Which of The Following H1 Antihistamines Is Non Sedating

Pharmacology Test 2 for clinical & midwifery nursing students
Date 15/04/2011
Time allowed: 1:30 hrs
Name: - _______________________________________________
ID number: - ___________________________________________
Part I: choose the best answer from the given alternatives & encircle the
letter of your choice.
1. Which of the following H1 antihistamines is non-sedating?
A. Cetrizine
B. Cyclizine
C. Chlorpheniramine
D. Promethazine
E. Cyproheptadine
2. Which is not a pharmacologic effect of histamine?
A. Vasoconstriction
B. Gastric acid secretion
C. Bronchoconstriction
D. Pain at cutaneous nerve endings
3. The predominant feature of anaphylaxis is:
A. Lapses in to unconsciousness
B. Convulsions
C. Vasodilation
D. Decreased blood Pressure
E. Broncho-constriction
4. Which prostaglandin is used clinically for its oxytocic activity?
A. Prostaglandin E2
B. Prostacyclin
C. Thromboxane A2
D. Leukotrien B4
E. Prostaglanding H
1
5. Antihistamines are used to treat all of the following except
A. Rhinitis
B. Rash
C. Conjunctivitis
D. Asthma
6. Side effects of antihistamines include all of the following except
A. Dizziness
B. Mucus Plugs
C. Urinary frequency
D. Sedation
7. Which one of the following drugs may cause a precipitous fall in blood pressure and
fainting on initial administration?
A. Atenolol
B. Hydrochlorthiazide
C. Nifedipine
D. Prazosine
8. When antihistamines are administered to patients receiving central nervous system

depressants, the nurse monitors the patient for
A. an increase in anticholinergic effects

B. excessive sedation
C. seizure activity
D. loss of hearing
9. Which drug would the nurse expect to be prescribed for a patient with digoxin
toxicity?
A. Digoxin immune fab (digoxin binding antibodies)

B. Milrinone
C. Inamrinone lactate
D. Any inotropic drug
2
10. Which one of the following drugs could significantly impair the ability to drive an
automobile?
A. Diphenhydramine.
B. cyclizine
C. cetrizine
D. Promethazine
E. Sumatriptan.
11. The therapeutic action of Beta-adrenergic blockers such as propranolol in angina

pectoris is believed to be primarily as a result of
A. Reduced production of cathecol-amines

B. Dilation of the coronary vasculature
C. Decreased requirement for myocardial oxygen
D. Increased peripheral resistance
E. Increased sensitivity of cathecol-amines
12. Effect of beta adrenergic blockers on angiotensin II levels:
A. increase
B. decrease
C. no effect
D. can’t be predicted
13. Direct acting, non-selective peripheral vasodilator that is 44% cyanide by weight
A. hydralazine
B. nitroprusside sodium
C. minoxidil
D. nitric oxide
14. Adverse effects associated with ACE inhibitor use:
A. rhinorrhea
B. proteinuria
3
C. angioedema
D. dry cough
E. all of the above
15. Anti-arrhythmic drugs classified as sodium channel blockers
A. quinidine gluconate
B. Flecainide
C. lidocaine
D. all of the above
16. Probable mechanistic bases for reduced blood pressure initially-when thiazides are
used
A. reduced vascular resistance
B. reduction in extracellular volume
C. reduction in cardiac output
D. B & C
E. A, B & C
17. Example(s) of centrally-acting sympatholytics:
A. trimetaphan
B. verapamil
C. methyl dopa
D. nitroprusside sodium
18. Which one of the following statements concerning H1 antihistamines is correct?
A. Second-generation H1 antihistamines are relatively free of adverse effects.

