Material Safety Data Sheet

R404 A

SECTION 1. PRODUCT AND COMPANY IDENTIFICATION

Product name : R404 A

Product Use Description : Refrigerant

Company : M/s.Refex Industries Ltd,

1/171,Old MahabalipuramRoad,
Thiruporur-603110,
Kanchipuram Dt.
Telephone No : 044-27445295

SECTION 2. HAZARDS IDENTIFICATION Emergency Overview

Form : Liquefied gas

Color : Colorless

Odor : weak

Hazard Summary : Warning! Container under pressure. This product is not flammable at
ambient temperatures and atmospheric pressure. Gas reduces oxygen
available for breathing. Causes asphyxiation in high concentrations. The
victim will not realize that he/she is suffocating. Inhalation may cause
central nervous system effects. May cause cardiac arrhythmia. May cause
drowsiness and dizziness. Do not breathe vapour. Irritating to eyes and
skin. Avoid contact with skin, eyes and clothing. At higher temperatures,
(>250 C),

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R404 A
Decomposition products may include hydrofluoric acid (HF) and
carbonyl halides. The ACGIH Threshold Limit Values (2007) for
Hydrogen Fluoride are TLV-TWA 0.5 ppm and Ceiling Exposure Limit 2 ppm.
Potential Health Effects

Skin : Avoid skin contact with leaking liquid (danger of frostbite).

May cause frostbite.
Irritating to skin.

Eyes : Causes serious eye irritation.

May cause frostbite.

Ingestion : Unlikely route of exposure.

Effects due to ingestion may include:
Gastrointestinal discomfort
Inhalation : Gas reduces oxygen available for breathing.
Causes asphyxiation in high concentrations.
The victim will not realize that he/she is suffocating.
Inhalation may cause central nervous system effects.
May cause cardiac arrhythmia.
Vapours may cause drowsiness and dizziness.
Chronic Exposure : None known.

Carcinogenicity No component of this product present at levels greater than or equal to 0.1% is identified as a
known or anticipated carcinogen by NTP, IARC, or OSHA.

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS

Chemical nature : Mixture

Chemical Name CAS-No. Concentration

1,1,1-Trifluoroethane 420-46-2 52 %

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R404 A
Pentafluoroethane 354-33-6 44%

1,1,1,2-Tetrafluoroethane 811-97-2 4%

SECTION 4. FIRST AID MEASURES

Inhalation : Move to fresh air. If breathing is irregular or stopped, administer artificial

respiration. Use oxygen as required, provided a qualified operator is present.
Call a physician. Do not give drugs from adrenaline-ephedrine group.

Skin contact : After contact with skin, wash immediately with plenty of water.
If there is evidence of frostbite, bathe (do not rub) with lukewarm (not hot)
water. If water is not available, cover with a clean, soft cloth or similar
covering. If symptoms persist, call a physician.

Eye contact : Rinse immediately with plenty of water, also under the eyelids, for at least 15
minutes. In case of frostbite water should be lukewarm, not hot. If symptoms
persist, call a physician.

Ingestion : Unlikely route of exposure. As this product is a gas, refer to the inhalation
section. Do not induce vomiting without medical advice. Call a physician
immediately.

Notes to physician

Treatment : Because of the possible disturbances of cardiac rhythm, catecholamine

drugs, such as epinephrine, should be used with special caution and only
in situations of emergency life support. Treatment of overexposure should
be directed at the control of symptoms and the clinical conditions. Treat
frostbitten areas as needed.

SECTION 5. FIREFIGHTING MEASURES

Suitable extinguishing media : The product is not flammable.
ASHRAE34
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

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Use extinguishing measures that are appropriate to local circumstances and
the surrounding environment.

Specific hazards during : Contents under pressure.

firefighting This product is not flammable at ambient temperatures and atmospheric
Pressure.
However, this material can ignite when mixed with air under pressure and
exposed to strong ignition sources.
Container may rupture on heating.
Cool closed containers exposed to fire with water spray. Do not allow run-off
from fire fighting to enter drains or water courses.
Vapours are heavier than air and can cause suffocation by reducing oxygen
available for breathing.
In case of fire hazardous decomposition products may be produced such
as: Hydrogen fluoride Carbon monoxide
Carbon dioxide (CO2)
Carbonyl halides

Special protective equipment : In the event of fire and/or explosion do not breathe fumes.
for firefighters Wear self-contained breathing apparatus and protective suit.
No unprotected exposed skin areas.

SECTION 6. ACCIDENTAL RELEASE MEASURES

Personal precautions : Immediately evacuate personnel to safe areas.

