SAFETY DATA SHEET

Cell Wash Solution I/NaOH-D

Version 1.3 Revision Date 09-18-2014 Print Date 02-17-2015

SECTION 1. IDENTIFICATION

Product name : Cell Wash Solution I/NaOH-D

Mat.-No./ Genisys-No. : 04880285190

Manufacturer or supplier's details

Company name of supplier : Roche Diagnostics
-

Address : 9115 Hague Road

46250 Indianapolis IN
Telephone : 1-800-428-5074
Emergency telephone number:
In case of emergencies: : CHEMTREC 1-800-424-9300 (U.S. or
Canada)
1-703-527-3887 (International)
Recommended use of the chemical and restrictions on use
Restrictions on use : For professional users only.

SECTION 2. HAZARDS IDENTIFICATION

GHS Classification
The product is a kit consisting of individual ingredients. The classification of the ingredients can
be obtained from section 3. Section Label elements contains the resulting labelling for the kit.

GHS Label element

Hazard pictograms :

Signal word : Warning

Hazard statements : H290 May be corrosive to metals.

Precautionary statements : Prevention:

P234 Keep only in original container.
Response:
P390 Absorb spillage to prevent material damage.
Storage:
P406 Store in corrosive resistant stainless steel container with a
resistant inner liner.

Other hazards
None known.

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS

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Cell Wash Solution I/NaOH-D

Version 1.3 Revision Date 09-18-2014 Print Date 02-17-2015

GHS Classification
Corrosive to metals, Category 1 H290: May be corrosive to metals.

Hazardous components
Chemical Name CAS-No. Concentration (%)
sodium hydroxide 1310-73-2 >= 1 - < 5

SECTION 4. FIRST AID MEASURES

General advice : Move out of dangerous area.

Consult a physician.
Show this safety data sheet to the doctor in attendance.
Do not leave the victim unattended.

If inhaled : Move to fresh air.

If unconscious place in recovery position and seek medical
advice.
If symptoms persist, call a physician.

In case of skin contact : Immediate medical treatment is necessary as untreated

wounds from corrosion of the skin heal slowly and with
difficulty.
If on skin, rinse well with water.
If on clothes, remove clothes.

In case of eye contact : Small amounts splashed into eyes can cause irreversible
tissue damage and blindness.
In the case of contact with eyes, rinse immediately with plenty
of water and seek medical advice.
Continue rinsing eyes during transport to hospital.
Remove contact lenses.
Protect unharmed eye.
Keep eye wide open while rinsing.
If eye irritation persists, consult a specialist.

If swallowed : Clean mouth with water and drink afterwards plenty of water.
Keep respiratory tract clear.
Do NOT induce vomiting.
Do not give milk or alcoholic beverages.
Never give anything by mouth to an unconscious person.
If symptoms persist, call a physician.
Take victim immediately to hospital.

Most important symptoms : No information available.

and effects, both acute and
delayed

Notes to physician : The first aid procedure should be established in consultation

with the doctor responsible for industrial medicine.

SECTION 5. FIREFIGHTING MEASURES

Suitable extinguishing media : Use extinguishing measures that are appropriate to local
circumstances and the surrounding environment.

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Cell Wash Solution I/NaOH-D

Version 1.3 Revision Date 09-18-2014 Print Date 02-17-2015

Unsuitable extinguishing : High volume water jet

media

Specific hazards during : Do not allow run-off from fire fighting to enter drains or water
firefighting courses.

Further information : Collect contaminated fire extinguishing water separately. This

must not be discharged into drains.
Fire residues and contaminated fire extinguishing water must
be disposed of in accordance with local regulations.

Special protective equipment : Wear self-contained breathing apparatus for firefighting if

for firefighters necessary.

SECTION 6. ACCIDENTAL RELEASE MEASURES

Personal precautions, : Use personal protective equipment.

protective equipment and Refer to protective measures listed in sections 7 and 8.
emergency procedures

Environmental precautions : Prevent product from entering drains.

