M.Sc. Part 1 Sem 2 (Wef 2021-22)
M.Sc. Part 1 Sem 2 (Wef 2021-22)
M.Sc. Part 1 Sem 2 (Wef 2021-22)
Affiliated to
University of Mumbai
Program : M.Sc. Chemistry
Proposed Courses for : M.Sc. Part I (Semester II)
Credit Based Semester and Grading System (CBCS) with effect from the
academic year 2021-22
1
M.Sc. Chemistry Part I Syllabus
Semester II
2
Semester II – Theory
Physical Chemistry II (Credits: 04 Lectures/Week: 04)
PSCHE201
15L
Unit I Chemical Thermodynamics-II
15L
Unit II Quantum Chemistry-II
3
15L
Unit III Chemical Kinetics & Molecular Reaction Dynamics
15L
Unit IV Solid State Chemistry & Phase Equilibria
4
Standard References:
Unit I
1. Peter Atkins and Julio de Paula, Atkin’s Physical Chemistry, 7th Edn., Oxford
University Press, 2002.
2. Puri, B.R.; Sharma, L.R.; Pathania, M.S.; Principles of Physical Chemistry, Vishal
Publishing Company, 2008.
3. K. L. Kapoor, ‘A textbook of Physical Chemistry’ Vol 2, 6th Edition Mc Graw Hill
education
4. K. L. Kapoor, ‘A textbook of Physical Chemistry’ Vol 3, 6th Edition Mc Graw Hill
education
Unit II
5. R.K. Prasad, Quantum Chemistry, 4th Revised Edn., New Age International Publishers,
2010 (Reprint 2018)
6. Donald A. McQuarrie, Quantum Chemistry, 2 Edition, University Science Books Mill
nd
Valley, California
7. Ira R. Levine, Physical Chemistry, 5th Edn., Tata McGraw-Hill New Delhi, 2002.
Unit III
8. K.J. Laidler and J.H. Meiser, Physical Chemistry, 2nd Ed., CBS Publishers and
Distributors, New Delhi, 1999.
9. Principles of Chemical Kinetics, 2nd Ed., James E. House, ELSEVIER, 2007
Unit IV
10. Solid State Chemistry [An Introduction], 3rd Ed., Lesley E. Smart & Elaine A.
Moore, Taylor & Francis, 2010.
11. Principles of the Solid State, H.V. Keer, New Age International Publishers, 2011.
12. Advanced Physical Chemistry by Gurtu and Gurtu
13. Puri, B.R.; Sharma, L.R.; Pathania, M.S.; Principles of Physical Chemistry, Vishal
Publishing Company, 2008.
14. K. L. Kapoor, ‘A textbook of Physical Chemistry’ Vol 3, 6th Edition Mc Graw Hill
education
Additional References:
15. Peter Atkins and Julio de Paula, Atkin’s Physical Chemistry, 7th Edn., Oxford
University Press, 2002.
16. Robert J. Silby and Robert A. Alberty, Physical Chemistry, 3 Edn., John Wiley and
rd
1983.
20. S. Glasstone, Text Book of Physical Chemistry, 2 Edn., McMillan and Co. Ltd.,
nd
London, 1962
21. B.K. Sen, Quantum Chemistry including Spectroscopy, Kalyani Publishers, 2003.
22. A.K. Chandra, Introductory Quantum Chemistry, Tata McGraw – Hill, 1994.
23. S. Glasstone, Thermodynamics for Chemists, Affiliated East-West Press, New Delhi,
1964.
24. W.G. Davis, Introduction to Chemical Thermodynamics – A Non – Calculus
Approach, Saunders, Philadelphia, 19772.
5
25. Peter A. Rock, Chemical Thermodynamics, University Science Books, Oxford
University Press, 1983.
26. Thomas Engel and Philip Reid, Physical Chemistry, 3 Edn., Pearson Education
rd
Limited 2013.
27. D.N. Bajpai, Advanced Physical Chemistry, S. Chand 1 Edn., 1992.
st
28. The Physics and ‘Chemistry of Solids, Stephen Elliott, Willey India, 2010
29. Solid State Chemistry, D.K. Chakrabarty, New Age International Publishers, 1996.
30. Principles of physical Chemistry , Marrown and Prutton 5th edition
31. Essentials of Physical Chemistry , Arun Bahl, B. S Bahl, G. D.Tulli , S Chand and Co.
Ltd , 2012 Edition.
32. Introduction of Solids L.V Azaroff , Tata McGraw Hill .
33. A Text book of physical Chemistry ; Applications of thermodynamics vol III, Mac
Millan Publishers India Ltd ,2011
34. New directions in solid state Chemistry, C.N.R. Rao and J Gopalkrishnan , Cambridge
University Press.
