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    8 - Soal 10 MCQ - Drug Interaction

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    Tati Haryati
    This document poses 10 multiple choice questions about drug interactions to be answered with explanations and citations. The questions cover topics like which drug's absorption would be reduced by antacids, reasons for different drug interaction profiles, genetic polymorphisms of drug metabolizing enzymes, interactions of St. John's Wort and other herbal supplements, mechanisms of various drug interactions, classification of interaction types, and effects of grapefruit juice on drug metabolism.

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    8 - Soal 10 MCQ - Drug Interaction

    Uploaded by

    Tati Haryati
    49 views3 pages
    This document poses 10 multiple choice questions about drug interactions to be answered with explanations and citations. The questions cover topics like which drug's absorption would be reduced by antacids, reasons for different drug interaction profiles, genetic polymorphisms of drug metabolizing enzymes, interactions of St. John's Wort and other herbal supplements, mechanisms of various drug interactions, classification of interaction types, and effects of grapefruit juice on drug metabolism.

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    8_soal 10 MCQ_drug interaction

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    This document poses 10 multiple choice questions about drug interactions to be answered with explanations and citations. The questions cover topics like which drug's absorption would be reduced by antacids, reasons for different drug interaction profiles, genetic polymorphisms of drug metabolizing enzymes, interactions of St. John's Wort and other herbal supplements, mechanisms of various drug interactions, classification of interaction types, and effects of grapefruit juice on drug metabolism.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    49 views3 pages

    8 - Soal 10 MCQ - Drug Interaction

    Uploaded by

    Tati Haryati
    This document poses 10 multiple choice questions about drug interactions to be answered with explanations and citations. The questions cover topics like which drug's absorption would be reduced by antacids, reasons for different drug interaction profiles, genetic polymorphisms of drug metabolizing enzymes, interactions of St. John's Wort and other herbal supplements, mechanisms of various drug interactions, classification of interaction types, and effects of grapefruit juice on drug metabolism.

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    © All Rights Reserved
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    Download as docx, pdf, or txt
    of 3

    TUGAS : sumber https://www.surveymonkey.

    com/r/7JZB5DK

    Jawablah dan beri penjelasan serta literatur yang digunakan

    1. Which of the following drugs would have its absorption significantly reduced by the
    co-administration of an antacid ?

    Warfarin
    Ketoconazole
    Fluconazole
    Terbinafine
    Acyclovir

    Jawab :
    Penjelasan jawaban :
    Sumber literatur :

    2. Cimetidine interacts with more drugs than ranitidine because;

    Its is subjected to greater first pass metabolism


    It is a more potent enzyme inducer
    It is a more potent enzyme inhibitor
    It has better oral absorption
    The dose administered is higher
    Jawab :
    Penjelasan jawaban :
    Sumber literatur :

    3. Which of these enzymes exhibits genetic polymorphism in humans ?

    CYP2E1
    CYP2D6
    CYP2B6
    CYP3A4
    Jawab :
    Penjelasan jawaban :
    Sumber literatur :

    4. Which of the following drugs is not known to interact with St John’s Wort ?

    Digoxin
    Cyclosporin
    Warfarin
    Saquinavir
    Ciprofloxacin
    Jawab :
    Penjelasan jawaban :
    Sumber literatur :

    5. Miconazole oral gel interacts with warfarin due to:

    Additive anticoagulant effects


    Miconazole inhibits renal excretion of warfarin
    Miconazole antagonizes the anticoagulant effects of warfarin
    Miconazole inhibits hepatic metabolism of warfarin
    Miconazole reduces the absorption of warfarin
    Jawab :
    Penjelasan jawaban :
    Sumber literatur :

    6. Which of the following is NOT an enzyme inducer ?

    Rifampicin
    Phenytoin
    St John’s Wort
    Carbamazepine
    Valproic Acid
    Jawab :
    Penjelasan jawaban :
    Sumber literatur :

    7. Which of the following is NOT an enzyme inhibitor ?

    Cimetidine
    Fluoxetine
    Norfluoxetine (a metabolite of Fluoxetine)
    Diazepam
    Erythromycin
    Jawab :
    Penjelasan jawaban :
    Sumber literatur :

    8. Which of the following would you classify as a pharmacodynamic interaction?


    Serotonin syndrome due to paroxetine and clomipramine
    Bradycardia due to fluoxetine and metoprolol
    Increased phenytoin plasma concentrations due to fluoxetine
    Increased bleeding due to cimetidine and warfarin
    Lithium toxicity due to addition of diclofenac
    Jawab :
    Penjelasan jawaban :
    Sumber literatur :

    9. Which of the following can interact with aspirin causing bleeding ?

    Valerian
    Liquorice
    Kava
    Saw Palmetto
    Ginkgo Biloba
    Jawab :
    Penjelasan jawaban :
    Sumber literatur :

    10. Which of the following drugs is unlikely to interact significantly with grapefruit
    juice?

    Felodipine
    Simvastatin
    Cyclosporin
    Cisapride
    Paroxetine
    Jawab :
    Penjelasan jawaban :
    Sumber literatur :

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