Prevent further leakage or spillage if safe to do so.
Local authorities should be advised if significant spillages
cannot be contained.

Methods and materials for : Soak up with inert absorbent material (e.g. sand, silica gel,
containment and cleaning up acid binder, universal binder, sawdust).
Keep in suitable, closed containers for disposal.

SECTION 7. HANDLING AND STORAGE

Advice on safe handling : Do not breathe vapours/dust.

Avoid contact with skin and eyes.
For personal protection see section 8.
Smoking, eating and drinking should be prohibited in the
application area.
Dispose of rinse water in accordance with local and national
regulations.
To prevent leaks or spillages from spreading, provide a
suitable liquid retention system.

Conditions for safe storage : Keep container tightly closed in a dry and well-ventilated
place.
Containers which are opened must be carefully resealed and
kept upright to prevent leakage.
Observe label precautions.
Electrical installations / working materials must comply with
the technological safety standards.

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION

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SAFETY DATA SHEET

Cell Wash Solution I/NaOH-D

Version 1.3 Revision Date 09-18-2014 Print Date 02-17-2015

Components with workplace control parameters

Components CAS-No. Value type Control Basis
(Form of parameters /
exposure) Permissible
concentration
sodium hydroxide 1310-73-2 C 2 mg/m3 ACGIH
C 2 mg/m3 NIOSH REL
TWA 2 mg/m3 OSHA Z-1
C 2 mg/m3 OSHA P0
Personal protective equipment
Hand protection

Material : Protective gloves

Remarks : The selected protective gloves have to satisfy the
specifications of EU Directive 89/686/EEC and the standard
EN 374 derived from it.This recommendation is only valid for
the product mentioned in the safety data sheet and provided
by us and for the application specified by us.Please observe
the instructions regarding permeability and breakthrough time
which are provided by the supplier of the gloves. Also take
into consideration the specific local conditions under which the
product is used, such as the danger of cuts, abrasion, and the
contact time.The suitability for a specific workplace should be
discussed with the producers of the protective gloves.
Eye protection : Eye wash bottle with pure water
Tightly fitting safety goggles
Wear face-shield and protective suit for abnormal processing
problems.

Skin and body protection : impervious clothing

Choose body protection according to the amount and
concentration of the dangerous substance at the work place.

Hygiene measures : When using do not eat or drink.

When using do not smoke.
Wash hands before breaks and at the end of workday.

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES

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Appearance : liquid

Colour : colourless

Odour : none

Flash point : does not flash

Flammability (solid, gas) : The product is not flammable.

Upper explosion limit : No data available

Lower explosion limit : No data available

Density : 1.0419 g/cm3

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Cell Wash Solution I/NaOH-D

Version 1.3 Revision Date 09-18-2014 Print Date 02-17-2015

Solubility(ies)
Water solubility : completely miscible

Auto-ignition temperature : No data available

Thermal decomposition : No data available

SECTION 10. STABILITY AND REACTIVITY

Reactivity : No dangerous reaction known under conditions of normal use.

Chemical stability : Stable under normal conditions.

Possibility of hazardous : Reacts with the following substances:

reactions Metals
Gives off hydrogen by reaction with metals.
Nitriles
Hydrogen cyanide (hydrocyanic acid)
Acids

No decomposition if stored and applied as directed.

Conditions to avoid : No data available

Incompatible materials : Aluminium

Light metals
Metals
Zinc
glass
Acids
Tin

Hazardous decomposition : Hydrogen, by reaction with metals

products

SECTION 11. TOXICOLOGICAL INFORMATION

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Information on likely routes of exposure
Acute toxicity
Not classified based on available information.
Skin corrosion/irritation
Not classified based on available information.
Product:
Remarks: Extremely corrosive and destructive to tissue.

Serious eye damage/eye irritation

Not classified based on available information.
Product:
Remarks: May cause irreversible eye damage.