Keep people away from and upwind of spill/leak.
Wear personal protective equipment. Unprotected persons must be kept
away.

Remove all sources of ignition.

Avoid skin contact with leaking liquid (danger of frostbite).
Ventilate the area.
After release, disperses into the air.
Vapours are heavier than air and can cause suffocation by reducing
Oxygen available for breathing. Avoid accumulation of vapours in low areas.
Unprotected personnel should not return until air has been
Tested and determined safe.
Ensure that the oxygen content is >= 19.5 %.

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Environmental precautions : Prevent further leakage or spillage if safe to do so. The product evaporates
readily.

Methods for cleaning up : Ventilate the area.

SECTION 7. HANDLING AND STORAGE Handling

Handling : Handle with care.

Avoid inhalation of vapour or mist.
Do not get in eyes, on skin, or on clothing.
Wear personal protective equipment.
Pressurized container. Protect from sunlight and do not
Expose to temperatures exceeding 50 °C.
Follow all standard safety precautions
For handling and Use of compressed gas cylinders.
Use authorized cylinders only.
Protect cylinders from physical damage.
Do not puncture or drop cylinders,
Expose them to open flame or excessive heat.
Do not pierce or burn, even after use.
Do not spray on a naked flame or any incandescent material.
Do not remove screw cap until immediately ready for use.
Always replace cap after use.
Advice on protection : The product is not flammable.
Against fire and explosion Can form a combustible mixture with air at pressures above atmospheric
pressure.

Storage
Requirements for storage: Pressurized container: protect from sunlight and do not expose areas
and containers to temperatures exceeding 50 °C. Do not pierce or
burn, even after use.
Keep containers tightly closed in a dry, cool and well-ventilated place.
Storage rooms must be properly ventilated.
Ensure adequate ventilation, especially in confined areas.
Protect cylinders from physical damage.

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R404 A
SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Protective measures : Do not breathe vapour.

Do not get in eyes, on skin, or on clothing.
Ensure that eyewash stations and safety showers are close
to the workstation location.
Engineering measures: General room ventilation is adequate for storage and handling.
Perform filling operations only at stations with exhaust ventilation facilities.

Eye protection : Wear as appropriate:

Safety glasses with side-shields
If splashes are likely to occur, wear:
Goggles or face shield, giving complete protection to eyes Hand
protection : Leather gloves
In case of contact through splashing:
Protective gloves Neoprene gloves
Polyvinyl alcohol or nitrile- butyl-rubber gloves

Skin and body protection: Avoid skin contact with leaking liquid (danger of frostbite).
Wear cold insulating gloves/ face shield/ eye protection.
Respiratory protection: In case of insufficient ventilation, wear suitable respiratory equipment.
Wear a positive-pressure supplied-air res pirator.
Vapours are heavier than air and can cause suffocation by
reducing oxygen available for breathing.
For rescue and maintenance work in storage tanks use self-contained
Breathing apparatus.
Hygiene measures : Handle in accordance with good industrial hygiene and safety practice.
Do not get in eyes, on skin, or on clothing.
Ensure adequate ventilation, especially in confined areas.
Remove and wash contaminated clothing before re-use.
Keep working clothes separately.
Exposure Guidelines
Components CAS-No. Value Control Updated Basis
parameters

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R404 A

1,1,1- 420-46-2 TWA : time (1,000 ppm)

Trifluoroethane weighted
average

1,1,1- 420-46-2 TWA : time 3,400 mg/m3 2007

Trifluoroethane weighted (1,000 ppm)
average

Pentafluoroethane 354-33-6 TWA : time 4,900 mg/m3 2007

weighted (1,000 ppm)
average

Pentafluoroethane 354-33-6 TWA : time (1,000 ppm)

weighted
average

1,1,1,2- 811-97-2 TWA : time (1,000 ppm)

Tetrafluoroethane weighted average

1,1,1,2- 811-97-2 TWA : time 4,240 mg/m3 2007

Tetrafluoroethane weighted average (1,000 ppm)

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES

Physical state : Liquefied gas

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 Material Safety Data Sheet

R404 A

Color : Colorless

Odor : weak

pH : neutral

Melting point/freezing point : no data available

Boiling point/boiling range : -47.8 °C

Flash point : not applicable

Evaporation rate : > 1 Method: Compared to CCl4.

Lower explosion limit : None

Upper explosion limit : None

Vapour pressure : 12,610 hPa at 21.1°C(70.0 °F)

25,572 hPa at 54.4 °C(129.9 °F)

Vapor density : 3.43 Note: (Air = 1.0)

Density : 1.08 g/cm3 at 21.1 °C

Water solubility : Note: Very slightly soluble in cold water, hot water.

