SECTION 1: Identification of The Substance/mixture and of The Company/undertaking

safety data sheet
according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU
o-Xylene ≥ 98% for synthesis
article number: 8749 date of compilation: 2016-06-30

Version: 1.1 en Revision: 2016-07-04
Replaces version of: 2016-06-30
Version: (1.0)
SECTION 1: Identification of the substance/mixture and of the

company/undertaking
1.1 Product identifier
Identification of the substance o-Xylene
Article number 8749
Registration number (REACH) This information is not available.
Index No 601-022-00-9
EC number 202-422-2
CAS number 95-47-6
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses: laboratory chemical
1.3 Details of the supplier of the safety data sheet
Carl Roth GmbH + Co KG
Schoemperlenstr. 3-5
D-76185 Karlsruhe
Germany
Telephone: +49 (0) 721 - 56 06 0

Telefax: +49 (0) 721 - 56 06 149
e-mail: [email protected]
Website: www.carlroth.de
Competent person responsible for the safety data : Department Health, Safety and Environment
sheet
e-mail (competent person) : [email protected]
1.4 Emergency telephone number
Emergency information service Poison Centre Munich: +49/(0)89 19240
SECTION 2: Hazards identification

2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 (CLP)
Classification acc. to GHS
Section Hazard class Hazard class and cat- Hazard

egory state-
ment
2.6 flammable liquid (Flam. Liq. 3) H226
3.1D acute toxicity (dermal) (Acute Tox. 4) H312
3.1I acute toxicity (inhal.) (Acute Tox. 4) H332
3.2 skin corrosion/irritation (Skin Irrit. 2) H315
3.3 serious eye damage/eye irritation (Eye Irrit. 2) H319
United Kingdom (en) Page 1 / 14

safety data sheet
article number: 8749
Classification acc. to GHS
Section Hazard class Hazard class and cat- Hazard

egory state-
ment
3.8R specific target organ toxicity - single exposure (respiratory tract ir- (STOT SE 3) H335
ritation)
3.9 specific target organ toxicity - repeated exposure (STOT RE 2) H373
3.10 aspiration hazard (Asp. Tox. 1) H304
Remarks
For full text of Hazard- and EU Hazard-statements: see SECTION 16.
2.2 Label elements
Labelling according to Regulation (EC) No 1272/2008 (CLP)
Signal word Danger
Pictograms
Hazard statements
H226 Flammable liquid and vapour.
H304 May be fatal if swallowed and enters airways.
H312+H332 Harmful in contact with skin or if inhaled.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
H373 May cause damage to organs through prolonged or repeated exposure.
Precautionary statements
Precautionary statements - prevention
P210 Keep away from heat, hot surfaces, sparks, open flames. No smoking.
P260 Do not breathe mist/vapours/spray.
Precautionary statements - response
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/physician.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P331 Do NOT induce vomiting.
Labelling of packages where the contents do not exceed 125 ml
Signal word: Danger

safety data sheet
Symbol(s)
H304 May be fatal if swallowed and enters airways.

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/physician.
P331 Do NOT induce vomiting.
2.3 Other hazards

There is no additional information.
SECTION 3: Composition/information on ingredients

3.1 Substances
Name of substance o-Xylene
Index No 601-022-00-9
EC number 202-422-2
CAS number 95-47-6
Molar mass 106,2 g/mol
SECTION 4: First aid measures

4.1 Description of first aid measures
General notes
Take off immediately all contaminated clothing. Symptoms can occur only after several hours.
Following inhalation
Provide fresh air. If breathing is irregular or stopped, immediately seek medical assistance and start
first aid actions.
Following skin contact
Gently wash with plenty of soap and water. In case of extensive skin contact serious poisoning pos-
sible. Call a physician in any case.
Following eye contact
Irrigate copiously with clean, fresh water for at least 10 minutes, holding the eyelids apart. Consult an
ophthalmologist.
Following ingestion
Rinse mouth immediately and drink plenty of water. Observe aspiration hazard if vomiting occurs.
Call a physician immediately.
4.2 Most important symptoms and effects, both acute and delayed
Irritation, Cough, Headache, Impairment of vision, Dizziness, Vertigo, Nausea, Vomiting, Diarrhoea,
Breathing difficulties, Unconsciousness, Aspiration hazard

