Production of Pharmaceutical Syrups: Solid Ingredients Dosing Systems Production Tanks

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PRODUCTION OF PHARMACEUTICAL SYRUPS MS

I Process description

Pharmaceutical syrups are produced by mixing purified water, sweeteners, active ingredients (API), aromas, flavours and other
ingredients (thickeners, etc.). The ingredients are added by means of metering or dosing systems like flow meters and load cells to one
or more reactors, the order and quantity of the ingredients to add is specified in the recipe. Usually, preparations are heated before
finishing the addition of components. Solid products are added by means of solid-liquid blenders or vacuum systems. When the
process is finished, the end product is filtered (if required) and sent to a storage tank. The product is transferred from the storage tanks
to the filling machines by pumps.

Solid ingredients
Dosing systems Production tanks
Liqud ingredients

Filling machines Storage tanks Filtration

I INOXPA solution
SORBITOL
PURIFIED
WTAER
VACUUM

LIQUID
API
PURIFIED

SOLID
WATER

INGREDIENTS

HEATING
COOLING
PURIFIED
WATER

PREPARATION
TANK

REACTOR

BLENDER FOR
LOBE ROTOR PUMP SOLID PARTICLES
STORAGE TANK

IN-LINE MIXER
FILLING
MACHINE

LOBE ROTOR PUMP LOBE ROTOR PUMP

FILTRATION
PRODUCTION OF PHARMACEUTICAL SYRUPS MS
I Process features

- High efficiency operation to produce different types of end product.

- The measuring systems ensure the correct dosing of each ingredient.

- INOXPA components designed according to the pharmaceutical standards.

- Equipment designed according to GMP biopharmaceutical standards.

- Production lines and tanks are prepared for CIP and sanitation.

- Automatic control allows repeatability in the manufacturing process, reducing the number of errors; greater flexibility
of manufacturing parameters; reduction in the number of plant operators.

- Validation protocols: design (DQ), installation (IQ) and operation (OQ).

I Required components

- Lobe rotor and centrifugal pumps.

- Agitation systems.

- High-shear mixers.

- Dosing systems for solid ingredients.

- Measuring devises.

- Heated preparation tanks.

- Vacuum system.
ME 4100 in-line mixer
- Filtration.

- Control system.

- Cleaning and sanitation system.

Diaphragm valves HLR lobe rotor pump


FAphSyrups.1.EN-0710

The information contained in this brochure is for guidance only. We reserve the right to modify any material or feature
without notice in advance. For further information, please, consult our web page. www.inoxpa.com

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