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Cell Wash Solution I/NaOH-D

Version 1.3 Revision Date 09-18-2014 Print Date 02-17-2015

Respiratory or skin sensitisation

Skin sensitisation: Not classified based on available information.
Respiratory sensitisation: Not classified based on available information.
Germ cell mutagenicity
Not classified based on available information.
Components:
sodium hydroxide:
Genotoxicity in vitro : Test Type: Ames test
Result: negative

Carcinogenicity
Not classified based on available information.

IARC No component of this product present at levels greater than or

equal to 0.1% is identified as probable, possible or confirmed
human carcinogen by IARC.

ACGIH No component of this product present at levels greater than or

equal to 0.1% is identified as a carcinogen or potential
carcinogen by ACGIH.

OSHA No component of this product present at levels greater than or

equal to 0.1% is identified as a carcinogen or potential
carcinogen by OSHA.

NTP No component of this product present at levels greater than or

equal to 0.1% is identified as a known or anticipated carcinogen
by NTP.

Reproductive toxicity
Not classified based on available information.
Components:
sodium hydroxide:
Effects on fertility :

Remarks: No data available

STOT - single exposure

Not classified based on available information.
Product:
Assessment: The substance or mixture is not classified as specific target organ toxicant, single
exposure.

Components:
sodium hydroxide:
Assessment: The substance or mixture is not classified as specific target organ toxicant, single
exposure.

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Cell Wash Solution I/NaOH-D

Version 1.3 Revision Date 09-18-2014 Print Date 02-17-2015

STOT - repeated exposure

Not classified based on available information.
Product:
Assessment: The substance or mixture is not classified as specific target organ toxicant,
repeated exposure.

Components:
sodium hydroxide:
Assessment: The substance or mixture is not classified as specific target organ toxicant,
repeated exposure.

Aspiration toxicity
Not classified based on available information.

SECTION 12. ECOLOGICAL INFORMATION

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Ecotoxicity

Product:
Ecotoxicology Assessment
Toxicity Data on Soil : Not expected to adsorb on soil.

Other organisms relevant to : No data available

the environment

Components:
sodium hydroxide:
Toxicity to fish : LC50 (Oncorhynchus mykiss (rainbow trout)): 45.4 mg/l
Exposure time: 96 h

LC50 (Leuciscus idus (Golden orfe)): ca. 7 mg/l

Toxicity to daphnia and other : EC50 (Daphnia magna (Water flea)): 40.38 mg/l
aquatic invertebrates Exposure time: 48 h

Ecotoxicology Assessment
Acute aquatic toxicity : This product has no known ecotoxicological effects.

Chronic aquatic toxicity : This product has no known ecotoxicological effects.

Toxicity Data on Soil : Not expected to adsorb on soil.

Other organisms relevant to : No data available

the environment

Persistence and degradability

No data available
Bioaccumulative potential
No data available

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Cell Wash Solution I/NaOH-D

Version 1.3 Revision Date 09-18-2014 Print Date 02-17-2015

Mobility in soil
No data available
Other adverse effects
No data available
Product:
Regulation 40 CFR Protection of Environment; Part 82 Protection of
Stratospheric Ozone - CAA Section 602 Class I Substances

Remarks This product neither contains, nor was manufactured with a

Class I or Class II ODS as defined by the U.S. Clean Air Act
Section 602 (40 CFR 82, Subpt. A, App.A + B).

SECTION 13. DISPOSAL CONSIDERATIONS

Disposal methods
Waste from residues : Do not contaminate ponds, waterways or ditches with
chemical or used container.
Send to a licensed waste management company.
Can be disposed as waste water, when in compliance with
local regulations.

Contaminated packaging : Empty remaining contents.

Dispose of as unused product.
Empty containers should be taken to an approved waste
handling site for recycling or disposal.
Do not re-use empty containers.