6
Semester II – Practical
Course: Physical Chemistry Practical II (Credits: 04, Practicals/Week: 01)
PSCHEPR201
Non-instrumental
1. Polar plots of atomic orbitals such as 1s, 2pz and 3dz2 orbitals
by using angular part of hydrogen atom wave functions.
2. To study the influence of ionic strength on the base catalysed
hydrolysis of ethyl acetate.
3. To study the phase diagram of three component system water
– chloroform /toluene - acetic acid.
4. To determine the rate constant of decomposition reaction of
diacetone alcohol by dialtometric method
Instrumental
REFERENCES:
1. Practical Physical Chemistry, B. Viswanathan and P.S.
Raghavan, Viva Books Private Limited, 2005.
2. Practical Physical Chemistry, A.M. James and F.E.
Prichard, 3 Edn., Longman Group Ltd., 1974.
rd
7
Semester II – Theory
Inorganic Chemistry II (Credits: 04 Lectures/Week: 04)
PSCHE202
15L
Unit I Inorganic Reaction Mechanism:
1.1 Rate of reactions, factors affecting the rate of reactions, techniques
for determination of rate of reaction (Direct chemical analysis,
spectrophotometric method, electrochemical and flow methods).
15L
Unit II Organometallic Chemistry of Transition Metals
2.1 Eighteen and sixteen electron rule and electron counting with
examples.
2.5 Structure and bonding on the basis of VBT and MOT in the
following organometallic compounds:
8
a. Zeise’s salt
b. Bis(triphenylphosphine)diphenylacetylene platinum (0)
c. [Pt(PPh3)2(HC≡CPh2]
d. Diallylnickel (II)
e. Ferrocene
f. Bis(arene)chromium (0)
15L
Unit III Introduction to Nanomaterials & Nanotechnology:
15L
Unit IV Bioinorganic Chemistry
9
4.5 Metal ion transport and storage: Ionophores, transferrin, ferritin and
metallothionins
Standard References:
Unit I
1. F. Basalo and R. G. Pearson, Mechanism of Inorganic Reactions, 2nd Ed., Wiley, 1967.
2. Selected topics in Inorganic Chemistry, Wahid U Malik, G.D Tuli, R.D Madan.
S.Chand and company.12th edition.
3. Fundamental concepts of Inorganic Chemistry. Vol 5. Asim K. Das. CBS Publishers
and distributors Pvt Ltd.
Unit II
4. Organometallic Chemistry of Transition metals, Robert Crabtree, john Wiley & Sons
publications,4th edition.
5. Basic Organometallic Chemistry, B.D. Gupta & A. Elias, Universities Press,2nd
Edition
6. R.C Mehrotra and A.Singh, Organometallic Chemistry- A unified Approach, 2nded,
New Age International Pvt Ltd, 2000.
Unit III
7. Kulkarni, S. K. Nanotechnology: Principles and Practices, Capitol Publishing
Company (2007)
8. Goyal,R.K. Nanomaterials and Nanocomposites: Synthesis, Properties,
Characterization Techniques and Applications, CRC press, Taylor & Francis (2018)
9. Rao, C.N.R., Müller & Cheetham, A.K., Eds. The Chemistry of Nanomaterials:
Synthesis, Properties and Applications, Wiley-VCH Verlag GmbH & Co. KGaA,
Weinheim (2004).
Unit IV
10. I. Bertini, H.B.Gray, S. J. Lippard and J.S. Valentine, Bioinorganic Chemistry, First
South Indian Edition, Viva Books, New Delhi, 1998.
11. S. J. Lippard and J. M. Berg, Principles of Bioinorganic Chemistry, University Science
Publications, Mill Valley, Caligronic, 1994.
Additional References:
12. P. Atkins, T. Overton, J. Rourke, M. Weller and F. Armstrong, Inorganic Chemistry,
5th Ed., Oxford University Press, 2010.
13. D. Banerjea, Coordination Chemistry, Tata McGraw Hill, 1993.
14. M. L. Tobe and J. Burgess, Inorganic Reaction Mechanism, Longman, 1999.
15. S. Asperger, Chemical kinetics and Inorganic Reaction Mechanism, 2nd Ed., Kluwer
Academic/ Plenum Publishers, 2002
16. Gurdeep Raj, Advanced Inorganic Chemistry-Vol.II, 12th Edition, Goel publishing
house, 2012.
17. B. R. Puri, L. R. Sharma and K. C. Kalia, Principles of Inorganic Chemistry, Milestone
Publishers, 2013-2014.
18. R. Gopalan and V. Ramlingam, Concise Coordination chemistry, Vikas Publishing
house Pvt Ltd., 2001.
