PHARMACOLOGY CONTINOUOS ASSESSMENT EXAMINATION

FOR: MBCHB YEAR 2

Examination Date– Wednesday, 13th October, 2021.

Time: 1Hour Total Marks: 100 Marks

Examiner: Mr. Reagan Kabuka

Student’s Number: ……………………………………………………….

Student’s Number: ……………………………………………………….

Instructions

1. Write your Name and student number on both question paper and answer
sheet.
2. Answer ALL questions in this paper.
3. All answers should be written down in the answer sheet provided.
1. Which of the drugs below is commonly referred to as arrow poison due to its neuromuscular
blocking action?
A. Suxamethonium
B. Atracurium
C. Edrophonium
D. Tubocurarine
E. Pancuronium

2. Which of the following is a depolarizing neuromuscular blocker?

A. Suxamethonium
B. Atracurium
C. Edrophonium
D. Tubocurarine
E. Pancuronium

3. The drugs below would not be ideal for the management of hypertension with bronchial
asthma
A. Furosemide
B. Nifedipine
C. Amlodipine
D. Hydrochlorothiazide
E. Atenolol

4. Which Pharmacology principle refers to the use of drugs to prevent, treat and diagnose
disease as well as to alter normal function?
A. Pharmacotherapeutics
B. Adverse drug reaction.
C. Pharmacokinetics
D. Pharmacodynamics
E. Pharmacovigilance

5. Activation of the sympathetic nervous system on the eye will lead to;
A. Mydriasis
B. Bradycardia
C. Miosis
D. Bronchoconstriction

6. The dose of drug to be administered to a patient by infusion is 50mg/kg per hour. If the
weight of the patient is 30kg, calculate the total quantity of drug delivered to the patient in a
24-h period. Circle the best answer only.
 A. 36g
B. 1500mg
C. 18g
D. 120 mg
E. 62.5mg

7. Asthmatic patients could experience bronchoconstriction problems with which of the

following agents?
A. Isoproterenol
B. Digoxin
C. Metoprolol
D. Dextromethorphan

8. Which of the following is a selective the beta blocker?

A. Nadolol
B. Pindolol
C. Propranolol
D. Metoprolol
E. Timolol

9. Which of the following would be a drug of choice in the management of an asthma

exacerbation?
A. Albuterol
B. Metoprolol
C. Xylometazoline
D. Phenylephrine
E. Metoprolol

10. What does First pass effects refer to?

A. Absorption of the drug from the small intestines
B. Local effects of the drug in the gastro-intestinal tract
C. Metabolism of a drug in the liver
D. Amount of drug that reaches the circulatory system
E. The time it takes for the concentration of a drug to come to half

11. Calculate the amount of drug that would be remaining after 40 hours, given that its half-life
is 8 hours. The Initial concentration of the drug is 500mg.
A. 250
B. 125
C. 65.5
 D. 31.3
E. 15.6

12. If the adult dose of a drug is 2000mg, calculate the dose for a 15kg child?
A. 400mg
B. 133mg
C. 429mg
D. 137mg
E. 352mg

13. Calculate the amount of cortisone to be administered when 4mg is prescribed and the
available stock is 200mgs in 10mls.
A. 1ml
B. 0.2ml
C. 0.3ml
D. 50ml
E. 20ml

14. If the prescribed dose of Prescribed of a drug is 20mg and the stock available is 500mcg per
tablet, calculate the number of tablets required per dose?
A. 40
B. 400
C. 25
D. 4
E. 4000

15. A drug is prescribed for a child at 50mg/kg/day. The frequency of the drug is BD. If the
Child’s weight is 7kg, calculate the size of each dose.
A. 7.1mg
B. 350mg
C. 700mg
D. 175mg
E. 125mg

16. A Patient is to receive 1000mls of Ringers lactate in 3 hours and the IV set delivers 60
drops/ml. calculate the rate of drops per minute.
A. 50
B. 5.5
C. 20000
D. 333
 E. 16.6

17. Which of the following is true about sympathomimetic drugs?

A. Do not bind to either alpha or beta but they mimic the effect of a sympathetic agonist
B. Do not bind to adrenergic receptors but mimic the effect of a sympathetic antagonist
C. Bind to adrenergic receptors to initiate a response
D. Bind to adrenergic receptors to block a response
E. Bind to sympathetic receptors to block a response

