YEAR 13 CHECK LIST Inherited Change

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Final touch 2019 O/N

Inherited change check list

1. explain what is meant by homologous pairs of chromosomes

2. explain the meanings of the terms haploid and diploid and the need for a reduction
division (meiosis) prior to fertilisation in sexual reproduction
I
3. outline the role of meiosis in gametogenesis in humans and in the formation of pollen
grains and embryo sacs in flowering plants
I
4. describe, with the aid of photomicrographs and diagrams, the behaviour of
chromosomes in plant and animal cells during meiosis, and the associated behaviour of
the nuclear envelope, cell surface membrane and the spindle (names of the main
stages are expected, but not the sub-divisions of prophase)
d
5. explain how crossing over and random assortment of homologous chromosomes during
meiosis and random fusion of gametes at fertilisation lead to genetic variation including
the expression of rare, recessive alleles
d
6. explain the terms gene, locus, allele, dominant, recessive, codominant, linkage, test
cross, F1 and F2, phenotype, genotype, homozygous and heterozygous.
d
7. use genetic diagrams to solve problems involving monohybrid and dihybrid crosses,
including those involving autosomal linkage, sex linkage, codominance, multiple alleles
and gene interactions (the term epistasis does not need to be used; knowledge of the
expected ratio for various types of epistasis is not required. The focus is on problem
solving)
d
8. use genetic diagrams to solve problems involving test crosses d) use the chi-squared
test to test the significance of differences
d
9. between observed and expected results (the formula for the chi-squared test will be
provided) (see Mathematical requirements) d
10. explain that gene mutation occurs by substitution, deletion and insertion of base pairs
in DNA and outline how such mutations may affect the phenotype
d
11. outline the effects of mutant alleles on the phenotype in the following human
conditions: albinism, sickle cell anaemia, haemophilia and Huntington’s disease
d
12. explain the relationship between genes, enzymes and phenotype with respect to the
gene for tyrosinase that is involved with the production of melanin
d
Final touch 2019 O/N

a) distinguish between structural and regulatory genes and between repressible and
inducible enzymes
d
b) explain genetic control of protein production in a prokaryote using the lac operon
d
c) explain the function of transcription factors in gene expression in eukaryotes
d
d) explain how gibberellin activates genes by causing the breakdown of DELLA protein
repressors, which normally inhibit factors that promote transcription
d

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