cefditoren. 4-8mg/kg (adult 200-400mg) 12H oral.

376
 Drug Doses
Ce rizine. NOT/kg: 2.5mg (6mo-2yr), 2.5-5mg Chlorphenasin. 1% ointment: apply 12H.
(2-5yr), 5-10mg (>5yr) daily oral. Chlorpheniramine. 0.1mg/kg (adult 4mg) 6-8H oral.
Cetrimide. See chlorhexidine. Chlorpheniramine 1.25mg + phenylephrine 2.5mg
Cetrorelix (GnRH antagonist). Adult (NOT/kg): 0.25 in 5ml. Syr (NOT/kg): 1.25-2.5ml (0-1yr), 2.5 -5ml (2-
mg SC on stimulation day 5, then dly till hCG given. 5yr), 5-10ml (6-12yr), 10-15ml (>12yr) 6-8H oral.
Cetuximab. 400mg/m IV over 2hr, then Chlorpromazine. Oral or PR: 0.5-2mg/kg (max
250mg/m wkly. 100mg) 6-8H; up to 20mg/kg 8H for psychosis.
Cetylpyridinium. See benzocaine + cetylpyridinium. IM (painful) or slow IV (beware hypotension):
Cevimeline. 0.6mg/kg (adult 30mg) 8H oral. 0.25-1mg/kg (usual max 50mg) 6-8H.
Charcoal, ac vated. Check bowel sounds present. Chlorpropamide. Adult (NOT/kg): ini ally 125-
1-2g/kg (adult 50-100g) NG; then 0.25g/kg hrly 250mg oral, max 500mg daily.
if redq. Laxa ve: sorbitol 1g/kg (1.4ml/kg of 70%) Chlorquinaldol. 5% paste: apply 12H.
once NG, may repeat x1. Chlortetracycline. 3% cream, ointment: apply 8-24H.
Chenodeoxycholic acid. 5-10mg/kg 12H oral. Chlortetracycline 115.4mg + demeclocycline
Chloral betaine. 1.7mg = 1mg chloral hydrate. 69.2mg + tetracycline 115.4mg. NOT/kg. >12yr:
Chloral hydrate. Hypno c: 50mg/kg (max 2g) 1 tab 12H oral.
stat (ICU up to 100mg/kg, max 5g). Seda ve: Chlorthalidone. 2mg/kg (max 100mg) 3 x /wk oral.
8mg/kg 6-8H oral or PR. Chlorzoxazone.5-15mg/kg (max 250-750mg) 6-8Horal
Chlorambucil. Typically 0.1-0.2mg/kg daily oral. Cholecalciferol (Vitamin D3). 1 mcg = 40u = 1mcg
Chloramphenicol. Severe in n: 40mg/kg (max 2g) ergocalciferol (qv). Osteodystrophy: 0.2mcg/kg
stat IV, IM or oral; then 25mg/kg (max 1g) daily (hepa c) 15-40mcg/kg (renal) daily oral.
(1st wk life) 12H (2-4 wk) 8H (>4wk) x5 days, Cholera, whole cell plus toxin b subunit recom-
then 6H. Eye drop, oint: apply 2-6H. Ear: 4drop 6H. binant vaccine (Dukoral). Inac vated. Dissolve
Serum level 20-30mg/L 2hr, <15mg/L trough. granules in 150ml water. 2-6yr: give 75ml x3
Chlordiazepoxide. 0.1mg/kg (adult 5mg) 12H doses 1wk apart oral, boost a er 6mo. >6yr:
oral, may incr to max 0.5mg/kg (adult 30mg) 6-8H. give 150ml x2 doses 1wk apart, boost a er 2yr .
Chlorhexidine. 0.1%: catheterisa on prep, Cholestyramine. NOT/kg. 1g (<6yr) 2-4g (6-12yr)
impe go. 0.2%: mouthwash. 1%: skin disinfec on. 4g (>12yr) dly oral, incr over 4wk to max 1-2x
2-4%: hand wash. ini al dose 8H.
Chlorhexidine 0.5% + alcohol 70%. Skin disinfection. Choline magnesium trisalicylate. See aspirin.
Chlorhexidine 1.5% + cetrimide 15%. / in water: Choline salicylate, mouth gel (Bonjela). Apply 3H prn
cleaning ssues, wounds or equipment. 140ml in Choline theophyllinate (200mg = theophylline
1 L water: disinfec ng skin, equipment (soak 127mg). See theophylline.
2 min, rinse in sterile water). Choriogonadotropin alfa. Adult(NOT/kg):250mcg SC
Chlorhexidine + cetrimide. 0.05%/0.5%, 0.1%/1% , Chorionic gonadotrophin. NOT/kg.
0.15%/0.15% soltn: wound cleaning. Cryptorchidism all ages: 500-1000u x1-2/wk for
Chlorhexidine 1% + hexamidine 0.15%. Powder: 5wk. A er FSH: 10,000iu IM once. Men: 7000iu
wounds. IM x2/wk, with 75iu FSH and 75iu LH IM x3/wk.
Chlormethiazole. IV (edisylate 0.8%): 1-2ml/kg Chymopapain. Adult (NOT/kg): 2000-4000 picokatal
(8-16 mg/kg) over 15min, then 0.5-1ml/kg/hr (4-8 units / disc, max 10,000 picokatal units per pa ent.
mg/kg/hr). Caps 192 mg base, adult (NOT/kg): 2-4 Ciclesonide. Inhaltn (adult): 160mcg in the
cap stat (may rpt in 1-2hr), then 1-2cap 8H, oral. evening, reducing to 80mcg if possible.
Chlormezanone. 5mg/kg (adult 200mg) 6-8H, or Ciclopirox. 1% cream or lo on: apply 12H.
10mg/kg (adult 400mg) at night oral.
Cidofovir. 5mg/kg over 1hr IV on day 0, 7, then every
Chlorophyllin copper complex. 2mg/kg 8-24H oral. 14 days (with probenecid). Papilloma: inject 6.25
Chloroprocaine. Max 11mg/kg (max 800mg). With mg/ml soltn (max total 0.6mg/kg) at 2wk intervals
adrenaline (1/200,000) max 14mg/kg (max 1000mg). Cilazapril. Usu. 0.02-0.1mg/kg (adult 1-5mg)dly oral.
Chloroquine, base. Oral: 10mg/kg (max 600mg) Renal hypertension: 0.005-0.01mg/kg dly oral.
daily x3 days. IM: 4mg/kg (max 300mg) 12H for Cilostazol. Adult (NOT/kg): 100mg 12H oral.
3 days. Prophylaxis: 5mg/kg (adult 300mg) oral
Cime dine. Oral: 5-10mg/kg (adult 300 - 400mg)
x1/wk. Lupus, rheu arth: 12mg/kg (max 600mg)
6H, or 20 mg/kg (adult 800mg) nocte. IV: 10-15mg/kg
daily, reduce to 4-8mg/kg (max 400mg) daily.
(adult 200mg) 12H (newborn), 6H (> 4wk).
Chlorothiazide. 5-20mg/kg (adult 0.25-1g)
12-24H oral, IV.

377
Drug Doses
Cinacalcet. Adult (NOT/kg) 30mg daily oral, incr Clobetasol. 0.05% spray, cream, ointment, gel,
every 2-4wk (to max 180mg) to control parathy- solu on, foam, lo on, shampoo: apply 12H.
roid hormone level. Parathyroid carcinoma: 30mg Clobetasone. 0.1% soltn: 1drop/eye 1-6H.
12H, incr every 2-4wk if reqd to control serum Clodronate. 10-30mg/kg (adult 0.6-1.8g) IV over
Ca to max 90mg 6H oral. 2hr every 2mo; or 6mg/kg (adult 300mg) IV
Cinnarizine. 0.3-0.6mg/kg (adult 15-30mg) 8H oral. over 2hr daily x7 days, then 15-30/mg/kg
Periph vasc dis: 1.5mg/kg (adult 75mg) 8H oral. (adult 0.8-1.6g) 12H oral.
Cinchocaine. Max dose 2mg/kg (0.4ml/kg of 0.5%) Clofarabine. 52mg/m IV over 2hr for 5 days
by injec on. Oint 0.5% with hydrocor sone 0.5%: every 2-6wk.
apply 8-24H. Clofazimine. 2mg/kg (adult 100mg) daily oral.
Cinoxacin. 10mg/kg (adult 500mg) 12H oral. Lepra reac on: up to 6mg/kg (max 300mg)
Ciprofibrate. 2-4mg/kg (adult 100-200mg) daily oral. daily for max 3 months
Ciprofloxacin. 5-10mg/kg (adult 250-500mg) 12H Clofibrate. 10mg/kg 8-12H oral.
oral, 4-7mg/kg (adult 200-300mg) 12H IV. Severe Clomethiazole. Equivalent ac on: cap 192mg
in n, or cys c fibrosis: 20mg/kg (max 750mg) 12H base, tab 500mg edisylate, syrup 250mg
oral, 10mg/kg (max 400mg) 8H IV; higher doses edisylate in 5ml. Adult (NOT/kg): 1-2 cap or tab,
used occasionally. Meningococcus prophylaxis: or 5-10ml syrup, at bed me oral.
15mg/kg (max 500mg) once oral. Clomiphene. Adult (NOT/kg): 50mg dly for 5d
Ciprofloxacin, eye drops. 0.3%. Corneal ulcer: oral, incr to 100mg dly for 5d if no ovula on.
1 drop /15min for 6hr then 1 drop/30 min for 18hr Clomipramine. 0.5-1mg/kg (adult 25-50mg) 12H
(day 1), 1drop 1H (day 2), 1drop 4H (day 3-14). oral, incr if reqd to max 2mg/kg (adult 100mg) 8H.
Conjunc vi s: 1 drop 4H; if severe 1 drop 2H Clonazepam. 1 drop = 0.1mg. 0.01mg/kg (max
when awake for 2 days, then 6H. 0.5mg) 12H oral, slowly incr to 0.05mg/kg
Ciprofloxacin, eye ointment. 0.3%. Apply 1.25cm (max 2mg) 6-12H oral. Status (may be rptd
8H for 3 days, then 12H for 3 or more days. if ven lated), NOT/kg: neonate 0.25mg, child
Cisatracurium. 0.1mg/kg (child) or 0.15mg/kg (adult) 0.5mg, adult 1mg IV.
IV stat, then 0.03mg/kg if reqd or 1-3mcg/kg/min. Clonidine. Hypertension: 1-5mcg/kg slow IV,
ICU: 0.15 mg/kg stat, then (1-10mcg/kg/min) IV. 1-6mcg/kg (adult 50-300mcg) 8-12H oral.
Cispla n. 60-100mg/m IV over 6hr every Migraine: start 0.5mcg/kg (adult 50-75mcg)12H oral
3-4wk x6 cycles. Analgesia: 2.5mcg/kg premed oral, 0.3 mcg/kg/hr
Citalopram. 0.4mg/kg (adult 20mg) dly, incr if reqd IV, 1-2mcg/kg local block; ventld 0.5-2 mcg/kg/hr
over 4wk to max 0.4mg/kg (adult 60mg) dly oral. (<12kg 1mcg/kg/hr is 50mcg/kg in 50ml at 1ml/hr,
Citric acid 0.25g + potassium citrate 1.5g. Urine >12kg 25 mcg/kg in 50ml at 2ml/hr) + midazolam
alkalinisa on >6yr (NOT/kg): 2 tab 8-12H oral. 1mcg/kg/min (3 mg/kg in 50ml at 1ml/hr).
Cladribine. Hairy cell leuk: usually 0.09mg/kg/day Clopidogrel. 1.5mg/kg (adult 75mg) daily oral.
for 7 days by con nuous IV infsn. Ch lymph leuk: Clorazepate. 0.3-2mg/kg (adult 15-90mg) nocte
0.12mg/kg/day over 2hr IV on days 1-5 of 28 day oral, or 0.1-0.5mg/kg (adult 5-30mg) 8H
cycle, max 6 cycles. Clostridia an toxin. See gas gangrene an toxin.
Clarithromycin. 7.5-15mg/kg (adult 250-500mg)12H Clotrimazole. Topical: 1% cream or solu on 8-12H.
oral. Slow rel tab, adult (NOT/kg): 0.5g or 1g dly. Vaginal (NOT/kg): 1% cream or 100mg tab daily for
Clavulanic acid. See amoxycillin, carcillin. 6 days, or 2% cream or 500mg tab daily for 3 days.
Clemas ne. 0.02-0.06mg/kg (adult 1-3mg) 12H oral Cloxacillin. 15mg/kg (adult 500mg) 6H oral, IM
Clenbuterol. Adult (NOT/kg): 20mcg (up to or IV. Severe in n: 25-50mg/kg (adult 1-2g) IV
40mcg) 12H oral. 12H (1st wk life), 8H (2-4wk), 4-6 H (>4wk) or
Clidinium. 0.05-0.1mg/kg (adult 2.5-5mg) 6-8H oral. constant infsn (>4wk).
Clindamycin. 6mg/kg (adult 150-450mg) 6H oral. IV Clozapine. 0.5mg/kg (adult 25mg) 12H oral, incr
over 30 min, or IM: 5mg/kg 12H (prem <1wk old), over 7-14 d to 2-5mg/kg (adult 100-300mg) 8-12H;
5mg/kg 8H (prem >1wk, term <1wk), 7.5mg/kg later reducing to 2mg/kg (adult 100mg) 8-12H.
8H (term >1wk), >28 days 10mg/kg (adult 600mg) Coagula on factor, human (Prothrombinex).
8H. Severe in n (>28 days): 15-20 mg/kg (adult Factors 2, 9 , 10; 250u/10ml. 1ml/kg slow IV daily.
900mg) 8H IV over 1hr. Acne soltn 1%: 12H. Risk of thrombosis in acute liver failure.
Clioquinol.10mg/g cream, 100% powder: apply 6 - 12H Coal tar, topical. 0.5% incr to max 10%, applied 6-8H.
Clobazam. 0.1mg/kg (adult 10mg) daily oral, incr if Cocaine. Topical: 1-3mg/kg.
reqd to max 0.4mg/kg (adult 20mg) 8-12H oral.

378
 Drug Doses
Codeine phosphate. Inac ve in 10% of adults, Cor sone acetate. 1-2.5mg/kg 6-8H oral.
poor ac vity in children <5yrs. Analgesic: 0.5- Physiological: 7.5 mg/m2 8H. Cor sone acetate
1mg/kg (adult 15-60mg) 4H oral, IM, SC. 1mg = hydrocor sone 1.25mg in mineralo-
Cough: 0.25-0.5mg/kg (adult 15-30mg) 6H. and gluco-cor coid ac on.
Co-danthramer, co-danthrusate. See dantron. Cosyntropin (ACTH subunit).NOT/kg: <2yr 0.125 mg ,
Co-dergocrine mesylate. Adult (NOT/kg): usually >2yr 0.25-0.75mg IM, IV, or infused over 4-8hr.
3.0-4.5mg daily before meal oral or sublingual; Cotrimoxazole (trimethoprim 1mg + sulpham-
300mcg daily IM, SC or IV infsn. ethoxazole 5mg). TMP 1.5-3mg/kg (adult 80-
Coenzyme Q10. See ubidecarenone. 160mg) 12H IV over 1hr or oral. Renal proph: TMP
Colaspase. Test 2-50u intradermal. Typical dose 2mg/kg (max 80mg) daily oral. Pneumocys s:
6000u/m every 3rd day x9 IV over 4hr, IM,SC proph TMP 5mg/kg daily on 3 days/wk; treatment
Colchicine. Acute gout: 0.02mg/kg (adult 1mg) 2H TMP 250mg/m stat, then 150mg/m 8H (<11yr)
oral (max 3 doses/day). Chronic use (gout, FMF): or 12H (> 10yr) IV over 1hr; in renal failure dose
0.01-0.04mg/kg (adult 0.5-2mg) daily oral. interval (hr) = serum crea nine (mmol/l) x 135
(max 48hr); 1hr post-infsn serum TMP 5-10mcg/
Colesevelam. 625mg tab. Adult (NOT/kg): 3 tab 12H
ml, SMX 100-200mcg/ml. IV infsn: TMP max
oral, or 6 tab dly. With statin: 4-6 tab/day(in 1-2 doses).
1.6mg/ml in 5% dext.
Coles pol hydrochloride. 0.1-0.2g/kg (adult
Coumarin. Oral: 1-8mg/kg (adult 50-400mg)
5-10g) 8H oral.
daily. Cream 100mg/g: apply 8-12H.
Colfosceril palmitate (Exosurf Neonatal).
Soltn 13.5 mg/ml. Prophylaxis: 5ml/kg intratra- Cromolyn, sodium. See sodium cromoglycate.
cheal over 5min straight a er birth, and at 12hr Crotamiton. 10% cream or lo on: apply x2-3/day.
and 24hr if s ll ven lated. Rescue: 5ml/kg intratra- Cryoprecipitate. Low factor 8: 1u/kg incr ac vity
cheal over 5min, repeat in 12hr if s ll ven lated. 2 % (t / = 12hr); usu. dose 5ml/kg or 1bag/4kg
Colis methate. See colistin sulfomethate sodium. 12H IV for 1-2 infns (muscle, joint), 3-6 infns (hip,
Colis n 3mg/ml + neomycin 3.3mg/ml. forearm, retroperitoneal, oropharynx), 7-14 infns
(intracranial). Low fibrinogen: usually 5ml/kg or
O c: 4 drops 8H.
1bag/4kg IV. Bag usu. 20-30ml: factor 8 5u/ml
Colis n sulphomethate sodium. 2.6mg = 1mg (100u/bag), fibrinogen 10mg/ml (200mg/bag).
colis n base = 30,000u. IM, or IV over 5min:
Cyanocobalamin (Vit B12). 20mcg/kg (adult
40,000u/kg (adult 2 million u) 8H, or 1.25-2.5mg/
1000mcg) IM daily for 7d then wkly (treatment),
kg of colis n base 12H. Oral or inhaled: 30,000-
monthly (prophyaxis). IV dangerous in megaloblas-
60,000 u/kg (adult 1.5-3 million u) 8H.
c anaemia. Maintenance treatment (adult
Colonic lavage, macrogol-3350 and macrogol- NOT/kg): 2mg daily oral, 500mcg wkly nasal.
4000 (polyethylene glyol) 105g/L. Poisoning, severe
Cyclizine. 1mg/kg (adult 50mg) 8H oral, IM or IV.
cons pa on: if bowel sounds present, 25ml/kg/hr
(adult 1.5L/hr) oral or NG for 2-4hr (un l rectal Cyclizine 30mg + dipipanone 10mg. Adult
euent clear). Before colonoscopy: clear fluids (NOT/kg): 1 tab 6H oral, incr dose by half tab if
only to noon, 1 whole 5mg bisacodyl tab per 10kg reqd, to max 3 tab 6H.
(adult 4 tab) at noon, wait for bowel mo on (max Cyclobenzaprine. 0.2-0.4mg/kg (adult 5-15mg)
6hr), then macrogol 4g/kg (adult 200g) in 40ml/kg 8H oral. Extended-release (adult, NOT/kg):
fluid (adult 2L) over 2hr oral or NG. 15mg or 30mg daily oral.
Colony s mula ng factors. See ancestrim, epoe n, Cyclopenthiazide. 5-10mcg/kg (adult 250-
filgrastim, lenograstim, molgramostim, sargramostim. 500mcg) 12-24H .
Coloxyl. See docusate sodium. Cyclopentolate. 0.5%, 1%: 1 drop/eye, repeat
Conivaptan. Adult (NOT/kg): 20mg over 30min IV, a er 5min. Pilocarpine 1% speeds recovery.
then 20mg (max 40mg) over 24hr by IV infusion. Cyclophosphamide. A typical regimen is 600mg/
Conjugated oestrogens (CO) + medroxyprogester- m IV over 30min dly x 3d, then 600mg/m IV wkly
one (MP). NOT/kg. CO (NOT/kg): 0.625mg (0.3- or 10mg/kg twice wkly (if leucocytes >3000/mm).
1.25mg) daily con nuously, with MP 10mg (up to Cycloserine. 5-10mg/kg (adult 250-500mg) 12H
20mg) daily oral for last 10-14 days of 28 day cycle. oral. Keep plasma conc <30mcg/ml.
Co-cyprindiol. See cyproterone acetate Cyclosporin. 1-3mcg/kg/min IV for 24-48hr, then
+ ethinyloestradiol. 5-8mg/kg 12H reducing by 1mg/kg/dose each
Cor corelin. 1-2mcg/kg (max 100mcg) IV. mth to 3-4 mg/kg/dose 12H oral. Eczema, juvenile
arthri s, nephro c, syndrome, psoriasis: 1.5-
Cor cotrophin releasing factor, hormone.
See cor corelin. 2.5mg/kg 12H.

379
Drug Doses
Cyclosporin. (cont.) Dapsone. 1-2mg/kg (adult 50-100mg) daily oral.
Usual target trough levels by Abbo TDx Derm herpet: 1-6mg/kg (adult 50-300mg) daily oral.
monoclonal specific assay (x 2.5 = non-specific Dapsone 100mg + pyrimethamine 12.5mg (Malo-
assay level) on whole blood: 100-250 ng/ml prim). 1-4yr qrtr tab wkly, 5-10yr half tab,>10yr 1 tab.
(marrow), 300-400 ng/ml first 3mth then Daptomycin. 4mg/kg IV over 30min daily.
100-300 ng/ml (kidney), 200-250 first 3mo then Darbepoe n alfa. Incr/reduce dose if reqd by 25 %
100-125 (liver), 100-400ng/ml (heart, lung). every 4wk. Renal failure: 0.45mcg/kg wkly (0.75mcg
Cyclosporin ophthalmic. 0.05% 1 drop each eye 12H. /kg wkly if not on dialysis) SC or IV. Cancer: 6.75mcg
Cyproheptadine. 0.1mg/kg (adult 4mg) 6-8H oral. /kg every 3wk, or 2.25mcg/kg every wk, SC or IV
Migraine 0.1mg/kg (adult 4mg), rpt in 30min if reqd. Darifenacin. Adult (NOT/kg): 7.5-15mg daily oral.
Cyproterone acetate. 1mg/kg (adult 50mg) Darunavir. Adult (NOT/kg): 600mg 12H oral.
8-12H oral. Prec puberty: 25-50mg/m2 8-12H Dasa nib. Adult (NOT/kg): 70mg (up to 100mg)
oral. Hyperandrogenism: 50-100mg daily days 12H oral.
5-14, with oestradiol valerate 1mg daily days 5-25. Daunorubicin. 30mg/m wkly slow IV, or 60-90
Cyproterone acetate + ethinyloestradiol. mg/m every 3wk. Max total dose 500mg/m.
(2mg/35mcg) x 21 tab, + 7 inert tab. In females DDAVP. See desmopressin.
for acne, contracep on, or hirsu sm: 1 tab
Decitabine. 15mg/m IV over 3hr 8H for 3 days,
daily, star ng 1st day of menstrua on.
rpt every 6wk (minimum of 4 cycles).
Cysteamine bitartrate. 0.05mg/m 6H oral,
Deferasirox. 20mg/kg (15-30mg/kg) daily oral.
incr over 6wk to 0.33mg/m/dose (<50kg) or
0.5mg/kg/dose (>50kg) 6H. Deferiprone. 25mg/kg 8H (max 100mg/kg/day) oral
Cytarabine. 100mg/m daily for 10 days by IV injn Deflazacort. Usu. 0.1-1.5mg/kg (adult 5-90mg)
or constant infsn. Intrathecal: 30mg/m every 4d 24-48H oral. 1.2 mg = 1mg prednisolone in
un l CSF normal (dissolve in saline not diluent). glucocor coid ac vity.
Dacarbazine. 250mg/m IV daily for 5 d every 3wk. Delavirdine. Adult (NOT/kg): 400mg 8H, or
600mg 12H oral.
Daclizumab. 1mg/kg IV over 15min every 2wk x5
Demecarium bromide. 0.125%, 0.25%
Dac nomycin. 400-600mcg/m IV daily for 5
ophthalmic soltn. Glaucoma: 1 drop x2/day to
days, repeat a er 3-4wk. x2/wk. Strabismus: 1 drop daily for 2wk, then 1
Dalfopris n 350mg + quinupristin 150mg (Synercid drop alternate days for 2-3wk.
IV 500mg vial). 7.5mg/kg (combined) 8H IV over 1hr. Demeclocycline. >8yr: 3mg/kg (adult 150mg)
Dalteparin sodium. Proph (adult): 2500-5000u 6H, or 6mg/kg (adult 300mg) 12H oral
SC 1-2hr preop, then daily. Venous thrombosis: Denileukin di itox. 9-18mcg/kg daily IV over
100u/kg 12H SC, or infuse 200u/kg/day IV (an -Xa
15min for 5 consecu ve days every 21 days.
0.5-1u/ml 4hr post dose). Haemodialysis: 5-10u/
kg stat, then 4-5u/kg/hr IV (acute renal failure, Dequalinium. NOT/kg: one 0.25mg pas le 4H oral.
an -Xa 0.2-0.4u/ml); 30-40u/kg stat, then 10-15u/ Deserpidine. 0.005-0.02mg/kg (adult 0.25-1mg)
kg/hr (chronic renal failure, an -Xa 0.5-1u/ml). daily oral.
Danaparoid. Preventn: 15u/kg (adult 750u) 12H SC. Desferrioxamine. An dote: 10-15mg/kg/hr IV for
Heparin inducd thrombocytopenia: 30u/kg stat IV, 12-24hr (max 6g/24hr) if Fe >60-90umol/l at 4hr
then 1.2-2u/kg/hr to maintain anti-Xa 0.4-0.8u/ml. or 8hr; some also give 5-10g (NOT/kg) once oral.
Danazol. 2-4mg/kg (adult 100-200mg) 6-12H oral. Thalassaemia (NOT/kg): 500mg per unit blood;
and 5-6 nights/wk 1-3g in 5ml water SC over 10hr,
Dantrolene. Hyperpyrexia: 1mg/kg/min un l
0.5-1.5g in 10ml water SC over 5min.
improves (max 10mg/kg), then 1-2mg/kg 6H
for 1-3day IV or oral. Spas city: 0.5mg/kg (adult Desirudin. 0.3mg/kg (adult 15mg) 12H SC.
25mg) 6H, incr over 2wk if reqd to 3mg/kg (adult Desloratadine. 0.1mg/kg (adult 5mg) daily oral.
50-100mg) 6H oral. Desmopressin (DDAVP). 1u = 1mcg. Nasal
Dantron + docusate (co-danthrusate). NOT/kg. (NOT/kg): 5-10mcg (0.05-0.1ml) per dose 12-24H;
50/60mg cap: 7-12yr 1cap, adult 1-3cap at night. enuresis 10-40mcg nocte. IV: 0.5-2mcg in 1L fluid,
50/60mg in 5ml: 1-6yr 2.5ml, 7-12yr 5ml, adult and replace urine output + 10% hrly (but much
5-15ml at night. be er to use vasopressin).
Dantron + poloxamer 188 (co-danthramer). Haemophilia, von Willebrands: 0.3mcg/kg (adult
NOT/kg. 25/ 200mg cap: 7-12yr 1cap, adult 1-3cap 20mcg) IV over 1hr 12-24H. More potent, longer
at night. 25/200mg in 5ml: 1-6yr 2.5ml, 7-12yr ac ng than vasopressin.
5ml, adult 5-15ml at night.

