SAFETY DATA SHEET

Solstice® 454B
000000025450
Version 1.0 Revision Date 10/07/2020 Print Date 09/23/2021

SECTION 1. IDENTIFICATION

Product name : Solstice® 454B

Number : 000000025450

Product Use Description : Refrigerant

Manufacturer or supplier's : Honeywell International Inc.

details 115 Tabor Road
Morris Plains, NJ 07950-2546
For more information call : 800-522-8001
+1-973-455-6300(Monday-Friday, 9:00am-5:00pm)

In case of emergency call : Medical: 1-800-498-5701 or +1-303-389-1414

: Transportation (CHEMTREC): 1-800-424-9300 or +1-703-
527-3887
:
: (24 hours/day, 7 days/week)

SECTION 2. HAZARDS IDENTIFICATION

Emergency Overview

Form : Liquefied gas

Color : colourless

Odor : slight ether-like

Classification of the substance or mixture

Classification of the : Flammable gases, Category 1
substance or mixture Gases under pressure, Liquefied gas
Simple Asphyxiant

GHS Label elements, including precautionary statements

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Solstice® 454B
000000025450
Version 1.0 Revision Date 10/07/2020 Print Date 09/23/2021

Symbol(s) :

Signal word : Danger

Hazard statements : Extremely flammable gas.

Contains gas under pressure; may explode if heated.
May displace oxygen and cause rapid suffocation.

Precautionary statements : Prevention:

Keep away from heat/ sparks/ open flames/ hot surfaces. No
smoking.

Response:
Leaking gas fire: Do not extinguish, unless leak can be stopped
safely.
Eliminate all ignition sources if safe to do so.

Storage:
Protect from sunlight. Store in a well-ventilated place.

Carcinogenicity

No component of this product present at levels greater than or equal to 0.1% is identified as a known
or anticipated carcinogen by NTP, IARC, or OSHA.

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS

Chemical nature : Mixture

Chemical name CAS-No. Concentration

Difluoromethane 75-10-5 68.90 %

2,3,3,3-Tetrafluoroprop-1-ene 754-12-1 31.10 %

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SAFETY DATA SHEET

Solstice® 454B
000000025450
Version 1.0 Revision Date 10/07/2020 Print Date 09/23/2021

SECTION 4. FIRST AID MEASURES

General advice : First aider needs to protect himself. Move out of dangerous
area. Take off all contaminated clothing immediately.

Inhalation : Remove to fresh air. If not breathing, give artificial respiration.

If breathing is difficult, give oxygen. Use oxygen as required,
provided a qualified operator is present. Call a physician.

Skin contact : Rapid evaporation of the liquid may cause frostbite. If there is
evidence of frostbite, bathe (do not rub) with lukewarm (not
hot) water. If water is not available, cover with a clean, soft
cloth or similar covering. Wash contaminated clothing before
re-use. Consult a physician.

Eye contact : Rinse immediately with plenty of water, also under the eyelids,
for at least 15 minutes. In case of frostbite water should be
lukewarm, not hot. Call a physician.

Ingestion : Unlikely route of exposure. As this product is a gas, refer to the

inhalation section. Do not induce vomiting without medical
advice. If conscious, drink plenty of water. Never give anything
by mouth to an unconscious person. Call a physician
immediately.

Notes to physician

Indication of immediate : Treat frost-bitten areas as needed. Treat symptomatically.

medical attention and
special treatment needed, if
necessary

SECTION 5. FIREFIGHTING MEASURES

Suitable extinguishing media : In case of fire, allow gas to burn if flow cannot be shut off
immediately.
Apply water from a safe distance to cool container and protect
surrounding area.
Use water spray, alcohol-resistant foam, dry chemical or
carbon dioxide.

Specific hazards during : Flammable gas.

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Solstice® 454B
000000025450
Version 1.0 Revision Date 10/07/2020 Print Date 09/23/2021

firefighting Contents under pressure.

Vapours are heavier than air and can cause suffocation by
reducing oxygen available for breathing.
Vapors may travel to areas away from work site before
igniting/flashing back to vapor source.
Fire or intense heat may cause violent rupture of packages.
Cool closed containers exposed to fire with water spray.
Do not allow run-off from fire fighting to enter drains or water
courses.
In case of fire hazardous decomposition products may be
produced such as:
Hydrogen fluoride
Carbonyl halides
Carbon monoxide
Carbon dioxide (CO2)

Special protective equipment : In the event of fire and/or explosion do not breathe fumes.
for firefighters Wear self-contained breathing apparatus and protective suit.
No unprotected exposed skin areas.

