Types of Vaccines

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Scientists take many approaches to designing vaccines.

These approaches are based on

information about the germs (viruses or bacteria) the vaccine will prevent, such as how it infects

cells and how the immune system responds to it. Practical considerations, such as regions of the

world where the vaccine would be used, are also important because the strain of a virus and

environmental conditions, such as temperature and risk of exposure, may be different in various

parts of the world. The vaccine delivery options available may also differ geographically. Today

there are five main types of vaccines that infants and young children commonly receive:

1. Live, attenuated vaccines fight viruses

These vaccines contain a version of the living virus that has been weakened so that it does not

cause serious disease in people with healthy immune systems. Because live, attenuated vaccines

are the closest thing to a natural infection, they are good teachers for the immune system.

Examples of live, attenuated vaccines include measles, mumps and rubella vaccine (MMR) and

varicella (chickenpox) vaccine. Even though these vaccines are very effective, not everyone can

receive them. Children with weakened immune systems—for example, those who are

undergoing chemotherapy—cannot get live vaccines

2. Inactivated Vaccines

These vaccines also fight viruses. These vaccines are made by inactivating, or killing, the virus

during the process of making the vaccine. The inactivated polio vaccine is an example of this
type of vaccine. Inactivated vaccines produce immune responses in different ways than live,

attenuated vaccines. Often, multiple doses are necessary to build up and/or maintain immunity.

3. Toxoid Vaccines

These vaccines prevent diseases caused by bacteria that produce toxins (poisons) in the body. In

the process of making these vaccines, the toxins are weakened so they cannot cause illness.

Weakened toxins are called toxoids. When the immune system receives a vaccine containing a

toxoid, it learns how to fight off the natural toxin. The DTaP vaccine contains diphtheria and

tetanus toxoids.

4. Subunit Vaccines

These vaccines include only parts of the virus or bacteria, or subunits, instead of the entire germ.

Because these vaccines contain only the essential antigens and not all the other molecules that

make up the germ, side effects are less common. The pertussis (whooping cough) component of

the DTaP vaccine is an example of a subunit vaccine.

5. Conjugate Vaccines

These vaccines fight a different type of bacteria. These bacteria have antigens with an outer

coating of sugar-like substances called polysaccharides. This type of coating disguises the

antigen, making it hard for a young child’s immature immune system to recognize it and respond

to it. Conjugate vaccines are effective for these types of bacteria because they connect (or

conjugate) the polysaccharides to antigens that the immune system responds to very well. This

linkage helps the immature immune system react to the coating and develop an immune
response. An example of this type of vaccine is the Haemophilus influenzae type B (Hib)

vaccine.

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