safety data sheet

4.3 Indication of any immediate medical attention and special treatment needed
none
SECTION 5: Firefighting measures

5.1 Extinguishing media
Suitable extinguishing media
Co-ordinate fire-fighting measures to the fire surroundings
water spray, foam, dry extinguishing powder, carbon dioxide (CO2)
Unsuitable extinguishing media
water jet
5.2 Special hazards arising from the substance or mixture
Combustible. Vapours can form explosive mixtures with air.
Hazardous combustion products
May produce toxic fumes of carbon monoxide if burning.
5.3 Advice for firefighters
Vapours are heavier than air. Beware of reignition. Fight fire with normal precautions from a reason-
able distance. Wear self-contained breathing apparatus.
SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures
For non-emergency personnel
Avoid contact with skin, eyes and clothes. Do not breathe vapour/spray. Use personal protective
equipment as required. Avoidance of ignition sources.
6.2 Environmental precautions
Keep away from drains, surface and ground water. Explosive properties.
6.3 Methods and material for containment and cleaning up
Advices on how to contain a spill
Covering of drains.
Advices on how to clean up a spill
Absorb with liquid-binding material (e.g. sand, diatomaceous earth, acid- or universal binding agents).
Other information relating to spills and releases
Place in appropriate containers for disposal. Ventilate affected area.
Reference to other sections
Hazardous combustion products: see section 5. Personal protective equipment: see section 8.
Incompatible materials: see section 10. Disposal considerations: see section 13.

safety data sheet
SECTION 7: Handling and storage

7.1 Precautions for safe handling
Provide adequate ventilation as well as local exhaustion at critical locations. Avoid exposure. When
not in use, keep containers tightly closed.
• Measures to prevent fire as well as aerosol and dust generation
Keep away from sources of ignition - No smoking.
Take precautionary measures against static discharge.

Advice on general occupational hygiene
Do not to eat, drink and smoke in work areas. Wash hands before breaks and after work.
7.2 Conditions for safe storage, including any incompatibilities
Store in a well-ventilated place. Keep container tightly closed. Protect from sunlight.
Incompatible substances or mixtures
Observe hints for combined storage.
Consideration of other advice
Ground/bond container and receiving equipment.
• Ventilation requirements
Use local and general ventilation.
• Specific designs for storage rooms or vessels
Recommended storage temperature: 15 - 25 °C.
7.3 Specific end use(s)
No information available.
SECTION 8: Exposure controls/personal protection

8.1 Control parameters
National limit values
Occupational exposure limit values (Workplace Exposure Limits)
Coun- Name of agent CAS No Identifier TWA TWA STEL STEL Source
try [ppm [mg/m³ [ppm [mg/m³
] ] ] ]
EU o-xylene 95-47-6 IOELV 50 221 100 442 2000/39/EC
GB o-xylene 95-47-6 WEL 50 220 100 441 EH40/2005
Notation
STEL Short-term exposure limit: a limit value above which exposure should not occur and which is related to a 15-
minute period unless otherwise specified
TWA Time-weighted average (long-term exposure limit): measured or calculated in relation to a reference period of 8
hours time-weighted average
Biological limit values

safety data sheet
Coun- Name of agent Parameter Identifier Value Material Source

try
GB o-xylene methylhippuric acids BMGV 650 urine EH40/2005

mmol/mol
Relevant DNELs/DMELs/PNECs and other threshold levels

• human health values
Endpoint Threshold Protection goal, Used in Exposure time
level route of exposure
DNEL 221 mg/m³ human, inhalatory worker (industry) chronic - systemic effects
DNEL 442 mg/m³ human, inhalatory worker (industry) acute - systemic effects
DNEL 221 mg/m³ human, inhalatory worker (industry) chronic - local effects
DNEL 442 mg/m³ human, inhalatory worker (industry) acute - local effects
DNEL 212 mg/kg human, dermal worker (industry) chronic - systemic effects
bw/day
• environmental values
Endpoint Threshold level Environmental compartment
PNEC 0,25 mg/l freshwater
PNEC 0,25 mg/l marine water
PNEC 0,25 mg/l water
PNEC 5 mg/l sewage treatment plant (STP)
PNEC 14,33 mg/kg freshwater sediment
PNEC 14,33 mg/kg marine sediment
PNEC 2,41 mg/kg soil
8.2 Exposure controls