380
 Drug Doses
Desogestrel. Contracep on: 75mcg daily oral, Dextran 70. 6% soltn: 10ml/kg x1-2 on day 1,
star ng 1st day of menstrua on. then 10ml/kg/day IV. Half life about 12hr.
Desogestrel + ethinyloestradiol (150mcg/30mcg, Dextromethorphan hydrobromide. 0.2-0.4mg
150/20) x21 tab, + 7 inert tab. Contracep on: 1 tab /kg (adult 10-20mg) 6-8H oral.
daily, star ng 1st day of menstrua on. Dextromoramide. 0.1mg/kg (adult 5mg) 8H, may
Desonide. 0.05% cream, ointment, lotion: apply8-12H incr to 0.5mg/kg (adult 20mg) 8H oral or PR.
Desoxymethasone. 0.05% or 0.25% cream, oint, Dextropropoxyphene. Hydrochloride 1.3mg/kg
gel: apply 12H. (adult 65mg) or napsylate 2mg/kg (adult 100mg)
Desoxyribonuclease. See fibrinolysin. 6H oral.
Dexamethasone. 0.1-0.25mg/kg 6H oral, IM or Dextrose. Infant seda on (NOT/kg): 1ml 50% D
IV. BPD: 0.1mg/kg 6H for 3 days, then 8H 3 days, oral. Hypoglycaemia: 0.5ml/kg 50%D or 2.5ml/kg
12H 3 days, 24H 3 days, 48H 7 days. Cerebral 10%D slow IV, then incr maintenance infsn rate.
oedema: 0.25-1mg/kg (adult 10-50mg) stat, then Hyperkalaemia: 0.1u/kg insulin + 2ml/kg 50%D IV.
0.1-0.2mg/kg (adult 4-8mg) 4H IV reducing over Neonates: 6g/kg/day (about 4mg/kg/min) day 1,
3-5 days to 0.05mg/kg (adult 2mg) 8-12H. Congen incr to 12 g/kg/day (up to 18g/kg/day with
adr hypopl: 0.27mg/m2 daily oral. Severe croup, hypoglycaemia). Infsn rate (ml/hr) = (4.17 x Wt
extubtn stridor: 0.6mg/kg (max 12mg) IV or IM x g/kg/day) / %D = (6 x Wt x mg/kg/min) / %D.
stat, then prednisolone 1mg/kg 8-12H oral. Eye Dose (g/kg/day) = (ml/hr x %D) / (4.17 x Wt). Dose
drops 0.1%: 1 drop/eye 3-8H. Dexamethasone (mg/kg/min) = (ml/hr x %D) / (6 x Wt). mg/kg/min
has no mineralocor coid ac on; 1mg = 25mg = g/kg/day / 1.44. 0.5ml/kg/hr of 50% = 6g/kg/day
hydrocor sone in glucocor coid ac on. Dextrose-heparin (dex-hep). Dextrose soltn
Dexamethasone 0.5mg/ml (0.05%) + framyce n (usually 5%) with heparin 1u/ml.
5mg/ml (0.5%) + gramicidin 0.05mg/ml (0.005%) Dextrothyroxine. Adult (NOT/kg): 1-2mg daily
(Sofradex). Eye 1 drop 1-3H, ear 2-3 drops 6-8H, oral, incr monthly if reqd to max 4-8mg daily.
ointment 8-12H. Dezocine. IM: 0.1-0.4mg/kg (adult 5-20mg) 3-
Dexamethasone 0.1% + neomycin 0.35% + poly- 6H. IV: 0.05-0.2mg/kg (adult 2.5-10mg) 2-4H.
myxin 6000u/g. 1 drop/eye 6-8H. 3,4-Diaminopyridine. Adult (NOT/kg): 10mg
Dexamethasone 0.1% + tobramycin 0.3%. 1 drop/ 6-8H oral, incr if reqd to max 20mg x5/day.
eye 4-6H; up to 2H for 2 days a er surgery if reqd. Diamorphine. Adult (NOT/kg): 5-10mg 4H IV,
Dexamethasone 20mcg + tramazoline 120mcg per IM, SC, oral.
dose. Aerosol: 1 pu in each nostril 4-8H. Diazepam. 0.1-0.4mg/kg (adult 10-20mg) IV or
Dexchlorpheniramine maleate. 0.05mg/kg PR. 0.04-0.2 mg/kg (adult 2-10mg) 8-12H oral. Do
(adult 2mg) 6-8H oral. Repetab (adult NOT/kg): not give by IV infsn (binds to PVC); emulsion can
6mg 12H oral. be infused. Premed: 0.2-0.4mg/kg oral, PR. 2-3mg
Dexfenfluramine. Adult: 15mg (NOT/kg) 12H oral. = 1mg midazolam.
Dexibuprofen. Adult (NOT/kg): 400mg 12H (max Diazoxide. Hypertension: 1-3mg/kg (max 150mg)
8H) oral stat by rapid IV injec on (severe hypotension
Dexketoprofen. Adult (NOT/kg): 12.5mg 4-6H, or may occur) repeat once if reqd, then 2-5mg/kg IV
25mg 8H (max 75mg/day) oral. 6H. Hyperinsulinism: <12mo 5mg/kg 8-12H oral;
Dexmedetomidine. ICU: 1mcg/kg IV over >12mo 30-100mg/m2 per dose 8H oral.
15min, then 0.2-0.7mcg/kg/hr for max 24hr. Dibromopropamidine. 0.15% cream on dressing prn.
Dexmethylphenidate. NOT/kg, given as two Dibucaine. See cinchocaine.
doses/day 4hr apart: 2.5mg/dose oral, incr Dichloralphenazone 100mg + isometheptene
if reqd to 10mg/dose. Use half the dose of mucate 65mg + paracetamol 325mg (Midrin).
racemic methylphenidate. Adult (NOT/kg): 2 capsules stat, then 1/hr if
Dexpanthenol. 5-10mg/kg (adult 250-500mg) reqd (max 5 cap in 12hr).
IM. 5% cream: apply 12-24H Dichlorphenamide. 2-4mg/kg (adult 100- 200mg)
Dexrazoxane. 10mg for each 1mg doxorubicin IV. stat, then 2mg/kg (adult 100mg) 12H until response
Extravasa on of anthracyclines: within 6hr give then 0.5-1mg/kg (adult 50mg) 8-24H oral.
1g/m (max 2g) IV over 2hr, repeated a er Diclofenac. 1mg/kg (adult 50mg) 8-12H oral, PR.
24hr; then 0.5g/m2 48hr a er first dose. Eye drops 0.1%: preop 1-5 drops over 3hr, postop
Dextran 1 (Promit). 15% soltn. 0.3ml/kg IV 1 drop stat, then 1 drop 4-8H. Topical gel 1%
1-2min before giving dextran 40 or dextran 70. (arthri s) 3% (keratoses): apply 2-4g 6-8H. Patch
Dextran 40. 10% soltn: 10ml/kg x1-2 on day 1, 1.3% (180mg) 10x14cm: apply 12H.
then 10ml/kg/day IV. Half life about 3hr.

381
Drug Doses
Diclofenac + misoprostal. Adult, NOT/kg. 50mg/ Dimercaprol (BAL). 3mg/kg (max 150mg) IM 4H for
200mcg tab 8-12H oral; 75mg/200mcg tab 12H oral. 2 days, then 6H for 1 day, then 12H for 10 days.
Dicloxacillin. 15-25mg/kg (adult 250-500mg) 6H Dimethicone. Infant colic (NOT/kg): 40mg/ml, 1-2
oral, IM or IV. Severe in n: 25-50mg/kg (max dropperfuls before each feed. 10%, 15%
2g) IV 12H (1st wk life), 8H (2-4 wk), 4-6H or barrier cream: apply prn.
constant infsn (>4 wk). Dimethindene. 0.02-0.04mg/kg (adult 1-2mg)
Dicobalt edetate. 10mg/kg (adult 300mg) IV 8H oral.
over 1-5min, repeat x2 if no response. Dimethyl sulfoxide (DMSO). 50% soltn: 50ml in
Dicyclomine. 0.5mg/kg (adult 10-20mg) 6-8H oral. bladder for 15 min every 2wk.
Dicycloverine. See dicyclomine. Dinoprost (Prostaglandin F2 alpha). Extra-
Didanosine. <90 days: 50mg/m 12H oral. amnio c: 1ml of 250mcg/ml stat, then 3ml 2H.
>90 days: 120mg/m (max 200mg) 12H, or Intra-amnio c: 40mg stat, then 10-40mg a er
240mg/m (max 400mg) daily oral. 24hr if required.
CNS disease: 150mg/m 12H. Dinoprostone (Prostaglandin E2). Labour induc
Dideoxycy dine (ddC). See zalcitabine. on: 1mg into posterior vagina, may rpt dose
Dienoestrol. 0.01% vaginal cream: 1 applicatorful (5g) 1-2mg a er 6hr (max 60mcg/kg over 6hr).
12-24H for 1-2wk, reducing gradually to x1-3/wk. Maintain PDA: 25mcg/kg 1H (less o en a er
Diethylcarbamazine. 6mg/kg daily for 12 days oral, 1wk) oral; or 0.003-0.01mcg/kg/min IV.
or a single dose of 6mg/kg rpt every 6-12 mths. Dioctyl sodium sulphosuccinate. See docusate sodium.
Diethylpropion hydrochloride. 6-12yr: 25mg Diphemanil methylsulphate. 20mg/g powder:
(NOT/kg) 12H oral. >12yr: 25mg (NOT/kg) 6-8H oral. apply 8-12H.
Diethyls lboestrol. See s lboestrol. Diphenhydramine hydrochloride. 1-2mg/kg
Diflorasone. 0.05% cream, ointment: apply 6-24H. (adult 50-100mg) 6-8H oral.
Diflunisal. 5-10mg/kg (adult 250-500mg) 12H oral. Diphenoxylate. See atropine + diphenoxylate
(Lomo l).
Digitoxin. 4mcg/kg (max 0.2mg) 12H oral for 4d, then
1-6mcg/kg (adult usu. 0.15mg, max 0.3mg) dly. Diphtheria an toxin (horse). IM or IV (NOT/kg):
2500u (nasal), 10,000u (unilateral tonsillar),
Digoxin. 15mcg/kg stat and 5mcg/kg a er 6H,
20,000u (bilateral tonsillar), 30,000u
then 3-5 mcg/kg (usual max 200mcg IV, 250mcg
(laryngeal), 50,000u (beyond tonsillar fossa),
oral) 12H slow IV or oral. Level 6hr or more a er
150,000u (bullneck). Repeat dose may be
dose: 1.0-2.5 nmol/L (x0.78=ng/ml).
needed. See also immunoglobulin, diphtheria.
Digoxin immmune FAB (an bodies). IV over
Diphtheria vaccine, adult (CSL). Inac vated.
30min. Dose (to nearest 40mg) = serum digoxin
0.5ml IM stat, 6wk later, and 6mo later (3
(nmol/L) x Wt (kg) x 0.3, or mg ingestd x 55. Give
doses). Boost every 10yr.
if >0.3mg/kg ingested, or level >6.4 nmol/L or
5.0ng/ml. Diphtheria vaccine, child <8yr (CSL). Inac vated.
0.5ml IM stat, in 6wk, then 6mo (3 doses).
Dihydrocodeine. 0.5-1mg/kg 4-6H oral.
Boost with adult vaccine.
Dihydroergotamine mesylate. Adult (NOT/kg):
Diphtheria + hepa s B + pertussis (acellular) +
1mg IM, SC, IV, rpt hrly x2 if needed. Max 6mg/wk.
polio + tetanus [DaPT-HepB-IPV] (Pediarix).
Dihydromorphinone. See hydromorphone. Inac vated. 0.5ml IM at 2mo, 4mo, 6mo (3
Dihydrotachysterol (1-OH vitamin D2). Renal doses), and (DaPT) 18mo.
failure, vit D resis. rickets: 20mcg/kg daily oral, incr Diphtheria + hepa s B + pertussis (acellular) +
by 20mcg/kg every 4-8wk accordg to serum Ca tetanus vaccine [DaPT-hepB] (Infanrix Hep B).
Dihydrotestosterone. See stanolone. Inac vated. 0.5ml IM at 2mo, 4mo, 6mo
Dihydroxyacetone. 5% soltn: apply 1-3 coats 1hr (3 doses), and (without hep B) 18mo.
apart, every 1-3 days. Diphtheria + hepa s B + Hib +pertussis (acellular)
Diiodohydroxyquin. See di-iodohydroxyquinoline. + tetanus vaccine [DaPT-hepB-Hib] (Infanrix Hexa).
Di-iodohydroxyquinoline. 10-13.3mg/kg (adult Inac vated. 0.5ml IM 2mo, 4mo, 6mo (3 doses).
650mg) 8H oral for 20 days. Diphtheria + Hib + pertussis (acellular) + polio +
Diloxanide furoate. 10mg/kg (adult 500mg) 8H oral. tetanus [DaPT-Hib-IPV] (Infanrix Penta, Pediacel).
Dil azem. 1mg/kg (adult 60mg) 8H, incr if reqd to Inac vated. 0.5ml IM at 2mo, 4mo, 6mo
max 3mg/kg (adult 180mg) 8H oral. Slow rel (adult, (3 doses), and (DaPT) 18mo.
NOT/kg): 120-240mg dly, or 90-180mg 8-12H oral Diphtheria + pertussis (whole cell) + tetanus vac-
Dimenhydrinate. 1-1.5mg/kg (adult 50-75mg) 4-6H cine [DPT] (Triple An gen). Inac vated. 0.5ml IM at
oral, IM or IV. 2mo, 4mo, 6mo, 18mo, 4-5yr age (5 doses).

382
 Drug Doses
Diphtheria + pertussis (acellular) + tetanus vaccine Docetaxel. Ini ally 75-100mg/m over 1hr IV
[DaPT] (Tripacel). Inac vated. 0.5ml IM at 2mo, every 3wk.
4mo, 6mo, 18mo and 4-5yr of age (5 doses). Docosanol. 10% cream: apply 5 mes a day.
Diphtheria + pertussis (acellular) + tetanus vac- Docusate sodium. NOT/kg: 100mg (3-10yr),
cine, adult [daPt] (Adacel, Boostrix). 120-240mg (>10yr) daily oral. Enema (5ml
Inac vated. 10yr: 0.5ml IM. 18% + 155ml water): 30ml (newborn), 60ml
Diphtheria + pertussis (acellular) + polio + (1-12mo), 60-120ml (>12mo) PR.
tetanus vaccine [DaPT-IPV] (Quadracel). Docusate sodium 50mg + sennoside 8mg, tab.
Inac vatd. 0.5ml IM at 2, 4, 6mo (3 doses). >12yr: 1-4 tab at night oral. See also bisacodyl;
Diphtheria + pertussis (acellular) + polio + casanthranol; dantron.
tetanus vaccine [DaPT-IPV] (Infanrix-IPV). Dofe lide. 10mcg/kg (adult 500mcg) 12H oral, less
Inac vated. 16mo-13yr: 0.5ml IM once as booster. if renal impairment or increased QTc interval.
Diphtheria + pertussis (acellular) + polio + Dolasetron. Cancer: 1.8mg/kg (adult 100mg) IV
tetanus vaccine [daPT-IPV] (Repevax). 30min before chemo, or 4mg/kg (adult 200mg)
Inac vated. >3yr: 0.5ml IM once as booster. oral 1hr before chemo. Surgery: 1mg/kg (adult
Diphtheria + pertussis (acellular) + polio + tetanus 50mg) oral at induc on, or 0.25mg/kg (adult
vaccine, adult [daPt-IPV] (Adacel Polio, Boostrix- 12.5mg) IV postop.
IPV). Inac vatd. 10yr: 0.5ml IM once as boostr. Domperidone. Oral: 0.2-0.4mg/kg (adult
Diphtheria + polio + tetanus vaccine [dT-IPV] 10-20mg) 4-8H. Rectal suppos: adult (NOT/kg)
(Revaxis). Inac vatd. >6yr: 0.5ml IM once as boostr 30-60mg 4-8H.
Diphtheria + tetanus vaccine, adult [dt] (ADT Donepezil. Adult (NOT/kg): 5mg at night oral,
Booster). Inac vated. 0.5ml IM for revaccina on incr to 10mg a er 1mo if reqd.
a er primary course. Dopamine. <30kg: 15mg/kg in 50ml 5%dex-hep
Diphtheria + tetanus vaccine, child <8yr [DT] at 1-4ml/hr (5-20mcg/kg/min) via CVC; >30kg:
(CDT). Inac vated. 0.5ml IM, in 6wk, 6mo later 6mg/kg in 100ml 5%dex-hep at 5-20ml/hr
(3 dose). Boost with ADT. (5-20mcg/kg/hr).
Dipipanone. See cyclizine. Dopexamine. IV infsn 0.5-6mcg/kg/min.
Dipivefrin. 0.1% soltn: 1 drop per eye 12H. Doripenem. 10mg/kg (adult 500mg) 8H IV.
Diprophylline. Usually 15mg/kg 6H oral or IM. Dornase alpha (deoxyribonuclease I). NOT/kg:
Dipyridamole. 1-2mg/kg (adult 50-100mg) 6-8H usually 2.5mg (max 10mg) inhaled daily (5-
oral. See also aspirin + dipyridamole. 21yr), 12-24H (>21yr).
Dirithromycin. 10mg/kg (adult 500mg) daily oral. Dorzolamide. 2% drops: 1 drop/eye 8-12H.
Disodium clodronate. See sodium clodronate. Dorzolamide 2% + molol 0.5%. 1 drop/eye 12H.
Disodium edetate. See trisodium edetate. Dosulepin hydrochloride. See dothiepin.
Disodium e dronate. See e donrate. Dothiepin. 0.5-1mg/kg (adult 25-50mg) 8-12H oral.
Disopyramide. Oral: 1.5-4mg/kg (adult 75- Doxacurium. 50-80mcg/kg stat, then 5-10mcg/
200mg) 6H. IV: 2mg/kg (max 150mg) over kg/dose IV.
5min, then 0.4mg/kg/hr (max 800mg/day). Doxapram. 5mg/kg IV over 1hr, then 0.5-1mg/
Level 9-15umol/L (x0.3395 = mcg/ml). kg/hr for 1hr (max total dose 400mg).
Dis gmine. Neurogenic bladder, megacolon: Doxazosin. Usu. 0.02-0.1mg/kg (adult 1-4mg) dly oral
0.01mg/kg (adult 0.5mg) IM daily, 0.1mg/kg Doxepin. 0.2-2mg/kg (adult 10-100mg) 8H oral.
(adult 5mg) oral daily. Myasth gravis: 0.1- 5% cream: apply x3-4/day.
0.2mg/kg 12-24H (max 20mg/day) oral. Doxercalciferol (1,25-OH D2 analogue). Ini ally
Disulfiram. Adult (NOT/kg): 500mg oral daily for 0.2mcg/kg (adult 10mcg) oral, or 0.08mcg/kg
1-2wk, then 125-500mg daily. (adult 4mcg) IV, x3/wk at end of dialysis. Aim
Dithranol. 0.1%-2% cream, ointment: start for blood iPTH 150-300pg/ml.
with lowest strength, apply daily, wash o a er Doxorubicin. 30mg/m IV over 15min wkly, or
10min incr to 30min. 30mg/m dly x2-3days every 3-4wk. Max tot. dose
Divalproex. Dose as for sodium valproate. 480mg/m (300mg/m if medias nal irradia on).
DMSA. See succimer. Doxorubicin, liposomal. Carcinoma: 50mg/m IV
Dobutamine. <30kg: 15mg/kg in 50ml 0.9% saline every 3wk. Kaposi: 20mg/m IV every 2wk.
with heparin 1u/ml at 1-4ml/hr (5-20mcg/kg/min), Doxycycline. Over 8yr: 2mg/kg (adult 100mg) 12H
CVC or periph IV; >30kg: 6mg/kg in 100ml 0.9% sal- for 2 doses, then daily oral. Severe: 2mg/kg 12H.
ine with hep 1u/ml at 5-20ml/hr (5-20mcg/kg/min). Malaria proph: 2mg/kg (adult 100mg) daily oral.

383
Drug Doses
Doxycycline 30mg + 10mg slow rel (Oracea). Eflornithine. 13.9% cream: apply 12H.
Rosacea in adults (NOT/kg): 1 tab daily oral. Eformoterol. Caps 12mg (NOT/kg): 1cap (5-12yr)
Doxylamine succinate. 0.25-0.5mg/kg (adult or 1-2 caps (adult) inhaled 12H.
12.5-25mg) 8H oral. Hypno c: 0.5-1mg/kg Electrolyte solu on. See glucose electrolyte solution.
(adult 25-50mg). Eletriptan. Adult (NOT/kg): 20-40mg, repeat
Dronabinol. Ini ally 5mg/m 2-4H (max 4-6 a er 2hr if reqd (max 80mg/day).
doses per day) oral, slow incr by 2.5mg/m/ EMLA cream. See lignocaine + prilocaine.
dose to max 15mg/m 4H. Emedas ne. 0.5mg/ml soltn: 1 drop/eye 12H.
Droperidol. An eme c: postop 0.02-0.05mg/kg Emtricitabine. Adult (NOT/kg) 200mg daily oral.
(adult 1.25mg) 4-6H IM or slow IV, chemother
Emtricitabine + tenofovir disoproxil (as fuma-
0.02-0.1 (adult 1-5mg) 1-6H. Psychiatry, neurolept,
analg, IM or slow IV: 0.1 mg/kg (adult 2.5mg) stat, rate). 200mg/245mg tab, 18yr (NOT/kg): 1tab
incr to max 0.3mg/kg (adult 15 mg) 4-6H. daily oral.
Psych, oral: 0.1-0.4mg/kg (adult 5-20mg) 4-8H. Enalapril. 0.1mg/kg (adult 2.5mg) daily oral,
Drospirenone + ethinyloestradiol (3mg/30mcg) incr over 2wk if reqd to max 0.5mg/kg (adult
x 21 tab + 7 inert tab. Contracep on: 1 daily 5-20mg) 12H.
star ng 1st day menstrua on. Enalaprilat. Usually 0.025mg/kg (max 1.25mg)
6H IV, max 0.1mg/kg (max 5mg) 6H.
Drospirenone + ethinyloestradiol (3mg/20mcg,
3mg/ 30mcg) x 24 tab, + 4 inert tab. Contracep Enfuvir de. Age >=6yr: 2mg/kg (max 90mg) 12H SC
on: 1 daily star ng 1st day of menstrua on. Enoxacin. 4-8mg/kg (adult 200-400mg) 12H oral.
Drospirenone + oestradiol (0.5mg/1mg, 2mg/ Enoxaparin (1mg=100u). 1.5mg/kg (<2mo),
1mg). Post-menopause (NOT/kg): 1 tab daily oral. 1mg/kg (2mo-18yr), 40mg (adult) 12H SC (an -Xa
Drotrecogin alfa (protein C), ac vated. 0.5-1u/ml 4hr post dose). Prophylaxis: 0.75mg/kg
24mcg/kg/hr for 96hr IV. Minor surgery: stop 12H (<2mo), 0.5 mg/kg 12H (2mo-18yr), 20-40mg
2hr before, restart straight a er. Major surgery: 2-12hr preop, then daily (adult) SC. Haemodialysis:
stop 2hr before, restart 12hr a er. 1mg/kg into arterial line at start 4hr session.
Duloxe ne. Adult, NOT/kg: 20-30mg 12H, or Enoximone. IV: 5-20mcg/kg/min.
60mg daily oral. Oral: 1-3mg/kg (adult 50-150mg) 8H.
Dutasteride. Adult (NOT/kg): 0.5mg daily oral. Entacapone. Adult (NOT/kg): 200mg with each
l-dopa/DDC inhibitor dose (av 800-1400mg/
Dyclonine hydrochloride. See dyclocaine
day, max 2000mg) oral.
hydrochloride.
Entecavir. Hepa s B (adult, NOT/kg): 0.5mg
Dydrogesterone. 0.2mg/kg (adult 10mg) 12-24H oral
daily oral; 1mg daily if refractory to lamivudine.
Dydrogesterone +oestradiol (5mg/1mg,10/1,10/2).
Ephedrine. 0.25-1mg/kg (adult 12.5-60mg) 4-8H
Adult (NOT/kg). Postmenopausal: 1 tab daily oral.
oral, IM, SC, IV. Nasal (0.25%-1%): 1drop each
Dydrogesterone 10mg tab + oestradiol patch nostril 6-8H, max 4 days.
(40 or 80 mcg/24hr). Adult (NOT/kg). Postmeno-
Epinas ne. 0.05% ophthalmic: 1 drop/eye 12H.
pausal: apply new patch every 3-4 days, 1tab
daily oral for last 14days of cycle. Epinephrine. See adrenaline.
Dyphylline. See diprophylline. Epirubicin. Adult: 75-90mg/m IV over 10min
every 3wk.
Econazole nitrate. Topical: 1% cream, powdr, lo on
8-12H. Vaginal: 75mg cream, 150mg ovule 2x/d Eplerenone. 0.5-1mg/kg (adult 25-50mg) 12-24H oral.
Ecothiopate iodide. 0.03%, 0.06%, 0.125%, 0.25% Epoe n alfa, beta, delta. 20-50u/kg x3/wk,
soltn: usu. 0.125% 1 drop/eye every 1-2 d bed me incr to max 240 u/kg x1-3/wk SC, IV. When Hb
>10g%: 20-100u/kg x2-3/wk.
Eculizumab. 600mg IV over 35min wkly for 4wk,
900mg the next wk, then 900mg every 2wk. Epoprostenol (prostacyclin, PGI2). Incompa ble
with all other drugs. <8kg: 60mcg/kg in 50ml
Edrophonium. Test dose 20mcg/kg (max 2mg),
diluent at 0.25-0.75 ml/hr (5-15ng/kg/min) via
then 1min later 80mcg/kg (adult 8mg) IV.
CVC or periph IV; >8kg: 500mcg in 50ml diluent at
SVT: 0.15mg/kg (max 2mg) incr to max
0.03-0.09ml/kg/hr (5-15ng/kg/min). Chronic pul
0.75mg/kg (max 10mg) IV, with atropine if reqd.
ht: 2ng/kg/min IV, incr to 20-40ng/kg/min.
EDTA. See sodium calciumedetate.
Eprosartan. 12mg/kg (adult 600mg) daily, incr if
Efalizumab. 0.7mg/kg stat, then 1mg/kg wkly SC. reqd to 6-8mg/kg (adult 300-400mg) 12H oral.
Efavirenz. Dly oral 10-15kg 200mg, 15-20mg Epsilon aminocaproic acid. See aminocaproic acid.
250mg, 20-25 kg 300mg, 25-33kg 350mg, 33-40kg
Eptacog alfa (recombinant factor 7a). See factor 7a.
400mg, >40kg 600mg.

384
 Drug Doses
Ep fiba de. Adult (NOT/kg): 180mcg/kg stat IV, Ethamsylate. 12.5mg/kg (max 500mg) 6H oral,IM,IV
then 2 mcg/kg/min for up to 72hr. Ethanol, dehydrated (100%). Vessel sclerosis:
Edosteine. Adult (NOT/kg): 300mg 12H oral. inject max of 1ml/kg.
Ergocalciferol (Vitamin D2). 40u = 1mcg = Ethanolamine oleate. 5% soltn, adult (NOT/kg):
1mcg cholecalciferol (D3). Cys c fib, cholestasis: 1.5-5ml per varix (max 20ml per treatment).
10-20mcg daily oral. Cirrhosis: adult 40-120mcg Ethchlorvynol. 10-20mg/kg (adult 0.5-1g) nocte oral
daily oral. Deficiency: 50-100mcg daily for Ethinyloestradiol. 10-50mcg daily for 21 days
2wk oral, then 10-625mcg daily (more if severe per month. See also cyproterone; desogestrel.
malabs); or 2.5-5mg (100,000-200,000u) every Ethinyloestradiol + ethynodiol diacetate (50mcg/
6-8wk. Monitor serum calcium; measure alk phos 0.5mg or 50mcg/1mg) x 21 tab, + 7 inert tab.
and parathyroid hormone a er 6-8wk. See also Contraceptn: 1 tab dly, from 1st day of menstruatn
doxercalciferol. Ethinyloestradiol + gestodene (30mcg/75mcg,
Ergoloid mesylates. See co-dergocrine mesylate. 20/75) x 21 tab + 7 inert tab.
Ergometrine maleate. Adult (NOT/kg): 250-500 1 daily, star ng 1st day of menstrua on.
mcg IM or IV; 500mcg 8H oral, sublingual or PR. Ethinyloestradiol + gestodene (30mcg/50mcg x
Ergometrine maleate 0.5mg + oxytocin 5u in 1ml. 6 tab + 40/70 x5 + 30/100 x10 + inert x7).
1ml IM; may rpt a er 2hr, max 3 doses in 24hr. 1 tab daily, star ng 1st day of menstrua on.
Ergonovine maleate. See ergometrine maleate. Ethinyloestradiol + levonorgestrel (20mcg/
Ergotamine tartrate. >10yr (NOT/kg): 2mg subling 90mcg). Contracep on: 1 tab daily (with no
stat, then 1mg/hr (max 6mg/episode, 10mg/wk). hormone-free interval).
Suppos (1-2mg): 1 stat, may repeat once a er 1hr. Ethinyloestradiol + levonorgestrel (30mcg/150mcg
Erlo nib. Adult (NOT/kg): 150 mg daily oral; or 50mcg/125mcg) x 21 tab, + 7 inert tab.
reduce to 100mg then 50mg daily if reqd. Contraceptn: 1 tab dly, from 1st day of menstruatn
Ertapenem. 20-40mg/kg (adult 1g) daily IM, IV Ethinyloestradiol + levonorgestrel (30mcg/50mcg
over 30min. x6 tab + 40/75 x5 + 30/125 x10 + inert x7).
Erythromycin. Oral or slow IV (max 5mg/kg/hr): 1 tab daily, star ng 1st day of menstrua on.
usually 10 mg/kg (adult 250-500mg) 6H; Ethinyloestradiol + levonorgestrel (30mcg/
150mcg) x 84 tab, then either 7 inert tab or 7
severe in n 15-25mg/kg (adult 0.75-1g) 6H.
tab ethinyloestradol 10 mcg.
Gut prokine c: 2mg/kg 8H. 2% gel: apply 12H. Contraceptn: 1 tab dly, from 1st day of menstruatn
Erythropoie n. See epoe n. Ethinyloestradiol + norelgestromin (20mcg/
Escitalopram. Adult (NOT/kg): 5mg daily oral, 150mcg, 0.75mg/6mg) patches. Contraceptn:
incr if reqd to max 20mg daily. apply 1 patch wkly x3, wk 4 patch-free.
Esmolol. 0.5mg/kg (500mcg/kg) IV over 1min, rpt if Ethinyloestradiol + norethisterone (35mcg/
reqd. Infsn (undiluted 10mg/ml soltn): 0.15-1.8ml/ 0.25mg, 30/0.5, 35/0.5, 35/0.75, 20/1, 35/1,
kg/hr (25-300mcg/kg/min); rarely given for >48hr. 30/1.5) x 21 tab, + 7 inert tab.
Esomeprazole. 0.4-0.8mg/kg (adult 20-40mg) daily Contraceptn: 1 tab dly, from 1st day of menstruatn
oral. H.pylori (adult NOT/kg): 20mg + amoxycillin Ethinyloestradiol + norethisterone (20mcg/
1g + clarithromycin 500mg 12H oral for 7 days. 1mg) x 24 tab, + 4 inert tab.
Estazolam. 0.02-0.1mg/kg (adult 1-4mg) nocte oral. Contraceptn: 1 tab dly, from 1st day of menstruatn
Estradiol. See oestradiol. Ethinyloestradiol + norethisterone (35mcg/
Estramus ne. 200mg/m2 8H oral (avoid milk). 0.5mg x7tab + 35/1 x14 + inert x7).
Eszopiclone. Adult (NOT/kg): 2mg (1-3mg) nocte oral. Contraceptn: 1 tab dly, from 1st day of menstruatn
Etamsylate. 12.5mg/kg (adult 500mg) 6H oral. Ethinyloestradiol + norethisterone (35mcg/
Etanercept. 0.4mg/kg (max 25mg) 2x /wk deep SC. 0.5mg x7tab + 35/1 x9 + 35/0.5 x5 + inert x7).
Contraceptn: 1 tab dly, from 1st day of menstruatn
Ethacrynic acid. IV: 0.5-1mg/kg (adult 25-50mg)
Ethinyloestradiol + norethisterone (35mcg/
12-24H. Oral: 1-4mg/kg (adult 50-200mg)
0.5mg x7tab + 35/0.75 x7 + 35/1 x7+ inert x7).
12-24H. Contraceptn: 1 tab dly, from 1st day of menstruatn
Ethambutol hydrochloride. 25mg/kg once daily Ethionamide. TB: 15-20mg/kg (max 1g) at night
for 8wk, then 15mg/kg daily oral. Intermi ent: oral. Leprosy: 5-8mg/kg (max 375mg) daily.
35mg/kg x3/wk. IV: 80% oral dose. Ethoheptazine. 3mg/kg (adult 150mg) 6-8H oral.
Ethosuximide. 10mg/kg (adult 500mg) daily oral,
incr by 50% each wk to max 40mg/kg (adult 2g)
daily. Trough level 0.3-0.7mmol/L.