10
19. Robert B. Jordan, Reaction Mechanisms of Inorganic and Organometallic Systems, 3rd
Ed., Oxford University Press 2008.
20. D. Banerjea, Coordination chemistry. Tata McGrew Hill, New Delhi,1993.
21. B.Doughlas, D.H McDaniel and J.J Alexander. Concepts and Models of Inorganic
Chemistry, 2nd edition, John Wiley and Sons. 1983.
22. Organometallic Chemistry by G.S Sodhi. Ane Books Pvt Ltd.
23. R. W. Hay, Bioinorganic Chemistry, Ellis Harwood, England, 1984.
24. J. A. Cowan, Inorganic Biochemistry-An introduction, VCH Publication, 1993.
25. G.N. Mukherjee and A. Das, Elements of Bioinorganic Chemistry, Dhuri & Sons,
Calcutta, 1988.
26. J.Chem. Educ. (Special issue), Nov, 1985.
27. E.Frienden, J.Chem. Educ., 1985, 62.
28. Robert R.Crechton, Biological Inorganic Chemistry – An Introduction, Elsevier
29. J. R. Frausto da Silva and R. J. P. Williams The Biological Chemistry of the Elements,
Clarendon Press, Oxford, 1991.
30. JM. D. Yudkin and R. E. Offord A Guidebook to Biochemistry, Cambridge University
Press, 1980.
11
Semester II – Practical
Course: Inorganic Chemistry Practical II (Credits: 04, Practicals/Week: 01)
PSCHEPR202
Ores and Alloys
1. Analysis of Devarda’s alloy
2. Analysis of Cu – Ni alloy
3. Analysis of Tin Solder alloy
4. Analysis of Limestone.
Instrumental
REFERENCES:
1. Advanced experiments in Inorganic Chemistry., G. N.
Mukherjee., 1 Edn., 2010., U.N.Dhur & Sons Pvt Ltd
st
12
Semester II – Theory
Organic Chemistry II (Credits: 04 Lectures/Week: 04)
PSCHE203
15L
Unit I Enols & Enolates
1.1 Acid & Base catalysed enolisation, enols & enolates from aldehydes,
ketones, esters, acids, amides; kinetic & thermodynamically stable
enols [2L]
1.2 Regioselectivity in formation of enolates- thermodynamic & kinetic
control, factors governing regioselectivity [3L]
1.3 Reactions of enols & enolates: [5L]
a. O-alkylation versus C-alkylation of enolates
b. Alkylation of enolates from nitriles, nitroalkanes, carboxylic
acids, esters, aldehydes & ketones
c. Regioselective formation of dianion and alkylation of
dianion
d. Acid and base catalysed halogenation, iodoform reaction
e. Nitrosation of enols
f. Conjugate addition of enolates to α,β-unsaturated carbonyls
(Michael reaction)
1.4 Acid and base catalysed aldol condensation, mixed aldol
condensation with aromatic aldehydes, chemoselectivity in mixed
reactions of aliphatic aldehydes and ketones, intramolecular aldol
& Robinson’s annulation [2L]
1.5 Nucleophilic reactions at carbonyl carbon- Mannich reaction,
Claisen condensation, Knoevenagel reaction [3L]
15L
Unit II Name Reactions & Rearrangements
Mechanism, stereochemistry (if applicable) and applications of the
following:
2.1 Reactions: Baylis-Hilman reaction, McMurry Coupling, Corey-
Fuchs reaction, Nef reaction, Passerini reaction
13
2.4 Anionic rearrangements: Brook, Neber, Von Richter, Wittig,
Gabriel–Colman, Payne
15L
Unit III Molecular Orbital Theory & Photochemistry
Photochemistry: (6L)
15L
Unit IV Organic Spectroscopy:
4.1 Uv Spectroscopy (2L): Principles of absorption spectroscopy,
chromophore, auxochrome; factors affecting position and intensity
of uv bands- conjugation, steric factor, pH and solvent polarity
Woodward-fieser rules for dienes & enones
14
vibrational frequencies of carbonyl compounds, aldehydes, ketones,
esters, amides, acids, acid halides, anhydrides, lactones, lactams and
conjugated carbonyl compounds.
4.4 Mass Spectrometry (3L): Molecular ion peak, base peak, isotopic
abundance, metastable ions. Nitrogen rule, Determination of
molecular formula of organic compounds based on isotopic
abundance and HRMS. Fragmentation pattern in various classes of
organic compounds (including compounds containing hetero
atoms), McLafferty rearrangement, Retro-Diels-Alder reaction,
ortho effect.