Individual protection measures (personal protective equipment)
Eye/face protection
Use safety goggle with side protection.
Skin protection
• hand protection
Wear suitable gloves. Chemical protection gloves are suitable, which are tested according to EN 374.
For special purposes, it is recommended to check the resistance to chemicals of the protective gloves
mentioned above together with the supplier of these gloves.

safety data sheet

• type of material
FKM (fluoro rubber)
• material thickness
0,4 mm.
• breakthrough times of the glove material
>480 minutes (permeation: level 6)
• other protection measures
Take recovery periods for skin regeneration. Preventive skin protection (barrier creams/ointments) is
recommended.
Respiratory protection
Respiratory protection necessary at: Aerosol or mist formation. Type: A (against organic gases and va-
pours with a boiling point of > 65 °C , colour code: Brown).
Environmental exposure controls
Keep away from drains, surface and ground water.
SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties
Appearance
Physical state liquid (fluid)
Colour colourless
Odour characteristic
Odour threshold No data available
Other physical and chemical parameters
pH (value) This information is not available.
Melting point/freezing point -25 °C
Initial boiling point and boiling range 144 °C
Flash point 30 - 32 °C
Evaporation rate no data available
Flammability (solid, gas) not relevant (fluid)
Explosive limits
• lower explosion limit (LEL) 0,9 vol%
• upper explosion limit (UEL) 6,7 vol%
Explosion limits of dust clouds not relevant
Vapour pressure 7 hPa at 20 °C
Density This information is not available.
Vapour density This information is not available.
Bulk density Not applicable
Relative density Information on this property is not available.

safety data sheet

Solubility(ies)
Water solubility ~ 0,2 g/l at 25 °C
Partition coefficient
n-octanol/water (log KOW) 3,16 (exp. Lit.)
(TOXNET)
Soil organic carbon/water (log KOC) 2,73 (ECHA)
Auto-ignition temperature 463 - 465 °C
Decomposition temperature no data available
Viscosity not determined
Explosive properties shall not be classified as explosive
Oxidising properties none
9.2 Other information
Temperature class (EU, acc. to ATEX) T1 (Maximum permissible surface temperature
on the equipment: 450°C)
SECTION 10: Stability and reactivity

10.1 Reactivity
risk of ignition. Vapours can form explosive mixtures with air.
10.2 Chemical stability
The material is stable under normal ambient and anticipated storage and handling conditions of tem-
perature and pressure.
10.3 Possibility of hazardous reactions
Violent reaction with: Oxidisers, Nitric acid, Sulphuric acid, Sulphur
10.4 Conditions to avoid
Keep away from heat.
10.5 Incompatible materials
plastic and rubber
10.6 Hazardous decomposition products
Hazardous combustion products: see section 5.
SECTION 11: Toxicological information

11.1 Information on toxicological effects
Acute toxicity
Exposure route Endpoint Value Species Source
oral LD50 4.300 mg/kg rat TOXNET
dermal LD50 1.700 mg/kg rabbit TOXNET
inhalation: vapour LC50 21,7 mg/l/4h rat GESTIS

safety data sheet

Skin corrosion/irritation
Causes skin irritation.
Serious eye damage/eye irritation
Causes serious eye irritation.
Respiratory or skin sensitisation
Shall not be classified as a respiratory or skin sensitiser.
Summary of evaluation of the CMR properties
Shall not be classified as germ cell mutagenic, carcinogenic nor as a reproductive toxicant
• Specific target organ toxicity - single exposure
May cause respiratory irritation.
• Specific target organ toxicity - repeated exposure
May cause damage to organs through prolonged or repeated exposure.
Aspiration hazard
May be fatal if swallowed and enters airways.
Symptoms related to the physical, chemical and toxicological characteristics

• If swallowed
diarrhoea, vomiting, aspiration hazard
• If in eyes
Causes serious eye irritation
• If inhaled
irritant effects, cough, breathing difficulties, pulmonary oedema
• If on skin
causes skin irritation, risk of absorption via the skin
Other information
Other adverse effects: Headache, Impairment of vision, Dizziness, Vertigo, Nausea, Dyspnoea,
Unconsciousness, Liver and kidney damage, Symptoms can occur only after several hours
SECTION 12: Ecological information