385
Drug Doses
Ethotoin. 5mg/kg (adult 250mg) 6H oral, incr to Famciclovir. Zoster, varicella: 5mg/kg (adult
max 15mg/kg (adult 750mg) 6H. 250mg) 8H oral x7 days; immunocompromised
E docaine. 0.5%-1.5% soltn: max 6mg/kg 10mg/kg (adult 500mg) 8H for 10 days.
(0.6ml/kg of 1%) parenteral, or 8mg/kg (0.8ml/ Genital herpes (adult, NOT/kg): 125mg 12H oral
kg of 1%) with adrenaline. for 5 days (treatment), 250mg (suppression) 12H;
E dronate. 5-20mg/kg daily oral (no food for immunocompromised 500mg 12H for 7 days
2hr before and a er dose) for max 6mo. IV: (treatment), 500mg daily (suppression).
7.5mg/kg daily for 3-7 days. Famo dine. 0.5-1mg/kg (adult 20-40mg)
E donate and calcium citrate. E dronate 12-24H oral. 0.5mg/kg (max 20mg) 12H slow IV
400mg tab daily 14 days, then calcium citrate Fat emulsion 20%. See lipid emulsion.
500mg daily for 76 days oral. Felbamate. 5mg/kg 6-8H (max 1200mg/day) oral,
Etodolac. 4-8mg/kg (adult 200-400mg) 6-8H oral. incr over 2-3wk to 15mg/kg 6-8H (max 3600mg /d)
Etomidate. 0.3mg/kg slow IV. Felodipine. 0.1mg/kg (adult 2.5mg) daily, incr
Etonogestrel. 68mg sub-dermal implant lasts 3yr. if reqd to 0.5 mg/kg (adult 10mg) daily oral.
Etoposide. 50-60mg/m IV over 1hr daily for 5 Fenbufen. 10mg/kg (adult 450mg) 12H oral.
days, rpt a er 2-4wk. Oral dose 2-3 mes IV dose. Fenfluramine. Adult (NOT/kg): 60mg daily oral.
Etoricoxib. Adult (NOT/kg). 60-90mg daily oral. Fenofibrate. 2mg/kg (adult 100mg) 6-12H oral.
Gout: 120 mg daily, max 8 days. Fenoldopam. 0.1mcg/kg/min IV infsn incr gradu-
Etre nate. 0.25mg/kg 8-12H oral for 2-4wk, then ally if reqd every 15-30min to max 1.6mcg/kg/min
6H (max 75mg dly) if reqd for 6-8wk, then 12-24H. Fenoprofen. 4mg/kg (adult 200mg) 6-8H oral, may
Etynodiol diacetate. Contracep on: 500mcg incr gradually to 12mg/kg/dose (max 800mg).
daily oral, star ng 1st day of menstrua on. Fenoterol. Oral: 0.1mg/kg 6H. Resp soltn 1mg/ml:
Everolimus. Adult (NOT/kg): 0.75mg 12H oral 0.5ml diluted to 2ml 3-6H (mild), 1ml dilutd to 2ml
adjusted to trough level 3-8ng/ml (chromato- 1-2H (moderate), undilutd con nuous (severe, in
graphic assay). ICU). Aerosol (200mcg/pu): 1-2 pus 4-8H.
Exemestane. Adult (NOT/kg): 25mg daily oral. Fentanyl. Not ven lated: 1-2 mcg/kg (adult 50-
Exena de. Adult, NOT/kg: 5mcg SC before 100mcg) IM or IV; infsn 2-4mcg/kg/hr (<10kg
morning and evening meals, incr if reqd to 100mcg/kg in 50ml 5%dex-hep at 1-2ml/hr; >10kg
10mcg/dose a er 1mo. amp 50mcg/ml at 0.04-0.08ml/kg/hr).
Eze mibe. Adult (NOT/kg): 10mg daily oral. Ven lated: 5-10mcg/kg stat or 50mcg/kg IV over
Factor 7a, recombinant (rFVIIa). Usually 1hr; infuse amp 50mcg/ml at 0.1-0.2ml/kg/hr (5-
90mcg/kg IV 2H un l haemostasis, then 3-6H. 10 mcg/kg/hr). Patch (lasts 72hr) in adult (NOT/
Factor 8 concentrate (vial 200-250u), recom- kg): 25 mcg/hr, incr if reqd by 25 mcg/hr every 3
binant -an haemophilic factor (rAHF). Joint days. Transmucosal tabs (adult, NOT/kg): 100mcg
20u/kg, psoas 30u/kg, cerebral 50u/kg. 2 x held between cheek and upper gum un l
dose(u/kg) = % normal ac vity, eg 35u/kg gives dissolved (15-30 min) 4-8H, incr if reqd to
peak level of 70% normal. max 800mg 4H. Epidural: 0.5 mcg/kg stat, or
0.4mcg/kg/hr.
Factor 8 inhibitor bypassing frac on. IV max
2u/kg/min: joint 50u/kg 12H, mucous mem Fen conazole vaginal pessaries. 600mg nocte
50u/kg 6H, so ssue 100u/kg 12H, cerebral once, or 200mg nocte for 3 nights.
100u/kg 6-12H. Ferrous salts. Prophylaxis 2mg/kg/day elemental
Factor 9. IV infsn (max 2u/kg/min): minor hge iron oral, treatment 6mg/kg/day elemental iron
25u/kg daily, joint 40u/kg 12-24H, surgery oral. Fumarate 1mg = 0.33mg iron. Gluconate 1mg
50u/kg stat then 30u/kg 12-24H, major surgery = 0.12mg iron; so Fergon (60 mg/ml gluconate)
85u/kg stat then 50u/kg 12-24H. Prophylaxis: prophylaxis 0.3ml/kg daily, treatment 1ml/kg
25-40u/kg x2/wk (trough >1u/dl). daily oral. Sulphate (dry) 1mg = 0.3mg iron; so
Ferro-Gradumet (350mg dry sulphate) prophylaxis
Factor 9 complex (factor 2, 9, 10, and some 7).
7mg/kg (adult 350mg) daily, treatment 20mg/kg
40-60 iu/kg, then 5-10iu/kg 12H IV.
(adult 1050mg) daily oral.
Prophylaxis: 10-20iu/kg x1-2/wk.
Fexofenadine. NOT/kg: 30mg 12H (6-11yr),
Factor 8 an bodies: 75iu/kg, rpt in 12hr prn.
60mg 12H or 180mg daily (>11yr) oral.
Factor 13. Vial 250u. Prophylaxis: 10u/kg IV
Fibrin glue. See thrombin glue.
every 4wk. Pre-op: up to 3u/kg just before
surgery, then 10u/kg daily x5. Severe hge: Fibrinolysin 8-10u/ml + desoxyribonuclease 500-
10-20u/kg daily. 667 u/ml. Ointment, soltn: apply topically 6-24H.

386
 Drug Doses
Filgras m (granulocyte CSF). Idiopathic or cyclic Fluoxymesterone. 0.1-0.2mg/kg (adult 5-10mg)
neutropaenia: 5mcg/kg daily SC or IV over 30min. daily oral.
Cong neutropaenia: 12mcg/kg daily SC or IV over Flupenthixol. Oral: 0.05-0.2mg/kg (adult 3-9mg)
1hr. Marrow trans: 20-30mcg/kg daily IV over 12H. Depot IM: usually 0.4-0.8mg/kg (up to 5mg/
4-24hr, reduce if neutrophil >1x109/L. kg, max 300 mg) every 2-4wk (1mg flupenthixol
Finasteride. Adult (NOT/kg). Alopecia: 1mg dly oral. deconate = 0.625mg fluphenazine decanoate =
Flavoxate. 2-4mg/kg (adult 100-200mg) 6-8H, or 1.25mg haloperidol).
single dose at bed me oral. Fluphenazine. 0.02-0.2mg/kg (adult 1-10mg)
Flecainide. 2-3mg/kg (max 100mg) 12H oral, may 8-12H oral.
incr over 2wk to 7mg/kg (max 200mg) 8-12H. IV Flurandrenolide. See flurandrenolone.
over 30min: 0.5-2mg/kg (max 150mg) 12H. Flurandrenolone. 0.025%, 0.05% cream, ointment
Floxuridine (FUDR). 100-300mcg/kg/day by or lo on: apply 6-24H. 4mcg/m tape: apply 12H.
constant intra-arterial infsn (400-600mcg/kg/ Flurazepam. Adult (NOT/kg): 15-30mg nocte oral.
day in hepa c artery). Stop if WCC <3500/mm Flurbiprofen. 1-2mg/kg (adult 50-100mg) 8H oral
or platelets <100,000/mm. or PR. 0.03% drops: 1 drop/eye every 30min x4
Flucloxacillin. Oral: 12.5-25mg/kg (adult 250- Flutamide. Adult (NOT/kg): 250mg 8H oral.
500mg) 6H. IM or IV: 25mg/kg (adult 1g) 6H. Flu casone. Inhaled (NOT/kg): 50-100mcg (child),
Severe in n: 50mg/kg (adult 2g) IV 12H (1st wk 100-500mcg (adult) 12H. 0.05% soltn: 1-4 sprays
life), 8H (2-4 wk), 6H or constant infsn (>4 wk). /nostril dly. 0.05% cream: apply sparingly dly.
See also ampicillin + flucloxacillin.
Flu casone + salmeterol. NOT/kg. Accuhaler:
Fluconazole. 6mg/kg (adult 200mg) stat, then 100mcg/ 50mcg (child), 250/50 or 500/50
3mg/kg (adult 100mg) dly oral or IV. Severe in n: (adult) x1-2 inhltn 12H. MDI: 50/25 (child),
12mg/kg (adult 400mg) stat, then 6-12mg/kg 125/25 or 250/25 x1-2 inhltn 12H.
(adult 200-400mg) daily IV; if haemofiltered
Fluvasta n. 0.4mg/kg (adult 20mg) nocte oral,
12mg/kg (adult 600mg) 12H.
incr to 0.8 mg/kg (adult 40mg) 12H if reqd.
Flucytosine (5-fluorocytosine). 400-1200mg/m Slow rel: 80mg nocte.
(max 2g) 6H IV over 30 min, or oral. Peak level 50-
Fluvoxamine. 2mg/kg (adult 100mg) 8-24H oral.
100mcg/ml, trough 25-50mcg/ml (x7.75=umol/L).
Folic acid. NOT/kg. Deficiency: 50mcg (neonate),
Fludarabine. 25mg/m daily x5 IV over 30min,
0.1-0.25mg (<4yr), 0.5-1mg (>4yr) daily IV, IM,
every 28 days.
SC or oral. Metabolic dis: 5mg/day oral.
Fludrocor sone acetate. 150mcg/m daily oral. Pregnancy: 0.5mg (high risk 4mg) daily oral.
Fludrocor sone 1mg = hydrocor sone 125mg in
Folinic acid. See calcium folinate.
mineralocor coid ac vity, 10mg in glucocor coid.
Follicle s mula ng hormone (FSH). Adult
Flumazenil. 5mcg/kg every 60sec to max total
(NOT/kg), monitor urinary oestrogen.
40mcg/kg (adult 2mg), then 2-10mcg/kg/hr IV. Anovulatn: usu. 50-150iu SC dly for 9-12 days.
Flunisolide. Asthma (250mcg/pu): 1-2 pus 12H. Superovulatn (2wk a er star ng GnRH agonist):
Nasal (25mcg/pu): 1-2 pus/nostril 8-24H. 100-225iu/kg daily star ng day 3 of cycle.
Flunitrazepam. Adult (NOT/kg): 0.5-2mg nocte oral Follitropin , . See follicle s mula ng hormone
Fluocinolone. See fluocinonide. Fomivirsen. Intravitreal injec on, adult (NOT/kg).
Fluocinonide. 0.025%, 0.05% cream, oint: apply 6-12H New disease: 165mcg/eye wkly x3, then every
Fluocortolone. 0.25% cream, ointment: apply 8-12H. 2wk. Previously treatd: 330mcg/eye stat, in 2wk,
Fluorescein. 1%, 2% drops: 1 drop/eye. 10% (100 then every 4wk
mg/ml), 25% (250mg/ml): 8mg/kg (max 500mg) IV. Fondaparin. Adult (NOT/kg): 2.5mg SC 6hr
Fluorescein 0.25% + oxybuprocaine 0.4%. postop, then daily for 5-9 days.
1 drop/eye. Formestane. Adult (NOT/kg): 250mg 2wkly deep IM
Fluorometholone. 0.1% soltn: 1 drop/eye 6-12H. Formoterol. >4yr (NOT/kg). Powder: 12mcg
Fluorouracil. 15mg/kg (max 1g) IV over 4hr daily inhala on 12H. Solutn: 20mcg in 2ml nebulised
un l side eects, then 5-10mg/kg wkly. See also 12H. See also budesonide.
adrenaline + fluorouracil; and folinic acid. Fosamprenavir. Adult (NOT/kg): 0.7g 12H, or 1.4g
Fluoxe ne. 0.5mg/kg (max 20mg) daily, incr daily oral.
to max 1mg/kg (max 40mg) 12H oral. Weekly Foscarnet. 20mg/kg IV over 30min, then 200mg/
90mg cap: 1 per wk. kg/day by constant IV infsn (less if crea nine
Fluoxe ne + olanzapine (25mg/6mg, 25mg/12mg, >0.11mmol/l) or 60 mg/kg 8H IV over 2hr.
50mg/6mg, 50mg/12mg). (NOT/kg): 1cap dly oral Chronic use: 90-120mg/kg IV over 2hr daily.

387
Drug Doses
Fosfestrol. Adult (NOT/kg) Ini al: 0.5g IV over 1hr Gas gangrene (Clostridia) an toxin. Prophylaxis:
day 1, then 1g x5 days. Maintenance: 120-240mg 25,000u IM / IV. Treatmnt: 75,000-150,000u IV over
8H oral, later reducing to 120-240mg daily. 1hr, rpt x1-2 a r 8-12hr; if severe give 100,000u IM.
Fosfomycin tromethamine. One 5.63g (3g base) Ga floxacin. 8mg/kg (adult 400mg) dly IV over 1hr.
sachet mixed with water once oral. Gonorrh: 8mg/kg (adult 400mg) once. 0.3%
Fosinopril. 0.2-0.8mg/kg (adult 10-40mg) dly oral ophthalmic: 1 drop/eye 2H when awake days 1-2,
Fosphenytoin. 75mg = 50mg phenytoin (qv). then x4/day days 3-7.
Prescribed / dispensed as phenytoin equivalents. Gaviscon. See alginic acid.
Fotemus ne. IV over 1hr, or IA over 4hr: 100mg Gefi nib. Adult (NOT/kg): 250mg daily oral.
/m wkly x3, rest 4-5wk, then every 3wk. Gela n, succinylated. 10-20ml/kg (may be
Framyce n sulfate (Soframycin). Subconjunc - repeated). Volume eect lasts 3-4hr.
val: 500mg in 1ml water daily x3 days. Bladder: Gemcitabine. 1g/m IV over 30min wkly for
500mg in 50ml saline 8H x10 days. 0.5%: eye 3wk, rest for 1wk, then repeat 4wk cycle.
1drop 8H, ear 3drops 8H, ointment 8H. Gemeprost (PGE analogue). Cervical dilata on:
Framyce n sulfate 15mg/g + gramicidin 0.05mg/g. 1 pessary (1mg) into posterior vagina 3hr before
Cream, ointmnt (Soframycin topical): apply 8-12H. surgery. Termina on: 1 pessary (1mg) into
See also dexamethasone + framycetin + gramicidin. posterior vagina 3H (max 5 pessaries).
Fresh frozen plasma. Contains all clo ng fac- Gemfibrozil. 10mg/kg (max 600mg) 12H oral.
tors. 10-20 ml/kg IV. 1 bag is about 230ml. Gemifloxacin. Adult (NOT/kg): 320mg daily oral.
Frusemide. Usually 0.5-1mg/kg (adult 20-40mg) Gemtuzumab ozogamicin. 9mg/m IV over 2hr,
6-24H (daily if preterm) oral, IM, or IV over 20min repeated a er 14 days.
(max 0.05 mg/kg/min IV). IV infsn: 0.1-1mg/kg/hr Gentamicin. IV or IM. 1wk-10yr: 8mg/kg day 1,
(<20kg 25 mg/kg in 50ml 0.9% saline with heparin then 6 mg/kg dly. >10yr: 7mg/kg day 1, then
1u/ml at 0.2-2 ml/hr; >20kg amp 10mg/ml at 5mg /kg (max 240-360mg) dly. Neonate, 5mg/kg
0.01-0.1ml/kg/hr); protect from light. dose: <1200g 48H (day 0-7 of life), 36H (8-30 days),
Fulvestrant. Adult (NOT/kg): 250mg IM once / mth 24H (>30 days); 1200-2500g 36H (day 0-7 of life),
Furazolidone. 2mg/kg (adult 100mg) 6H oral 7-10 d 24H (>7 days); term 24H (0-7 days of life), then
as for 1 wk-10yr. Trough level <1.0mg/L.
Fusafungine. 125mcg spray: oral 1spray/10kg (adult
5 sprays) x5/d, nasal 1spray/20kg (adult 3sprays) x5/d Gentamicin, eye drops. 0.3% 1drop/eye every
15min if severe, reducing to 1drop 4-6H.
Fusidate, sodium. See sodium fusidate.
Gestodene. See ethinyloestradiol + gestodene.
Fusidic acid. Fusidic acid (susp) absorp on only
70% that of sodium fusidate (tabs). Suspension: Gestrinone. Adult (NOT/kg): 2.5mg x2/wk on day 1
15-20mg/kg (adult 750mg) 8H oral. Eye %: 1drop/ & 4 of menstrual cycle, then same days each wk
eye 12H. For tablets and IV, see sodium fusidate. Gestronol. Adult (NOT/kg): 200-400mg every 5-7d IM
Gabapen n. An convulsant: 10mg/kg (adult Ginkgo biloba. Adult (NOT/kg): 1200mg 12H oral.
300mg) once day 1 oral, 12H day 2, 8H day 3 Glibenclamide. Adult (NOT/kg): ini ally 2.5mg
then adjusted to 10-20 mg/kg (adult 300-1200mg) daily oral, max 20mg daily.
8H. Premed: 25mg/kg (adult 1200mg) 1hr preop. Glibenclamide + me ormin. Adult (NOT/kg):
Analgesia: 2mg/kg (adult 100mg) 8H, incr if reqd 1.25mg/ 250mg 12-24H oral, incr if reqd to 2.5mg
to 15mg/kg (adult 800mg) or higher if tolerated. /500mg or 5mg/ 500mg (max 10mg/1000mg) 12H.
Galantamine. Adult (NOT/kg): 4mg 12H x 4wk, then Gliclazide. Adult (NOT/kg): ini ally 40mg daily
8mg 12H, incr a r 4wk if reqd to 8-12mg 12H oral oral, max 160mg 12H.
Gallamine. 1-2mg/kg (adult 50-100mg) IV. Glimepiride. Adult(NOT/kg): 2-4mg (max 6mg) dly oral
Gallium nitrate. 100-200mg/m/day x5days Glimepiride + pioglitazone (2mg/30mg,
constant IV infsn. 4mg/30mg). Adult (NOT/kg): 1 tab daily oral.
Gamma benzene hexachloride. See lindane. Glimepiride + rosiglitazone (1mg/4mg, 2mg/4mg,
4mg/4mg). (NOT/kg): 1-2 tab dly (max
Gamma hydroxybutyrate. See sodium oxybate.
4mg/8mg) oral.
Gamolenic acid. 2-5mg/kg(adult 120-240mg) 12H oral
Glipizide. Adult (NOT/kg): 5mg dly oral, max 20mg 12H
Ganciclovir. 5mg/kg 12H IV over 1hr for 2-3wk;
then 5mg/kg IV daily, or 6mg/kg IV on 6 days/ Gliquidone. 0.25-1mg/kg (adult 15-60mg) 8-12H oral
wk, or 20 mg/kg (adult 1g) 8H oral. Glucagon. 1u=1mg. 0.04mg/kg (adult 1-2mg) IV
Congenital CMV: 7.5mg/kg 12H IV over 2hr. / IM stat, then 10-50mcg/kg/hr (0.5mg/kg in
Ganirelix. Adult (NOT/kg): 0.25mg daily SC from 50ml at 1-5ml/hr) IV. -blocker overdose: 0.1mg/
day 6 of FSH to day of ovula on induc on. kg IV stat, then 0.3-2 mcg/kg/min.

388
 Drug Doses
Glucose. See dextrose. Guanadrel. 0.1mg/kg (max 5mg) 12H oral, incr
Glucose electrolyte solu on. Not dehydrated: to max 0.5mg/kg (max 25mg) 8-12H.
1 heaped teaspoon sucrose in large cup of water Guanethidine. 0.2mg/kg (max 10mg) daily oral,
(4% sucrose = 2% glucose); do NOT add salt. incr to 0.5-6mg/kg (max 300mg) daily. Regnl
Dehydrated: 1 sachet of Gastrolyte in 200ml symp block (adult): cu 55mmHg >syst BP, 10-
water; give frequent sips, or infuse by NG tube. 20mg in 10-25ml saline (arm) or 15-30mg in
Glutamic acid. 10-20mg/kg (adult 0.5-1g) oral 15-50ml (leg) IV, wait 10-20min, release cu
with meals. over 5min; >=7 days betw injctns (max 12/yr)
Glyburide. See glibenclamide. Guanfacine. 0.02mg/kg (max 1mg) daily oral, incr
Glycerin. See sorbolene + glycerin cream. over several wks to max 0.06mg/kg (max 3mg) dly.
Glycerol. Supp: 0.7-1g infant, 1.4-2g child, 2.8-4g adult. Guar gum.1g/10kg(adult 5g) 8Horal in fluid 40ml/g gum
Glyceryl trinitrate. Adult (NOT/kg): subling. tab Haem arginate. 3-4mg/kg daily IV over 30-60min.
0.3-0.9 mg/dose (lasts 30-60min); subling. aerosol Haemaccel. See polygeline.
0.4-0.8 mg/dose; slow-release buccal tab 1-10mg Haemophilus influenzae type b, vaccines. Inac-
8-12H; transdermal 0.5-5cm of 2% ointment, vated. <12mo: give diphtheria protein conjugate
or 5-15mg patch 8-12H. IV infsn 0.5-5mcg/kg/min (HibTITER, ProHIBiT), or tetanus conjugate
(<30kg 3mg/kg in 50ml 5%dex-hep at 0.5-5ml/hr; (Act-HIB, Hiberix) 0.5ml IM at 2mo, 4mo, 6mo
>30kg 3mg/kg made up to 100ml in 5%dex-hep at and 15mo; or meningococcal conjugate (Pedvax
1-10ml/hr); use special non-PVC tubing. HIB) 0.5ml IM at 2mo, 4mo and 15mo. If 1st dose
Glycopyrrolate. To reduce secre ons or treat >18mo: give 1 dose of HibTITER or Pedvax HIB.
bradycardia: 5-10mcg/kg (adult 0.2-0.4mg) Haemophilus influenzae type b + hepa s B
6-8H IV or IM. With 0.05mg/kg neos gmine: vaccine (Comvax). Inac vated. 0.5ml IM 2mo,
10-15mcg/kg IV. An cholinergic: 4 mo, 12-15 mo (3 doses).
0.02-0.04mg/kg (max 2mg) 8H oral. Haemophilus influenzae type b + meningococ-
Glycopyrronium bromide. As for glycopyrrolate. cus type c vaccine (Menitorix). Inac vated. 0.5ml
GM-CSF. See sargramos m. IM 2mo, 3mo, 4mo (3 doses); boost from 12mo.
Gold sodium thiomalate. See sodium aurothiomalate Halcinonide. 0.1% cream: apply sparingly 8-12H.
Gonadorelin (GnRH or LHRH). Pituitary func on Halobetasol. 0.05% cream, ointmnt: apply 12-24H
test, child or adult: 100mcg IV. See also leuprorelin. Halofantrine. 10mg/kg (max 500mg) 6H for 3
Gonadotrophin. See chorionic gonadtrn, and doses oral, repeat a er 1wk if nonimmune.
menotrophin. Haloperidol. 0.01mg/kg (max 0.5mg) daily, incr
Goserelin. Adult (NOT/kg): 3.6mg SC every 28 d;imp- up to 0.1 mg/kg 12H IV or oral. Acutely disturbed:
lant 10.8mg SC every 12wk. See also bicalutamide. 0.1-0.2mg/kg (adult 5-10mg) IM. Long-ac ng
Gramicidin 0.025% + neomycin 0.25% + decanoate ester: 1-6mg/kg IM every 4wk.
nysta n 100,000 u/g + triamcinolone 0.1%. Hemin. 1-3mg/kg 12-24H IV over 30min.
Kenacomb ointment: apply 8-12H. Kenacomb Heparin. 1mg=100u. Low dose: 75u/kg IV stat,
o c oint, drops: apply 8-12H (2-3 drops). then 500u/kg in 50ml 0.9% saline at 1-1.5ml/hr
Gramicidin 25mcg/ml + neomycin 2.5mg/ml + (10-15u/kg/hr) IV. Full dose: 75u/kg (adult
polymyxin B 5000u/ml (Neosporin). Eye drops: 5000u) IV stat, then 500u/kg in 50ml saline at
1 drop/eye every 15-30min, reducing to 6-12H. 2-4ml/hr (20-40u/kg/hr)<12mo, 2-3ml/hr
See also dexamethasone. (20-30 u/kg/hr) child, 1.5-2ml/hr (15-20u/kg/
Granisetron. 0.04mg/kg (adult 1mg) IV over 5min hr) adult; adjust to give APTT 60-85 sec, or
daily. Chemo: 0.05mg/kg (adult max 1-3mg) IV an -Xa 0.3-0.7u/ml. Hep lock: 100u/ml.
over 5min; up to 3 doses/day, at least 10min apart. Heparin calcium. Low dose: 75u/kg SC 12H.
Granulocyte-macrophage colony s mula ng Heparin, low molecular weight. See certoparin,
factor (GM-CSF). See lenogras m, sargramos m. dalteparin, danaparoid, enoxaparin, nadroparin.
Griseofulvin (Grisovin, Fulcin). 10-20mg/kg Hepa s A vaccine (Havrix). Inac vated. 0.5ml
(adult 0.5-1g) daily oral. (child) or 1ml (adult) IM stat, and in 6-12mo
Griseofulvin, ultramicrosize (Griseosta n). (2doses). Boost every 5yr.
5.5-7mg/kg (adult 330-660mg) daily oral. Hepa s A vaccine (VAQTA). Inac vated. 0.5ml
Growth hormone. See somatropin. (child) or 1ml (>17yr) IM stat, > 6-18mo (2 doses)
Guaiphenesin. 4-8mg/kg (adult 200-400mg) 4H oral Hepa s A + hepa s B vaccine (Twinrix)
Guanabenz. 0.1mg/kg (max 4mg) 12H oral, incr Inac vated. 1-15yr 0.5ml, >15yr 1ml IM stat, a er
to max 0.6mg/kg (max 32mg) 12H. 1mo, and a er 6mo (3 doses). Boost every 5yr.

389
Drug Doses
Hepa s B vaccine (Engerix-B, HB Vax II). Hydroflumethiazide. 0.5-2mg/kg (adult 25-
Inac vated. Engerix-B 10mcg/dose (<10yr),20mcg 100mg) 12-48H.
(>9yr); HB Vax II 2.5mcg/dose (<10yr), 5mcg (10- Hydrogen peroxide. 10 volume (3%). Mouthwash
19yr), 10mcg (>19yr), 40mcg (dialysis) IM stat, 1:2 parts water. Skin, ear disinfectant 1:1 pt water.
a er 1mo, and a r 6mo (3 doses). Boost every 5yr. Hydromorphone. Oral: 0.05-0.1mg/kg (adult 2-
Herpes zoster vaccine (Zostavax). Live. Age 50yr: 4mg) 4H. IM, SC: 0.02-0.05mg/kg (adult 1- 2
0.65ml SC once. See also Immunoglobulin, zoster. mg) 4-6H. Slow IV: 0.01-0.02mg/kg (adult 0.5-1
Hetastarch. 6% 10-20ml/kg IV. mg) 4-6H. Pallia ve care: incr to 40-50mg/day
Hexachlorophane. 3% emulsion. >12mo: apply (up to 500mg/day) oral in divided doses.
5ml, scrub for 3min. Hydroquinone. 4% cream: apply 12H.
Hexamethylmelamine. 150-260mg/m daily Hydrotalcite. 20mg/kg (adult 1g) 6H oral.
oral for 14-21 consecu ve days of 28 day cycle. Hydroxocobalamin (Vit B12). 20mcg/kg (adult
Hexamidine. See chlorhexidine. 1000mcg) IM dly for 7 d then wkly (treatment),
Hexamine. 20mg/kg (adult 1g) 6H oral. then every 2-3mo (prophylaxis); IV dangerous in
Hexe dine. 0.1% soln: rinse/gargle 15ml 8-12H. megaloblas c anaemia. Homocys nuria, methyl-
malonic aciduria: 1mg daily IM; a r response,
Histamine phosphate. 1mg/ml base: prick,
some pa ents maintained on 1-10mg daily oral.
puncture or scratch tes ng. 0.1mg/ml base:
intradermal tes ng. Hydroxyapa te. 20-40mg/kg (adult 1-2g) 8H oral.
Histrelin. Usually 10mcg/kg daily SC. Hydroxycarbamide. See hydroxyurea.
Homatropine. 2%, 5% soltn: 1 drop/eye 4H. Hydroxychloroquine sulphate. Doses as sulphate.
Malaria: 10mg/kg (max 600mg) daily for 3d;
Human chorionic gonadotrophin. See Chorionic
prophylaxis 5mg/kg (max 300mg) once a
gonadotrophin.
wk oral. Arthri s, SLE: 3-6.5mg/kg (adult 200-
Human papillomavirus vaccine (Cervarix, 600mg) daily oral.
Gardasil). Inac vated. Females 10-46yr, males 9-
Hydroxyethylcellulose. 0.44% 1 drop per eye 6-8H.
15yr: 0.5ml IM, in 1-2mo, and 6mo later (3 doses).
Hydroxypropyl (methyl)cellulose. See hypromellose.
Hyaluronic acid. Gel 20mg/ml:0.7-1.4ml inj. in wrinkles
Hydroxyethylrutosides. 5mg/kg (adult 250mg)
Hyaluronidase. Hypodermoclysis: add 1-1.5u/ml
fluid. Local anaesthesia: add 50u/ml soltn. 6-8H for 3-4wk, then 12-24H; or 10mg/kg (adult
Hydralazine. 0.1-0.2mg/kg (adult 5-10mg) 500mg) 12H for 3-4wk, then daily oral.
stat IV or IM, then 4-6mcg/kg/min (adult 200- Hydroxyprogesterone. Adult (NOT/kg): 250-
300mcg/min) IV. Oral: 0.4 mg/kg (adult 20mg) 500mg/wk IM.
12H, slow incr to 1.5mg/kg (max 50mg) 6-8H. Hydroxypropylcellulose. 5mg insert: 1 in each eye dly
Hydrochloric acid. Use soltn of 100mmol/L Hydroxyquinone. 4% cream: apply 12H.
(0.1M = 0.1N = 100mEq/L); give IV by central Hydroxyurea. 80mg/kg oral every 3rd day,
line only. Alkalosis: dose(ml) = BE x Wt x 3 (give or 20-30mg/kg daily. CNS tumors: 1.5-3g/m
half this); maximum rate 2ml/kg/hr. Blocked oral stat, in 2wk, then every 4-6wk.
central line: 1.5ml/lumen over 2-4hr. Sickle cell: 15mg/kg daily, incr by 5mg/kg every
Hydrochlorothiazide. 1-1.5mg/kg (adult 25- 12wk to max 35mg/kg daily.
50mg) 12-24H. Hydroxyzine. 0.5-2mg/kg (adult 25-100mg) 6-8H
Hydrochlorothiazide + quinapril 10/12.5, oral. 0.5-1mg/kg(adult 25-100mg) 4-6H if reqd IM
20/12.5. Adult (NOT/kg): 10/12.5 tab dly oral, incr Hylan. 8mg inj into knee wkly x3; max 6 doses in 6mo.
if reqd to 20/12.5 tab, max two 10/12.5 tab daily. Hyoscine hydrobromide (scopolamine hydrobro-
Hydrocodone. 0.1-0.2mg/kg (max 10-15mg) 4-6H oral mide). 6-8mcg/kg (adult 400-600mcg) 6-8H IV,
Hydrocor sone. Usually 0.5-2mg/kg (adult 25- IM, SC. Mo on sickness 300mcg tab (NOT/kg):
50mg) 6-8H oral, reducing as tolerated. 0.5%, 0.25 tab (2-7yr), 0.5 tab (7-12yr), 1-2 tab (>12yr)
1% cream, ointment: apply 6-12H. 1% cream 6-24H oral 30 min before, may repeat in 4hr.
+ clioquinol: apply 8-24H. 10% rectal foam: Transdermal (1.5mg patch): >10yr 1 every 72hr.
125mg/dose. 2.5% eye ointment: apply 6H. Hyoscine hydrobromide(0.4mg/ml) +papaveretum
Hydrocor sone sodium succinate. 2-4mg/kg (20mg /ml). 0.008 mg/kg (H) + 0.4 mg/kg (P) =
3-6H IM, IV reducing as tolerated. 0.02ml/kg/dose IM.
Physiological: 5mg/m2 6-8H oral; 0.2mg/kg 8H Hyoscine methobromide (methscopolamine).
IM, IV. Physiological, stress: 1mg/kg 6H IM, IV. 0.2mg/kg (adult 2.5-5mg) 6H oral.
Hydrocor sone 1% + pramocaine 1%. Cream, Hyoscine butylbromide. 0.5 mg/kg (adult 20-
foam: apply 8-12H a er defaeca on. 40mg) 6-8H IV, IM or oral.