Partition coefficient: n- : log Pow: 1.06

octanol/water Test substance : 1,1,1,2-tetrafluoroethane (HFC-134a)

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R404 A
Ignition temperature : < 750 °C

Decomposition temperature : > 250 °C

Global warming potential : 3,784

(GWP)
Ozone depletion potential : 0 (ODP)
SECTION 10. STABILITY AND REACTIVITY

Chemical stability : Stable under normal conditions.

Possibility of hazardous : Hazardous polymerisation does not occur. reactions Conditions to

avoid : Pressurized container. Protect from sunlight and do not
Expose to temperatures exceeding 50 °C.
Decomposes under high temperature.
Some risk may be expected of corrosive and
toxic decomposition products.
Can form a combustible mixture with air at pressures
above atmospheric pressure.
Do not mix with oxygen or air above atmospheric pressure.
Incompatible materials to : Finely divided aluminium
avoid Potassium
Calcium
Powdered metals
Aluminium
Magnesium
Zinc

Hazardous decomposition : In case of fire hazardous decomposition products may be products

produced such as:
Gaseous hydrogen fluoride (HF).
Carbonyl halides
Carbon monoxide
Carbon dioxide (CO2)

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SECTION 11. TOXICOLOGICAL INFORMATION

Acute inhalation toxicity

1,1,1-Trifluoroethane : LC50: > 540000 ppm

Exposure time: 4 h
Species: rat
LC50: > 106 mg/l
Exposure time: 4 h
Species: rat

Pentafluoroethane : > 769000 ppm

Exposure time: 4 h
Species: rat

1,1,1,2-Tetrafluoroethane : LC50: > 500000 ppm

Exposure time: 4 h
Species: rat

Sensitisation
1,1,1-Trifluoroethane : Cardiac sensitization
Species: dogs
Note: 1,1,1,2-tetrafluoroethane (HFC-134a):
Cardiac sensitisation threshold (dog): 80000 ppm. Pentafluoroethane
: Cardiac sensitization
Species: dogs
Note: No-observed-effect level
75 000 ppm
Lowest observable effect level
100 000 ppm

1,1,1,2-Tetrafluoroethane : Cardiac sensitization

Species: dogs
Note: No-observed-effect level
50 000 ppm
Lowest observable effect level
75 000 ppm
Repeated dose toxicity

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R404 A

1,1,1-Trifluoroethane : Species: rat

Application Route: Inhalation
Exposure time: (90 d)
NOEL:40000ppm
Subchronic toxicity

Pentafluoroethane : Species: rat

Application Route: Inhalation Exposure time: (4 Weeks)
NOEL:50000ppm
Subchronic toxicity

1,1,1,2-Tetrafluoroethane : Species: rat

NOEL: 40000 ppm

Genotoxicity in vitro
1,1,1-Trifluoroethane : Test Method: Ames test
Result: negative

Pentafluoroethane : Test Method: Ames test

Result: negative

1,1,1,2-Tetrafluoroethane : Note: In vitro tests did not show mutagenic effects

: Cell type: Human lymphocytes
Result: negative
: Cell type: Human lymphocytes
Result: negative
: Cell type: Chinese Hamster Ovary Cells
Result: negative
Genotoxicity in vivo

1,1,1-Trifluoroethane : Species: mouse

Cell type: Bone marrow

Application Route: Inhalation
Result: negative
Teratogenicity

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R404 A

1,1,1-Trifluoroethane : Species: rat

Application Route: Inhalation exposure
NOAEL,Teratog: 40,000 ppm
NOAEL,Maternal: 40,000 ppm
Note: Did not show teratogenic effects in animal experiments.

Species: rabbit
Application Route: Inhalation exposure
NOAEL,Teratog: 40,000 ppm
NOAEL,Maternal: 40,000 ppm
Note: Did not show teratogenic effects in animal experiments.

Pentafluoroethane : Species: rabbit

Application Route: Inhalation exposure
NOAEL,Teratog: 50,000 ppm
NOAEL,Maternal: 50,000 ppm
Note: Did not show teratogenic effects in animal experiments.

Species: rat
Application Route: Inhalation exposure
NOAEL,Teratog: 50,000 ppm
NOAEL,Maternal: 50,000 ppm
Note: Did not show teratogenic effects in animal experiments.

