SLE211 Week 4 Class 2 - Skeletal Muscle Physiology (1) - 4 Slides Per Page
SLE211 Week 4 Class 2 - Skeletal Muscle Physiology (1) - 4 Slides Per Page
SLE211 Week 4 Class 2 - Skeletal Muscle Physiology (1) - 4 Slides Per Page
Key concepts
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• Muscles are the largest group of tissues in the body – • Propulsion of contents through
approximately half of your body weight hollow internal organs
• 40% in men, 32% in women
• 10% smooth and cardiac muscle
• Expulsion of contents of organs
into the internal environment
(parturition)
• Muscles can develop tension or shorten to produce
movement
• Maintenance of homeostasis
2
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Voluntary Involuntary
muscle muscle
3
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I band
4
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5
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Portion of
myofibril
H zone
Thick Thin
filament filament Sarcomere A band I band
Tropomyosin (blocker)
Actin
• Actin is the primary structural protein in thin filaments • Thread-like protein that lies in the groove of the actin
• Each actin molecule is globular (spherical) in shape
spiral
• Actin filament resembles two strands of pearls twisted around each • When in the groove tropomyosin covers the myosin
other (double helical chain) binding site on the actin filament
• Each actin filament has a binding site for the myosin head • Blocks the interaction between actin and myosin (cross
bridge formation) that leads to muscle contraction –
tropomyosin is in this position in a relaxed muscle fibre
Binding site for
attachment with myosin
Actin molecules cross bridge
Tropomyosin Troponin
Actin helix
6
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Summary
Actin + Tropomyosin + Troponin • Muscle- organised as bundles within bundles
= Thin filament • Much of the machinery for contraction is due to specialised intracellular
organisation
Thin filament
7
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Summary