Module 10 Kin 267 Muscle Tissue
Module 10 Kin 267 Muscle Tissue
Module 10 Kin 267 Muscle Tissue
Neuromuscular Junctions
Release of neurotransmitter (ACH) Nerve signaling at the synaptic end bulb stimulate gated
channels to open. Calcium flows inward through the open channels, and stimulates the synaptic
vessels o undergo exocytosis. Synaptic vesicles fuse to neuron’s plasma membrane, and
transferring Ach into synaptic cleft. Then Ach diffuses across the synaptic cleft between motor
neurons and motor end plate.
Ach bind to the Ach receptors on the motor end plate. This allows the Ach receptor channel to
open and cations like sodium flows across the membrane.
Production of muscle action potential the inflow of Na+ makes the inside of muscle fiber
more positively charged. This change in the membrane potential triggers a muscle action
potential. The muscle action potential travels along a sarcolemma into the system T tubules.
This causes sarcoplasmic reticulum to release its stored calcium into sarcoplasm and muscle
contraction happens.
When Ach is no longer released, it’s rapidly broken down by AChE Acetylcholinesterase. And
this ends the production of action potential. Ca2_ moves from the sarcoplasm of the muscle
fiber back into the sarcoplasmic reticulum, and the Ca2_ release channels in the sarcoplasmic
reticulum membrane close.
Motor Unit
Consists of a motor neuron and all the skeletal muscles fibers it stimulates.
High precision
Fewer muscle fibers per neuron
Laryngeal and extraocular muscles (2-20)
Low precision
Many muscle fibers per neuron
Thigh muscles (2,000-3,000)