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Ep 3056906 A1 20160817 (En)

This document relates to biomarkers for diagnosing and predicting the prognosis of corneal ectasia. Specifically, it describes methods for determining a diagnosis of corneal ectasia in a subject, assessing the risk of developing ectasia, predicting clinical outcomes, and selecting subjects for ectasia therapy based on the expression levels of TLR2 and/or TLR4 markers. The document also describes using TLR2 and/or TLR4 as diagnostic and prognostic markers for corneal ectasia.

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CHIRANJEEVI
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11 views

Ep 3056906 A1 20160817 (En)

This document relates to biomarkers for diagnosing and predicting the prognosis of corneal ectasia. Specifically, it describes methods for determining a diagnosis of corneal ectasia in a subject, assessing the risk of developing ectasia, predicting clinical outcomes, and selecting subjects for ectasia therapy based on the expression levels of TLR2 and/or TLR4 markers. The document also describes using TLR2 and/or TLR4 as diagnostic and prognostic markers for corneal ectasia.

Uploaded by

CHIRANJEEVI
Copyright
© © All Rights Reserved
Available Formats
Download as PDF, TXT or read online on Scribd
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Title (en)

Biomarkers for diagnosis and prognosis of corneal ectasia

Title (de)
Biomarker zur Diagnose und Prognose von Hornhautektasie

Title (fr)
Biomarqueurs pour le diagnostic et le pronostic d'ectasie cornéenne

Publication
EP 3056906 A1 20160817 (EN)

Application
EP 15382060 A 20150216

Priority
EP 15382060 A 20150216

Abstract (en)
The invention relates to the field of the diagnosis and prognosis methods of molecular pathologies. In particular, the invention relates to methods for
determining the diagnosis of an ectatic disease of the cornea in a subject, for determining the risk of developing an ectatic disease of the cornea in a
subject, for determining the clinical outcome of a subject suffering from an ectatic disease of the cornea and for selecting a subject to be treated with
a therapy for an ectatic disease of the cornea based on the determination of the expression levels of TLR2 and/or TLR4 markers. The invention also
relates to the use of the TLR2 and/or TLR4 as diagnosis and prognosis markers for an ectatic disease of the cornea.

IPC 8 full level (invention and additional information)


G01N 33/68  (2006.01); C07K 14/705  (2006.01)

CPC (invention and additional information)


G01N 33/6893 (2013.01); C07K 14/705 (2013.01); C07K 14/70596 (2013.01); G01N 2800/16 (2013.01)

Citation (applicant)
• SAMBROOK, J. ET AL.: "Molecular cloning: a Laboratory Manual", vol. 1-3, 2001, COLD SPRING HARBOR LABORATORY
PRESS
• ALTSCHUL, S. ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
• DOWDY; WEARDEN: "Statistics for Research", 1983, JOHN WILEY & SONS

Citation (search report)


• [A] WO 2011066621 A1 20110609 - UNIV SYDNEY [AU], et al
• [A] US 2007248970 A1 20071025 - RABINOWITZ YARON S [US], et al
• [X] WO 2013107826 A2 20130725 - PASTEUR INSTITUT [FR], et al

• [X] "ADVANCES IN OPHTHALMOLOGY", 1 January 2012 (2012-01-01), pages FP - 570, XP055234152, Retrieved from the
Internet <URL:http://downloadketab.net/download/133/Advances_in_Ophthalmology.pdf> [retrieved on 20151207]
• [A] MICERA A ET AL: "Toll-like receptors and the eye", CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, vol.
5, no. 5, 1 January 2005 (2005-01-01), LIPPINCOTT WILLIAMS AND WILKINS, US, pages 451 - 458, XP009108411, ISSN:
1528-4050, DOI: 10.1097/01.ALL.0000182537.55650.99
• [A] LI YINGCHAO ET AL: "Pretreatment With TLR2 and TLR4 Ligand Modulates Innate Immunity in Corneal Fibroblasts Challenged
With Aspergillus fumigatus", IOVS, vol. 54, no. 6, June 2013 (2013-06-01), pages 4261 - 4270, XP002751883, ISSN: 0146-0404
• [A] XIAOYONG YUAN ET AL: "Toll-like Receptors Involved in the Pathogenesis of Experimental Candida albicans Keratitis",
INVESTIGATIVE OPTHALMOLOGY & VISUAL SCIENCE, vol. 51, no. 4, 1 April 2010 (2010-04-01), US, pages 2094 - 2100,
XP055233775, ISSN: 1552-5783, DOI: 10.1167/iovs.09-4330
• [A] ALESSANDRO LAMBIASE ET AL: "Toll-like receptors in ocular surface diseases: overview and new findings", CLINICAL
SCIENCE., vol. 120, 1 May 2011 (2011-05-01), GB, pages 441 - 450, XP055234090, ISSN: 0143-5221
• [A] JOHNSON A C ET AL: "Activation of toll-like receptor (TLR)2, TLR4, and TLR9 in the mammalian cornea induces MyD88-
dependent corneal inflammation", vol. 46, no. 2, 1 February 2005 (2005-02-01), ASSOCIATION FOR RESEARCH IN VISION
AND OPHTHALMOLOGY, US, pages 589 - 595, XP008146428, ISSN: 0146-0404, Retrieved from the Internet <URL:http://
iovs.arvojournals.org/article.aspx?articleid=2124771> [retrieved on 20151204], DOI: 10.1167/IOVS.04-1077

Designated contracting state (EPC)


AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)


BA ME

DOCDB simple family


EP 3056906 A1 20160817; AU 2016221761 A1 20170928; CA 2975951 A1 20160825; EP 3259599 A1 20171227; JP 2018510651 A 20180419;
KR 20170138400 A 20171215; MX 2017010516 A 20180615; SG 11201706249R A 20170830; US 2018067128 A1 20180308; WO 2016131840
A1 20160825

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