390
 Drug Doses
Hyoscyamine (L-atropine). 2-5mcg/kg (adult Immunoglobulin, normal, human. Hypogamma-
100-300 mcg) 4-6H oral, sublingual, IM or IV. globulinaemia: 10-15ml/kg of 6% soltn (600-900
Hypromellose. 0.5% soltn: 1 drop/eye prn. mg/kg) IV over 5-8hr, then 5-7.5 ml/kg (300-450
Hypromellose 0.3% + dextran 70 0.1%. mg/kg) over 3-4hr mthly; or 0.6ml/kg of 16% soltn
1 drop/eye prn. (100mg/kg) every 2-4wk IM. Sepsis: 0.5g/kg IV
over 4hr. Kawasaki, Guillain-Barre, ITP, myasthenia
Ibandronate (ibandronic acid). Adult, NOT/kg.
gravis, S lls disease: 35ml/kg of 6% soltn (2g/kg) IV
Hypercalcaemia: 2-4mg IV over 2hr once.
over 16hr stat, then if required 15 ml/kg (900mg
Osteoporosis: 2.5mg daily, or 150mg each
/kg) IV over 8hr each month. Preven on hepa s
month oral; or 3mg IV bolus evey 3mo.
A: 0.1ml/kg (16mg/kg) IM. Preven on measles:
Ibuprofen. 5-10mg/kg (adult 200-400mg) 4-8H 0.2ml/kg (32mg/kg) IM (repeat next day if
oral. Arthri s: 10mg/kg (adult 400-800mg) 6-8H. immunocompromised).
Cys c fibrosis: 20-30mg/kg 12H. PDA: 10mg/kg
Immunoglobulin, rabies (Hyperab, Imogam).
stat, then 5mg/kg a r 24 and 48 hr IV over 15min.
20iu (0.133 ml)/kg IM once (half SC around
Ibu lide. 0.017mg/kg (max 1mg) IV over 10min,
then wait 10min and repeat once if reqd. wound), with rabies vaccine.
Ichthammol. 1-10% cream, ointment. Apply 6-8H. Immunoglobulin, Rh (an -D). 1ml (625iu,
125mcg) IM within 72hr of exposure. Large
Icodextrin 7.5% in electrolyte soltn. Adults: 1.5-
transfusion: 0.16ml (100iu, 20mcg) per ml RH
2.5 litres as once daily replacemnt for a 6-12hr
posi ve red cells (maternal serum should be
glucose dialysis.
an - D posi ve 24-48hr a er injec on).
Idarubicin. 12mg/m IV over 15min dly for 3 days.
Immunoglobulin, respiratory syncy al virus.
Idebenone. Adult (NOT/kg): 30mg 8H oral. 750mg/kg every month IV (50mg/ml: 1.5ml/kg/hr
Idoxuridine. 0.1% eye drops: 1 drop every 15min for 15min, 3ml/kg/hr for 15min, then 6ml/kg/hr).
for 2hr, then hly by day, 2hly at night. 0.1% soltn or Immunoglobulin, subcutanoeus (SCIG).
0.5% ointment: apply hourly first 24hr, then 4H.
Mul ply previous IV immunoglobulin dose by
Ifosfamide.Usu. 1.2-2.0g/m IV over 4hr dly x5, or
1.37, and divide this into weekly doses. Usually
5-6 g/m (max 10g) IV over 24hr x1. Rpt every 2-4wk.
100-200mg/kg by SC infusion weekly.
Iloprost. Adult(NOT/kg): 2.5-5mcg x6-9/day by inhalatn
Immunoglobulin, tetanus (TIG). IM prepara on,
Ima nib. Adult (NOT/kg): 400mg daily (chronic
prophylaxis: 250-500iu (1-2amp). IV prepara on,
CML), 600mg daily (blast crisis) or 400mg 12H
treatmnt:4000iu (100ml) at 0.04ml/kg/min for 30
(unresponsive blast) oral.
min, then 0.075 ml/kg/min IV; intrathecal usu. 250iu
Imidapril. 0.1mg/kg (adult 5mg) daily oral, incr if
Immunoglobulin, zoster. 1iu = approx 1.5mg.
reqd to 0.2-0.3mg/kg (adult 10-20mg) daily.
Within 96hr of exposure: 0-10kg 300mg, 11-
Imiglucerase. Usu. ini al dose 60u/kg every 2wk IV
over2hr, adjust as per response; reduce every 3-6mo. 30kg 600mg, >30kg 900mg IM.
Imipenem (+ cilasta n). 15mg/kg (adult 500mg) Indapamide. 0.03-0.05mg/kg (max 1.5-2.5mg) dly oral
6H IV over 30min. Severe in n: 25mg/kg IV Indinavir. >28 days: 500mg/m (adult 800mg) 8H oral
over 1hr (adult 1g) 12H (1st wk life), 8H (2-4 Indocyanine green. IV. Dye dilutn: 0.1mg/kg
wk), 6-8H or constant infsn (4+ wk). (adult 5mg). Pulsion monitor: 0.25-0.5mg/kg.
Imipramine. 0.5-1.5mg/kg (adult 25-75mg) 8H Liver func on: 0.5mg/kg.
oral. Enuresis: 5-6yr 25mg, 7-10yr 50mg, >10yr Indomethacin. 0.5-1mg/kg (adult 25-50mg) 8H
50-75mg nocte. (max 6H) oral or PR. PDA: 0.1mg/kg (<1kg) or
Imiquimod. 5% cream: apply x2-3/wk (max 0.2mg/kg (>=1kg) day 1, then 0.1mg/kg daily
16wk) before bed; wash o a er 6-10hr. days 2-7 oral or IV over 1hr.
Molluscum: 0.2% cream x3/wk. Indoramin. 0.5-1.5mg/kg (adult 25-75mg) 8-12H oral.
Immunoglobulin, CMV. 100-200mg/kg IV over2hr. Infliximab. 3mg/kg (arthri s, with methotrexate)
Transplant: dly for first 3 days,wkly x6, mthly x6 5mg/kg (Crohns) IV over 2hr, then (if response)
Immunoglobulin, diphtheria. 250u IM once. a er 2wk, 6wk, and then 5-10mg/kg every 8wk.
Immunoglobulin, hepa s B. 400u IM within 5 Influenza A and B vaccine (Fluvax, Vaxigrip).
days of needle s ck, repeat in 30 days; 100u Inac vated. 0.125ml (3mo-2yr), 0.25ml (2-6yr),
IM within 24hr birth to baby of Hep B carrier. 0.5ml (>6yr) SC stat and 4wk later (2 doses).
Immunoglobulin, an lymphocyte (thymocyte). Boost annually (1 dose).
Horse (Atgam): 10-15mg/kg daily for 3-5 days Influenza A and B live nasal vaccine (Flumist).
IV over 4hr; occasionally up to 30mg/kg daily. >5yr: 0.25 ml/nostril; rpt a er 6wk if age 5-8yr
Rabbit (ATG-Fresenius). 2.5-5mg/kg dly over4-6hr IV and prev unimmunised. Boost annually (1 dose).

391
Drug Doses
Inosine acedoben dimepranol. Herpes, genital Irbesartan. 3mg/kg (adult 150mg) daily oral, incr
warts: 20 mg/kg (adult 1g) 6-8H oral. SSPE: to 6mg/kg (adult 300mg) daily if reqd.
10-15mg/kg 4H oral. Irinotecan. 350mg/m IV over 90min every 3wk;
Inositol nico nate. 20mg/kg (adult 1g) 6-8H oral. reduce to 250-300mg/m every 3wk if toxicity.
Insulin. Regular insulin IV: 0.025-0.1u/kg prn, or Iron. See ferrous gluconate, ferrous sulphate.
0.025-0.1 u/kg/hr (2.5u/kg in 50ml 4% albumin at Iron dextran, iron polymaltose. Fe 50mg/ml:
0.5-2ml/hr); later 1u/10g dextrose. dose (ml) = 0.05 x Wt in kg x (15 - Hb in g%) IM
For hyperkalaemia: 0.1u/kg insulin and 2ml/kg (o en in divided doses). IV infsn possible (but
50% dextrose IV. In TPN: 5-25u/250g dextrose. dangerous).
SC insulin (onset/peak/dura on): glulisine, lispro Isoconazole. 1% cream 12H. Vaginal: 600mg (2
10-15min/1hr/ 2-5hr; aspart 15-20min/1hr/3-5hr; tab) once.
inhaled 10-15min/1hr/6hr; regular -1hr/2hr/6- Isoetharine. Inhaltn soltn (1%): 0.5ml diltd to
8hr; detemir 1-2hr/flat/24hr; glargine 1-2hr/ 4ml 3-6H (mild), 1ml diltd to 4ml 1-2H (moder
flat/24hr; isophane (NPH) 2-4hr/4-12 hr/18-20hr; ate), undiltd constant (severe, in ICU). Aerosol
zinc (lente) 2-3hr/7-15hr/24hr; crystalline zinc 340mcg/pu: 1-2 pus 4-6H.
(ultralente) 4-6hr/10-30hr/24-36hr; protamine
Isometheptene. 2.5mg/kg (max 130mg) stat,
zinc 4-8 hr/ 15-20hr/24-36hr.
then 1.5mg/kg (max 65mg) 1H to max 7mg/kg
Insulin (Exubera). Ini ally 30-39kg 1mg, 40-59kg (max 325mg) in 12hr oral. See also dichloral
2mg, 60-79kg 3mg, 80-99kg 4mg, inhaled phenazone.
10min before meal.
Isoniazid (INAH). 10mg/kg (max 300mg) daily
Interferon alfa-2a, recombinant. Haemangioma: oral, IM or IV. TB meningi s: 15-20mg/kg (max
1 million u/m daily SC or IM incr over 4wk to 500mg) daily.
2-3 million u/m dly for 16-24wk, then x3/wk.
Isoniazid 50mg + pyrazinamide 300mg +
Hep B, C: 3-6 million u/m x3/wk SC or IM for
rifampicin 120mg tab. 30-39kg x3, 40-49kg x4,
4-6mo; higher doses may be required in hep B.
50-64kg x5, 65kg x6tab daily.
Interferon alfa-2b, recombinant. Condylomata:
Isoniazid + rifampicin. 30-49kg 150mg/100mg
1 mil. unit into each lesion (max 5) x3/wk x 5wk.
tabs x3 dly, 50kg 300mg/150mg tabs x2 dly oral
Haemangioma: as for interferon alfa-2a. Hep B:
monotherapy as for interferon alfa-2a. Hep C Isoprenaline. IV infsn: <33kg 0.3mg/kg in 50ml
(adult, NOT/kg) 3 million unit x3/wk SC, + ribavirin 5%dex-hep at 0.5-10ml/hr (0.05-1mcg/kg/
1000mg (1200mg if >75kg) dly oral, x 24-48wk. min); >33kg give 1/5000 (0.2 mg/ml) soltn at
0.015-0.15ml/kg/hr (0.05-0.5mcg/kg/min).
Interferon alfa-2a / alfa-2b, pegylated.
See peginterferon. Isoproterenol. See isoprenaline.
Interferon alfa-n3. Warts (NOT/kg): 250,000u Isosorbide dinitrate. Subling: 0.1-0.2mg/kg (max
injected into base of wart (max 10 doses/ 10mg) 2H or as needed. Oral: 0.5-1mg/kg (max
session) x2/wk for max 8wk. 40mg) 6H or as needed. Slow rel tab, adult (NOT/
kg): 20-80mg 12H. IV infsn 0.6-2mcg/kg/min.
Interferon alfacon-1. Hepa s C (adult, NOT/kg):
usu. 9mcg (7.5mcg if not tolerated) x3/wk SC Isosorbide mononitrate. Slow release tab, adult
for 24wk; if relapse 15mcg x3/wk SC for 6mo. (NOT/kg): 60-120mg daily oral.
Interferon beta-1a. Mult sclerosis (NOT/kg): Isotre noin. Adult: 0.5-1mg/kg daily oral for 2-
Avonex 30mcg (6 million IU) once a wk IM, 4wk, reducing if possible to 0.1-0.2mg/kg dly
Rebif 44mcg x3/wk SC. for 15-20wk. 0.05% gel: apply sparingly at night
Interferon beta-1b. Mult sclerosis (NOT/kg): Isoxsuprine. 0.2-0.5mg/kg (adult 10-20mg) 6-12H oral
250mcg (8 million IU) SC alternate days. Ispaghula husk. Adult (NOT/kg): 1-2 x5ml tea
Interferon gamma-1b. Chronic granulomatous spoonfuls 6-12H oral. Half this dose 6-12yr.
disease: 1.5mcg/kg (body area <=0.5m) or Isradipine. 0.05mg/kg 12H oral, may incr a er 2-
50mcg/m (area >0.5m) x3/wk SC. 4wk gradually to 0.1-0.2mg/kg (max 10mg) 12H
Interleukin-2. See aldesleukin. Itraconazole. 2-4mg/kg (adult 100-200mg)
Iodoquinol. See di-iodohydroxyquinoline. 12-24H oral a er food. Trough level >0.5
Ipecacuanha syrup (total alkaloids 1.4mg/ml). mcg/ml at 10-14 days.
1-2ml/kg (max 30ml)stat oral, NG. May rpt 1x in 30min Ivabradine. 0.1mg/kg (adult 5mg) 12H oral,
Ipratropium bromide. Resp soltn (250mcg/ml): range 0.05-0.15 mg/kg (adult 2.5-7.5mg) 12H.
0.25-1ml dilutd to 4ml 4-8H; severe a ack every Ivermec n. 0.15-0.4mg/kg (adult 12-24mg) oral
20min for 3 doses, then 4-6H. Aerosol 20mcg/ every 6-12 mo. Lice: 0.2mg/kg (adult 12mg)
pu: 2-4 pus 6-8H. Nasal: 84mcg/nostril 6-12H. oral, repeat a er 7 days.

392
 Drug Doses
Ixabepilone. 40mg/m IV over 3hr every 21 days Lansoprazole. 1.5mg/kg (max 30mg) 12-24H oral.
for median of 4 cycles. Vary dose with CYP3A4 Lanthanum carbonate. Adult (NOT/kg) 0.5-1g
inhibitors or inducers. 8H with meal.
Japanese encephali s vaccine (Je-Vax). Inac - Lapa nib. Adult, NOT/kg: 1.25g every day oral
vated. 0.5ml (1-3yr), 1ml (>3yr) SC stat, 7-14 days (plus capecitabine 2g/m/day on days 1-14 of a
later, and (op onally) 1mo later. Boost a er 1yr. repea ng 21 day cycle).
Kanamycin. Single daily dose IV or IM. Neonate: Laronidase. 0.58mg/kg IV once a week.
15mg/kg stat, then 7.5mg/kg (<30wk) 10mg/ L-asparaginase. See colaspase.
kg (30-35wk) 15mg/kg (term <1wk) daily. 1wk- Latanoprost. 50mcg/ml: 1drop/eye daily.
10yr: 25mg/kg day 1, then 18mg/kg daily.
Latanoprost 0.005% + molol 0.5%. 1drop per
>10yr: 20mg/kg day 1, then 15mg/kg (max
eye daily.
1.5g) daily. Trough level <5.0mg/L.
Laureth-9. Spider veins: inject 0.1-0.2ml of 0.5%
Ketamine. Seda on, analgesia: 2-4mg/kg
(10mg /2ml). Small varices: 0.1-0.3ml of 1%
IM, 4mcg/kg/min IV. Premed: 5mg/kg oral.
(20mg/2ml). Medium varices: 0.5-1ml of 3%
Anaesthesia: 5-10mg/kg IM, 1-2mg/kg IV, infsn
(60mg/2ml). Max 2mg/kg/day.
30mg/kg in 50ml 5%dex-hep at 1-4ml/hr (10-
40mcg/kg/min). Incompa ble with aminophyll Leflunomide. Adult (NOT/kg): 100mg daily x3,
ine, magnesium and salbutamol. then 20mg daily oral.
Ketoconazole. Oral: 5mg/kg (adult 200mg) Lenalidomide. Adult (NOT/kg): 10mg daily oral;
12-24H. 2% cream: apply 12-24H. 2% sham- or 25mg daily on days 1-21 of 28 day cycles.
poo: wash hair, apply liquid for 5min, wash o. Lenogras m (rHuG-CSF, Granocyte). 150mcg/m
Ketoprofen. 1-2mg/kg (adult 50-100mg) 6-12H daily SC or IV over 30min. Keep wbc count
(max 4mg/kg or 200mg in 24hr) oral, IM, PR. 5,000-10,000/mm.
Slow release, adults (NOT/kg): 200mg daily. Lepirudin. 0.4mg/kg IV stat, then 0.15mg/kg/hr
Ketorolac. Oral: 0.2mg/kg (adult 10mg) 4-6H (max (adjusted by APTT) for 2-10 days.
0.8mg/kg/day or 40mg/day). IV or IM: usually Lercanidipine. 0.2mg/kg (adult 10mg) daily oral,
0.2mg/kg (adult 10mg) 6H; but may use 0.6mg/kg incr to 0.4mg/kg (adult 20mg) daily if reqd.
(max 30mg) stat, then 0.2-0.4mg/kg (max 20mg) Letrozole. Adult (NOT/kg): 2.5mg daily oral.
4-6H for 5 days, then 0.2mg/kg (max 10mg) 6H. Leucovorin. See folinic acid.
Eye drops 0.5%: 1 drop 8H. Leuprorelin (GnRH or LHRH). 7.5mg depot mthly
Keto fen. Child >2yr (NOT/kg): 1mg 12H oral with IM; or microspheres 11.25mg SC every 3mo.
food. Adult (NOT/kg): 1-2mg 12H oral with food. Levamisole. Anthelmin c: 3mg/kg (adult
Labetalol. Oral: 1-2mg/kg (adult 50-100mg) 12H, 150mg) oral once (ascaris), repeat in 1wk
may incr wkly to max 10mg/kg (max 600mg) 6H. (hookworm). Adenocarcinoma colon (with
IV: 0.25-0.5mg/kg (adult 20mg) over 2min rpt 5-fluorouracil 450mg/m IV wkly): 1mg/kg
every 10min if reqd, then 0.25-3mg/kg/hr. (adult 50mg) 8H oral for 3 days every 2wk.
Lacidipine. 0.04-0.12mg/kg (adult 2-6mg) dly oral. Leve racetam. 10mg/kg (adult 500mg) 12H
Lactase. See lactase. oral, incr every 2-4wk to max 30mg/kg (adult
Lactulose. 3.3g/5ml soltn. Laxa ve: 0.5ml/kg 12- 1500mg) 12H if reqd.
24H oral. Hepa c coma: 1ml/kg hrly un l Levobetaxolol. 0.5% soltn: 1drop/eye 12H.
bowel cleared, then 6-8H. Levobunolol. 0.25%-0.5% soltn: 1drop/eye 12-24H.
Lamivudine. Neonate <30 days: 2mg/kg 12H Levobupivacaine. See bupivacaine.
oral. Child >30 days: 4mg/kg 12H oral. Adult Levocabas ne. 0.5mg/ml: 1drop/eye 6-12H max
<50kg: 2mg/kg 12H oral. Adult >50kg: 150mg 8wk, 2 sprays/nostril 6-12H max 8wk.
12H or 300mg daily oral. Hepa s b: 3-4 mg/ Levoce rizine. 2.5mg (6-11yr) 5mg (adult) dly
kg (max 100mg) daily oral. See also abacavir. Levodopa + benserazide (4:1). Adult (NOT/kg):
Lamivudine + zidovudine. 150mg/300mg tab. ini ally levodopa 100mg 8H oral; if not control
>12yr (NOT/kg): 1tab 12H oral. led, incr wkly by 100mg/day to max 250mg 6H.
Lamotrigine. 0.2mg/kg (adult 25mg) oral daily, Levodopa + carbidopa. 250mg/25mg and 100mg/
double dose every 2wk if reqd to max 1-4mg/ 10mg tabs. Adult (NOT/kg): ini ally one 100/10
kg (adult 50-200mg) 12H. Double dose if taking tab 8H oral; if not controlld, use one 250/25 tab
carbamazepine, phenobarbitone, phenytoin; for one 100/25 tab every 2nd day; if not controlld
halve dose if taking valproate. on 250/25 8H, incr by one 250/25 tab every 2nd
Lanreo de. 0.5-1.0mg/kg (adult 30mg) IM every day to max 6-8 tab/day.
2wk (adjust dose and frequency according to resp)

393
Drug Doses
Levofloxacin. 5-10mg/kg (adult 250-500mg) Lisinopril. 0.1mg/kg (adult 5mg) daily oral, may incr
12-24H oral or IV over 1hr. Eye 5mg/ml: 1drop over 4-6wk to 0.2-1mg/kg (adult 10-20mg) daily.
x8/day for 2 days, then 6H. Lithium (salts). 5-20mg/kg 8-24H oral. Slow rel tab
Levomepromazine. See methotrimeprazine. 450mg (adult, NOT/kg): 1-2 tab 12H. Maintain
Levomethadyl acetate. Adult (NOT/kg): usual trough 0.8-1.6mmol/L (>2mmol/L toxic).
star ng dose 20-40mg every 2-3 days oral. Lodoxamide. 0.1% soltn: 1 drop/eye 6H.
Levonorgestrel. Contracep on: 30mcg daily oral, Lofepramide. Adult: 70mg morning 70-140mg
star ng 1st day menstruatn. Intrauterine T-system nocte oral.
52mg: insert within 7 days of start of menstruatn, Lofexidine. 2-8mcg/kg (max 100-400mcg) 6-12H oral
replace a er 3yr. Lomefloxacin. 8mg/kg (adult 400mg) daily oral.
Levonorgestrel + oestradiol (7mcg/50mcg, Lomus ne (CCNU). 100-130mg/m oral every 6 wk
15mcg/45mcg per day) patch. Post-menopausal Loperamide. 0.05-0.1mg/kg (adult 2-4mg)8-12H
(NOT/kg): 1 patch per wk. oral, incr if reqd to max 0.4mg/kg (max 4mg) 8H
Levorphanol. 0.03-0.1mg/kg 12-24H oral or SC. Lopinavir + ritonavir. >2yr: 230/57.5 mg/m
Levosimendan. 0.3mg/kg (adult 0.15-0.3mg/kg) (max 400/100mg) 12H oral; with nevirapine or
in 6ml/kg 5%dex (no heparin) and give 1.5ml/ efavirenz 300/75mg/m (max 533/133mg) 12H
kg/hr for 10min (12.5mcg/kg), then 0.24ml/kg/ Loprazolam. (NOT/kg): 1mg (max 2mg) nocte oral
hr (0.2mcg/kg/min; adult 0.1-0.2mcg/kg/min) Loracarbef. 4-8mg/kg (max 200-400mg) 12H oral
for 24hr IV. Via CVC or peripheral IV;
Loratadine. 5mg (2-5yr), 10mg (>5yr) dly oral
compa ble only with frusemide or GTN.
Lorazepam. 0.02-0.06mg/kg (adult 1-3mg)
Levothyroxine sodium. See thyroxine.
8-24H oral. IV: 0.05-0.2mg/kg IV over 2min,
Lignocaine. IV: 1% soltn 0.1ml/kg (1mg/kg) over then 0.01-0.1mg/kg/hr.
2min, then 0.09-0.3ml/kg/hr (15-50mcg/kg/
Lormetazepam. Adult (NOT/kg): 0.5mg (max
min); or 30mg/kg in 50ml 5%dex-hep at 50ml/
hr for 2min, then 1.5-15ml/hr (15-50mcg/kg/ 1.5mg) nocte oral.
min). Nerve block: without adrenaline max Losartan. 0.5-2mg/kg (adult 25-100mg) dly oral.
4mg/kg (0.4ml/kg of 1%), with adrenaline Lovasta n. 0.4-0.8mg/kg (adult 20-40mg) 12-24H
7mg/kg (0.7ml/kg of 1%). Topical spray: max oral. Slow rel (adult, NOT/kg): 10-60mg nocte
3-4mg/kg (Xylocaine 10% spray pack: about Lovasta n + slow-release niacin (20/500mg,
10mg/pu). Topical 2% gel, 2.5% compound 20/750mg, 20/1000mg). 20mg/500mg at bed
mouth paint/gel (SM-33), 2% and 4% soltn, 5% me oral, incr if reqd every 4wk by 500mg
ointment, 10% dental ointment: apply 3H prn. niacin to max 40mg/2000mg.
Lignocaine 2.5% + prilocaine 2.5%. Cream (EMLA): Loxapine. 0.2-1mg/kg (max 10-60mg) 6-12H oral, IM
1.5g/10cm under occlusive dressing for 1-3hr Lubiprostone. Adult (NOT/kg): 24mcg 12-24H
Lincomycin. 10mg/kg (adult 600mg) 8H oral, IM oral with food.
or IV over 1hr. Severe in n: 15-20mg/kg (adult Lumefantrine (benflumetol). See artemether.
1.2g) IV over 2hr 6H. Lumiracoxib. Adult, NOT/kg: 100mg daily oral.
Lindane. 1% cream, lo on. Scabies: apply neck Lutropin alfa (luteinising hormone. Adult
down, wash o a er 8-12hr. Lice: rub into hair for (NOT/kg): 75iu daily SC, with 75-150iu FSH
4min, then wash o; rpt a er 24hr (max x2/wk). Lymecycline. 408mg = 300mg tetracycline base.
Linezolid. 10mg/kg 8-12H (child) or 400-600mg Adult (NOT/kg): 408mg 12H oral.
12H (adult), IV over 1-2hr or oral. Lymphocyte immune globulin. See immuno-
Linoleic acid. See fa y acids. globulin, lymphocyte immune.
Liothyronine sodium (T3). Oral: 0.2mcg/kg Lypressin (lysine-8-vasopressin). 1 spray (2.5iu)
(adult 10mcg) 8H, may incr to 0.4mcg/kg (adult into 1 nostril 4-8H, may incr to 1 spray both
20mcg) 8H. IV: 0.1-0.4mcg/kg (adult 5-20mcg) nostrils 4-8H.
8-12H. Sep c shock: 0.1-0.2mcg/kg/hr (adult Lysuride. Migraine: 0.5mcg/kg (adult 25mcg) 8H
100-200mcg/day) IV infsn. oral. Parkinsons, adults (NOT/kg): 0.2mg dly, incr
Liotrix. Liothyronine (T3) + thyroxine (T4) mixture. by 0.2mg daily each wk to max 1.6mg 8H oral.
Lipase, lipoly c enzymes. See pancrea c enzymes. Macrogol 3350, 105g/L. 2-11yr 6.563g in 60ml
Lipid. 20%: 1-3g/kg/day IV (ml/hr = g/kg/day x water, >11yr 13.125g in 125ml water: 1 sachet dly
Wt x 0.21). oral, incr to 2-3/day if reqd. Faecal impactn >2yr:
Lisdexamphetamine dimesylate. NOT/kg. one 13.125g sachet in 125ml water per 5kg body
6-12yr: 30mg daily oral, incr over 2-3wk to max wt (adult 8 sachet) consumed in <6hr (max 3 days
70mg daily. therapy). See also colonic lavage.