Further information : Evacuate personnel to safe areas.

Leaking gas fire: Do not extinguish, unless leak can be
stopped safely.
Eliminate all ignition sources if safe to do so.

SECTION 6. ACCIDENTAL RELEASE MEASURES

Personal precautions, : Immediately evacuate personnel to safe areas.

protective equipment and Keep people away from and upwind of spill/leak.
emergency procedures Wear personal protective equipment. Unprotected persons
must be kept away.
Wear self-contained breathing apparatus and protective suit.
Eliminate all ignition sources if safe to do so.
Avoid skin contact with leaking liquid (danger of frostbite).
Ventilate the area.
Vapors may travel to areas away from work site before
igniting/flashing back to vapor source.
Vapours are heavier than air and can cause suffocation by
reducing oxygen available for breathing.
Avoid accumulation of vapours in low areas.
Unprotected personnel should not return until air has been
tested and determined safe.
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Solstice® 454B
000000025450
Version 1.0 Revision Date 10/07/2020 Print Date 09/23/2021

Ensure that the oxygen content is >= 19.5%.

Environmental precautions : Prevent further leakage or spillage if safe to do so.

The product evaporates readily.
Discharge into the environment must be avoided.

Methods and materials for : Use explosion-proof equipment.

containment and cleaning No sparking tools should be used.
up Ventilate the area.
Allow to evaporate.

SECTION 7. HANDLING AND STORAGE

Handling

Precautions for safe : Handle with care.

handling Wear personal protective equipment.
Do not breathe vapour.
Avoid contact with skin, eyes and clothing.
Use only in well-ventilated areas.
Pressurized container. Protect from sunlight and do not expose
to temperatures exceeding 50 °C.
Follow all standard safety precautions for handling and use of
compressed gas cylinders.
Use authorized cylinders only.
Protect cylinders from physical damage.
Do not puncture or drop cylinders, expose them to open flame
or excessive heat.
Do not remove screw cap until immediately ready for use.
Always replace cap after use.

Advice on protection : Container hazardous when empty.

against fire and explosion Vapours may form flammable mixture with air.
Keep product and empty container away from heat and
sources of ignition.
Do not pressurize, cut, weld, braze, solder, drill, grind or
expose containers to heat or sources of ignition.
Take measures to prevent the build up of electrostatic charge.
Electrical equipment should be protected to the appropriate
standard.
Use explosion-proof equipment.
No sparking tools should be used.
No smoking.

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Solstice® 454B
000000025450
Version 1.0 Revision Date 10/07/2020 Print Date 09/23/2021

Storage
Conditions for safe storage, : Pressurized container: protect from sunlight and do not expose
including any to temperatures exceeding 50 °C. Do not pierce or burn, even
incompatibilities after use.
Keep containers tightly closed in a dry, cool and well-ventilated
place.
Keep away from heat and sources of ignition.
Storage rooms must be properly ventilated.
Ensure adequate ventilation, especially in confined areas.
Protect cylinders from physical damage.
Store away from incompatible substances.
Store in original container.

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Protective measures : Ensure that eyewash stations and safety showers are close to
the workstation location.
Do not breathe vapour.
Avoid contact with skin, eyes and clothing.

Engineering measures : Use with local exhaust ventilation.

Eye protection : Safety goggles

Hand protection : Protective gloves

Gloves must be inspected prior to use.
Replace when worn.

Skin and body protection : Avoid skin contact with leaking liquid (danger of frostbite).
Wear suitable protective equipment.

Respiratory protection : No personal respiratory protective equipment normally

required.
When workers are facing concentrations above the exposure
limit they must use appropriate certified respirators.
Use NIOSH approved respiratory protection.

Hygiene measures : Handle in accordance with good industrial hygiene and safety
practice.
Ensure adequate ventilation, especially in confined areas.
When using do not eat, drink or smoke.

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SAFETY DATA SHEET

Solstice® 454B
000000025450
Version 1.0 Revision Date 10/07/2020 Print Date 09/23/2021

Remove and wash contaminated clothing before re-use.

Keep working clothes separately.
Do not breathe vapour.
Avoid contact with skin, eyes and clothing.

Exposure Guidelines
Components CAS-No. Value Control Upda Basis
parameters te
Difluoromethane 75-10-5 TWA : 2,200 mg/m3 2007 WEEL:US. OARS.
Time (1,000 ppm) WEELs Workplace
weighted Environmental
average Exposure Level
Guide, as amended

Difluoromethane 75-10-5 TWA : (1,000 ppm) 1994 Honeywell:Limit

Time established by
weighted Honeywell
average International Inc.