12.1 Toxicity
acc. to 1272/2008/EC: Shall not be classified as hazardous to the aquatic environment.
Aquatic toxicity (acute)
Endpoint Value Species Source Exposure
time
LC50 2,6 mg/l rainbow trout (Onco- ECHA 96 h

rhynchus mykiss)
ErC50 4,7 mg/l algae ECHA 72 h
Aquatic toxicity (chronic)

time
ErC50 4,36 mg/l algae ECHA 73 h
EC50 2,2 mg/l Pseudokirchneriella sub- ECHA 73 h

capitata
NOEC 1,17 mg/l Ceriodaphnia dubia ECHA 7d

safety data sheet

time
growth (EbCx) 10% 1,91 mg/l aquatic invertebrates ECHA 21 d
12.2 Process of degradability

The substance is readily biodegradable.
Process Degradation rate Time
carbon dioxide generation 50 % 23 d
oxygen depletion 94 % 28 d
12.3 Bioaccumulative potential

Does not significantly accumulate in organisms.
n-octanol/water (log KOW) 3,16
BCF >5,5 - <12,2
12.4 Mobility in soil
Predicted Environmental Concentration 2,38
The Organic Carbon normalised adsorption 2,73
coefficient
12.5 Results of PBT and vPvB assessment
Data are not available.
12.6 Other adverse effects
Data are not available.
SECTION 13: Disposal considerations

13.1 Waste treatment methods
This material and its container must be disposed of as hazardous waste. Dispose of con-
tents/container in accordance with local/regional/national/international regulations.
Sewage disposal-relevant information
Do not empty into drains.
Waste treatment of containers/packagings
It is a dangerous waste; only packagings which are approved (e.g. acc. to ADR) may be used.
13.2 Relevant provisions relating to waste
The allocation of waste identity numbers/waste descriptions must be carried out according to the
EEC, specific to the industry and process.
13.3 Remarks
Waste shall be separated into the categories that can be handled separately by the local or national
waste management facilities. Please consider the relevant national or regional provisions.

safety data sheet
SECTION 14: Transport information

14.1 UN number 1307
14.2 UN proper shipping name XYLENES
Hazardous ingredients o-Xylene
14.3 Transport hazard class(es)
Class 3 (flammable liquids)
14.4 Packing group III (substance presenting low danger)
14.5 Environmental hazards none (non-environmentally hazardous acc. to the danger-
ous goods regulations)
14.6 Special precautions for user

Provisions for dangerous goods (ADR) should be complied within the premises.
14.7 Transport in bulk according to Annex II of MARPOL and the IBC Code
The cargo is not intended to be carried in bulk.
14.8 Information for each of the UN Model Regulations
• Transport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN)
UN number 1307
Proper shipping name XYLENES
Particulars in the transport document UN1307, XYLENES, 3, III, (D/E)
Class 3
Classification code F1
Packing group III
Danger label(s) 3
Excepted quantities (EQ) E1

Limited quantities (LQ) 5L
Transport category (TC) 3
Tunnel restriction code (TRC) D/E
Hazard identification No 30
Emergency Action Code 3YE
• International Maritime Dangerous Goods Code (IMDG)
UN number 1307
Proper shipping name XYLENES
Particulars in the shipper's declaration UN1307, XYLENES, 3, III, 30°C c.c.
Class 3
Packing group III

safety data sheet

Danger label(s) 3
Special provisions (SP) 223

Excepted quantities (EQ) E1
Limited quantities (LQ) 5L
EmS F-E, S-D
Stowage category A
SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
Relevant provisions of the European Union (EU)
• Regulation 649/2012/EU concerning the export and import of hazardous chemicals (PIC)
Not listed.
• Regulation 1005/2009/EC on substances that deplete the ozone layer (ODS)
Not listed.
• Regulation 850/2004/EC on persistent organic pollutants (POP)
Not listed.
• Restrictions according to REACH, Annex XVII
not listed
• List of substances subject to authorisation (REACH, Annex XIV)
not listed
• Seveso Directive
2012/18/EU (Seveso III)
No Dangerous substance/hazard categories Qualifying quantity (tonnes) for the ap- Notes
plication of lower and upper-tier re-
quirements
P5c flammable liquids (cat. 2, 3) 5.000 50.000 51)
Notation
51) Flammable liquids, categories 2 or 3 not covered by P5a and P5b
• Limitation of emissions of volatile organic compounds due to the use of organic solvents in
certain paints and varnishes and vehicle refinishing products (2004/42/EC, Deco-Paint Directive)
VOC content 100 %
• Directive on industrial emissions (VOCs, 2010/75/EU)
VOC content 100 %