Further information : Note: Acute Health Hazard Ethane, pentafluoro- (HFC-125):

Cardiac sensitisation threshold (dog): 75000 ppm. 1,1,1trifluoroethane (HFC-143a): Cardiac
sensitisation threshold (dog): >250000 ppm. 1,1,1,2-tetrafluoroethane (HFC-134a): Cardiac sensitisation
threshold (dog): 80000 ppm. Vapours are heavier than air and can cause suffocation by reducing oxygen
available for breathing. Irritating to eyes and skin. Rapid evaporation of the liquid may cause frostbite.
Avoid skin contact with leaking liquid (danger of frostbite). May cause cardiac arrhythmia. Chronic Health
Hazard 1,1,1trifluoroethane (HFC-143a): Not mutagenic in AMES Test.
SECTION 12. ECOLOGICAL INFORMATION

Biodegradability
Pentafluoroethane : Result: Not readily biodegradable.
Value: 5 %

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R404 A

Method: OECD 301 D

Further information on ecology

Additional ecological
This product contains greenhouse gases which may
information contribute to global warming. Do NOT vent to the atmosphere.

SECTION 13. DISPOSAL CONSIDERATIONS

Disposal methods : Observe all Federal, State, and Local Environmental

regulations.
SECTION 14. TRANSPORT INFORMATION

DOT UN/ID No.: UN 3337

Proper shipping name : REFRIGERANT GAS R 404A
Class 2.2
Packing group 2.2
Hazard Labels

IATA UN/ID No. : UN 3337

Description of the goods : REFRIGERANT GAS R 404A
Class : 2.2
Hazard Labels : 2.2
Packing instruction (cargo : 200 aircraft)
Packing instruction : 200
(passenger aircraft)

IMDG UN/ID No. : UN 3337

Description of the goods : REFRIGERANT GAS R 404A Class
: 2.2

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R404 A

Hazard Labels : 2.2

EmS Number : F-C, S-V
Marine pollutant : no
SECTION 15. REGULATORY INFORMATION

Inventories

US. Toxic Substances : On TSCA Inventory Control Act

Australia. Industrial : On the inventory, or in compliance with the inventory
Chemical (Notification and Assessment)
Act

Canada. Canadian : All components of this product are on the Canadian DSL list.
Environmental Protection
Act (CEPA). Domestic
Substances List (DSL)

Japan. Kashin-Hou Law : On the inventory, or in compliance with the inventory

List

Korea. Existing Chemicals : On the inventory, or in compliance with the inventory Inventory (KECI)

Philippines. The Toxic : On the inventory, or in compliance with the inventory Substances
and Hazardous and Nuclear Waste Control

Act

China. Inventory of Existing : On the inventory, or in compliance with the inventory

Chemical Substances
NZIOC - New Zealand : On the inventory, or in compliance with the inventory

National regulatory information

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R404 A

Hazards : Acute Health Hazard

Sudden Release of Pressure Hazard

Spill or releases resulting in the loss of any ingredient at or about its RQ require immediate
notification to the National Response Center and your local Emergence Planning
Committee

CAS Number : 1,1,1-Trifluoroethane 420-46-2

WHMIS Classification : A : Compressed Gas

This product has been classified according to the hazard criteria
of the CPR and the MSDS contains all of the information required
by the CPR.

Global warming potential : 3,784

Ozone depletion potential : 0 (ODP)

SECTION 16. OTHER INFORMATION

HMIS III NFPA
Health hazard :1 2
Flammability :1 1
Physical Hazard :0
Instability : 0

Hazard rating and rating systems (e.g. HMIS® III, NFPA): This information is intended solely for the
use of individuals trained in the particular system.

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Further information

The information provided in this Safety Data Sheet is correct to the best of our knowledge,
information and belief at the date of its publication. The information given is designed only as a
guidance for safe handling, use, processing, storage, transportation, disposal and release and is not
to be considered a warranty or quality specification. The information relates only to the specific
material designated and may not be valid for such material used in combination with any other
materials or in any process, unless specified in the text. Final determination of suitability of any
material is the sole responsibility of the user. This information should not constitute a guarantee for
any specific product properties.

Refex Believes that the information and recommendations contained herein including data and
statements are accurate as of the data hereof.NO WARRANTY OF FITNESS FOR ANY PARTICULAR
PURPOSE,WARRANTY OF MERCHANTABILITY,OR ANY OTHER WARRANTY,EXPRESSED OR
IMPLIED,IS MADE CONCERNING THE INFORMATION PROVIDED HEREIN.The information provided
herein relates only to the specific product designated and may not be valid where such product is used in
combination with any other methods of use of the product and of the information referred to herein are
beyond the control of Refex Industries Limited.Refex Industries Ltd expressly disclaims any and all
liability as to any results obtained or arising from any use of the product or reliance on such information.

Prepared by: Refex Industries Limited

Issuing Date:09/01/2017 Revision Date:09/01/2020
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