18. The following drugs are adrenergic agonists, except

A. Xylometazoline
B. Dobutamine
C. Phenylephrine
D. Phentolamine
E. Salbutamol

19. A Patient is to receive 500mls of 0.9% Saline solution in 45 minutes and the IV set delivers
15 drops/ml. calculate the rate of drops per minute.
A. 166
B. 1500
C. 11
D. 33
E. 150

20. The following are expectorant drugs except;

A. Acetylcystein
B. Ammonium chloride
C. Sodium acetate
D. Guaifenesin

21. The following are Mucolytic drugs except;

A. Carbocystein
B. Bromohexine
C. Iodide
D. Acetylcystein
E. None of the above

22. Which of the drugs below would be ideal choice for management of hypertension with heart
failure?
A. Spironolactone
B. Pindolol
 C. Propranolol
D. Amlodipine
E. Atenolol

23. The following are Antitussive drugs except

A. Benzonatate
B. Carbatepentane
C. Dextromethorphan
D. Noscapine
E. Carbocystein

24. Which of the following is part of the mechanism of action of Beta adrenoreceptor agonists
in asthma?
A. Bronco-constriction
B. Decreased Ciliary activity of bronchial Mucosa
C. Promotes release of mast cell mediators
D. All the above
E. None of the above

25. The name of a class of drugs that liquefy or breakdown bronchial secretions is;
A. Expectorants
B. Demulcents
C. Mucolytics
D. Bromhexine

26. You are presented with a 30-year-old patient that has had an irritating cough for 3 days.
There are bronchial secretions when the patient coughs. Which of the following classes of
drugs would be appropriate for use?
A. Demulcents
B. ACEs
C. Expectorants
D. Antitussives
E. Opioids

27. Which of the following classes of drugs can cause dry cough as a side effect?
A. Nifedipine
B. GTN
C. Furosemide
D. Phentolamine
E. Lisinopril
28. Which of the following is the daily recommended per day to reduce blood pressure and prevent
cardiovascular complications?
A. 2g
B. 6g
C. 14g
D. 21g

29. Drug therapy of acute Myocardial infarction includes the following, except;
A. Beta blockers
B. Oxygen
C. Morphine
D. Diuretics
E. Streptokinase

30. Which of the following is an examples of a calcium channel blockers?

A. Nifedipine
B. Verapamil
C. Diltiazem
D. All of the above
E. None of the above

31. Which of the following drugs can cause dry cough as a side effect?
A. Furosemide
B. Propranolol
C. Captopril
D. Diltiazem
E. Nifedipine

32. Which of the following includes the mechanism of action of calcium channel blockers in
Angina pectoris?
A. Produce coronary vasodilatation
B. Increase Myocardial contractility
C. Increase afterload
D. All of the above
E. None of the above

33. The drugs below can be used for management of hypertension in pregnancy except?
A. Hydralazine
B. Amiloride
C. Labetalol
D. Nifedipine
 E. Methyldopa

34. Which of the following would not be ideal for the management of hypertension with
vasospasmic angina?
A. Amlodipine
B. Furosemide
C. Verapamil
D. Hydrochlorothiazide
E. Atenolol

35. Which type of angina occurs with physical exercise and subsides with rest?
A. Stable Angina
B. Vasospasmic Angina
C. Unstable Angina
D. Variant Angina
E. None of the above

36. In which Class of Heart failure do the symptoms occur at minimal activity?
A. Class I
B. Class II
C. Class III
D. Class IV
E. Class V

Below is a diagram showing the Pathophysiology of Congestive cardiac failure. The questions apply
to the diagram below
37. Based on Mechanism of action, which of the following classes of drugs could best represent
the action of drug class 1 from the diagram?
A. Inotropic drugs
B. Hydralazine
C. Diuretic drugs
D. Venodilators
E. ACEIs

38. Based on Mechanism of action, which of the following classes of drugs could best represent
the action of drug class 2 from the diagram?
A. Inotropic drugs
B. Hydralazine
C. Diuretic drugs
D. Venodilators
E. ACEIs

39. Based on Mechanism of action, which of the following classes of drugs could best represent
the action of drug class 3 from the diagram?
 A. Inotropic drugs
B. Hydralazine
C. Diuretic drugs
D. Venodilators
E. ACEIs

40. Based on Mechanism of action, which of the following classes of drugs could best represent
the action of drug class 4 from the diagram?
A. Inotropic drugs
B. Hydralazine
C. Diuretic drugs
D. Venodilators
E. ACEIs

41. Based on Mechanism of action, which of the following classes of drugs could best represent
the action of drug class 5 from the diagram?
A. Inotropic drugs
B. Hydralazine
C. Diuretic drugs
D. Venodilators
E. ACEIs

42. One of the non-pharmacological interventions in Congestive cardiac failure patients is to

minimize sodium intake. Which of the following is the daily recommended per day for CCF
patients?

