Types of Vaccines
Types of Vaccines
Types of Vaccines
information about the germs (viruses or bacteria) the vaccine will prevent, such as how it infects
cells and how the immune system responds to it. Practical considerations, such as regions of the
world where the vaccine would be used, are also important because the strain of a virus and
environmental conditions, such as temperature and risk of exposure, may be different in various
parts of the world. The vaccine delivery options available may also differ geographically. Today
there are five main types of vaccines that infants and young children commonly receive:
These vaccines contain a version of the living virus that has been weakened so that it does not
cause serious disease in people with healthy immune systems. Because live, attenuated vaccines
are the closest thing to a natural infection, they are good teachers for the immune system.
Examples of live, attenuated vaccines include measles, mumps and rubella vaccine (MMR) and
varicella (chickenpox) vaccine. Even though these vaccines are very effective, not everyone can
receive them. Children with weakened immune systems—for example, those who are
2. Inactivated Vaccines
These vaccines also fight viruses. These vaccines are made by inactivating, or killing, the virus
during the process of making the vaccine. The inactivated polio vaccine is an example of this
type of vaccine. Inactivated vaccines produce immune responses in different ways than live,
attenuated vaccines. Often, multiple doses are necessary to build up and/or maintain immunity.
3. Toxoid Vaccines
These vaccines prevent diseases caused by bacteria that produce toxins (poisons) in the body. In
the process of making these vaccines, the toxins are weakened so they cannot cause illness.
Weakened toxins are called toxoids. When the immune system receives a vaccine containing a
toxoid, it learns how to fight off the natural toxin. The DTaP vaccine contains diphtheria and
tetanus toxoids.
4. Subunit Vaccines
These vaccines include only parts of the virus or bacteria, or subunits, instead of the entire germ.
Because these vaccines contain only the essential antigens and not all the other molecules that
make up the germ, side effects are less common. The pertussis (whooping cough) component of
5. Conjugate Vaccines
These vaccines fight a different type of bacteria. These bacteria have antigens with an outer
coating of sugar-like substances called polysaccharides. This type of coating disguises the
antigen, making it hard for a young child’s immature immune system to recognize it and respond
to it. Conjugate vaccines are effective for these types of bacteria because they connect (or
conjugate) the polysaccharides to antigens that the immune system responds to very well. This
linkage helps the immature immune system react to the coating and develop an immune
response. An example of this type of vaccine is the Haemophilus influenzae type B (Hib)
vaccine.