Hischsprug Disease by Hamad
Hischsprug Disease by Hamad
Hischsprug Disease by Hamad
Rarely, the aganglionosis extends into the small bowel or even more
proximally to encompass the entire bowel ( total intestinal aganglionosis)
Embryology and Etiology
Embryologic defect
Failure of neural crest migration
Marked increase in nerve fibers which extend into the submucosa (seen
with acetylcholinesterase stain)
Local:
1. Obstructive toxic enterocolitis (fever,
diarrhea and abdominal distension) >>
cause of death.
2. Acute obstruction.
Matary-GIT_Surgery_2013
Bailey And Love's Short Practice of Surgery 26th Edition by Norman
Williams