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    Experiment 8 Pre-Lab Comparative Reactions of Carboxylic Acid Derivatives

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    gian odell
    This document describes an experiment comparing the reactivity of various carboxylic acid derivatives. Students are asked to arrange the derivatives in order of decreasing reactivity towards nucleophiles and explain the order based on their leaving group ability. The experiment involves performing hydrolysis, alcoholysis, aminolysis, and hydroxamic acid tests on samples of acetyl chloride, acetic anhydride, ethyl acetate, and benzamide to observe their reactions. In the post-lab, students formulate general reactions and identify which derivative provides the best leaving group.

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    Experiment 8 Pre-Lab Comparative Reactions of Carboxylic Acid Derivatives

    Uploaded by

    gian odell
    248 views3 pages
    This document describes an experiment comparing the reactivity of various carboxylic acid derivatives. Students are asked to arrange the derivatives in order of decreasing reactivity towards nucleophiles and explain the order based on their leaving group ability. The experiment involves performing hydrolysis, alcoholysis, aminolysis, and hydroxamic acid tests on samples of acetyl chloride, acetic anhydride, ethyl acetate, and benzamide to observe their reactions. In the post-lab, students formulate general reactions and identify which derivative provides the best leaving group.

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    This document describes an experiment comparing the reactivity of various carboxylic acid derivatives. Students are asked to arrange the derivatives in order of decreasing reactivity towards nucleophiles and explain the order based on their leaving group ability. The experiment involves performing hydrolysis, alcoholysis, aminolysis, and hydroxamic acid tests on samples of acetyl chloride, acetic anhydride, ethyl acetate, and benzamide to observe their reactions. In the post-lab, students formulate general reactions and identify which derivative provides the best leaving group.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    248 views3 pages

    Experiment 8 Pre-Lab Comparative Reactions of Carboxylic Acid Derivatives

    Uploaded by

    gian odell
    This document describes an experiment comparing the reactivity of various carboxylic acid derivatives. Students are asked to arrange the derivatives in order of decreasing reactivity towards nucleophiles and explain the order based on their leaving group ability. The experiment involves performing hydrolysis, alcoholysis, aminolysis, and hydroxamic acid tests on samples of acetyl chloride, acetic anhydride, ethyl acetate, and benzamide to observe their reactions. In the post-lab, students formulate general reactions and identify which derivative provides the best leaving group.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
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    EXPERIMENT 8 Pre-lab

    COMPARATIVE REACTIONS OF CARBOXYLIC ACID DERIVATIVES

    Group number Section Score


    Seat number Name Date

    1. Arrange the following acyl compounds in decreasing order of reactivity towards a nucleophile.
    (1 being the most reactive)
    ______ carboxylic acid amide
    ______ carboxylic acid halide
    ______ carboxylic acid ester
    ______ carboxylic acid
    ______ carboxylic acid anhydride

    2. Rationalize the order of reactivity based on the answers in #1.

    3. Write the general formula that describes each carboxylic acid derivative in #1.

    1
    EXPERIMENT 8 Data sheet
    COMPARATIVE REACTIONS OF CARBOXYLIC ACID DERIVATIVES

    Group number Section Score


    Seat number Name Date

    A. Hydrolysis
    Observations
    Sample
    Warming effect Reaction with 2% AgNO3 Reaction with sat’d. NaHCO3
    Acetyl chloride

    Acetic anhydride

    Ethyl acetate Odor:

    Benzamide Color change in litmus paper:

    B. Alcoholysis: Ester Formation


    Sample Odor Formation of layers

    Acetyl chloride

    Acetic anhydride

    C. Aminolysis: Anilide Formation


    Sample Color of precipitate formed

    Acetyl chloride

    Acetic anhydride

    D. Hydroxamic Acid Test for Carboxylic Acid Derivatives


    Sample Color of resulting mixture

    Acetyl chloride

    Acetic anhydride

    Ethyl acetate

    Benzamide

    2
    EXPERIMENT 8 Post-lab
    COMPARATIVE REACTIONS OF CARBOXYLIC ACID DERIVATIVES

    Group number Section Score


    Seat number Name Date

    1. Formulate a general reaction for each of the carboxylic acid derivatives with the corresponding
    nucleophile for the following reactions: hydrolysis, alcoholysis, aminolysis and the hydroxamic acid
    test.

    2. Which among the carboxylic acid derivatives studied in the experiment provided the best leaving
    group? Why?

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