394
 Drug Doses
Macrogol 400 (polyethylene glycol) 1% + tet- Meclizine. See meclozine.
rahydrozoline 0.05%. 1 drop/eye 8-12H. Meclofenamate. 1-2mg/kg (adult 50-100mg)
Mafenide acetate. 8.5% cream: apply 2mm 6-8H oral.
layer 12-24H. 5% soltn: apply 4-8H to keep Meclozine. 0.5-1mg/kg (adult 25-50mg) 12-24H oral.
dressings wet. Mecysteine. Adult (NOT/kg): 200mg 8-12H oral.
Maggots of Lucilia sericata, sterile. Packs: Medroxyprogesterone. Adult (NOT/kg): 5mg
standard (for std wound), boot (toe, amputatn dly for 5-10 days per mth oral; precoc. puberty
stump), boot (foot), sleeve (limb wound). 5-10mg dly; to achieve amenorrhoea 10-20mg
Change maggots a er 3 days; sooner if reqd. dly; uterine hge 60mg dly reducing over 10 d to
See www.ZooBioc.co.uk/products-LarvE.htm 10mg; malignancy 0.5g dly IM or oral for 4wk,
Magnesium chloride 10%. 0.48g/5ml = Mg then 1g wkly. Depot contracep ve: 150 mg
1mmol/ml. 0.4ml/kg 12H slow IV. Myoc infarct deep IM during 1st 5 days of cycle, then repeat
(NOT/kg): 5ml/hr IV for 6hr, then 1ml/hr for every 12wk. See also conjugated oestrogens.
24-48hr. VF: 0.1-0.2ml/kg IV. Medroxyprogesterone + oestradiol (2.5mg/
Magnesium hydroxide. Antacid: 10-40mg/kg 1mg, 5/0.625, 5/1, 5/2) tabs. 1 tab daily oral.
(max 2g) 6H oral. Laxa ve: 50-100mg/kg Medroxyprogesterone 10mg tab + oestradiol
(max 5g) oral. See also aluminium hydroxide + 4mg patch. NOT/kg: 10mg tab daily oral for first
magnesium hydroxide + simethicone. 10-14 days of each 28 day cycle, and 4mg
Magnesium sulphate 50% (2mmol/ml). patch x2/wk con nuously.
Deficiency: 0.2ml/kg (max 10ml) 12H IM, slow IV. Medrysone. 1% soltn: 1 drop/eye 6-12H.
Asthma, digoxin tachycardia, eclampsia, prem Mefenamic acid. 10mg/kg (adult 500mg) 8H oral.
labour, pul ht: 0.1ml/kg (50mg/kg) IV over 20min, Mefloquine. 15mg/kg (adult 750mg) stat, then
then 0.06 ml/kg/hr (30 mg/kg/hr); keep serum 10mg/kg (adult 500mg) a er 6-8hr.
Mg 1.5-2.5mmol/l (pul ht 3-4mmol/l). Myocardial Prophylaxis: 5mg/kg (adult 250mg) wkly.
infarct (NOT/kg): 2.5 ml/hr (5mmol/hr) IV for
Mefruside. 0.5-1mg/kg (up to 2mg/kg for 3 d) dly
6hr, then 0.5ml/hr (1mmol/hr) for 24-48hr. VF:
10-14 d, then 0.5-1mg/kg (25-50mg) every 2-3 d.
0.05-0.1ml/kg (0.1-0.2mmol/kg) IV. Incompa ble
with aminophylline, ketamine, salbutamol. Megestrol acetate. NOT/kg: 80mg/dose 12H oral.
Laxa ve: 1ml/kg = 0.5g/kg (max 15g) as 10% soltn Meglumine an monate. Soltn 85mg/ml of
8H for 2 days oral. pentavalent an mony. Same dose as sodium
Malathion. See maldison. s bogluconate, deep IM.
Maldison. 0.5% liq: 20ml to hair, wash o a r 12hr. Melatonin. Usu. 0.1mg/kg (adult 6mg) nocte oral.
Mannitol. 0.25-0.5g/kg IV (2-4ml/kg of 12.5%, Meloxicam. 0.15-0.3mg/kg (max7.5-15mg) dly oral, PR
1.25-2.5ml/kg of 20%, 1-2ml/kg of 25%) 2H Melphalan. Usu. 6mg/m dly x5, rpt every 6wk.
prn, if serum osmolality <320-330mmol/L. Meman ne. Adult (NOT/kg): 5mg daily oral, incr
Mapro line. 0.15-1mg/kg (max 10-50mg) 8-24H oral. by 5mg wkly to max 10mg 12H.
Maraviroc. Adult (NOT/kg): 150mg (with strong Menapthone sodium bisulphite (vitamin K3).
CYP3A inhibitors, incl protease inhibitors), (Menadione, menadiol). NOT/kg: 5-10mg x1-2/
300mg (with pranavir or ritonavir), 600mg wk (infant) 10mg daily (child) 10mg 8H (adult) oral.
(with CYP3A inducers, incl efavirenz) 12H oral. Mitochondrial dis (all ages, not/kg): 10mg 6H oral.
Marimastat.(NOT/kg): 5-25mg (usu. 10mg) 12H oral Meningococcus gp A, C, W135, Y vaccine
Mazindol. (NOT/kg): 0.5mg dly oral, up to 3mg dly (Mencevax ACWY, Menomune). Inac ve. >2yr:
Measles vaccine (Attenuvax). Live. >12mo: 0.5ml SC x1 ml SC. Boost 1-3yrly.
Measles + mumps vaccine (Rimparix). Live. Meningococcus gp A, C, W135 and Y conjugated
>12mo: 0.5ml SC once. vaccine (Menactra). Inac vated. >10yr: 0.5ml IM.
Measles + mumps + rubella vaccine (MMRII, Meningococcus gp C, conjugate vaccine (Men-
Priorix). Live. >12mo: 0.5ml SC. ingitec, Menjugate, NeisVac-C). Inac vated.
0.5ml IM: 3 doses 1-2mo apart (6wk-6mo), 2
Mebendazole. NOT/kg: 100mg 12H x3 days.
doses (6-12mo), 1 dose (>12mo).
Enterobiasis: 100mg once, may rpt a er 2-4wks.
Mepivacaine. Max dose 5-7mg/kg.
Mebeverine. 135mg tab: (NOT/kg) 1-3 tab dly oral
Meprobamate. 5-10mg/kg (max 800mg) 8-12H oral.
Mebhydrolin. 1-2mg/kg (max 50-100mg) 8-12H oral
Meptazinol. 4mg/kg (adult 200mg) 3-6H oral.
Mecamylamine. 0.05mg/kg (adult 2.5mg) 12H
oral; may incr to max 0.5mg/kg (25mg) 6H oral. Mepyramine. 2-4mg/kg (adult 100-200mg) 8H oral.
Mecasermin. 40-80mcg/kg (max 120mcg/kg) 12H SC. Mequitazine. 0.1mg/kg (adult 5mg) 12H oral.
Mechlorethamine. See mus ne HCl. Mercaptamine. See cysteamine.

395
Drug Doses
Mercaptopurine (6MP). 75-100mg/m daily oral. Methotrexate. Leukaemia: typically 3.3mg/m
Meropenem. 10-20mg/kg (adult 0.5-1g) 8H IV IV dly for 4-6wk; then 2.5mg/kg IV every 2wk,
over 5-30min. Severe in n: 20-40mg/kg (adult 1- or 30mg/m oral or IM x2/wk; higher doses with
2g) 12H (1st wk life) 8H (>1wk) or constant infsn. folinic acid rescue. Intrathecal: 12mg/m wkly for
Mesalazine (Mesalamine). Usu. high ini al dose, 2wk, then mthly. Arthri s: 10-20mg/m wkly oral,
lower maintenance. Mesasal, Salofalk: 15-20mg/kg IV, IM or SC. Adult psoriasis: 0.2- 0.5mg/kg wkly
(adult 500mg) 8H, decr to 10mg/kg (adult 250mg) oral, IV or IM un l response, then reduce.
8H oral. Adult, NOT/kg: 0.4-1.6g 8H (Asacol, Coltec); Methotrimeprazine. 0.25-1mg/kg (adult 12.5-50
0.5-1g 6H (Pentasa, ethyl-cellulose coat) 6H oral; 2-4 mg) 6-8H oral, IM, IV. Up to 1g/d severe psychosis
tab daily (Lialda, delayed-release 1.2g tab) oral. Methoxamine. 0.1-0.4mg/kg (adult 5-20mg) IM,
or 6mo. Suppos: 0.5-1g 8H. Enema: 1-4g nocte. or 0.1-0.2 mg/kg (adult 5-10mg) IV over
Mesna. IV over 30min: 20% of cyclophospha- 5-10min (at least 15min between doses).
mide or ifosfamide dose at 0, 4 and 6 hr. Oral: Nose drop 0.25%: 1-3drop/nostril 6-12H.
40% of dose of cytotoxic at -2, 2 and 6hr. Methoxsalen. Adult (NOT/kg): 20mg 2hr bef UV
Nebuliser: 0.6-1.2g (NOT/kg) 4-6H. exposure. 1% lo on: wkly bef 1min of UV light.
Mesoridazine. Oral: 0.25-3mg/kg (adult 25-150mg) Methscopolamine. See hyoscine methobromide.
8H. IM: 0.5mg/kg (adult 25mg, max 200mg/day). Methsuximide. 5mg/kg (adult 300mg) dly, may
Mesterolone. 0.5mg/kg (adult 25mg) 6-12H oral. incr to max 10mg/kg (adult 400mg) 8-12H oral.
Mestranol 50mcg + norethisterone 1mg. Methyl aminolevulinate. See Aminolevulinic acid.
Contracep on: 1 tab daily from 5th to 25th day Methyclothiazide. 0.05-0.2mg/kg (adult 2.5-
of menstrual cycle. 10mg) daily oral.
Metaproterenol. See orciprenaline. Methylcellulose. Cons pa on: 30-60mg/kg
Metaraminol. IV: 0.01mg/kg stat (repeat prn), (adult 1.5-3g) with at least 10ml/kg (adult
then 0.15 mg/kg in 50ml 5% dextrose (no 300ml) fluid 12H oral. Obesity: 30mg/kg (adult
heparin) at 1-10ml/hr (0.05-0.5 mcg/kg/min) 1.5g) with 5ml/kg water hr before a meal.
and trate dose against BP. SC: 0.1mg/kg. Methylcysteine. 4mg/kg (adult 200mg) 6-12H oral.
Metaxalone. 15mg/kg (max 800mg) 6-8H oral. Methyldopa. 3mg/kg (adult 150mg) 8H oral,
Me ormin. Adult (NOT/kg): ini ally 500mg 8-24H may incr to max 15mg/kg/dose (adult 750mg).
oral, max 1g per dose 8H. See also glibenclamide. Methyldopate. 5-20mg/kg (adult 0.25-1g) 6H
Methacycline. NOT/kg: 150mg (>8y) 300mg IV over 1hr.
(>12y) 12H oral. Methylene blue. 1-2mg/kg (G6PD deficiency
Methadone. 0.1-0.2mg/kg (adult 5-10mg) 0.4mg/kg) IV prn. Sep c shock: 2mg/kg stat IV,
6-12H oral, SC, IM. then 0.25-2mg/kg/hr.
Methamphetamine. See methylamphetamine. Methylergometrine. Adult (NOT/kg): 200mcg IM,
Methazolamide. 1-2mg/kg (adult 50-100mg) IV over 5min, or oral; may rpt in 2hr, then 4-6H.
8-12H oral Methylergonovine. See methylergometrine.
Methdilazine. 0.1-0.3mg/kg (adult 4-16mg) Methylphenidate. 0.1mg/kg oral 8am, noon and
12-24H oral (occasionally) 4pm; incr if reqd to max 0.5mg/
Methenamine hippurate / mandelate. See hexamine. kg/dose (adult 20mg). Long ac ng: 20-60mg
Methenolone. (NOT/kg). Oral: 5-10mg 12H (18-54mg in US) in morning. Transdermal
IM: 100mg every 1-2wk or 200mg every 2-3wk patch: apply for up to 9hr; start with 12.5cm,
(carcinoma); 50-100mg every 2wk, then every and incr to 18.75cm, 25cm, 37.5cm if rqd.
3-4wk (osteopor). Methylprednisolone. Asthma: 0.5-1mg/kg 6H
Methimazole. 0.3-1mg/kg (adult 20-60mg) dly oral, IV or IM day 1, 12H day 2, then 1mg/kg
oral, reducing to 0.1-0.5mg/kg (adult 5-30mg) dly. daily, reducing to minimum eec ve dose. Severe
Methionine. 50mg/kg (max 2.5g) oral 4H for 4 croup: 4mg/kg IV stat, then 1mg/kg 8H. Severe
doses. Prophylaxis: 1mg to paracetamol 5mg. sepsis before an bio cs (or within 4hr of 1st
dose): 30mg/kg IV once. Spinal cord injury (within
Methocarbamol. Oral: 30mg/kg (adult 1.5g) 6H
8hr): 30mg/kg stat, then 5mg/kg/hr 2 days. Lo on
for 3 d, then 15-20mg/kg (adult 0.75-1g) 6-8H. IV
0.25%: apply sparingly 12-24H. Methylpred 1mg
over 5-10 min or IM: 15mg/kg (adult 750mg) 6H.
= hydrocor sone 5mg in glucocor coid ac vity,
Methohexital. See methohexitone. 0.5mg in mineralocor coid.
Methohexitone. 1-2mg/kg (adult 50-120mg) slow IV Methylprednisolone aceponate. 0.1% cream,
Methoin. 1mg/kg (adult 50mg) dly oral, may incr by ointment: apply 12-24H.
1mg/kg each wk to max 10mg/kg (adult 600mg) dly Methyltestosterone. 2.5-12.5mg/day buccal.

396
 Drug Doses
Methysergide maleate. 0.02mg/kg (adult 1mg)12H Miglitol. (NOT/kg): 25mg 8-24H incr over 3-6mo to
oral, incr to max 0.04mg/kg (adult 2mg) 8H for 3-6mo usu. maintenance dose 50mg (max 100mg) 8H oral
Me pranolol. 0.1%, 0.3%, adult: 1 drop/eye 12H. Milrinone. <30kg: 1.5mg/kg in 50ml 5%dex-hep,
Me rosine. 5-20mg/kg (adult 0.25-1g) 6H oral. 2.5ml over 1hr (75mcg/kg), then 1-1.5 ml/hr
Metoclopramide. 0.15-0.3mg/kg (adult 10-15mg) (0.5-0.75mcg/kg/min). >30kg: 1.5mg/kg made up
6H IV, IM, oral; 0.2-0.4mg/kg (adult 10-20mg) 8H to 100ml in 5%dex-hep, 5ml over 1hr (75mcg/kg),
PR. Periop: 0.5 mg/kg (adult 15-20mg) IV stat, then 2-3ml/hr (0.5-0.75mcg/kg/min).
then 0.2mg/kg (adult 10mg) 4-6H if reqd. With Mineral mixture (Aminogram). <5.5kg: 1.5g/kg
chemotherapy: up to 1-2mg/kg 4H IV. daily oral, mixed with feed. >5.5kg: 8g dly
Metocurine iodide. ICU: 0.4mg/kg IV prn. Theatre: Mineral oil. See paran liquid.
0.1-0.4 mg/kg stat, then 0.01-0.02mg/kg/dose. Minocycline. Over 8yr: 4mg/kg (max 200mg) stat,
Metolazone. 0.1-0.2mg/kg (adult 5-10mg) dly oral. then 2mg/kg (max 100mg) 12H oral or IV over 1hr.
Up to 0.5mg/kg (adult 30mg) dly short term. Sustained rel tabs (NOT/kg): 45mg (45-59kg),
Metoprolol. IV: 0.1mg/kg (adult 5mg) over 5 min, 90mg (60-89kg), 135mg (90kg or more) dly oral.
rpt every 5 min to max 3 doses, then 1-5mcg/kg/ Minoxidil. 0.1mg/kg (max 5mg) daily, incr
min. Oral: 1-2mg/kg (adult 50-100mg) 6-12H. to max 0.5mg/kg (max 25mg) 12-24H oral.
Metronidazole. 15mg/kg (max 1g) stat, then Mirtazapine. 0.3-1mg/kg (adult 15-60mg) dly oral.
7.5mg/kg (max 1g) 12H in neonate (1st maint. Misoprostol (PGE1 analogue). 5mcg/kg (max
dose 48hr a er load if <2kg, 24hr in term baby), 200mcg) 4-6H oral. See also mifepristone.
8H (4+ wk) IV, PR or oral. Giardiasis: 30mg/kg Mitomycin-C. 2mg/m IV daily x10 days, repeat
(adult 2g) dly x3 oral. Amoebiasis: 15mg/kg (adult only if wbc >3000/mm + platelets >75,000.
750-800mg) 8H oral x 10 d, then diloxanide furoate Mitotane. 10-80mg/kg (adult 0.5-4g) 6H oral.
10mg/kg (adult 500mg) 8H oral x 10 d. C.dicile: Mitozantrone (Mitoxantrone). Breast cancer,
10mg/kg (adult 500mg) 8H oral. Topical gel 0.5%: lymphoma: 10-14mg/m IV over 10min every 3wk.
apply dly. Level 60-300umol/ml (x0.17mcg/ml). Leukaemia: 10-12mg/m IV over 10min dly x 3-5 d
Metyrapone. Diagnosis: 15mg/kg (min 250mg) 4H Mivacurium. 0.15mg/kg stat, then 0.1mg/kg/
x6 dose oral. Cushing: 1-20mg/kg (max 1g) 4H. dose IV. Infsn: 5-15mcg/kg/min.
Mexile ne. IV infsn: 2-5mg/kg (max 250mg) over Mizolas ne.(NOT/kg): slow rel tab, 10mg dly oral
15 min, then 5-20mcg/kg/min (max 250mg/hr). Moclobemide. 2-3mg/kg (adult 50-150mg) 6-12H oral
Oral: 8mg/kg (max 400mg) stat, then 4-8mg/kg
Modafinil. 2-4mg/kg (adult 100-200mg) 12H oral.
(max 400mg) 8H star ng 2hr a er loading dose.
Adult (NOT/kg): 200mg morng (obs sleep apnoea),
Mezlocillin. 50mg/kg 6-8H (1st wk life), 4-6H (2+ 1hr before shi (night work sleep disorder) oral.
wk) IM or IV. Serious in n: 60mg/kg (max 3g) 4H.
Moexipril. 0.15-0.2mg/kg (adult 7.5-10mg) 8-24H oral
Mianserin. 0.2-0.5mg/kg (adult 10-40mg) 8H oral.
Molindone. 0.1-1.5mg/kg (adult 50-75mg) 8H oral.
Micafungin. 3mg/kg (adult 50-150mg) dly IV over
Molgramos m. 5-10mcg/kg dly SC or IV over 6hr.
1hr. Prophylaxis: 1mg/kg (adult 50mg) dly IV over 1hr.
Mometasone. 0.1% cream or oint: apply daily.
Miconazole. 7.5-15mg/kg (adult 0.6-1.2g) 8H IV over
50mcg spray: adult 2 sprays/nostril daily.
1hr. Topical: 2% cream, powder, lotion, tincture, gel
12-24H. Vaginal: 2% cream or 100mg ovule dly x7. Montelukast. NOT/kg: 4mg (2-5yr) 5mg (6-14yr)
10mg (>14yr) daily at bed me, oral.
Microlax enema. <12mo 1.25ml, 1-2yr 2.5ml, >2yr 5ml.
Moracizine. 4-6mg/kg (adult 200-300mg) 8H oral.
Midazolam. Seda on: usually 0.1-0.2mg/kg
(adult 5mg) IV or IM, up to 0.5mg/kg used in Moroctogog alfa. Recombinant human factor 8;
children; 0.2mg/kg (repeated in 10min if reqd) see Factor 8.
nasal; 0.5 mg/kg (max 20mg) oral. Infusion Morphine. / life 2-4 hr. IM: neonat 0.1mg/kg, child
(ventltd): 3mg/kg in 50ml 5%dex-hep at 1-4ml/ 0.1-0.2 mg/kg, adult 10-20mg; / this IV over 10 min.
hr (1-4mcg/kg /min); fi ng usually 2-4 ml/hr IV (ventltd): 0.1-0.2mg/kg/dose (adult 5-10mg).
(range 1-24ml/hr); 1mg = 2-3mg diazepam. Infsn of 1mg/kg in 50ml 5%dex-hep: ven lated
Midodrine. 0.06mg/kg (adult 3mg) morning neonat 0.5-1.5 ml/hr (10-30mcg/kg/hr), child/adult
and 4-6pm oral, incr gradually if required to 1-4ml/hr (20-80mcg/kg/hr). Pa ent controlled:
max 0.2-0.4mg/kg (adult 10-20mg) morning, 20mcg/kg boluses (1ml of 1mg/kg in 50ml)
noon, and late a ernoon (not a er 6pm). with 5min lockout me + (in child) 5mcg/kg/hr.
Oral double IM dose; slow release: start with
Mifepristone. Termina on (NOT/kg): 200-600mg
0.6mg/kg 12H and incr every 48hr if reqd.
oral once, then if abor on incomplete
gemeprost 1mg PV or misoprostol 400mcg Morrhuate sodium. Adult (NOT/kg): 50-250mg
oral or misoprostol 800mcg PV in 48hr. per injtn.

397
Drug Doses
Moxifloxacin. 10mg/kg (adult 400mg) daily oral. Naproxen. 1mg = 1.1mg naproxen sodium. >2yr:
0.5% ophthalmic: 1 drop/eye 8H for 7 days. 5-10mg/kg (adult 250-500mg) 8-12H oral.
Moxisylyte. Adult (NOT/kg): 40-80mg 6H oral. Adult: 500mg 12H PR.
Moxonidine. 4mg/kg (adult 200mg) 8-24H oral. Naratriptan. 0.05mg/kg (adult 2.5mg), may rpt aftr 4hr
Mumps vaccine (Mumpsvax). Live. >12mo: 0.5ml Natalizumab. Adult (NOT/kg): 300mg IV over
SC once. See also measles, mumps, rubella vacc. 1hr every 4wk.
Mupirocin. 2% ointment: apply 8-12H. Nateglinide. Adult (NOT/kg): 60-120mg 8H oral.
Muromonab-CD3 (Orthoclone OKT3). 0.1mg/kg Nebivolol. 0.1mg/kg (adult 5mg) daily oral, incr
(adult 5mg) daily for 10-14 days IV over 1min. to max 1mg/kg (adult 40mg) daily.
Mus ne HCl (nitrogen mustard). 0.1mg/kg IV Nedocromil. Inhltn: 4mg (2 pus) 6H,
daily for 3-4 days. Hodgkins: 6mg/m IV. reducing to 12H when improved. 2% eye
Mycophenolate mofe l. 600mg/m 12H oral. drops: 1 drop/eye 6-24H.
Nabilone. Adult: 1mg 12H, up to 2mg 8H oral. Nefazodone. 1mg/kg (adult 50 mg) 12H oral, incr
Nabumetone. 10-20mg/kg (adult 0.5-1g) 12-24H oral by 1mg/kg/dose (adult 50mg) each wk to 4-6mg/
kg (adult 200-300mg) 12H. Slow rel: dly dose.
Nadolol. 1-5mg/kg (adult 40-240mg) daily oral.
Nefopam hydrochloride. Oral: 0.5-2mg/kg
Nadroparin. Venous thrombosis: 90an -XaU/kg
(adult 30-90mg) 8H. IM: 0.4mg/kg (adult
12H SC. Prophylaxis: genrl surgery 2850an -XaU
20mg), may rpt in 6hr.
(adult, NOT/kg) daily SC; orthopaedics 40an -XaU
/kg 24H (start 12hr pre-surgery) SC, then 55 an - Neisseria meningi dis vaccine.
XaU/kg daily. Haemodialysis: 65an -XaU/kg into See meningococcal vaccine
arterial line at start 4hr session. Nelarabine. Child: 650mg/m IV over 1hr dly
Nafarelin. Adult: 200mcg spray to 1 nostril 12H. x 5 d; rpt every 21 days. Adult: 1500mg/m IV
over 2hr on days 1, 3 and 5; rpt every 21 days.
Nafcillin. Oral: 15-30mg/kg 6H. Severe in n
(slow IV, IM): 40mg/kg (max 2g) 12H (1st wk Nelfinavir. Infant 40-75mg/kg 12H oral, child
life), 8H (2nd wk), 6H or constant infsn (>2wk). 50-60mg/kg 12H, adult 750mg 8H or 1250-
1500mg 12H.
Na ifine. 1% cream, gel: apply daily.
Neomycin. 1g/m 4-6H oral (max 12g/day).
Na idrofuryl. 2-4mg/kg (adult 100-200mg) 8H
Bladder washout: 40-2000mg/L. See also
(oral) or 12H (IM, or IV or IA infsn over 2hr).
colis n; dexamethasone; gramicidin.
Nalbuphine. 0.2-0.5mg/kg (adult 20-30mg) 3-6H
Neomycin 0.5% + prednisolone sodium
SC, IM or IV. Anaesthesia: 0.3-1mg/kg IV over
phosphate 0.5%. 1 drop/eye 4-6H.
15min, then 0.2-0.5mg/kg every 30min.
Neos gmine. Reverse relaxants: 0.05-0.07
Nalidixic acid. 15mg/kg (adult 1g) 6H oral, reduc-
mg/kg (adult 0.5-2.5mg) IV; suggested dilutn:
ing to 7.5mg/kg (adult 500mg) 6H a er 2wk.
neos gmine (2.5mg/ml) 0.5ml + atropine (0.6mg
Nalmefene. Opiate intoxica on: 0.007mg/kg IV, /ml) 0.5ml + saline 0.5ml, give 0.1ml/kg IV.
and 0.0014 mg/kg a er 2-5min (15min if IM, Myasthenia gravis: 0.2-0.5mg/kg (adult 1-
SC) if reqd. Postop sedtn: 0.25mcg/kg every 2.5mg) 2-4H IM, SC.
2-5min (max 4 doses). Half life 10hr.
Nesiri de. 2mcg/kg IV, then 0.01mcg/kg/min
Naloxone. Postop sedatn: 0.002mg/kg/dose (range 0.005-0.03mcg/kg/min).
(0.4mg dilutd to 20ml, give 0.1ml/kg/dose) rpt
Ne lmicin. IV or IM. 1wk-10yr: 8mg/kg day1, then
every 2min x4 if reqd, then 0.3mg/kg in 30ml
6mg/kg dly. >10yr: 7mg/kg day 1, then 5mg/kg
5%dex-hep at 1ml/hr (0.01 mg/kg/hr) IV.
(max 240-360mg) dly. Neonate: 5mg/kg dose:
Opiate overdose (including newborn): 0.01 mg/kg
<1200g 48H (0-7 days of life), 36H (8-30 days),
(max 0.4mg) (0.4mg dilutd to 10ml, give 0.25ml/kg
24H (>30 days); 1200-2500g 36H (0-7 days of life),
/dose), rpt every 2min (15min if IM or SC) x4 if
24H (>7 days); term 24H (0-7 days of life), then as
reqd, then 0.3mg/kg in 30ml 5%dex-hep at 1ml/hr
for 1wk-10yr. Trough level <1.0mg/L.
(0.01mg/kg/hr) IV.
Nevirapine. Child: 120mg/m daily for 2wk oral,
Naltrexone. 0.5mg/kg (adult 25mg) stat, then
then 150-200mg/m daily for 2wk, then 12H
1mg/kg (adult 50mg) daily oral. Adult (NOT/
if no rash. Adult (NOT/kg): 200mg daily for
kg): 380mg every 4wk IM.
2wk, than 12H oral if no rash.
Nandrolone decanoate. Anaemia: 1-4mg/kg
Niacin + lovasta n. See lovasta n + niacin.
(adult 50-200mg) wkly deep IM. Osteoporsis:
adult (NOT/kg) 50mg deep IM every 3wk. Niacin + simvasta n (500mg/20mg, 750/20,
Naphazoline. 0.012-0.1%: 1-2drop/nostril, 1000/20). Adult (NOT/kg): 500mg/20mg nocte
1 drop/eye 3-4H. oral, incr by 500mg every 4wk to max 2000/40mg.