E. 2g
F. 6g
G. 14g
H. 21g

43. Which of the following would not be ideal for the management of hypertension with vasospasmic
angina?
A. Nifedipine
B. Furosemide
C. Amlodipine
D. Hydrochlorothiazide
E. Atenolol

44. The drugs below would be ideal for the management of hypertension with diabetes except;
A. Enalapril
B. metoprolol
C. Captopril
D. Candesartan
E. losartan

45. Which of the following parameters is used for monitoring Enoxaparin therapy?
A. INR
B. D-Dimers
C. PSA test
D. Full blood count
E. CRP

46. Which of the following parameters is used for monitoring therapy of Warfarin?
A. INR
B. Full blood count
C. RPR
D. D-Dimers
E. CRP

47. Which of the following drugs is a Short acting beta-adrenergic agonist?

A. Salmeterol
B. Terbutaline
C. Formeterol
D. Epinephrine
E. Ephedrine

48. Which of the following ia an angiotensin receptor blocker?

A. Lisinopril
B. Verapamil
C. Bisoprolol
D. Telmisartan
E. Ramipril

49. Which of the following classes of drugs can cause dry cough as a side effect?
A. Furosemide
B. Nifedipine
C. Amiloride
D. Atenolol
E. Ramipril

50. Which of the following drugs would be best suited for the management of Coumarin poisoning?
A. Protamine
B. Vitamin K
C. Warfarin
D. Fenofibrate
E. Phytomenadione

51. Which of the drugs would be best suited for the management of Heparin toxicity?
A. Protamine
B. Vitamin K
C. Warfarin
D. Fenofibrate
E. Phytomenadione

52. Which of the following Mucolytic drugs can also ne used management of paracetamol poisoning?

A. Carbocystein
B. Bromohexine
C. Dextromethorphan
D. Acetylcystein
E. Pholcodein

53. Which of the following drugs are contained in the brand Septrin?
A. Amiloride + Hydrochlorthiazide
B. Sulphadoxine + Pyrimethamine
C. Sulphamethoxazole + Trimethoprime
D. Primaquine + Malathione
E. Folic acid + Ferrous sulphate

54. Corticosteroids are a class of drugs that can be used in the management of Asthma. The following
drugs are corticosteroids that can be used in asthma except;
A. Budesonide
B. Beclomethasone
C. Prednisolone
D. Zilueton
E. Budesonide

55. Which of the following is an example of a non-selective beta agonist

A. Salmeterol
B. Terbutaline
C. Formeterol
D. Salbutamol
E. Ephedrine
56. What term best describes an effect of a drug, wheather therapeutic or adverse, that is
secondary to the one intended?
A. Side effect
B. Adverse drug reaction.
C. Drug abuse
D. Adverse event
E. Dependence

57. Which of the following is an example of a Pharmacokinetic drug interaction?

A. Tetracycline + Magnesium
B. Sulphadoxine + Pyrimethamine
C. Artemether + Lumefantrine
D. Sulphamethoxazole + Trimethoprime
E. Paracetamol + Codein

58. According to the FDA classification for drug use during pregnancy, which category of drugs
are “use with caution when benefits outweigh the risks”?
A. Class A
B. Class B
C. Class C
D. Class D
E. Class X

59. Which of the following opioids is considered safer during in pregnancy and hasnless
tendancy to cause Asphyxia neonatorum?
A. Pethidine
B. Codein
C. Morphine
D. Fentanyl
E. Buprenorphine

60. Which of the following type of receptors fall under the parasympathetic nervous system?
A. Alpha receptors
B. Histamine receptors
C. ACE receptors
D. Dopamine receptors
E. Muscarinic receptors