SECTION 14. TRANSPORT INFORMATION

International Regulation

IATA-DGR
UN/ID No. : UN 1824
Proper shipping name : Sodium hydroxide solution
Class : 8
Packing group : II
Labels : Corrosives
Packing instruction (cargo : 855
aircraft)
Packing instruction : Not permitted for transport
(passenger aircraft)
IMDG-Code
UN number : UN 1824
Proper shipping name : Sodium hydroxide solution
Class : 8
Packing group : II
Labels : 8
EmS Code : F-A, S-B
Marine pollutant : no

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Cell Wash Solution I/NaOH-D

Version 1.3 Revision Date 09-18-2014 Print Date 02-17-2015

Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable for product as supplied.
National Regulations

49 CFR
UN/ID/NA number : UN 1824
Proper shipping name : Sodium hydroxide solution
Class : 8
Packing group : II
Labels : Class 8 - Corrosive
ERG Code : 154
Marine pollutant : no

SECTION 15. REGULATORY INFORMATION

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EPCRA - Emergency Planning and Community Right-to-Know Act

CERCLA Reportable Quantity

Components CAS-No. Component RQ Calculated product RQ
(lbs) (lbs)
Sodium hydroxide 1310-73-2 1000 *
*: Calculated RQ exceeds reasonably attainable upper limit.

SARA 304 Extremely Hazardous Substances Reportable Quantity

This material does not contain any components with a section 304 EHS RQ.
SARA 302 : No chemicals in this material are subject to the reporting
requirements of SARA Title III, Section 302.

SARA 313 : This material does not contain any chemical components with
known CAS numbers that exceed the threshold (De Minimis)
reporting levels established by SARA Title III, Section 313.

Clean Air Act

This product does not contain any hazardous air pollutants (HAP), as defined by the U.S. Clean
Air Act Section 12 (40 CFR 61).
This product does not contain any chemicals listed under the U.S. Clean Air Act Section 112(r) for
Accidental Release Prevention (40 CFR 68.130, Subpart F).
This product does not contain any chemicals listed under the U.S. Clean Air Act Section 111
SOCMI Intermediate or Final VOC's (40 CFR 60.489).
Clean Water Act
The following Hazardous Substances are listed under the U.S. CleanWater Act, Section 311,
Table 116.4A:
sodium hydroxide 1310-73-2 4%
The following Hazardous Chemicals are listed under the U.S. CleanWater Act, Section 311, Table
117.3:
sodium hydroxide 1310-73-2 4%
This product does not contain any toxic pollutants listed under the U.S. Clean Water Act Section
307
Massachusetts Right To Know
sodium hydroxide 1310-73-2 1-5%

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Cell Wash Solution I/NaOH-D

Version 1.3 Revision Date 09-18-2014 Print Date 02-17-2015

Pennsylvania Right To Know

water 7732-18-5 90 - 100 %
sodium hydroxide 1310-73-2 1-5%
New Jersey Right To Know
water 7732-18-5 90 - 100 %
sodium hydroxide 1310-73-2 1-5%

California Prop 65 : This product does not contain any chemicals known to State
of California to cause cancer, birth defects, or any other
reproductive harm.

SECTION 16. OTHER INFORMATION

Further information

R1 (B / C)
NFPA: HMIS III:
Flammability

HEALTH 0
0
Instability
Health

0 0 FLAMMABILITY 0
1
3 PHYSICAL HAZARD 0
B
Special hazard. N
0 = not significant, 1 =Slight,
2 = Moderate, 3 = High
G 4 = Extreme, * = Chronic
6
6
6
Revision Date ( : 09-18-2014
*
The information provided in this Safety Data Sheet is correct to the best of our knowledge,
information and belief at the: date of its publication. The information given is designed only as
a guidance for safe handling, 0 use, processing, storage, transportation, disposal and release
and is not to be considered 1 a warranty or quality specification. The information relates only to
the specific material designated
G and may not be valid for such material used in combination
with any other materials or in any process, unless specified in the text.
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