B. Because of the established long-term safety of first-generation H1 antihistamines,
they are the first choice for initial therapy.
C. The motor coordination involved in driving an automobile is not affected by the
use of first-generation H1 antihistamines.
4
D. H1 antihistamines can be used in the treatment of acute anaphylaxis.
E. Both first- and second-generation H1 antihistamines readily penetrate the blood-
brain barrier.
19. Which of the following adrenergic receptor activation mechanisms is involved with
MAO inhibitors?
A. Direct binding to the receptor

B. Promoting release of nor-epinephrine
C. Inhibiting reuptake of nor-epinephrine
D. Inhibiting inactivation of nor-epinephrine
20. Which of the following agonists would be used for cardiogenic shock, cardiac
arrest, heart block, or heart failure?
A. α1-agonist
B. α2-agonist
C. β1-agonist
D. β2-agonist
E. β3-agonis
21. Which of the following is NOT an indication for β-blocker therapy?
A. Hypotension
B. Angina pectoris
C. Arrhythmias
D. Myocardial infarction
E. Glaucoma
22. Prior to an operation to remove a pheo-chromocytoma (neuro-endocrine tumor of

the medulla of the adrenal glands), which of the following should be given to the
patient?
A. α-agonist
B. α-blocker
5
C. β-agonist
D. β-blocker
23. Which of the following is NOT considered cardio-selective?
A. Metoprolol
B. Atenolol
C. Esmolol
D. Carvedilol
24. Angina pectoris, tachycardia, and arrhythmias are possible adverse effects of
which of the following agonists?
A. α2-agonist
B. α1-agonist
C. β3-agonist
D. β2-agonist
E. β1-agonist
25. Which of the following is NOT an adverse affect of the β1 blockade by drugs like
propranolol?
A. Bradycardia
B. Decreased cardiac output
C. AV node block
D. Increased arrhythmias
E. Heart failure
26. Which of the following groups of patients is most at risk for adverse effect seen in
β2-blockers?
A. Asthmatics
B. Congestive heart failure patients
C. Trauma patients
D. Diabetics
6
Questions 27-31 are based on the following Case. Read carefully and answer the questions
comes after.
Arlie woods, 33 years old female receives epinephrine (adrenalin) in the emergency room
for severe Asthma attack. Health care personnel should have the following information
27. Adrenaline has all of the following actions EXCEPT
A. Peripheral vasodilator
B. Dilation of pupil
C. Bronchodilator
D. Cardiac stimulant
28. Epinephrine is also used to treat all of the following conditions EXCEPT
A. Nosebleed
B. Hypertension
C. Anaphylaxis
D. Cardiac arrest
29. Side effects can include all of the following EXCEPT
F. Tremors
G. Hypoglycemia
H. Tachycardia
I. Insomnia
30. She should be told all of the following about epinephrine EXCEPT
A. May cause sedation

B. Avoid alcohol
C. May cause headaches
D. Palpitations Possible

Which of The Following H1 Antihistamines Is Non Sedating

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Pharmacology Test 2 for clinical & midwifery nursing students

2. Which is not a pharmacologic effect of histamine?

3. The predominant feature of anaphylaxis is:

8. When antihistamines are administered to patients receiving central nervous system

A. an increase in anticholinergic effects

A. Digoxin immune fab (digoxin binding antibodies)

11. The therapeutic action of Beta-adrenergic blockers such as propranolol in angina

A. Reduced production of cathecol-amines

12. Effect of beta adrenergic blockers on angiotensin II levels:

14. Adverse effects associated with ACE inhibitor use:

E. all of the above

15. Anti-arrhythmic drugs classified as sodium channel blockers

D. all of the above

A. reduced vascular resistance

B. reduction in extracellular volume

C. reduction in cardiac output

17. Example(s) of centrally-acting sympatholytics:

18. Which one of the following statements concerning H1 antihistamines is correct?

A. Second-generation H1 antihistamines are relatively free of adverse effects.

A. Direct binding to the receptor

21. Which of the following is NOT an indication for β-blocker therapy?

22. Prior to an operation to remove a pheo-chromocytoma (neuro-endocrine tumor of

27. Adrenaline has all of the following actions EXCEPT

29. Side effects can include all of the following EXCEPT

A. May cause sedation

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