2,3,3,3- 754-12-1 TWA : (500 ppm) 2009 WEEL:US. OARS.

Tetrafluoroprop- Time WEELs Workplace
1-ene weighted Environmental
average Exposure Level
Guide, as amended

2,3,3,3- 754-12-1 TWA : (500 ppm) 03 15 Honeywell:Limit

Tetrafluoroprop- Time 2010 established by
1-ene weighted Honeywell
average International Inc.

2,3,3,3- 754-12-1 STEL : (1,500 ppm) 03 15 Honeywell:Limit

Tetrafluoroprop- Short 2010 established by
1-ene term Honeywell
exposure International Inc.
limit

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES

Physical state : Liquefied gas
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SAFETY DATA SHEET

Solstice® 454B
000000025450
Version 1.0 Revision Date 10/07/2020 Print Date 09/23/2021

Color : colourless

Odor : slight ether-like

Odor threshold : Note: No data available

pH : Note: neutral

Melting point/range : Note: No data available

Boiling point/boiling range : -50.9 °C

Flash point : Note: Not applicable

Evaporation rate : >1

Method: Compared to CCl4.

Flammability : Flammable gas.

Lower flammability limit : 11.25 %(V) at 23 °C

Upper flammability limit : 22 %(V) at 23 °C

Vapor pressure : 1,411 kPa

at 21 °C(70 °F)

Vapor density : 2.2 Note: (Air = 1.0)

Density : Note: No data available

Water solubility : Note: No data available

Partition coefficient: n- : Note: No data available

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SAFETY DATA SHEET

Solstice® 454B
000000025450
Version 1.0 Revision Date 10/07/2020 Print Date 09/23/2021

octanol/water

Ignition temperature : 496 °C

Viscosity, dynamic : Note: No data available

Viscosity, kinematic : Note: No data available

Oxidizing properties : The substance or mixture is not classified as oxidizing.

SECTION 10. STABILITY AND REACTIVITY

Reactivity : Not classified as a reactivity hazard.

Chemical stability : Stable under normal conditions.

Possibility of hazardous : Hazardous polymerisation does not occur.

reactions
Conditions to avoid : Keep away from heat and sources of ignition.
Pressurized container. Protect from sunlight and do not
expose to temperatures exceeding 50 °C.
Do not pressurize, cut, weld, braze, solder, drill, grind or
expose containers to heat or sources of ignition.
Decomposes under high temperature.
Some risk may be expected of corrosive and toxic
decomposition products.

Incompatible materials : Alkali metals

Oxidizers (e.g. peroxide residues present in insufficiently
cured rubbers)
Finely divided metal powders such as aluminum, magnesium,
or zinc.

Hazardous decomposition : In case of fire hazardous decomposition products may be

products produced such as:
Hydrogen fluoride
Carbonyl halides
Carbon monoxide
Carbon dioxide (CO2)

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SAFETY DATA SHEET

Solstice® 454B
000000025450
Version 1.0 Revision Date 10/07/2020 Print Date 09/23/2021

SECTION 11. TOXICOLOGICAL INFORMATION

Acute inhalation toxicity

Difluoromethane : LC50: > 520000 ppm
Exposure time: 4 h
Species: Rat

2,3,3,3-Tetrafluoroprop-1- : LC50: > 400000 ppm

ene Exposure time: 4 h
Species: Rat
Method: OECD Test Guideline 403

Skin irritation
2,3,3,3-Tetrafluoroprop-1- : Note: Not applicable
ene study technically not feasible

Eye irritation
2,3,3,3-Tetrafluoroprop-1- : Note: Not applicable
ene study technically not feasible

Sensitisation
Difluoromethane : Cardiac sensitization
Species: dogs
Note: No-observed-effect level
>350 000 ppm

2,3,3,3-Tetrafluoroprop-1- : Dermal
ene Note: Not applicable, as this product is a gas.
study technically not feasible

Repeated dose toxicity

Difluoromethane : Species: Rat
Application Route: Inhalation
Exposure time: (90 d)
NOEL: 50000 ppm
Subchronic toxicity

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Solstice® 454B
000000025450
Version 1.0 Revision Date 10/07/2020 Print Date 09/23/2021

