This document discusses the adrenergic and cholinergic systems. It describes the neurotransmitters, receptors, and effects of various agonists and antagonists. Adrenergic drugs such as epinephrine, dopamine, and beta blockers affect the heart rate, vasculature, and bronchioles. Their effects are mediated by alpha and beta receptors. Cholinergic drugs such as acetylcholine, donepezil, and physostigmine act through nicotinic and muscarinic receptors to influence various organ systems like the heart, lungs, eyes, GI tract, and urinary system. Anticholinergic drugs block acetylcholine and are used to treat conditions like Parkinson's disease and IBS
This document discusses the adrenergic and cholinergic systems. It describes the neurotransmitters, receptors, and effects of various agonists and antagonists. Adrenergic drugs such as epinephrine, dopamine, and beta blockers affect the heart rate, vasculature, and bronchioles. Their effects are mediated by alpha and beta receptors. Cholinergic drugs such as acetylcholine, donepezil, and physostigmine act through nicotinic and muscarinic receptors to influence various organ systems like the heart, lungs, eyes, GI tract, and urinary system. Anticholinergic drugs block acetylcholine and are used to treat conditions like Parkinson's disease and IBS
Original Description:
Original Title
Adrenergic and Cholinergic (2017_11_01 22_03_49 UTC)
This document discusses the adrenergic and cholinergic systems. It describes the neurotransmitters, receptors, and effects of various agonists and antagonists. Adrenergic drugs such as epinephrine, dopamine, and beta blockers affect the heart rate, vasculature, and bronchioles. Their effects are mediated by alpha and beta receptors. Cholinergic drugs such as acetylcholine, donepezil, and physostigmine act through nicotinic and muscarinic receptors to influence various organ systems like the heart, lungs, eyes, GI tract, and urinary system. Anticholinergic drugs block acetylcholine and are used to treat conditions like Parkinson's disease and IBS
This document discusses the adrenergic and cholinergic systems. It describes the neurotransmitters, receptors, and effects of various agonists and antagonists. Adrenergic drugs such as epinephrine, dopamine, and beta blockers affect the heart rate, vasculature, and bronchioles. Their effects are mediated by alpha and beta receptors. Cholinergic drugs such as acetylcholine, donepezil, and physostigmine act through nicotinic and muscarinic receptors to influence various organ systems like the heart, lungs, eyes, GI tract, and urinary system. Anticholinergic drugs block acetylcholine and are used to treat conditions like Parkinson's disease and IBS
Download as DOCX, PDF, TXT or read online from Scribd
Download as docx, pdf, or txt
You are on page 1of 2
Adrenergic – stimulated by SNS “fight or flight”, expect to see increased heart rate
- Neurotransmitters: epi, norepi, dopamine
- Alpha 1 – vasoconstriction of s. muscle. Phenylephrine = vasopressive drug - Beta 1 – heart: increase heart rate, contractility, force of conduction - Beta 2 – lungs: vasodilation of s. muscle (bring blood to areas) Albuterol = bronchodilator - Metabolized by enzymes: MAO and COMT - Dobutamine = cardiac decompensation - Dopamine = low-dialate blood vessles in heart, kidney, brain. High-beta 1. Higher-alpha 1. to treat the patient’s hypovolemic shock secondary to severe blood loss. - Epi = anaphylaxis, cardiac life support, Increased heart rate and contractility - Fenoldopam = hypertensive emergency - Midodrine = ortho hypotension - Norepi and Phenylephrine = hypotension and shock - Murabegron = overactive bladder Monoamine oxidase inhibitors (MAOIs) used with adrenergic’s causes hypertensive crisis
Phentolamine = is an alpha blocker that causes vasodilation, thus counteracting the vasoconstrictive effects of the infiltrated dopamine. The vasodilation will increase blood flow to the site and decrease the risk of tissue necrosis.
Atenolol (Tenormin) and metoprolol (Lopressor) = abrupt medication withdrawal may lead to rebound hypertension
Phentolamine (Regitine) = treat pheochromocytoma
Metoprolol (Lopressor) = Risk for decreased cardiac tissue perfusion related to effects of medication and if you take your pulse and it is less than 60 beats/min, hold your medicine and call your health care provider for instructions
Carvedilol (Coreg) = used with digoxin, furosemide, ace inhibitors to treat heart failure
Beta blockers drug interactions = alcohol, diuretics, anticholinergics, oral hypoglycemic
Cholinergic – stimulated by PSNS “rest and digest” ***Effects same as adverse effects
- Neurotransmitter: acetylcholine (nictonic and muscarinic)
- Increase ach in brain by inhibiting cholinesterase - Stimulate constriction of pupil, increase GI secretion and motility, increase urinary frequency - Cause sweating, salvation, decrease heart rate and vasodiatlion, bronchi constrict and airways narrow - Direct acting – treat glaucoma - Indirect acting – treat Alzheimer’s and myasthenia gravis: edrophonium (Tensilon) - Cholinergic crisis can be reversed promptly by administering atropine! (cholinergic antagonist) - bethanechol (Urecholine = treat urinary atony - donepezil (Aricept) = increase levels of Ach in the brain, treat Alzheimer’s - physostigmine (Antilirium) = take 30 mins before meals - cholinergic drugs are contraindicaited in disorders like COPD, GI obstruction, bradycardia, and hypotension