Standard References:
Unit I
1. Organic Chemistry, J. Clayden, N. Greeves, S. Warren and P. Wothers, Oxford
University Press
2. Advanced Organic Chemistry, F.A. Carey and R.J. Sundberg, Part A and B, Plenum
Press.
Unit II
3. Name Reactions- A collection of Detailed Mechanisms and Synthetic Applications, Jie
Jack Li, Fourth Edition, Springer Publisher.
4. Name Reactions and Reagents in Organic Synthesis, Bradford P. Mundy, M.G.
Ellerd, and F.G. Favaloro, John Wiley & Sons.
5. Organc Reaction Mechanisms, V.K. Ahluwalia, R.K. Parasher, Alpha Science
International, 2011.
Unit III
6. Molecular Orbitals and Organic Chemical Reactions, Ian Fleming, Reference Edition
2010, Wiley & Sons Ltd.
7. Advanced Organic Chemistry, F.A. Carey and R.J. Sundberg, Part A, Plenum Press.
8. Principles of Organic Synthesis, R.O.C. Norman and J.M Coxon, Third edition,
Blackie Academic & Professional Publishers.
Unit IV
15
9. Introduction to Spectroscopy, Donald L. Pavia, Gary M. Lampman, George S. Kriz,
Thomson Brooks.
10. Organic Spectroscopy- Principles and applications, Jag Mohan, Narosa Publication
11. Spectrometric Identification of Organic Compounds, R. Silverstein, G.C. Bassler and
T.C. Morrill, John Wiley and Sons.
Additional References:
16
Semester II – Practical
Course: Organic Chemistry Practical II (Credits: 04, Practicals/Week: 01)
PSCHEPR203
Separation of Binary Mixture:
Minimum three mixtures from each type and a total of ten mixtures
are expected.
REFERENCES:
1. Organic Analytical Chemistry: Theory and Practice, Jag Mohan,
Alpha Science, 2003
2. Advanced Practical Organic Chemistry – N. K. Vishnoi, Third
Addition, Vikas Publishing House PVT Ltd
3. Vogel's Textbook of Practical Organic Chemistry, Fifth
edition,2008, B.S.Furniss, A. J. Hannaford, P. W. G. Smith, A. R.
Tatchell, Pearson Education
4. Laboratory Manual of Organic Chemistry, Fifth edition, R K
Bansal, New Age Publishers.
5. Comprehensive Practical Organic Chemistry: Preparation and
Quantitative Analysis- V. K. Ahluwalia and Renu Aggarwal,
Universities Press India Ltd., 2000
17
Semester II – Theory
Analytical Chemistry II (Credits: 04 Lectures/Week: 04)
PSCHE204
15L
Unit I Chromatography [15L]
15L
Unit II Thermal Methods, Hyphenation & Automation in Chemical Analysis
18
Introduction, need for hyphenation, possible hyphenation,
interfacing devices and applications of the following: GC-MS,
GC-IR, MS-MS, LC-MS
15L
Unit III Surface Analytical Techniques [15L]
15L
Unit IV Electroanalytical Methods
4.1 Ion Selective Potentiometry: Ion selective electrodes and their
applications (solid state, precipitate, liquid –liquid, enzyme and gas
sensing electrodes), ion selective field effect transistors,
biocatalytic membrane electrodes and enzyme based biosensors.
[6L]
19
Standard References:
Unit I
1. Fundamentals of Analytical Chemistry, By Douglas A. Skoog, Donald M. West,
F. James Holler, Stanley R. Crouch, 9 Edition, 2004.
th
Additional References:
20
Semester II – Practical
Course: Analytical Chemistry Practical II (Credits: 04, Practicals/Week: 01)
PSCHEPR204
1. To determine percentage purity of sodium carbonate in washing
soda pH metrically.
2. To determine the amount of Ti(III) and Fe(II) in a mixture by
titration with Ce(IV) potentiometrically.
3. To determine the percentage purity of a sample (glycine/sodium
benzoate/primary amine) by titration with perchloric acid in a non
aqueous medium using glass calomel system potentiometrically.
4. To determine the amount of nitrite present in the given water sample
colorimetrically.
5. To determine the amount of Fe(II) and Fe(III) in a mixture using
1,10-phenanthroline spectrophotometrically.
6. Simultaneous determination of Cr(VI) and Mn(VII) in a mixture
spectrophotometrically.
7. To determine the percentage composition of HCl and H2SO4 on
weight basis in a mixture of two by conductometric titration with
NaOH and BaCl2.
8. To determine the amount of potassium in the given sample of
fertilizers using a flame photometer by standard addition method.
REFERENCES:
1. Quantitative Inorganic Analysis including Elementary Instrumental
Analysis by A. I. Vogels, 3 Ed. ELBS (1964)
rd
21
Evaluation Scheme
22