2,3,3,3-Tetrafluoroprop-1- : Species: Rat

ene Application Route: Inhalation
Exposure time: (2 Weeks)
No-observed-effect level: 50000 ppm
Method: OECD Test Guideline 412

Species: Rat
Application Route: Inhalation
Exposure time: (4 Weeks)
NOAEL (No observed adverse effect level): 50000 ppm
Method: OECD Test Guideline 412

Species: Rat
Application Route: Inhalation
Exposure time: (13 Weeks)
NOAEL (No observed adverse effect level): 50000 ppm
Method: OECD Test Guideline 413

Species: Rabbit, male

Application Route: Inhalation
Exposure time: (28 d)
No-observed-effect level: 500 ppm
Method: OECD Test Guideline 412
There are no observed toxicological effects, which result in
classification as a specific target organ toxicant.

Species: Rabbit, female

Application Route: Inhalation
Exposure time: (28 d)
No-observed-effect level: 1000 ppm
Method: OECD Test Guideline 412
There are no observed toxicological effects, which result in
classification as a specific target organ toxicant.

Species: Mini-pig
Application Route: Inhalation
Exposure time: (28 d)
NOAEL (No observed adverse effect level): 10000 ppm
highest exposure tested

Genotoxicity in vitro
Difluoromethane : Test Method: Ames test
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Solstice® 454B
000000025450
Version 1.0 Revision Date 10/07/2020 Print Date 09/23/2021

Result: negative

2,3,3,3-Tetrafluoroprop-1- : Test Method: Ames test

ene Result: 20% and higher, positive in TA 100 and e. coli WP2
uvrA, negative in TA98, TA100, and TA1535.
Method: OECD Test Guideline 471

: Cell type: Human lymphocytes

Result: negative
Method: Mutagenicity (in vitro mammalian cytogenetic test)

: Test Method: Chromosome aberration test in vitro

Result: negative

: Test Method: Chromosome aberration test in vitro

Cell type: Human lymphocytes
Result: negative
Method: OECD Test Guideline 473
Note: Dose 760,000 ppm

Genotoxicity in vivo
Difluoromethane : Species: Mouse
Cell type: Bone marrow
Method: Mutagenicity (micronucleus test)
Result: negative

2,3,3,3-Tetrafluoroprop-1- : Species: Mouse

ene Cell type: Micronucleus
Dose: up to 200,000 ppm (4 hour)
Method: OECD Test Guideline 474
Result: negative

: Test Method: Unscheduled DNA synthesis

Dose: up to 50,000 ppm (4 weeks)
Method: OECD Test Guideline 486
Result: negative

: Species: Rat
Cell type: Micronucleus
Dose: up to 50,000 ppm (4 weeks)
Method: OECD Test Guideline 474
Result: negative

Carcinogenicity
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SAFETY DATA SHEET

Solstice® 454B
000000025450
Version 1.0 Revision Date 10/07/2020 Print Date 09/23/2021

2,3,3,3-Tetrafluoroprop-1- : Species: Rat

ene Note: Not classified as a human carcinogen. Substance not
expected to be a carcinogen based on available data.

Teratogenicity
Difluoromethane : Species: Rat
Dose: NOEL - 50,000 ppm
Note: Did not show teratogenic effects in animal experiments.

Species: Rabbit
Dose: NOEL - 50,000 ppm
Note: Did not show teratogenic effects in animal experiments.

SECTION 12. ECOLOGICAL INFORMATION

Toxicity to fish
2,3,3,3-Tetrafluoroprop-1- : LC50: > 197 mg/l
ene Exposure time: 96 h
Species: Cyprinus carpio (Carp)
Method: OECD Test Guideline 203
Note: No demonstrable toxic effect in saturated solution.

Toxicity to daphnia and other aquatic invertebrates

2,3,3,3-Tetrafluoroprop-1- : EC50: > 83 mg/l
ene Exposure time: 48 h
Species: Daphnia magna (Water flea)
Method: OECD Test Guideline 202

Toxicity to algae
2,3,3,3-Tetrafluoroprop-1- : EC50: > 100 mg/l
ene Species: Scenedesmus capricornutum (fresh water algae)
Method: OECD Test Guideline 201

Bioaccumulation
2,3,3,3-Tetrafluoroprop-1- : Note: Due to the distribution coefficient n-octanol/water,

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Solstice® 454B
000000025450
Version 1.0 Revision Date 10/07/2020 Print Date 09/23/2021

ene accumulation in organisms is not expected.