398
 Drug Doses
Nicardipine. 0.4-0.8mg/kg (adult 20-40mg) 8H Nonacog alfa (Recombinant human factor 9).
oral. 1-3mcg/kg/min (max 20mg/hr) IV. See factor 9.
Niclosamide. 50mg/kg (adult 2g) oral. Noradrenaline. 0.15mg/kg in 50ml 5%dex-hep
Nico namide. 4% gel: apply sparingly 12-24H at 1-10ml/hr (0.05-0.5mcg/kg/min). Flow
Nicorandil. 0.1-0.6mg/kg (adult 5-30mg) 12H oral. <2ml/h may cause swings in BP.
Nico ne inhaler. 10mg cartridges. Adult: inhale 6 - Norepinephrine. See noradrenaline.
12 cartridges/day x 3mo, then reduce over 6-8wk. Norethisterone (Norethindrone). Contraceptn:
Nico ne resin chewing gum. NOT/kg: 2-4mg 350mcg dly, start 1st day menstruatn; or 200mg
chewed over 30min when inclined to smoke; oily soltn IM in 1st 5d of cycle, rpt once a r 8wk.
usually need 16-24mg/day, max 60mg/day. Menorrhagia: 10mg 3H un l hge stops, then 5mg
Nico ne transdermal patches. Usu. 21mg, 6H x 1wk, then 5mg 8H x 2wk; or 5mg 8-12H on
14mg, and 7mg per 24hr. Adult: if smoked day 19-26 cycle.
>20cig/day apply strongest patch dly 3-4wk, Norfloxacin. 10mg/kg (adult 400mg) 12H oral.
medium patch dly 3-4wk (ini al dose if smoked Normacol granules. 6mo-5yr half teasp 12H,
<=20cig/day), then weakest patch dly 3-4wk. 6-10yr 1 teasp 12H, >10yr 1 teasp 8H.
Nico nic acid. Hypercholesterolaemia and Nortriptyline. 0.5-1.5mg/kg (adult 25-75mg) 8H oral
hypertriglyceridaemia: 5mg/kg (adult 200mg) 8H, Noxythiolin. 1-2.5% soltn into body cavity 12-24H,
gradually incr to 20-30mg/kg (adult 1-2g) 8H oral. left at least 30min. Max dly dose 200mg/kg (max 10g)
Nico nyl alcohol tartrate. Adult (NOT/kg): 25-50 NTBC (nitro-trifluoromethylbenzoyl
mg 6H, slow release tab 150-300mg 12H oral. cyclohexanedione). 0.5mg/kg 12H oral.
Nicoumalone. 0.2mg/kg (adult 10mg) day 1, Nysta n. 100,000u <12mo, 500,000u (1 tab)
0.12m/kg (adult 6mg) day 2, then 0.02- >12mo 6H NG or oral. Prophylaxis 50,000u
0.25mg/kg (adult 1-12mg) dly oral. INR 2-2.5 <12mo, 250,000u >12mo 8H.
for prophylaxis, 2-3 for treatment. Topical: 100,000u/g gel, cream,ointment 12H.
Nifedipine. Caps 0.25-0.5mg/kg (adult 10-20mg) Vaginal: 100,000u 12-24H. See also gramicidin
6-8H, tabs 0.5-1mg/kg (adult 20-40mg) 12H + neomycin + nysta n + triamcinolone cream
oral or sublingual. and ointment.
Nilo nib. Adult (NOT/kg): 400mg 12H oral. Octocog alfa (Recombinant factor 8). See Factor 8.
Nilutamide. Adult (NOT/kg): 300mg daily oral for Octreo de. Diarrhoea: 1mcg/kg (adult 50mcg)
4wk, then 150mg daily. 12-24H SC, may incr to 10mcg/kg (adult
Nimodipine. 10-15mcg/kg/hr (adult 1mg/hr) IV 250mcg) 8H. IV: 1mcg/kg stat, then 1-5mcg/
for 2hr, then 10-45mcg/kg/hr (adult 2 mg/hr). kg/hr. Chyle: 5mcg/kg/hr IV.
Adult: 60mg 4H oral. Acromegaly (NOT /kg): 0.05-0.1mg 8-12H SC
Nisoldipine. Slow rel: 0.2 mg/kg (adult 10mg) dly incr if reqd to max 0.5mg 8H for 4wk, then
oral, incr to 0.4-0.8mg/kg (adult 20-40mg) dly. slow 20mg (10-30mg) every 4wk deep IM.
Nitazoxanide. 100mg (12-47mo) 200mg (4- Oestradiol. NOT/kg. Oesteoporosis: every wk
11yr) 500mg (>11yr) 12H for 3 days oral. apply a patch releasing 12.5mcg/day.
Induc on puberty: 0.5mg alternate days oral,
Nitrazepam. Child epilepsy: 0.125-0.5mg/kg 12H
incr over 2-3yr to 2mg/day (add progestogen
oral. Hypno c (NOT/kg): 2.5-5mg (child) 5- for 14 days/mo when dose 1.5mg/day or
10mg (adult) nocte. when bleeding occurs).
Nitric oxide. 1-40ppm (up to 80ppm used Tall stature: 12mg/day oral un l bone age
occasionally). 0.1 L/min of 1000ppm added to >16yr (add progestogen for 14 days/ cycle).
10 L/min gas gives 10ppm. [NO] = Cylinder Gonadal failure: 2mg/day oral (add progestogen
[NO] x (1 - (Pa ent FiO2 / Supply FiO2)). [NO] = for 14 days/cycle).
Cylinder [NO] x NO flow / Total flow. Oestriol. Induc on puberty: 0.25 mg/day incr to
Nitrofurantoin. 1.5mg/kg (adult 50-100mg) 6H oral. 2mg/day (+ progestogen 12d/cycle) oral.
Prophylaxis: 1-2mg/kg (adult 50-100mg) nocte Epiphyseal maturatn: 10mg/d (+ progestogen
Nitrofurazone. 0.2% cream, soltn: apply every 1-3d 12d/cycle). Vaginal: 0.5mg dly, reducing to x2/wk.
Nitrogen mustard. See mus ne HCl. Oestrone. Hypogonadism: 1.25-7.5mg dly oral.
Nitroglycerine. See glyceryl trinitrate. Oestropipate. Adult (NOT/kg): 0.625-7.5mg dly
Nitroprusside. See sodium nitroprusside. start 1st day menstrua on, for 3 of every 4wk oral
Niza dine. 3-5mg/kg (adult 150mg) 12H oral for Ofloxacin. 5mg/kg (adult 200mg) 8-12H, or 10mg/kg
max 8wk, then dly. H pylori (adult): 300mg 12-24H. (adult 400mg) 12H oral or IV over 1hr. 0.3%: 1 drop/
eye hrly x 2 days (4H overnight), reducing to 3-6H.

399
Drug Doses
OKT3. See muromonab-CD3. Oxeru n. 10mg/kg (adult 500mg) 12H oral.
Olanzapine. 0.1-0.2mg/kg (adult 5-10mg) daily Oxethazaine. 10mg/5ml (with Al hydrox + Mg
oral; slow incr to 0.4mg/kg (adult 20mg) daily if hydrox): adult (NOT/kg) 5-10ml 6-8H oral.
reqd. See also fluoxe ne. Oxiconazole. 1% cream, lo on: apply 12-24H.
Olmesartan. 0.4-0.8mg/kg (adult 20-40mg) daily Oxitropium. Inhaltn: 200mcg (NOT/kg) 8-12H.
oral. See also amlodipine + olmesartan. Oxpen fylline (Pentoxifylline). Adult (NOT/kg):
Olopatadine. 0.1% soltn: 1 drop/eye twice a day. slow release tab 400mg 8-12H oral.
Olpadronate. 0.5mg/kg daily oral. Oxprenolol. 0.5-2mg/kg (adult 30-120mg) 8-12H oral
Olsalazine. NOT/kg: 250mg 12H, incr to max Oxybuprocaine. 4mg/ml (0.4%): 1 drop/eye
500mg 6H oral. Maintenance: 500mg 12H. 8-12H. Deep anaes: 1 drop/eye every 90sec x3
Omalizumab. NOT/kg: 150-375mg SC every 2-4wk doses. See also fluorescein + oxybuprocaine.
depending on body weight and serum IgE level. Oxybutynin. <5yr: 0.2mg/kg 8-12H oral. >5yr
Omeprazole. Usually 0.4-0.8mg/kg (adult (NOT/ kg): 2.5-5mg 8-12H oral. Slow rel: adult
20-40mg) 12-24H oral. ZE synd: 1mg/kg (adult 5-30mg daily oral. Adult: apply 39cm patch
60mg) 12-24H oral, incr up to 3mg/kg (adult (3.9mg/day) x2/wk.
120mg) 8H if reqd. IV: 2mg/kg (adult 80mg) Oxycodone. 0.1- 0.2mg/kg (adult 5-10mg) 4-6H
stat, then 1mg/kg (adult 40mg) 8-12H. oral, SC or IV (beware hypoven latn); incr if reqd.
H.pylori: 0.8mg/kg (adult 40mg) daily oral IV infsn: 0.05mg/kg/hr (adult 2mg/hr) adjusted.
+ metronidazole 8mg/kg (adult 400mg) 8H + Slow rel: 0.6-0.9mg/kg (adult 10mg) 12H oral, incr
amoxycillin 10mg/kg (adult 500mg) 8H for 2wk if reqd. Suppos: adult 30mg 6-8H PR.
Ondansetron. IV: prophylaxis 0.15mg/kg (adult Oxymetazoline. 0.25mg/ml = 0.025% (<6yr),
4mg); treatment 0.2mg/kg (adult 8mg) over 5 0.5mg/ml = 0.05% (>6yr): 2-3 drops or sprays
min, or 0.2-0.5mcg /kg/min. Oral: 0.1-0.2 in each nostril 8-12H.
mg/kg (usual max 8mg) 6-12H. Oxymetholone. 1-2mg/kg (up to 5mg/kg) dly oral
Oprelvekin (IL-11). 2mg/m (adult 50mcg/kg) SC dly Oxymorphone. Usu. 0.02-0.03mg/kg (adult 1-
Oral rehydratn soltn (ORS). See glucose 1.5mg) 4-6H IM or SC. Slow IV: 0.01mg/kg
electrolyte soltn. (adult 0.5mg) 4-6H. Oral: 0.1-0.4mg/kg (adult
Orciprenaline. Oral: 0.25-0.5mg/kg (adult 20mg) 5-20mg) 4-6H; slow-rel adult 5mg 12H. PR:
6H. Resp soltn (2%): 0.5ml diltd to 4ml 3-6H 0.1mg/kg (adult 5mg) 4-6H.
(mild), 1ml diltd to 4ml (moderate), undiluted Oxytetracycline. >8yr (NOT/kg): 250-500mg 6H
con nuously (severe, in ICU). oral, or 250-500mg 6-12H slow IV.
Aerosol 750mcg/dose: 2 pus 4-6H. Oxytocin. Labour (NOT/kg): 1-4mU/min IV, may
Orlistat. 1.5-3mg/kg (adult 60-120mg) with each incr to 20 mU/min max. Lacta on: 1 spray (4iu)
main meal containing fat (max 3 doses/day). into each nostril 5min before infant feeds.
Ornipressin (POR 8). IV: 0.1u/kg/hr (max 6u/hr) Paclitaxel. 175mg/m IV every 3wk, x3-6 doses.
for max 4hr, then 0.03u/kg/hr (max 1.5u/hr). Albumin-bound: 260mg/m IV every 3wk.
SC: 5u in 30ml saline, max total dose 0.1u/kg. Palifermin. 60mcg/kg IV daily for 3 days before
Orphenadrine. 1-2mg/kg (adult 50-100mg) 8H oral. chemo, and for 3 days a er.
Osalazine. Adult (NOT/kg): 500mg 6H oral. Palivizumab. 15mg/kg IM once a month.
Oseltamivir. 2mg/kg (adult 75mg) 12H for 5 days Paliperidone (3mg, 6mg, 9mg slow release).
oral. Prophylaxis: 2mg/kg (adult 75mg) daily. Adult (NOT/ kg): usually 6mg daily oral; may
Oxacillin. 15-30mg/kg 6H oral, IV, IM. Severe incr by 3mg every 5-7 days.
in n: 40 mg/kg (max 2g) 12H (1st wk life), 8H Palonosetron. Adult: 0.25mg IV 30min bef. chemo
(2nd wk), 6H or infsn (>2wk). Pamidronate. Osteoporosis, OI: 3-7mg/kg dly oral,
Oxalipla n. 85mg/m every 2wk over 2-6hr IV 1mg/kg (adult 15-90mg) IV over 4hr dly x3 every
before 5-FU. 4mo, or x1 every 3-4wk. Hypercalcaemia 20-50mg/
Oxandrolone. 0.1-0.2mg/kg (adult 2.5-20mg) m (depending on Ca level) IV over 4hr every 4wk.
daily oral. Turners synd: 0.05-0.1mg/kg daily. Pancrea c enzymes. Cotazyme, Creon, Nutrizym,
Oxaprozin. Usually 20mg/kg (max 1200mg), Pancrease, Pancrex, Ultrase, Viokase. NOT/kg: usu.
range 10-26mg/kg (max 1800mg), daily oral. 1-5 caps with meals. Max lipase 10,000u/kg/d.
Oxazepam. 0.2-0.5mg/kg (adult 10-30mg) 6-8H oral Pancuronium. ICU: 0.1-0.15mg/kg IV prn.
Oxcarbazepine. 4-5mg/kg (adult 300mg) 12H Theatre: 0.1mg /kg IV, then 0.02mg/kg prn.
oral; incr wkly by max 5mg/kg/dose (adult Infusion: 0.25-0.75mcg/kg/min.
300mg) to usually 15mg/kg/dose (adult Panitumumab. 6mg/kg IV over 1-2hr every 14 days.
750mg), max 25mg/kg/dose (adult 1200mg).

400
 Drug Doses
Pantoprazole. 1.0mg/kg (adult 40mg) 12-24H oral, Penicillin, benzathine. 1mg = 1250u. Usu.
IV. GI hge, adult: 80mg stat, then 8mg/hr. ZE: 25mg/kg (max 900mg) IM once.
80mg 8-12H adjusted to achieve acid <10mmol/l. Venereal disease: 40mg/kg (max 1.8g) IM x 1.
Papaveretum (Omnopon). 0.2mg/kg IV, 0.4mg/ Strep prophyaxis: 25mg/kg (max 900mg) IM
kg IM ( t/ 2-4hr). ICU: 0.3mg/kg IV, 0.6mg/kg IM. 3-4wkly, or 10mg/kg IM 2wkly.
See also hyoscine + papaveretum. Penicillin, benzathine + procaine. 900mg/
Papaverine. (NOT/kg): 150-300mg 12H oral,12-40 300mg in 2ml: 0-2yr / vial, 3yr 1 vial IM x 1.
mg x1-2/wk intracavernosal. IA lines: 0.12mg/ml. Penicillin, benzyl (penicillin G, crystalline).
Para-aminobenzoic acid. See aminobenzoate. 1mg = 1667u. 30mg/kg 6H. Severe in n:
Para-aminohippuric acid. See aminohippuric acid. 50mg/kg (max 2g) IV 12H (1st wk life), 6H (2-4
Paracetamol. Oral or IV: 20mg/kg stat, then wk), 4H or constnt infsn (>4 wk).
15mg/kg 4H (max 4g/day); child usual daily Penicillin, procaine. 1mg = 1000u. 25-50mg/kg
max 90mg/kg for 48hr, then max 60mg/kg. (max 1.2-2.4g ) 12-24H IM. Single dose:
Rectal: 40mg/kg stat, then 30mg/kg 6H (max 100mg/kg (max 4.8g).
5g/day). Overdose: acetylcysteine. Penicillin V. See phenoxymethylpenicillin.
Paran. Liquid: 1ml/kg (adult 30-45ml) dly oral. Penicilloyl polylysine (Prepen). 0.00006 molar.
Liqd 50% + white so 50%, ointmnt: apply 6-12H Scratch: 1 drop. Intradermal: 0.01-0.02ml
Paraldehyde. IM: 0.2ml/kg (adult 10ml) stat, Pentaerythritol tetranitrate. 0.2-1mg/kg (adult
then 0.1 ml/kg 4-6H. IV: 0.2ml/kg (adult 10ml) 10-60mg) 6-8H oral.
over 15 min, then 0.02ml/kg/hr (max 1.5ml/hr). Pentagastrin. 6mcg/kg SC, or 0.6mcg/kg/hr IV.
Rectal, NG: 0.3ml/kg (adult 10ml) dilute1:10. Pentamidine isethionate. 3-4mg/kg (1.7-2.3mg/
Parathyroid hormone. Adult (NOT/kg): 100mcg kg base) IV over 2hr or IM daily for 10-14 days
daily SC. See also teripara de. (1mg base = 1.5mg mesylate = 1.74mg
Parecoxib. Adult (NOT/kg): 40mg stat IM or IV, isethionate). Neb: 600mg/6ml daily for 3wk
then 20-40mg 6-12H; max 80mg/day. (treatment), 300mg/3ml every 4wk (prophylaxis).
Paricalcitol. 0.04-0.1mcg/kg x2-3/wk IV during Pentastarch. 10% soltn: 10-40mg/kg IV.
dialysis, may incr every 2-4wk to max 0.24 Pentazocine. Oral: 0.5-2.0mg/kg (adult 25-100mg)
mcg/kg. Or dose in mcg = [iPTH picomol/L] / 7. 3-4H. SC, IM or slow IV: 0.5-1mg/kg (adult 30-
Paroxe ne. 0.4mg/kg (adult 10mg) dly oral, may 60mg) 3-4H. PR: 1mg/kg (adult 50mg) 6-12H.
incr over 4wk to 1mg/kg (adult 20-60mg) daily. Pentobarbitone. 0.5-1mg/kg (adult 30-60mg)
Pegademase. 10u/kg IM wkly, incr to 20u/kg wkly. 6-8H oral, IM, slow IV. Hypno c: 2-4mg/kg
Pegaptanib sodium. Adult: 1.65mg (0.3mg of (adult 100-200mg).
free acid form) by intravitreous inj every 6wk. Pentosan. 2mg/kg (adult 100mg) 8H oral.
Pegaspargase. 82.5iu/kg (<0.6m) or 2500iu/m Pentosta n. 4mg/m IV wkly.
(>0.6m) IM, or IV over 2hr, every 14 days. Pentoxifylline. See oxpen fylline.
Pegfilgras m. >44kg: 6mg SC 24hr a er chemo. Pentoxyverine. 0.3mg/kg (adult 15mg) 3-6H oral.
Peginterferon alfa-2a. Hep C (NOT/kg): 180mcg wkly Peppermint oil. (NOT/kg). 0.2ml cap: 1-2 8H oral
SC, + ribavirin 1g (1.2g if >75kg) dly oral, x 48wk Pergolide. Parkinsons: 1mcg/kg (max 50mcg)
Peginterferon alfa-2b. Hep C: 1.5mcg/kg wkly, daily, incr to max 25mcg/kg (max 2mg) 8H oral.
+ ribavirin 15mg/kg (adult 800mg) dly oral, x48wk. Hyperprolac naemia: 0.5-3mcg/kg daily.
Pegvisomant. 40mg SC stat, then 10mg dly Perhexiline. 2mg/kg (adult 100mg) dly oral; adjust
adjustd up/down by 5mg (max 30mg/d) every every 2-4wk to max 6-8mg/kg (adult 300-400mg)
4-6wk based on serum IGF-1 concentra on. dly. Maintain plasma level 150-600mcg/l.
Pemetrexed. 500mg/m IV over 10min every 3wk. Pericyazine. 0.5mg/yr of age (1-10yr) 10mg
(>10yr) daily oral, incr if reqd to max 1mg/yr
Pemoline. >6yr (NOT/kg): 20-120mg daily oral.
(1-10yr) 25mg (>10yr) 8H.
Penbutolol. 0.4-1.5mg/kg (adult 20-80mg) dly oral
Perindopril. 0.05-0.15mg/kg (adult 2-8mg)
Penciclovir. 1% cream (10mg/g): apply x6/d x 4d
daily oral.
Penicillamine (d-penicillamine). Arthri s:
Permethrin. 1% creme rinse (head lice): wash
1.5mg/kg (adult 125mg) 12H oral, incr over
hair, apply creme for 10min, wash o; may repeat
3mo to max 3mg/kg (adult 375 mg) 6-8H.
in 2wk. 5% cream (scabies): wash body, apply to
Wilsons disease, lead poisoning: 5-7.5 mg/kg
whole body except face, wash o a er 12-24hr.
(adult 250-500mg) 6H oral.
Cys nuria: 7.5mg/kg (adult 250-1000 mg) 6H Perphenazine. 0.1-0.3mg/kg (max 5-20mg) 8-12H oral
oral, trated to urine cys ne <100-200mg/day.

401
Drug Doses
Pertussis. See diphtheria + tetanus + pertussis vacc. Phenylephrine. IV: 2-10mcg/kg stat (adult
Pethidine. 0.5-1mg/kg (adult 25-50mg) IV, 0.5 - 500mcg), then 1-5mcg/kg/min. SC or IM:
2mg/kg (adult 25-100mg) IM (half life 2-4hr). 0.1-0.2mg/kg (max 10mg). Oral: 0.2mg/kg
Infsn: 5mg/kg in 50ml at 1-4ml/hr (0.1-0.4mg/ (max 10mg) 6-8H. 0.15%, 10% eye drops:
kg/hr). PCA 5mg/kg in 50ml: usu. bolus 2ml 1 drop/eye 6-8H. 0.25%, 0.5% nose drops:
with lockout 5min, op onl backgrnd 0.5ml/hr. 1-3 drops/sprays per nostril 6-8H.
Phenacemide. 10-20mg/kg (adult 0.5-1g) 8H oral. Phenylephrine 0.12% + prednisolone acetate 1%.
Phenazone. See benzocaine + phenazone. 1 drop per eye 6-12H.
Phenazocine. 0.1-0.4mg/kg (adult 5-20mg) 4-6H Phenytoin. Loading dose in emergency:
oral or sublingual. 15-20mg/kg (max 1.5g) IV over 1 hr. Ini al
Phenazopyridine. 4mg/kg (adult 200mg) 6H oral x 2d maintenance, oral or IV: 2mg /kg 12H (prem);
3mg/kg 12H (1st wk life), 8H (2wk-4yr), 12H
Phendimetrazine. 0.4-1.4mg/kg (adult 20-
(5-12yr); 2mg/kg (usual max 100mg) 8H >12 yr.
70mg) 8H oral.
Level 40-80 umol/L (x0.25 = mcg/ml).
Phenelzine. 0.3-2mg/kg (adult 15-90mg) 8H oral.
Pholcodine. 0.1-0.2mg/kg (adult 5-15mg) 6-12H oral
Phenindamine. 0.5-1mg/kg (adult 25-50mg)
Phosphate, potassium (1mmol/ml).
8-12H oral.
0.1-1.5mmol/kg/day (max 70mmol/day) IV infsn.
Phenindione. 2mg/kg (adult 100mg) 12H day
Phosphate, sodium. Laxa ve, diluted, NOT/kg:
1, 1mg/kg (adult 50mg) 12H day 2, then 0.25-
250mg (2-4yr) 250-500mg (>4yr) 6H oral.
1mg/kg (adult 12.5-50mg) 12H oral. INR for
prophylaxis 2-2.5, treatment 2-3. Phosphate, sodium (Fleet enema).
Na 1.61m Eq/L + PO 4.15 mEq/L + K 1.38m Eq/L:
Pheniramine. 0.5-1mg/kg (adult 25-50mg) 6-8H
33ml (2-5yr), 66ml (5-11yr), 133ml (adult) rectal.
oral. Slow release tab 75mg at night.
Phospha dylcholine. 60mg/kg (max 3g) dly oral
Phenobarbitone. Loading dose in emergency:
20-30mg/kg IM or IV over 30min stat. Phosphocysteamine. 10mg/kg 6H oral, incr by2.5mg
Ven lated: repeat doses of 10-15mg/kg up to /kg/dose every 2wk to 10-20mg/kg 6H so leukocyte
100mg/kg per day (beware hypotension). half-cysteine <2nmol / mg protein 6hr a er dose.
Usual maintenance: 5mg/kg (adult 300mg) Physos gmine. 0.02mg/kg (max 1mg) IV every
daily IV, IM or oral. Infant colic: 1mg/kg 4-8H 5 min un l response (max 0.1mg/kg), then
oral. Level 80-120 umol/L (x0.23=mcg/ml). 0.5-2.0mcg/kg/min.
Phenolphthalein. 0.5-5mg/kg (adult 30-270mg) Phytomenadione (vitamin K1). Deficiency with
nocte oral. See also agar + paraffin + phenolphthalein. hge: FFP 10ml/kg, then 0.3mg/kg (max 10mg),
Phenoperidine. 0.03-0.05mg/kg (adult 1mg) IM or IV over 1hr. Prophylaxis in neonates
every 40-60min. Ven lated: 0.1-0.15mg/kg (NOT/kg): 1mg (0.1ml) IM at birth.
(adult 2-5mg) every 40-60min. Warfarin reversal: 0.1mg/kg (max 5mg) SC
or oral (repeat if reqd); if severe hge 0.3mg/kg
Phenothrin. Apply; shampoo a er 30min (0.5%
(max 10mg) with FFP 10ml/kg.
mousse) 2hr (0.2% lo on), 12hr (0.5%
Mitochondrial disease (NOT/kg): 10mg 6H oral.
emulsion); comb hair when wet.
Picibanil (OK-432). 1 Klinishe Einheit = 0.1mg.
Phenoxybenzamine. 0.2-0.5mg/kg (adult 10-
1 mg into tumour 1-2wk preop, then
40mg) 8-12H oral. Cardiac surgery: 1mg/kg IV
0.5mg/2wk ID for 1yr postop.
over 1-4hr stat, then 0.5 mg/kg 8-12H IV over
1hr or oral. Pilocarpine. 0.1mg/kg (adult 5mg) 4-8H oral. 0.5%,
1%, 2%, 3%, 4% eye drops: 1 drop/eye 6-12H.
Phenoxymethylpenicillin (penicillin V).
7.5-15mg/kg (adult 250-500mg) 6H oral. Pimecrolimus. 1% cream: apply 12H.
Prophylaxis: 12.5mg/kg (adult 250mg) 12H. Pimozide. 0.04mg/kg (adult 20mg) daily oral,
Phentermine. Adult (NOT/kg): 30-40mg daily incr if reqd to max 0.4mg/kg (adult 20mg) dly.
oral, reducing to 15-40mg daily. Pindolol. 0.3mg/kg (adult 15mg) 8-24H oral.
Phentermine resin. (NOT/kg): 15-30mg dly oral. Pine tar. Gel, solu on: 5ml to baby bath, 15-
Phentolamine. 15mg/kg in 50ml 5% dex-hep at 30ml to adult bath; soak for 10min.
1-10ml/hr (5-50mcg/kg/min) IV. May accumm- Pioglitazone. Adult (NOT/kg): 15-45mg dly oral.
ulate (t / 19min, longer if renal impairment). Pipecuronium. 20-85mcg/kg IV stat, then 5-
Phenylbutazone. Ini ally 2mg/kg (adult 100mg) 25mcg/kg prn.
4H, reducing to 1-2mg/kg (adult 50-100mg) Piperacillin. 50mg/kg (adult 2-3g) 6-8H IV. Severe
6-8H oral. in n: 75mg/kg (adult 4g) 8H (1st wk life) 6H (2-
Phenyltoloxamine. 1mg/kg (adult 50mg) 8H oral. 4 wk) 4-6H (>4wk) or constant infsn.

402
 Drug Doses
Piperacillin 1g + tazobactam 125mg. As for Polythiazide. 0.02-0.1mg/kg (adult 1-4mg) dly oral.
piperacillin. Polyvinyl alcohol. 1.4%, 3% soltn: 1 drop/eye prn.
Piperazine. 75mg/kg (max 4g) oral daily for 2 POR 8. See ornipressin.
days (ascaris), 7 days (pinworm). Porfimer. 2mg/kg IV, then 630nm laser light
Piperazine oestrone sulphate. Induc on puberty a er 40-50hr and 96-120hr; max 3 courses at
(NOT/kg): 0.156mg daily, incr over 2-3yr to 1.25mg least 30 days apart.
(add progestogen for 12 days per cycle). Posaconazole. Invasive in n: 4mg/kg (adult
Piperonyl butoxide bioallethrin. Apply enough 200mg) 6H oral. Oral candida: 4mg/kg (adult
to wet scalp or body, leave 30min, wash o. 200mg) stat, then 2mg/kg (adult 100mg) daily.
Pipo azine. Oily injtn: ini ally 0.5mg/kg (adult Prophylaxis: 4mg/kg (adult 200mg) daily.
25mg), then gradual incr to 1-4mg/kg (adult Potassium. Deficiency: usually 0.3mmol/kg/hr
50-200mg) every 4wk IM. (max 0.4 mmol/kg/hr) for 4-6 hr IV, then
Piracetam. 15mg/kg (max 800mg) 8H oral, IM or IV 4 mmol/kg/day. Max oral dose 1 mmol/kg
Pirbuterol. Oral: 0.2-0.3mg/kg (adult 10-15mg) (<5yr), 0.5 mmol/kg (>5yr). Maintenance
6-8H. In-haltn (NOT/kg): 0.2-0.4mg 4-6H. 2-4 mmol/kg/day. If peripheral IV, max 0.05
Piroxicam. 0.2-0.4mg/kg (adult 10-20mg) dly oral. mmol/ml. 1g KCl = 13.3mmol K, 7.5% KCl =
Gel 5mg/g: apply 1g (3cm) 6-8H for up to 2wk. 1 mmol/ml.
Pivampicillin. 15mg/kg (adult 500mg) 8-12H oral. Potassium citrate. See citric acid + potassium citrate.
Pivampicillin 1.25mg + pivmecillinam 1mg. 10mg Potassium guaiacolsulfonate. 1-3mg/kg (adult
/kg/dose (adult 250mg) of pivampicillin 12H oral. 50-160 mg) 4-6H oral.
Pivmecillinam. 5-10mg/kg (adult 200-400mg) Pralidoxime. 50mg/kg (adult 2g) over 30min,
6-8H oral. then 20 mg/kg/hr (adult 1g/hr) for 48hr, then
Pizo fen. NOT/kg: 0.5mg daily oral, incr if reqd 20mg/kg (adult 1g) 4H.
to max 0.5mg morning and 1mg at night. Pramipexole. Adult (NOT/kg): 0.125mg 8H incr
Plicamycin. Tes cular tumours: 25-30mcg/kg by 0.125-0.25mg every 5-7 days to 0.5-1.5mg
dly for 8-10 days IV over 6hr, rpt mthly if resp. 8H oral. Restless legs: 0.125mg (max 0.5mg)
Hypercalcaemia: 25mcg/kg daily for 3-4 days, 2-3 hours before bed.
then x1-3/wk. Pramlin de. Reduce insulin dose by 50%
Pneumococcal vaccine, polysaccharide ini ally. (NOT/kg) Type 1 diabetes: 15mcg SC
(Pneumovax 23). Inac vated. >2yr: 0.5ml SC before meals (x4/day), incr if tolerated to 30-
or IM once. Boost every 5yr. 60mcg/dose. Type 2: 60mcg SC before meals
(x4/day), incr if toleratd to 90-120mcgdose.
Pneumococcal vaccine, CRM conjugate
(Prevenar). Inac vated. 0.5ml IM. <6mo: 2mo, Pramocaine. See hydrocor sone + pramocaine
3mo, 4mo, 12-15mo (4 doses). 6-11mo: 6mo, cream.
7mo, 12-15mo (3 doses). 12-23mo: 2 doses Pramoxine. 1% cream, lo on: apply 6-8H.
2mo apart. >23mo: 1 dose. Pravasta n. Adult (NOT/kg): 20-80mg nocte oral
Podophyllotoxin. 0.5% paint: apply 12H for 3 Praziquantel. 20mg/kg oral once (tapeworm),
days, then none for 4 days; 4wk course. 4H x3 doses (schistosomiasis), 8H x6 doses
Podophyllum. 15%-25% soltn, oint: apply to (other flukes), 8H 14 days (cys cercosis).
wart x2/day. Prazosin. 5mcg/kg (max 0.25mg) test dose, then
Poliomyeli s vaccine, oral (Sabin). Live. 2 drops 0.025-0.1 mg/kg (adult 1-5mg) 6-12H oral.
oral at 2mo, 4mo and 6mo (3 doses). Boost at Prednisolone. Oral.
5yr, and if going to epidemic area. Alopecia, autoimmune liver, epilepsy, SLE,
Poliomyeli s vaccine, SC (IPOL). Inac vated. ulcera ve col: 2mg/kg dly, gradually reducing.
0.5ml SC stat, 8wk later, and 8wk later (3 Asthma: 0.5-1mg/kg 6H for 24hr, 12H x2, then
doses). Boost 12mo later, and at school entry. 1mg/kg daily.
Poloxamer (Poloxalkol). 10% soltn: <6mo 10drops, Croup: 1mg/kg stat and in 12hr; severe 4
6-18mo 15drops, 18mo-3yr 25drops 8H oral. mg/kg stat, then 1mg/kg 8H.
ITP: 4mg/kg daily.
Polyethylene glycol. See colonic lavage, macrogol.
Nephro c syndr: 60mg/m (max 80mg) daily,
Polymyxin B. See bacitracin; dexamethasone. reducing over several months.
Polynoxylin. 10% gel: apply 12H. Physiological: 4-5mg/m daily.
Polygeline. 10-20ml/kg (may rpt). Half life 2hr. Eye 0.5%: ini ally 1drop/eye 2H, then 6-12H.
Polystyrene sulphonate. See sodium 1 mg = hydrocor sone 4mg in glucocor coid
polystyrene sulphonate ac vity, 0.8mg in mineralocor coid.