safety data sheet

Directive 2011/65/EU on the restriction of the use of certain hazardous substances in electrical
and electronic equipment (RoHS) - Annex II
not listed
Regulation 166/2006/EC concerning the establishment of a European Pollutant Release and
Transfer Register (PRTR)
not listed
Directive 2000/60/EC establishing a framework for Community action in the field of water policy
(WFD)
not listed
National inventories
Substance is listed in the following national inventories:
- EINECS/ELINCS/NLP (Europe)
- REACH (Europe)
15.2 Chemical Safety Assessment
No Chemical Safety Assessment has been carried out for this substance.
SECTION 16: Other information

Abbreviations and acronyms
Abbr. Descriptions of used abbreviations
2000/39/EC Comission Directive establishing a first list of indicative occupational exposure limit values in implementa-
tion of Council Directive 98/24/EC
ADN Accord européen relatif au transport international des marchandises dangereuses par voies de navigation
intérieures (European Agreement concerning the International Carriage of Dangerous Goods by Inland Wa-
terways)
ADR Accord européen relatif au transport international des marchandises dangereuses par route (European
Agreement concerning the International Carriage of Dangerous Goods by Road)
BCF BioConcentration Factor
CAS Chemical Abstracts Service (service that maintains the most comprehensive list of chemical substances)
CLP Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures
CMR Carcinogenic, Mutagenic or toxic for Reproduction
DMEL Derived Minimal Effect Level
DNEL Derived No-Effect Level
EH40/2005 EH40/2005 Workplace exposure limits (http://www.nationalarchives.gov.uk/doc/open-government-licence/)
EINECS European Inventory of Existing Commercial Chemical Substances
ELINCS European List of Notified Chemical Substances
EmS Emergency Schedule
GHS "Globally Harmonized System of Classification and Labelling of Chemicals" developed by the United Nations
IMDG International Maritime Dangerous Goods Code
index No the Index number is the identification code given to the substance in Part 3 of Annex VI to Regulation (EC)
No 1272/2008
IOELV indicative occupational exposure limit value
MARPOL International Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant)
NLP No-Longer Polymer

safety data sheet
Abbr. Descriptions of used abbreviations
PBT Persistent, Bioaccumulative and Toxic
PNEC Predicted No-Effect Concentration
ppm parts per million
REACH Registration, Evaluation, Authorisation and Restriction of Chemicals
RID Règlement concernant le transport International ferroviaire des marchandises Dangereuses (Regulations
concerning the International carriage of Dangerous goods by Rail)
STEL short-term exposure limit
TWA time-weighted average
VOC Volatile Organic Compounds
vPvB very Persistent and very Bioaccumulative
WEL workplace exposure limit
Key literature references and sources for data

- Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU
- Regulation (EC) No. 1272/2008 (CLP, EU GHS)
List of relevant phrases (code and full text as stated in chapter 2 and 3)
Code Text
H226 flammable liquid and vapour
H304 may be fatal if swallowed and enters airways
H312 harmful in contact with skin
H315 causes skin irritation
H319 causes serious eye irritation
H332 harmful if inhaled
H335 may cause respiratory irritation
H373 may cause damage to organs through prolonged or repeated exposure
Disclaimer
The above information describes exclusively the safety requirements of the product and is based on
our present-day knowledge. The information is intended to give you advice about the safe handling of
the product named in this safety data sheet, for storage, processing, transport and disposal. The in-
formation cannot be transferred to other products. In the case of mixing the product with other
products or in the case of processing, the information on this safety data sheet is not necessarily valid
for the new made-up material.

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safety data sheet

according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU

o-Xylene ≥ 98% for synthesis

article number: 8749 date of compilation: 2016-06-30