Biodegradability
Difluoromethane : Note: Minimal

2,3,3,3-Tetrafluoroprop-1- : Result: Not readily biodegradable.

ene Method: OECD Test Guideline 301F

Further information on ecology

SECTION 13. DISPOSAL CONSIDERATIONS

Disposal methods : Observe all Federal, State, and Local Environmental

regulations.

SECTION 14. TRANSPORT INFORMATION

DOT UN/ID No. : UN 3161
Proper shipping name : LIQUEFIED GAS, FLAMMABLE, N.O.S.
(Difluoromethane, R-1234yf)
Class 2.1
Packing group
Hazard Labels 2.1

IATA UN/ID No. : UN 3161

Description of the goods : LIQUEFIED GAS, FLAMMABLE, N.O.S.
(Difluoromethane, R-1234yf)
Class : 2.1
Hazard Labels : 2.1
Packing instruction (cargo : 200
aircraft)

IMDG UN/ID No. : UN 3161

Description of the goods : LIQUEFIED GAS, FLAMMABLE, N.O.S.
(DIFLUOROMETHANE, R-1234yf)
Class : 2.1
Hazard Labels : 2.1
EmS Number : F-D, S-U
Marine pollutant : no

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SAFETY DATA SHEET

Solstice® 454B
000000025450
Version 1.0 Revision Date 10/07/2020 Print Date 09/23/2021

SECTION 15. REGULATORY INFORMATION

Inventories

US. Toxic Substances : On TSCA Inventory

Control Act

Australia. Industrial : On the inventory, or in compliance with the inventory

Chemical (Notification and
Assessment) Act

Canada. Canadian : All components of this product are on the Canadian DSL
Environmental Protection
Act (CEPA). Domestic
Substances List (DSL)

Japan. Kashin-Hou Law : On the inventory, or in compliance with the inventory

List

Korea. Existing Chemicals : On the inventory, or in compliance with the inventory

Inventory (KECI)

Philippines. The Toxic : On the inventory, or in compliance with the inventory

Substances and Hazardous
and Nuclear Waste Control
Act

China. Inventory of Existing : On the inventory, or in compliance with the inventory

Chemical Substances
(IECSC)

New Zealand. Inventory of : On the inventory, or in compliance with the inventory

Chemicals (NZIoC), as
published by ERMA New
Zealand

TSCA 12B : US. Toxic Substances Control Act (TSCA) Section 12(b) Export
Notification (40 CFR 707, Subpt D)

2,3,3,3-Tetrafluoroprop-1-ene 754-12-1

National regulatory information

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SAFETY DATA SHEET

Solstice® 454B
000000025450
Version 1.0 Revision Date 10/07/2020 Print Date 09/23/2021

SARA 302 Components : No chemicals in this material are subject to the reporting
requirements of SARA Title III, Section 302.

SARA 313 Components : This material does not contain any chemical components with
known CAS numbers that exceed the threshold (De Minimis)
reporting levels established by SARA Title III, Section 313.

SARA 311/312 Hazards : Fire Hazard

Sudden Release of Pressure Hazard
Acute Health Hazard

California Prop. 65 :
WARNING:This product can expose you to chemicals,
listed below, known to the State of California to cause cancer
and birth defects or other reproductive harm. For more
information go to www.P65Warnings.ca.gov.
Dichloromethane 75-09-2
Chloromethane 74-87-3

Massachusetts RTK : Dichloromethane 75-09-2

Pennsylvania RTK : Difluoromethane 75-10-5

SECTION 16. OTHER INFORMATION

HMIS III NFPA
Health hazard : 1 2
Flammability : 4 4
Physical Hazard : 0
Instability : 0

Hazard rating and rating systems (e.g. HMIS® III, NFPA): This information is intended solely for the
use of individuals trained in the particular system.

Further information

The information provided in this Safety Data Sheet is correct to the best of our knowledge,
information and belief at the date of its publication. The information given is designed only as a
guidance for safe handling, use, processing, storage, transportation, disposal and release and is not

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Solstice® 454B
000000025450
Version 1.0 Revision Date 10/07/2020 Print Date 09/23/2021

to be considered a warranty or quality specification. The information relates only to the specific
material designated and may not be valid for such material used in combination with any other
materials or in any process, unless specified in the text. Final determination of suitability of any
material is the sole responsibility of the user. This information should not constitute a guarantee for
any specific product properties.

Changes since the last version are highlighted in the margin. This version replaces all previous
versions.
Prepared by Honeywell Performance Materials and Technologies Product Stewardship Group

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