403
Drug Doses
Prednisolone sodium phosphate. 0.5%: ear 2-3 Propiverine. 0.3mg/kg (adult 15mg) 6-12H oral.
drops/ear, eye 1 drop/eye 2-6H. Propofol. Seda on in ICU: 1-3mg/kg/hr (max
Pregabalin. Adult (NOT/kg): 50mg 8H oral, incr 4mg/kg/hr) IV, for no longer than 48 hr.
gradually if reqd to max 200mg 8H. Short-term anaesthesia: child 2.5-3.5mg/kg
Prilocaine. Max dose 6mg/kg (0.6ml/kg of 1%). stat, then 7.5-15mg/kg/hr IV; adult 1-2.5mg/kg
With adrenaline max dose 9mg/kg (0.9ml/kg of 1%). stat, then 3-12 mg/kg/hr IV.
Primaquine. Usually 0.3mg/kg (adult 15mg) Propoxyphene. See dextropropoxyphene.
daily for 14-21 days oral. Gameteocyte: 0.7mg/ Propranolol. 0.2-0.5mg/kg (adult 10-25mg) 6-
kg (adult 45mg) once. 12H oral, slow incr to max 1.5mg/kg (max
Primidone. Ini ally 2.5mg/kg (adult 125mg) nocte, 80mg) 6-12H if required.
may incr to max 15mg/kg (adult 750mg) 12H oral. Propylthiouracil. 50mg/m 8H oral, reduce with
Trough level (phenobarbitone) 60-120umol/L. response.
Probenicid. 25mg/kg (adult 1g) stat, then Proscillaridin. 10-15mcg/kg (adult 500-750mcg)
10mg/kg (adult 500mg) 6H oral. 8-12H oral.
Probucol. 10mg/kg (adult 500mg) 12H oral. Prostacyclin. See epoprostenol.
Procainamide. IV: 0.4mg/kg/min (adult 20mg/ Prostaglandin. See alprostadil (PGE1), carboprost
min) for max 25min, then 20-80mcg/kg/min (max (15-Me-PGF2-alpha), dinoprost (PGF2-alpha),
2g/day). Oral: 5-8mg/kg 4H. Level 3-10mcg/ml. dinoprostone (PGE2), epoprostenol (PGI2,
Procaine. Max dose 20mg/kg (1ml/kg of 2%). prostacyclin), gemeprost (PGE1 analogue), and
Procarbazine. 1mg/kg (adult 50mg) daily oral, misoprostol (PGE1 analogue).
incr over 4-6 days to 4-6mg/kg (adult 200- Protamine. IV 1mg/100u heparin (0.5mg/100u
300mg) daily un l remission, then 1-2mg/kg if >1hr since heparin dose) slow IV stat;
(adult 50-100mg) daily. Suspend if wbc <3000/ subsequent doses of protamine 1mg/kg (max
mm or platelets <80,000/mm. 50mg). 1mg per 25ml pump blood.
Prochlorperazine. 1mg base = approx 1.5mg Heparin 1mg=100u (half life 1-2hr).
edisylate, maleate or mesylate. Only use if >10kg. Protein C, ac vated. See drotrecogin alfa.
Oral (salt): 0.2mg/kg (adult 5-10mg) 6-8H, may incr Prothionamide. TB: 15-20mg/kg (adult 0.75-1g)
slowly to max 0.6mg/kg (max 35mg) 6H in psychosis. at night oral. Leprosy: 5-8mg/kg (adult 250-
IM, slow IV (salt): 0.2mg/kg (adult 12.5mg) 8-12H. 375mg) daily.
Buccal (salt): 0.05-0.1mg/kg (max 6mg) 12-24H. Prothrombinex. See coagula on factor, human.
PR (base): 0.2mg/kg (adult 25mg) 8-12H. Pro relin. NOT/kg: 200mcg IV stat.
Procyclidine. 0.05-0.2mg/kg (adult 2.5-10mg) Protriptyline. 0.1-0.4mg/kg (adult 5-20mg) 6-8H oral.
6-8H oral. Proxymetacaine. 0.5% soltn: 1 drop/eye stat,
Progesterone. Adult (NOT/kg). Premenst syndr: then 1 drop every 10min for 5-7 doses.
200-400mg PV or PR 12-24H (last half of cycle). Pseudoephedrine. 1mg/kg (adult 60mg) 6-8H
Dysfunc onal uterine hge: 5-10mg/day IM oral. Slow rel: adult (NOT/kg) 120mg 12H.
for 5-10 days before menses. Prevent abor on:
Pseudoephedrine 60mg +triprolidine 2.5mg
25-100mg IM every 2-4 days.
(Ac fed). 10ml elixir=1tab. NOT/kg: 2.5ml (<2yr), 2.5-
Proguanil. 3.5mg/kg (adult 200mg) daily oral 5ml (2-5yr), 0.5tab (6-12yr), 1tab (>12yr) 6-8H oral
a er food. See also atovaquone + proguanil.
Psyllium. Usu. 0.1-0.2g/kg (adult 5-10g) 8-24H oral.
Promazine. Oral: 2-4mg/kg (adult 100-200mg)
Pumactant (ALEC). Prem babies (NOT/kg):
6H. IM 0.7mg/kg (max 50mg) 6-8H. disconnect ETT, rapidly inject 100mg in 1ml
Promethazine. An histamine, an eme c: saline via catheter at lower end ETT, flush with
0.2-0.5mg/kg (adult 10-25mg) 6-8H IV, IM or 2ml air; repeat a er 1hr and 24hr. Prophylaxis
oral. Seda ve, hypno c: 0.5-1.5mg/kg (adult if unintubated: 100mg into pharynx.
25-100mg). Pyrantel. Threadworm: 10mg/kg (adult 750mg)
Proxymetacaine. 0.5%: 1 drop/eye before procedure once oral, may repeat 2wkly x3 doses.
Propacetamol. IV prepara on: Roundworm, hookworm: 20mg/kg (adult 1g)
1g = 0.5g paracetamol. once, may repeat in 7 days. Necator: 20mg/kg
Propafenone. Oral: 70mg/m (adult 150mg) 8H, (adult 1g) daily x2-3 doses.
incr if reqd to max 165mg/m (adult 300mg) Pyrazinamide. 20-35mg/kg (max 1.5g) daily oral,
8H. IV: 2mg/kg over 2hr, then 4mcg/kg/min or 75 mg/kg (max 3g) x2/wk.
incr if reqd to max 8mcg/kg/min. Pyrethrins + piperonyl butoxide. Lice: apply
Propamidine. 0.1%: 1 drop/eye 6H for up to 2d enough shampoo to wet hair, wash o in
Propantheline. 0.3-0.6mg/kg (adult 15-30mg) 6H oral 15min; repeat in 10 days.
404
 Drug Doses
Pyridos gmine. Myasthenia gravis: 1mg/kg Ramipril. 0.05mg/kg (adult 2.5mg) oral dly, may incr
(adult 60mg) 4-6H oral, incr to max 2-3mg/kg over 4-6wk to 0.1-0.2mg/kg (adult 5-10mg) dly
(adult 120-180mg) 4-6H if reqd. 180mg slow Rani dine. IV: 1mg/kg (adult 50mg) slowly 6-8H,
rel tab (Timespan), adult (NOT/kg): 1-3 tab 12- or 2mcg/kg/min. Oral: 2-4mg/kg (adult
24H oral. 1mg IV, IM or SC = 30mg oral. 150mg) 8-12H, or 300mg (adult) at night.
Pyridoxine. With isoniazid or penicillamine Rani dine bismuth citrate. 8mg/kg (adult 400mg)
(NOT/kg): 5-10mg daily IV or oral. Seizures: 12H oral; to eradicate H.pylori, add an bio cs.
10-15mg/kg daily IV or oral. Sideroblastc Rapacuronium. Ini ally 2mg/kg (child), 1.5mg/kg
anaemia: 2-8mg/kg (max 400mg) dly IV or oral. (adult), 2.5mg/kg Caesar); maint. 33-50% ini al.
Pyrilamine. See mepyramine. Ramelteon. 8mg oral at bed me.
Pyrimethamine. Adult (NOT/kg): 25mg tab wkly oral Ranibizumab. 0.5mg by intravitreous injec on
Pyrimethamine 25mg + sulphadoxine 500mg every month.
(Fansidar). <4yr tab once, 4-8yr 1 tab, 9-14yr Ranolazine. Adult (NOT/kg): 0.5-1g 12H oral.
2 tab, >14yr 3 tab. Prophylaxis: <4yr tab wkly, Rasagiline. Adult (NOT/kg): 0.5-1mg daily oral.
4-8yr tab, 9-14yr tab, >14yr 1 tab. See also
Rasburicase. 0.15-0.2mg/kg IV daily for 5-7 days.
dapsone + pyrimethamine.
Razoxane. 2mg/kg (max 125mg) 8-24H oral; or 7.5-
Quazepam. 0.15-0.6mg/kg (adult 15-30mg) nocte oral
15mg/kg (max 750mg) dly for 2-3 d every 1-4wk.
Que apine. Adult (NOT/kg) 12H oral/dose: 25mg Kaposi sarc, leukaemia: max 0.33g/m 8H oral.
day 1, 50mg day 2, 100mg day 3, 150mg day 4,
Reboxe ne. Adult (NOT/kg): 2-4mg 12H oral,
then 150-250mg (range 75-400mg) 12H.
incr gradually if reqd to max 10mg 12H.
Quinagolide. 0.5mcg/kg (adult 25mcg) nocte, incr
Recombinant an haemophilic factor. See Factor 8
to 1.5-3 mcg/kg (adult 75-150mcg) nocte oral.
Remifentanil. 0.05-0.2mcg/kg/min. Ven lated:
Quinalbarbitone. Sedativ 5mg/kg. Premed 10mg/kg
usually 0.5-1 mcg/kg/min; occasionally up to
Quinapril. 0.2-0.8mg/kg (adult 10-40mg) daily 8 mcg/kg/min if reqd.
oral. See also hydrochlorothiazide.
Repaglinide. Adult (NOT/kg) before main meals,
Quinidine, base. 10mg/kg stat, then 5mg/kg oral: ini ally 0.5mg, incr every 1-2wk to 4mg
(max 333mg) 4-6H oral. IV: 6.3mg/kg (10mg/kg (max 16mg/day).
of gluconate) over 2hr, then 0.0125mg/kg/min.
Reproterol. Aerosol 0.5mg/pu: 1-2 pus 3-8H.
IM: 15mg/kg stat, then 7.5mg/kg (max 400mg) 8H.
NOTE: 1mg base = 1.2mg sulphate = 1.3mg Reserpine. 0.005-0.01mg/kg (adult 0.25-0.5mg)
bisulphate = 1.6mg gluconate. 12-24H oral.
Quinine, base. Oral: 8.3mg/kg (max 500mg) 8H Residonrate. Adult (NOT/kg): 5mg daily oral;
for 7-10 days. Parenteral: 16.7mg/kg (20mg/kg slow release 35mg once a week.
of dihydrochloride) IV over 4hr or IM, then Resonium. See sodium polystyrene sulphonate.
8.3mg/kg 8H IV over 2hr or IM for 2-3 days, Retapamulin. 1% ointment: apply 12H for 5 d.
then 8.3mg/kg 8H oral for 5 days. Reteplase. Adult (NOT/kg) for myocard infarct:
NOTE: 1mg base = 1.7mg bisulphate = 1.2mg give heparin 5000u IV + aspirin 250-350mg
dihydrochloride = 1.2mg ethyl carbonate = oral; then reteplase 10u IV over 2min + 2nd
1.3mg hydrobromide = 1.2mg hydrochloride dose 30min later; then heparin 1000u/hr for
= 1.2mg sulphate. 24-72hr and aspirin 75-150mg/d ll discharge.
Quinupris n. See dalfopris n + quinupris n. Re nol A. See vitamin A.
Rabeprazole. (NOT/kg): 20mg dly oral 4-8wk Reviparin. Child >2mo: 100u/kg 12H SC. Adult:
(DU), 6-12wk (GU), 4wk then 10-20mg dly 1432u 2hr before surgery, then dly SC
(reflux). ZE: 60mg daily, incr if reqd to 12H. Ribavirin. Inhalatn (Viratek nebulizer): 20mg/ml
H.pylori: 20mg + clarithromycin 500mg + at 25ml/hr (190mcg/l of gas) for 12-18hr/day
amoxicillin 1g all 12H for 7 days. for 3-7 days. Oral: 5-15mg/kg 8-12H.
Rabies vaccine, inac vated (Rabipur). 1ml IM Hepa s C: see interferon alfa-2b.
stat, 7 days later, and 28 days later (3 doses). Riboflavine. NOT/kg: 5-10mg daily oral. Organic
Boost every 2yr. Postexposure: immune, 1ml acidosis (NOT/kg): 50-200mg dly oral, IM or IV.
IM day 0 and day 3; non-immune, give 1ml IM Rifabu n. Pulmonary TB: 3-5 mg/kg (adult 150-
on days 0,3,7,14,30 and 90, with immunoglobln. 300mg) dly oral. Resistant pulm TB: 5-7.5mg/
Raloxifene. 1mg/kg (adult 60mg) daily oral. kg (adult 300-450mg) daily. Mycobact avium
Raltegravir. Adult (NOT/kg): 400mg 12H oral. complex: 7.5-12mg/kg (adult 450-600mg) dly;
Ral trexed. Initially 3mg/m IV over 15min every 3wk prophylaxis 5mg/kg (adult 300mg) daily.

405
Drug Doses
Rifampicin. 10-15mg/kg (max 600mg) daily oral Rubella vaccine (Ervevax, Meruvax II). Live.
fas ng, or IV over 3hr (monitor AST). >12mo: 0.5ml SC once.
Prophylaxis: N.meningi dis 10 mg/kg daily Salbutamol. 0.1-0.15mg/kg (adult 2-4mg) 6H
(neonate), 10 mg/kg (max 600mg) 12H for 2d; oral. Inhaltn: mild resp soltn (5mg/ml, 0.5%)
H.influenzae 10mg/kg dly (neonate), 20mg/kg 0.5ml diluted to 4ml, or nebule 2.5mg/2.5ml
(max 600mg) daily for 4 days. 3-6H; moderate 0.5% soltn 1ml diluted to 4ml,
Rifapen ne. Usually 10-15 mg/kg (adult 600mg) or nebule 5mg/2.5ml 1-2H; severe (in ICU)
x2/wk for 2mo, then wkly for 4 months. 0.5% soltn undiluted con nuous.
Rifaximin. Adult (NOT/kg): 200mg 8H for 3 days. Aerosol 100mcg/pu: 1-2 pu 4-6H.
Riluzole. 1mg/kg (adult 50mg) 12H oral. Rotahaler: 200-400mcg 6-8H.
Rimantadine. 2.5mg/kg (adult 100mg) 12H oral. IM or SC: 10-20 mcg/kg (adult 500mcg) 3-6H.
Rimexolone. 1%. 1drop/eye 6H. Uvei s: 1drop IV in child: amp 1mg/ml at 0.3-0.6ml/kg/hr
1H in day me for 1wk, 2H for 1wk, 6H for 1wk, (5-10mcg/kg/min) for 1hr, then 0.06-0.12ml/
daily 1wk. kg/hr (1-2mcg/kg/min).
IV infusion incompa ble with aminophylline,
Rimonabant. Adult: 20mg oral before breakfast
ketamine and magnesium.
Risedronate. Osteoporosis: 0.1mg/kg (adult
5mg) daily oral; slow release 35mg (adult) Salcatonin. Hypercalcaemia: 5u/kg 12-24H IM,
wkly. Pagets: 0.5mg/kg (adult 30mg) dly oral. SC or IV over 6-12hr. Pagets: adult 50-100u dly.
Cancer bone pain: 4u/kg (adult 200u) up to x4/d
Risperidone. 0.02mg/kg (adult 1mg) 12H, incr
if reqd to 0.15mg/kg (adult 2-4mg, max 8mg) Salicylic acid. Cradle cap: 6% soltn (Egocappol)
12H oral. 12H 3-5 days. Plantar warts: 15% soltn x1-
2/day, 40% medicated disc 24-48H. See also
Ritonavir. 250mg/m (adult 300mg) 12H, incr
benzoic acid + salicylic acid.
over 5 days if toleratd to 400mg/m (infant
450mg/m, adult 600mg) 12H oral. Salicylsalicylic acid. See salsalate.
Rituximab. Leukaemia: 260-370mg/m by Salmeterol. Aerosol, diskhaler (NOT/kg): 50-
IV infsn wkly x4. Rheumatoid arthri s (adult, 100mcg 12H. See also flu casone + salmeterol.
NOT/kg): 1g IV twice, 2wk apart. Salmonella typhi vaccine. See typhoid vaccine.
Rivas gmine. Adult (NOT/kg): ini ally 1.5mg Salsalate. 10-20mg/kg (adult 0.5-1g) 6H oral.
12H, incr every 2wk to max 6mg 12H oral. Saquinavir. So gel caps preferred. Child: 50mg/
Patch: apply 4.6mg (5cm2) daily for 4wk, then kg 8H oral; 33mg/kg 8H with nelfinavir. Adult
9.5mg (10cm2) daily. (NOT/kg): 1200mg 8H, or 1600mg 12H oral.
Rizatriptan. Adult (NOT/kg): 10mg oral, may Saracenia purpurea (Sarapin). Adult (NOT/kg):
rpt x1 in 2hr. 2-10ml nerve block, 5-10ml local infiltra on.
Rocuronium. 0.6-1.2mg/kg IV stat, then 0.1- Sargramos m (GM-CSF, Leucomax). 3-5mcg/kg
0.2mg/kg boluses or 5-15mcg/kg/min. dly SC, or IV over 6hr. Keep wbc 5,000-10,000/mm.
Ropinirole. Adult (NOT/kg): 0.25mg dly x2d, 0.5mg Scopolamine. See hyoscine hydrobromide.
x5 d, then 1mg dly; incr wkly to max 4mg dly Secbutobarbitone. 0.3-0.6mg/kg (adult 15-30mg)
oral. Restless legs: 0.25mg (max 4mg) 2hr nocte 6-8H, or 1-4mg/kg (adult 50-200mg) nocte oral.
Ropivacaine. 4-5mg/kg (adult max 200-250mg). Secre n. 1cu = 4chr units. 1-2cu/kg slow IV.
Intrathecal: 1mg/kg (0.1ml/kg of 1%). Postop Selegiline. Adult (NOT/kg): 10mg daily, oral.
infsn 0.2-0.4mg/kg/hr (0.1-0.2ml/kg/hr of 0.2%). Transdermal patch: 6mg daily; incr to max
Rosiglitazone. Adult (NOT/kg): 4mg daily oral, 9-12mg daily if reqd.
incr a er 6-8 wk to 4mg 12H if reqd. Selenium sulphide. 2.5% shampoo x2/wk for 2wk.
Rosuvasta n. 10mg daily oral, incr if reqd to Senna, Sennoside. Tab 7.5mg, granules 15mg/
20mg then 40mg at 4wk intervals. 5ml. Daily (NOT/kg): 6mo-2yr 7.5mg, 3-10yr
Rotavirus vaccine, human (Rotarix). Live, 7.5-15mg, >10yr 1-30mg.
monovalent. 1ml oral at 6-14wk, and at least Sermorelin (GHRH). 1mcg/kg fas ng in morning IV.
4wk later at 14-24wk (2 doses).
Sertaconazole. 2% cream: apply 12H for 4wk.
Rotavirus vaccine, human-bovine (RotaTeq).
Ser ndole. Adult 4mg dly, incr to 12-24mg dly oral
Live, penta-valent. 2ml oral at age 2mo, 4mo,
6mo (3 doses). Sertraline. 0.5mg/kg (adult 25mg) dly oral, may
incr to 1-2mg/kg (adult 50-100mg) dly; may give
Ro go ne. Adult, NOT/kg: 2mg patch dly for
3-4mg/kg (adult 150-200mg) dly for up to 8wk.
1wk, then 4mg daily; incr if reqd to 6mg daily.
Sevelamer. 20-40mg/kg (adult 800-1600mg) 8H
Roxithromycin. 2.5-4mg/kg (adult 150mg) 12H oral
oral, trated to serum phosphorus.

406
 Drug Doses
Sibutramine. Adult (NOT/kg): usually 10mg Sodium fusidate. Tablets: 10-15mg/kg (adult
(range 5-15mg) daily oral. 250-500mg) 8H oral. IV over 2-8hr: 10mg/kg
Sildenafil. Pulm hypertension: 0.3mg/kg 3-6H (adult 500mg) 8H; severe in n 15mg/kg (adult
incr un l eec ve or systemic hypotension 750mg). Peak level 30-200umol/L (x0.52 =
occurs (usual max 2-3 mg/kg/dose); adult mcg/ml). For suspension, see fusidic acid.
(NOT/kg) usually 20mg 8H oral. 1hr before Sodium hyaluronate. Adult (NOT/kg). Cys s
stopping NO: 0.4mg/kg oral once. 800mcg/ml: 50ml into bladder wkly x4, then
Silver nitrate, s ck. Apply dly to aected area only. 4wkly. Ophthalmic: 10-15 mg/ml (1-1.5%) 0.2-
Silver sulfadiazine 1% + chlorhexidine 0.2%. 0.6ml into anterior chamber; 0.18% drops 1/
Cream: apply in 3-5mm layer. eye as reqd. Osteoarthri s 10-15mg/ml: 2-
Simethicone. See aluminium hydroxide compound 2.5ml intra-ar cular wkly x3-5.
Simvasta n. Adult (NOT/kg): 10mg daily oral, Sodium nitrite. 3%: 0.2ml/kg (max 10ml) IV over 5 min
incr if reqd every 4wk to max 80mg daily. Sodium nitroprusside. <30kg: 3mg/kg in 50ml
Sinecatechins. 15% ointmnt: apply 8H for up to 16wk 5%dex-hep at 0.5-4ml/hr (0.5-4mcg/kg/min) IV.
>30kg: 3mg/kg made to 100ml in 5%dex-hep at
Sirolimus. 3mg/m (adult 6mg) stat, then
1-8ml/hr (0.5-4mcg/kg/min). If used >24hr, max
1mg/m (adult 2mg) daily oral.
rate 4mcg/kg/min. Max total 70mg/kg with
Sitaglip n. 2mg/kg (adult 100mg) daily oral. normal renal func on (or sodium thiocyanate
Sitaxentan. 2mg/kg (adult 100mg) daily oral. <1725 umol/L, x0.058=mg/L). Protect from light.
Sodium. Deficit (ml saline) = Sodium oxybate. Narcolepsy (NOT/kg): 2.25g
Wt(kg) x 4 x (140 - [Na]) / % saline. nocte, rpt 2-4hr later; incr if reqd by 0.75g
To incr serum Na by 0.5 mmol/L /hr (max safe every 2wk to max 4.5g + 4.5g (9g per night).
rate), infsn rate (ml/hr) = 2 x Wt(kg) / (% saline Sodium phenylbutyrate. 10-13g/m/day divided
infusd); hrs of infsn = 2 x (140 - serum Na). into equal amounts with each feed /meal, oral.
4ml/kg of X% saline raises serum Na by Xmmol/L.
Sodium phosphate. See phosphate, sodium.
Need 2-6 mmol/kg/day. NaCl MW = 58.45,
1g NaCl = 17.1mmol Na, NaCl 20% = 3.4mmol/ml. Sodium picosulphate. 2.5mg (1-4yr), 2.5-5mg
(4-10yr), 5-10mg (>10yr) at night oral.
Sodium aurothiomalate. 0.25mg/kg wkly IM,
incr to 1 mg/kg (max 50mg) wkly for 10wk, Sodium polystyrene sulphonate (Resonium).
then every 2-6wk. 0.3-1 g/kg (adult 15-30g) 6H NG (give
lactulose) or PR.
Sodium benzoate. Neonate: 250mg/kg over 2hr
Sodium s bogluconate. Soltn 100mg/ml of pen-
stat, then 10-20mg/kg/hr IV.
tavalent an mony. 20mg/kg (max 850mg) dly
Sodium bicarbonate. See bicarbonate. IV over 5-10min for 20 d (visceral) or at least
Sodium calcium edetate (EDTA). 25-40mg/kg 4wk (mucocutaneous); 10-15mg/kg 12H if
12H IM, IV over 1hr for 5 d; rpt a r 3 d if reqd. toxicity or poor response. Early cutaneous:
With dimercaprol: 12.5mg/kg 4H for 3-7 days. infiltrate lesions with 1-3ml, rpt x1-2 if reqd a r
Sodium cellulose phosphate (Calcisorb). 1-2 d. Severe cutaneous: 20mg/kg dly IV over
Adult: 5g (NOT/kg) 8H oral. 5-10min un l 3 d a er cure (usually), for 4wk
Sodium citrate. Cons patn (adult, NOT/kg) usu. (L.braziliensis), or 3mo a r cure (L.amazonensis)
450mg in 5ml as enema, o en with sodium lauryl Sodium tetradecyl sulphate. NOT/kg: 0.25-1ml
sulphoacetate, glycerol, sorbitol or sorbic acid. per vein as 1% (max 10 small veins) or 3% (max
Sodium citrotartrate. 40-80mg/kg (adult 2-4g) 4 large veins).
in 50ml water 8-12H oral. Sodium thiosulphate. 1ml/kg (adult 50ml) 25%
Sodium cromoglycate. Inhala on (Intal): 1 cap soltn IV over 10min.
(20mg) 6-8H, 2ml soltn (20mg) 6-8H, aerosol Sodium valproate. 5mg/kg (adult 200mg)
1-10mg 6-8H. Eye drops 2%: 1 drop/eye 4-6H. 8-12H oral, incr if reqd to max 20mg/kg (adult
Oral: 5-10mg/kg (max 200mg) 6H oral. Nasal 1g) 8-12H. Level 2hr a er dose 300-700umol/l
2% or 4%: 1 dose to each nostril 3-12H. (x0.14=mg/l).
Sodium ferric gluconate. Fe 12.5mg/ml. Solifenacin. Adult (NOT/kg): 5-10mg daily oral.
0.05ml/kg (adult 2ml) test dose IV over 1hr, Somatosta n. See octreo de.
then 0.25ml/kg (adult 10ml) IV over 1hr with Somatrem. 4u/m 3 days a wk IM.
each dialysis (usually for 8 doses).
Somatropin. 1mg = 3iu. Usually 2-3iu/m on 5-7
Sodium fluoride. NOT/kg: <2yr 0.55mg oral dly, days a wk SC, or 4-6iu/m on 3 days a wk IM.
2-4yr 1.1 mg, >4yr 2.2mg. Osteoporosis,
Sorafenib. Adult (NOT/kg): 400mg 12H (or
Pagets, (NOT/kg): 20-40mg 8-12H. 24- 48H) oral.

407
Drug Doses
Sorbitol 70%. 0.2-0.5ml/kg (adult 20-30ml) 8-24H oral. Sulindac. 4mg/kg (adult 200mg) 12H oral.
With activated charcoal: 1g/kg (1.4ml/kg) NG, x1-2 Sulphacetamide. 100mg/ml 1 drop/eye 2-3H
Sorbolene cream; pure, with 10% glycerin, or during the day.
with 5% or 10% olive oil or peanut oil. Sulphadoxine. See pyrimethamine + sulphadoxine.
Skin moisturiser: apply prn. Sulphafurazole. 75mg/kg (adult 4g) stat, then
Sotalol. IV: 0.5-2mg/kg (adult 25-120mg) over 10 35mg/kg (adult 1.5g) 4-6H oral.
min 6H. Oral: 1-4mg/kg (adult 50-160mg) 8-12H. Sulphamethizole. 10mg/kg (adult 0.5-1g) 6H oral.
Sparfloxacin. 10mg/kg (adult 400mg) stat, then Sulphamethoxazole + trimethoprim.
5mg/kg (adult 200mg) daily oral. See cotrimoxazole.
Spec nomycin. 40-80mg/kg (adult 2-4g) IM once. Sulphasalazine. Ac ve coli s: 20mg/kg 6-12H
Spironolactone. Oral (NOT/kg): 0-10kg 6.25mg (max 4g/day) oral; remission 7.5mg/kg (max
12H, 11-20kg 12.5mg 12H, 21-40kg 25mg 12H, 0.5g) 6-8H, suppos (NOT/kg) adult 0.5-1g 12H.
over 40kg 25mg 8H. Female hirsu sm 50mg Arthri s: 5mg/kg 12H, incr if reqd to 10mg/kg
8H. IV: see potassium canrenoate. 8-12H (max 2g/day).
Stanolone. 2.5% gel. Male: apply 5-10g dly to large Sulphinpyrazone. 2-3mg/kg (max 200mg) 6-12H oral
area of skin and allow 5 min to dry. Female (lichen Sulpiride. 4mg/kg (adult 200mg) 12H, slow incr
sclerosus): apply 2.5g to vulva on alternate days. if reqd to 4-24mg/kg (adult 0.2-1.2g) 12H oral.
Stanozolol. 0.05-0.2mg/kg oral (adult 2.5-10mg) Sulthiame. 1mg/kg (adult 50mg) 8-12H oral,
daily at first, then every 2-3 days. may incr to 5mg/kg (adult 200mg) 8H.
Stavudine (d4T). 1 mg/kg (<30kg), 30mg (30-60 Sumatriptan. Oral: 1-2mg/kg (adult 50-100mg)
kg), 40mg (>60kg) 12H oral. Slow rel (adult, stat, may rpt twice. SC: 0.12mg/kg (max 6mg)
NOT/kg): 75mg (<60kg), 100mg (>60kg) dly oral stat, may rpt once a er 1hr. Nasal: 10-20mg,
Sterculia. NOT/kg: 3.5-7g 12-24H oral. may rpt x1 a er 2hr.
S bogluconate. See sodium s bogluconate. Suni nib. Adult (NOT/kg): 50mg (37.5-87.5mg)
Streptokinase (SK). Short term (myocard infarct): daily oral for 4wk, then 2wk o.
30,000u/kg (max 1,500,000u) IV over 60min, Surfactant. See beractant (Survanta), calfactant
rpt if occlusion recurs <5 days. (Infasurf), colfosceril palmitate (Exosurf),
Long term (DVT, pulm emb, arterial thrombosis): pumactant (ALEC).
2,000 u/kg (max 100,000u) IV over 10min, then Suxamethonium. IV: neonate 3mg/kg, child
1000u/kg/hr (max 100,000u/hr); stop heparin 2mg/kg , adult 1mg/kg. IM: double IV dose.
and aspirin, if PTT <x2 normal at 4hr give extra Tacrine. Adult (NOT/kg): 10mg 6H oral for 6wk,
10,000u/kg (max 500,000u) IV over 30min, may incr by 10mg every 6wk to max 40mg 6H.
stop SK if PTT >x5 normal then give 1000u/kg/hr. Tacrolimus. IV infusion: 2mg/m/day. Oral: 3mg/m
Local infsn: 50 u/kg/hr (con nue heparin 10- 12H. Trough level: whole blood 10-15ng/ml
15u/kg/hr). Blocked IV cannula: 5000u/kg in
Tacrolimus ointment. 2-16yr: apply 0.03%
2ml in cannula for 2hr then remove, may rpt x2.
sparingly 12H for max 3wk, then daily. >16yr:
Streptomycin. 20-30mg/kg (max 1g) IM daily. apply 0.1% sparingly 12H for max 3wk, then
Streptozocin. 1-1.5g/m wkly IV. 0.03% 12H.
Stron um ranelate. Adult, NOT/kg: 2g dly nocte Tamoxifen. Adult (NOT/kg): 20mg daily, incr to
Succimer. 350mg/m 8H for 5d, then 12H x14d oral 40mg daily if no response a er 1mo.
Succinyl choline. See suxamethonium. Tamsulosin. Adult 400mcg daily a r breakfast oral.
Sucralfate. 1g tab (NOT/kg): 0-2yr quarter tab Tazarotene. 0.05%, 0.1% gel, cream: apply thin
6H, 3-12 yr half tab 6H, >12yr 1 tab 6H oral. layer to aected area daily (or on alternate
Sucrose. Analgesia in infants: 0.17g/kg (0.5ml/kg days) in the evening.
of 33% soltn) 2min before procedure. Tazobactam. See piperacillin + tazobactam.
Sufentanil. 2-50mcg/kg slow IV; then infuse so that Tegafur 100mg + uracil 224mg. 100mg/m
total dose is 1mcg/kg/hr of expected surgical me tegafur + 224 mg/m uracil (with 30mg calcium
Sulbactam. See ampicillin + sulbactam. folinate) 8H oral for 28d, 7d o, then rpt cycle.
Sulconazole. 1% cream: apply 12H for 3wk a er Tegaserod. Adult (NOT/kg): 6mg 12H for 4-12wk oral
clinical cure. Teicoplanin. 250mg/m IV over 30min stat, then
Sulfadiazine. 50mg/kg (max 2g) 6H slow IV. 125mg/m IV, IM dly. Severe in n: 250mg/m
Sulfadoxine. See pyrimethamine + sulphadoxine. 12H x3 doses, then 250mg/m2 IV or IM daily.
Sulfametopyrazine. 40mg/kg (adult 2g) wkly oral. Telbivudine. Adult (NOT/kg): 600mg daily oral.
Sulfisoxazole. See sulphafurazole. Telithromycin. Adult (NOT/kg): 800mg oral daily.

408
 Drug Doses
Telmisartan. 1mg/kg (adult 40mg) daily, incr if Tetracosactrin zinc injec on (Synacthen Depot).
reqd to 2 mg/kg (adult 80mg) daily oral. 600 mcg/m (max 1mg) IM every 1-7 days.
Temazepam. 0.3mg/kg (adult 20-40mg) oral. Tetracycline. >8yr (NOT/kg): 250-500mg 6H oral.
Temocillin. 25-50mg/kg (adult 1-2g) 12H IV, IM. Acne (NOT/kg): 500mg 12H, reducing to
Temoporfin. 150mcg/kg IV over 10min; 96hr 250mg 12H. Eye: apply 2-8H.
later give 652 nm laser for about 200 sec to Tetrahydrobiopterin. Defec ve synthesis: 20mg/
give 20J/cm; repeat once a er 4wk if reqd. kg daily oral. Defec ve regenera on: 5mg/kg
Temozolomide. 200mg/m dly oral for 5d per 28d 6H oral. Loading test: 20mg/kg oral, 2mg/kg IV.
cycle (150mg/m for 1st cycle if previous chemo). Tetrahydrozoline. 0.05%: 1 drop/eye 8-12H. See
Temsirolimus. (Adult, NOT/kg): 25mg IV over 1hr wkly also macrogol + tetrahydrozoline.
Tenecteplase. 1mg = 200u. Myocardial infarct Thalidomide. 4mg/kg (adult 200mg) 12H oral,
(adult): 100u/kg (max 10,000u) IV over 10sec reducing over 2-4wk to 0.5-1mg/kg (adult
once; also give aspirin 150-325mg/day, and 25-50mg) 12H.
heparin to maintain APTT 50-75sec. THAM. See trometamol.
Teniposide. 100-150mg/m IV over 1hr wkly. Theophylline. 80mg theophylline = 100mg
Tenofovir disoproxil fumarate. 300mg of aminophylline).
tenofovir DF = 245mg tenofovir D. Loading dose: 8mg/kg (max 500mg) oral.
Adult (NOT/kg): 300mg daily oral. Maintenance: 1st wk life 2mg/kg 12H; 2nd wk
Tenoxicam. 0.2-0.4mg/kg (adult 10-20mg) dly oral 3mg/kg 12H; 3wk-12mo ((0.1 x age in wk) + 3)
mg/kg 8H; 1-9yr 4mg/kg 4-6H, or 10mg/kg s
Terazosin. 0.02mg/kg test, then 0.04-0.4mg/kg
slow rel 12H; 10-16yr or adult smoker 3mg/kg
(adult 2-20 mg) daily oral. 4-6H, or 7mg/kg 12H slow rel; adult non-
Terbinafine. 62.5mg (<20kg), 125mg (20-40kg), smoker 3mg/kg 6-8H; elderly 2mg/kg 6-8H.
250mg (adult) daily oral. 1% cream, gel: apply Serum level: neonate 60-80umol/L, asthma
12-24H to dry skin. 60-110 (x0.18 =mcg/ml).
Terbutaline. Oral: 0.05-0.1mg/kg (adult 2.5-5mg) Thiabendazole. 25mg/kg (max 1.5g) 12H oral 3d
6H. SC: 5-10mcg/kg (adult 0.25-0.5mg). Thiamine. Beriberi: 1-2mg/kg IV, IM or oral dly.
IV: child 3-6mcg/kg/min for 1hr, then 0.4- Metabol dis (NOT/kg): 100mg 8H IV, IM, SC, oral.
1mcg/kg/min; adult 0.25mg stat over 10min,
Thiethylperazine maleate. >10kg: 0.2mg/kg
then 1-10mcg/kg/hr.
(adult 10mg) 8-24H oral, IM, or PR.
Inhaltn: mild resp soltn (1%, 10mg/ml) 0.25ml
dilutd to 4ml 3-6H; moderate 0.5ml of 1% Thioguanine. 100mg/m daily oral;
dilutd to 4ml, or respule 5mg/2ml 1-2H; or 100mg/m 12H for 5-7 days.
severe (in ICU) undiluted con nuous. Thiopentone. 2-5mg/kg slowly stat (beware
Aerosol 250mcg /pu: 1-2 pus 4-6H. hypotension). IV infsn: amp 25mg/ml at 0.04-
Terfenadine. 30mg (6-12yr), 60mg (adult) 12H oral. 0.2ml/kg/hr (1-5mg/kg/hr). Level 150-
200umol/L (x0.24 = mcg/ml).
Teripara de. Adult (NOT/kg): 20mcg SC daily.
Thioridazine. 0.5-3mg/kg (adult 25-150mg) 6-8H
Terlipressin. 0.04mg/kg (adult 2mg) IV, then
oral or IM.
0.02-0.04mg/kg (adult 1-2mg) 4-6H for max
72hr. Slow onset, long ac on: con nuous infsn Thiosulphate. See sodium thiosulphate.
may cause necrosis. Thiotepa. 10-14mg/m IV every 1-4wk.
Testolactone. 5-10mg/kg (max 250mg) 6H oral. Thiotepa. 1 in 2000: 1 drop/eye 4-6H for 6wk.
Testosterone. Esters (NOT/kg): 100-500mg IM Thiothixene. >12yr (NOT/kg): ini ally 2mg 8H
every 2-4wk. Implant: 8mg/kg (to nearest oral, slow incr to 2-20mg per dose.
100mg) every 16-24wk. Threonine. 15-30mg/kg (adult 0.75-1.5g) 8H oral.
Undecanoate (NOT/kg): 40mg dly oral, incr to Thrombin glue. 10,000u thrombin in 9ml mixed
80-120mg dly. 1% gel: 5g tube (50mg testoste- with 1ml 10% calcium chloride in syringe 1,
rone) to skin dly. 30mg buccal tab: applied just 10ml cryoprecipitate in syringe 2: apply to
above incisor 12H. bleeding sites together. Do not inject.
Testosterone level: <16yr 5-10nmol/L, >16yr Thrombin, topical. 100-2000u/ml onto bleeding
10-30nmol/L. surface.
Tetanus toxoid (Tet-Tox). 0.5ml IM stat, 6wk Thymidine. 75g/m every 4-6wk IV over 24hr.
later, and 6mo later. Boost every 10yr, or if Thymoxamine. Adult (NOT/kg): 40-80mg 6H oral.
contaminated wound. Thyrotropin alfa. Adult (NOT/kg): 0.9mg IM 24H
Tetrabenazine. 0.5-2mg/kg (adult 25-100mg) 12H oral x2 doses, or 72H x3 doses.
Tetracaine. See amethocaine.

409
Drug Doses
Thyroxine. 50mcg tab. 100mcg/m rounded to Tocainide. 5-10mg/kg (max 400-800mg) 8-12H
nearest quartr tab (adult 100-200mcg) dly oral. IV over 30min or oral.
Tiagabine. Usu. 0.1mg/kg (adult 5mg) 12H, incr Tocopherol. See alpha-tocopheryl acetate, and
wkly to 0.1-0.5mg/kg (adult 5-15mg) 8H oral. vitamin E.
Tiaprofenic acid. 2-4mg/kg (adult 100-200mg) Tolazamide. 2-5mg/kg (adult 100-250mg) 6-24H oral
8H oral. Tolazoline. Newborn: 1-2mg/kg slowly stat
Tibolone. Adult (NOT/kg): 2.5mg daily oral. (beware hypotension), then 2-6mcg/kg/min
Ticarcillin. 50mg/kg (adult 3g) IV 6-8H (1st wk (0.12-0.36mg/kg/hr) IV. Note: 1-2mg/kg/hr too
life), 4-6H or constant infsn (2+ wk). Cys c fib: much (Pediatrics 1986;77:307).
100mg/kg (max 6g) 8H IV. Tolbutamide. Adult (NOT/kg): ini ally 1g 12H
Ticarcillin + clavulanic acid. Dose as for carcillin. oral, o en reducing to 0.5-1g daily.
Ticlopidine. 5mg/kg (adult 250mg) 12H oral. Tolcapone. Adult (NOT/kg): 100mg 8H oral; if
Tigecycline. 2mg/kg (adult 100mg) IV over 1hr no response, try maximum dose of 200mg 8H.
stat, then 1mg/kg (adult 50mg) IV over 30min 12H. Monitor ALT and AST.
Tilactase. 200u/drop: 5-15 drops/L added to Tolfenamic acid. 4mg/kg (adult 200mg) oral,
milk 24hr before use. 3300u/tab: 1-3tabs may repeat once a er 2hr.
with meals oral. Tolme n. 5-10mg/kg (adult 400-600mg) 8H oral.
Tiludronate disodium. Adult 400mg dly x12 wk oral Tolna ate. 1% cream, ointmnt, powdr, soltn:
Timolol. 0.1mg/kg (adult 5mg) 8-12H, incr to apply 8-12H.
max 0.3mg/kg (adult 15mg) 8H. Eye drops Tolterodine. 0.05mg/kg (adult 2mg) 12H oral.
(0.25%, 0.5%): 1 drop/eye 12-24H; Slow rel: adult 2-4mg daily oral.
Timolol 5mg/ml + travoprost 40mcg/ml. Topiramate. 1mg/kg (adult 50mg) 12-24H oral,
1 drop/eye daily. incr slowly if reqd to 4-10mg/kg (adult 100-
Tinidazole. Giardia, trichomonas: 50mg/kg 500mg) 12H.
(adult 2g) daily for 2 days oral, or 25mg/kg Topotecan. 1.5mg/m daily x5 IV over 30min,
(adult 1g) daily x5 days. Amoebiasis: 50mg/kg repeat every 3wk for at least 4 courses.
(adult 2g) daily for 3-5 days, usually followed Torasemide. 0.1-1mg/kg (adult 5-50mg) daily
by diloxanide furoate 10mg/kg (adult 500mg) oral or IV. Rarely up to 4mg/kg (adult 200mg)
8H for 10 days. daily in renal failure.
Tinzaparin. 1mg =75 an -Xa IU. Prophylaxis: 50u Toremifene. Adult (NOT/kg): 60mg daily oral.
/kg SC 2hr before surgery, then dly for 7-10d. Tramadol. 2-3mg/kg (adult 50-100mg) stat, then
Treatment: 175u/kg SC daily for at least 6 days. 1-2mg/kg (adult 50-100mg) 4-6H (usual max
Tioconazole. 280mg/ml: apply to nails 12H for 400mg/day, up to 600 mg/day) oral or IV over
6-12mo. 3min. IV infusion 2-8mcg/kg/min.
Tioguanine. Usu, 200mg/m daily oral for 5-20d Tramazoline. Nasal: 82mcg each nostril x3-6/d
Tiopronin. 3-10mg/kg (adult 150-500mg) 6-8H oral. See also dexamethasone + tramazoline.
Tiotropium. NOT/kg: 18mcg cap daily by inhaler. Trandolapril. 0.01-0.1mg/kg (adult 0.5-4mg)
Tipranavir. Adult (NOT/kg): 500mg 12H with daily oral.
food (and ritonavir 200mg) oral. Tranexamic acid. Oral: 15-25mg/kg (adult 1-
Tirilazad. 1.5mg/kg 6H IV over 30min. 1.5g) 8H for up to 4 days. IV: 10-15mg/kg
(adult 0.5-1g) 8H.
Tirofiban. 0.4mcg/kg/min x30min, then 0.1mcg/kg
/min x2-5 d; also give heparin to APTT x2 normal Tranylcypromine. 0.2mg/kg (adult 10mg) 8-12H oral.
Tissue plasminogen ac vator. See alteplase. Trastuzumab. 4mg/kg IV over 90min load, then
2mg/kg IV over 30min wkly. Early cancer a er
Tizanidine. 0.01mg/kg (adult 0.5mg) 8H, incr grad-
chemo: 8 mg/kg IV over 90min, then 6mg/kg
ually to 0.1-0.25mg/kg (adult 6-12mg) 8H oral.
IV over 90min every 3wk.
Tobramycin. IV or IM. 1wk-10yr: 8mg/kg day 1,
Travoprost. 40mcg/ml (0.004%): 1drop/eye in
then 6 mg/kg daily. >10yr: 7mg/kg day 1, then
evening. See also molol + travoprost.
5mg/kg (max 240-360mg) daily.
Neonate, 5mg/kg dose: <1.2kg 48H (0-7 days Trazodone. 1-4mg/kg (adult 50-200mg) 8H oral.
of life), 36H (8-30 days), 24H (>30 days); 1.2 - Trepros nil. 1.25ng/kg/min SC infsn, incr each wk
2.5kg 36H (0-7 days of life), 24H (>7 days); by 1.25-2.5ng/kg/min to max 20-60ng/kg/min.
term 24H (0-7 days of life), then as for 1wk- Tre noin. 22.5mg/m 12H oral. Cream or lo on
10yr. Trough level <1.0mg/L. 0.05%, gel 0.01%: apply daily for 3-4 months,
Inhaltn: 80mg diluted to 4ml 12H; or TOBI then x1-3/wk.

410
 Drug Doses
Triamcinolone. Joint, tendon (NOT/kg): 2.5-15 Trospium chloride. 0.4mg/kg (adult 20mg) 12H oral
mg stat. IM: 0.05-0.2mg/kg every 1-7 days. Trovafloxacin. 4mg/kg (adult 200mg) daily oral.
Cream or ointment 0.02%, 0.05%: apply Severe in n: 6mg/kg (adult 300mg) daily oral.
sparingly 6-8H. Triamcinolone has no mineral- Tryptophan, L isomer. Adult (NOT/kg) 1-2g 8H oral.
cor coid ac on, 1mg = 5mg hydrocor sone in Tyloxapol. See colfosceril palmitate.
glucocor coid ac on.
Tulobuterol. 0.04mg/kg (adult 2mg) 8-12H oral.
Triamterene. 2mg/kg (adult 100mg) 8-24H oral.
Typhoid vaccine, oral (Vivo f). Live. 1 cap oral
Triazolam. 0.005-0.01mg/kg (adult 0.125-0.5mg)
days 1, 3, 5 and (for be er immunity) 7.
nocte oral. 30 min preop: 0.01-0.03 mg/kg
Boost yearly.
(adult 0.5mg) oral.
Typhoid vaccine, parenteral, polysaccharide
Triclofos. 25-30mg/kg (adult 0.5-1g) nocte oral.
(Typherix, Typhim Vi). Inac vated. >5yr: 0.5ml
Triclosan. 0.5%-5% lo on: 2ml to wet skin for
IM once. Boost 3yrly.
30sec, rinse and rpt. Bath oil: 20ml in 20cm
bath, soak 15min. Ubidecarenone. 1-3mg/kg (adult 50-150mg)
12H oral
Trien ne. 10mg/kg (adult 500mg) 6-12H oral.
Uracil. See tegafur + uracil.
Triethylenethiophosphoramide. See thiotepa.
Urea. 10% cream: apply 8-12H.
Trifluoperazine. 0.02-0.4mg/kg (adult 1-10mg,
occasionally 20mg) 12H oral. Caps: adult 15mg dly. Urofollitrophin. See follicle s mula ng hormone.
Trifluridine. 1% soltn: 1 drop/eye 2H (max 9 drops Urokinase. 4000u/kg IV over 10min, then
/d) un l epithelialisd, then 4H (max 5 drops/d) x7d 4000u/kg/hr for 12hr (start heparin 3-4hr
later). Blocked cannula: ins ll 5000-25000u
Trihexyphenidyl. See benzhexol.
(NOT/kg) in 2-3ml saline for 2-4hr.
Triiodothyronine (T3). See liothyronine. Empyema: 2ml/kg of 1500u/ml in saline,
Trilostane. 0.5-4mg/kg (adult 30-240mg) 6H oral. posi on head up/down and right side
Trimeprazine. An histamine: 0.1-0.5mg/kg up/down 30min each, then drain.
(adult 2.5-25mg) 6H oral. Pericardial eusion: 10,000u/ml, 1ml/kg
Seda on: 0.5-1mg/kg IM, 2-4mg/kg oral. (max 20ml), clamp 1hr, drain.
Trimethobenzamide. 5mg/kg (adult 250mg) Ursodeoxycholic acid. 5-10mg/kg (adult 200-
6-8H oral,IM,PR. 400mg) 12H oral.
Trimethoprim. 3-4mg/kg (max 150mg) 12H, Ursodiol. See ursodeoxycholic acid.
or 6-8mg/kg (usual max 300mg) dly oral, IV. Valaciclovir. 20mg/kg (adult 1g) 8H oral. Genital
Urine prophylaxis: 1-2mg/kg (adult 150mg) herpes (NOT/kg): treatment 500mg 12H,
nocte preven on 500mg daily (<10 episodes/yr) 1g
Trimethoprim + sulphamethoxazole. daily (>9 episodes/yr). Orolabial: 40mg/kg
See cotrimoxazole. (adult 2g) 12H for 2 doses.
Trimethylglycine. See betaine hydrochloride. Valcyte. Adult (NOT/kg): 900mg 12H oral for
Trimetrexate. 45mg/m IV over 90min dly x21d, 3wk, then 900mg daily.
with folinic acid 20mg/m IV over 10min 6H x24 d Valdecoxib. Adult(NOT/kg): 10mg daily
Trimipramine. 1-2mg/kg (adult 50-100mg) 8-24H oral (arthri s), 20mg 12H (dysmenorrhoea) oral.
Trioxysalen. Adult: 5-10mg dly 2hr bef. UV exposure Valganciclovir. Adult (NOT/kg): 900mg 12H oral
Tripelennamine. 1.25mg/kg (adult 75mg) 6H oral. with food for 21 days, then 900mg daily.
Tripotassium dicitratobismuthate. Valproic acid, valproate. See sodium valproate.
See bismuth subcitrate. Valrubicin. Adult (NOT/kg): 800mg wkly x6
Triprolidine. See pseudoephedrine + triprolidene. intravesical
Triptorelin. Adult (NOT/kg). Depot: 3.75-4.2mg Valsartan. 0.8-3mg/kg (adult 40-160mg) daily
IM every 28 days. Long ac ng: 11.25mg IM oral. See also amlodipine + valsartan.
every 12wk. Vancomycin. 10mg/kg (adult 500mg) 6H IV over
Trisodium edetate. 40-70mg/kg (max 3g) IV over 1hr, or 1g 12H in adult IV over 2hr. Newborn:
6hr daily x5 d; max 3 courses each 2 d apart. 10mg/kg 8H IV over 1hr. C.dicile: 10mg/kg
Trometamol (THAM). ml of 0.3 molar(18g/ (adult 500mg) 6H oral. Intraventricular
500ml) soltn = (Wt in kg) x BE; give half this IV (NOT/kg): 10mg 48H.
over 30min, then repeat if reqd. Trough 5-10mg/L (peak 20-40mg/L).
Tropicamide. 0.5%, 1%: 1 drop/eye, rpt a r 5min Varenicline. Adult (NOT/kg): 0.5mg oral daily for
Tropisetron. 0.1mg/kg (adult 5mg) slow IV just 3 days, 12H days 4-7; then 1mg 12H for 11wk
before chemotherapy, then oral 12-24H. (23wk if stopped smoking).

411
Drug Doses
Varicella vaccine (Varilix, Varivax). Live. 9mo- Vitamin B2. Metabolic disease: 50-150mg
12yr: 0.5ml SC once. >12yr: 0.5ml SC stat, and 12-24H oral
4-8wk later. See also Herpes zoster vaccine, Vitamin B6. See pyridoxine.
and Immunolobulin zoster. Vitamin B12. See hydroxocobalamin.
Vasopressin, aqueous. IM, SC: 2.5-10u 6-12H. Vitamin C. See ascorbic acid.
IV: put 2-5u in 1L fluid, and replace urine out Vitamin D2. See ergocalciferol.
put + 10% each hour. Hypotension (brain
Vitamin D3. See cholecalciferol.
death, sepsis, post-bypass): 1u/kg in 50ml
5% dex-hep at 1-3ml/hr (0.02-0.06 units/kg/hr) Vitamin E. 1u = 1mg. Preterm babies,
+ adrenaline 0.1-0.2mcg/kg/min. Coperol E (NOT/kg): 40u (2 drops) daily oral.
GI hge: 6u/kg in 50ml at 1-5ml/hr IV, 1ml/hr Cys c Fibrosis, malabsorp on: 50-100u (<3yr)
local IA. See desmopressin, lypressin. 200-400u (>3yr) daily oral. Cholestasis: 50u/kg
daily oral, incr if reqd in 50u/kg increments.
Vasopressin, oily. 2.5-5u (NOT/kg) IM every 2-4 d.
A-beta-lipoproteinaemia: 35-70 u/kg 8H oral.
Vecuronium. ICU: 0.1mg/kg prn IV. Theatre: HUS: 0.25g/m2 6H oral. See alpha-tocopheryl.
0.1mg/kg stat, then 0.5-2mcg/kg/min; up to
Vitamin K1. See phytomenadione.
10mcg/kg/min occasionally.
Vitamin K3. See menapthone sodium bisulphite.
Venlafaxine. Adult (NOT/kg): 37.5mg 12H oral,
incr if reqd to max 150mg 12H. Slow rel: 75mg Vitamins, parenteral. MVI-12 (for adult): 5ml in
daily oral, incr if reqd to max 225mg daily. 1 L IV fluid. MVI Paediatric, added to IV fluid:
65% of a vial (<3kg), 1 vial (3kg to 11yr).
Verapamil. IV: 0.1-0.2mg/kg (adult 5-10mg)
over 10min, then 5mcg/kg/min. Voriconazole. Oral, IV over 2hr: 8mg/kg (child
Oral: 1-3 mg/kg (adult 80-120mg) 8-12H. >2yr) 200mg (adult <40kg) 400mg (adult > 40 kg)
rpt a er 12hr, then 6mg/kg (child >2yr) 100mg
Veregen. 15% ointment: apply 8H for up to 16wk.
(adult <40kg) 200mg (adult >40kg) 12H.
Versenate. See sodium calcium edetate. Increase maintenance by 50% if required.
Verteporfin. 6mg/m over 10min IV; 15min Vorinostat. Adult (NOT/kg): 400mg daily oral;
a er start of infsn give diode laser of 689nm may need to decrease to 300mg daily, or
at 600mW/cm for 83sec. 300mg on 5 days a week.
Vidarabine. Eye ointment: x5/day un l Warfarin. Usually 0.2mg/kg (adult 5mg) stat,
epithelialised, then 12H 7 days. 0.2mg/kg (adult 5mg) next day providing INR
IV infsn: 10mg/kg/day 5-10 d (varicellazoster), <1.3, then 0.05-0.2mg/kg (adult 2-5mg) daily
15mg/kg/day 10 days (herpes encephali s). oral. INR usually 2-2.5 for prophylaxis, 2-3 for
Vigabatrin. 40mg/kg (adult 1g) dly oral, may incr to treatment. Beware drug interac ons.
80-150mg/kg (max 4g) dly (given in 1-2 doses). Xamoterol. 4mg/kg (adult 200mg) 12-24H oral.
Viloxazine. 2-5mg/kg (adult 100-250mg) morning, Xipamide. 0.5-1.5mg/kg (adult 20-80mg) dly oral
and 2-3mg/kg (adult 100-150mg) noon oral.
Xylometazoline. <6yr: 0.05% 1 drop or spray
Vinblas ne. 6.5mg/m IV over 1 min every 1-4wk. 8-12H. 6-12yr: 0.05% 2-3 drops or sprays 8-
Vincris ne. 1.5mg/m wkly IV over 1 min. 12H. >12yr: 0.1% 2-3 drops or sprays 6-12H.
Vindesine. 3-4mg/m IV every 7-10 day if wbc Yellow fever vaccine (Stamaril). Live. >12mo:
count >2500/mm. 0.5ml SC once. Boost every 10yr.
Vinorelbine. 30mg/m IV over 10min weekly. Yohimbine. 0.05-0.1mg/kg (adult 2.7-5.4mg)
Vitamin A. High risk (NOT/kg): 100,000iu (<8kg), 8H oral.
200,000iu (>8kg) oral or IM every 4-6mo. Zafirlukast. NOT/kg: 10mg (>7yr) 20-40mg
Severe measles: 400,000iu (NOT/kg) once. (adult) 12H oral.
Cys c fibrosis: 1500u daily (<3yr) 5000u daily Zalcitabine. Usually 0.015mg/kg (adult 1mg)
(3-10yr) 10000u daily (>10yr) oral. >10,000iu 12H oral.
daily or >25000u per wk may be teratogenic.
Zaleplon. Adult (NOT/kg): 10mg (5-20mg) nocte oral
Vitamin A, B, C, D compound (Pentavite, infant).
Zanamivir. Adult (NOT/kg): 10mg 12H for 5 days
<3yr (NOT/kg): 0.15ml daily, incr by 0.15ml/day
inhaled. Prophylaxis: 10mg daily inhaled.
to 0.45ml/day.
Zicono de. Adult (NOT/kg): 2.4mcg/day by
Vitamin A, B, C, D compound (Pentavite, child).
intrathecal infusion, incr every 24-48hr to max
<3yr (NOT/kg): 2.5ml daily. >3yr (NOT/kg):
21.6mcg/day.
5ml daily.
Vitamin B group. Amp: IV over 30 min. Tab: 1-2/d
Vitamin B1. See thiamine.

412
 Drug Doses
Zidovudine (AZT). Preterm: 1.5mg/kg 12H IV,
or 2mg/kg 12H oral to 2wk, then 2mg/kg 8H.
Term: 2mg/kg 6H oral, 1.5mg/kg 6H IV.
Child: usually 180mg/m 12H oral; 120 mg/m
6H IV, or 20mg/m/hr IV (range 90-180 mg/m
6-8H IV).
Adult (NOT/kg): usually 200mg 8H oral, or
300mg 12H oral, or 150mg 8H IV.
See abacavir + lamivudine + zidov.
Zileuton. Adult (NOT/kg): 600mg 6H oral.
Zinc chloride. 5.3mg/ml = 2.5mg/ml Zn =38umol/
ml Zn. 2-4umol/kg/d (<1yr), 1umol/kg/d (child),
40-60umol/d (adult). Serum zinc 11-22 umol/l.
Zinc sulphate. (220mg cap = 50mg Zn = 765umol
Zn). Deficiency, acroderm enteropath: ini ally
3mg/kg (adult 220mg) 8-12H oral, adjusted to
achieve serum zinc 11-22umol/L (0.7-1.4mg/L).
Diarrhoea child (NOT/kg): 10-20mg daily oral.
Ziprasidone. Adult (NOT/kg): 20mg 12H, incr if
reqd to max 80mg 12H oral.
Zoledronate. 0.025-0.05mg/kg (adult 4mg) IV
over 15min; usually repeated every 4wk.
Zolmitriptan. Adult (NOT/kg): 2.5-5mg oral, rpt
in 2hr if reqd; max 15mg in 24hr. Nasal: 5mg
spray in each nostril, repeat in 2hr if reqd; max
twice in 24hr.
Zolpidem. 0.1-0.4mg/kg (adult 5-20mg) nocte oral.
Zonisamide. 2mg/kg (adult 100mg) daily oral,
incr if reqd a er 2wk to 12H, then 3mg/kg
(adult 150mg) 12h, then 4mg/kg (adult
200mg) 12H; rarely up to 6mg/kg (adult
300mg) 12H. Level 10-20mg/l.
Zopiclone. 0.1-0.3mg/kg (adult 5-15mg) nocte oral.
Zotepine. 0.5mg/kg (adult 25mg) 8H oral,
adjusted every 4 days to 0.5-2mg/kg 8H.
Zuclopenthixol. 0.4-3.0mg/kg (adult 20-150mg)
daily oral.

413