JAI HIND COLLEGE

BASANTSING INSTITUTE OF SCIENCE

&
J.T.LALVANI COLLEGE OF COMMERCE
(AUTONOMOUS)
"A" Road, Churchgate, Mumbai - 400 020, India.

Affiliated to
University of Mumbai
Program : M.Sc. Chemistry
Proposed Courses for : M.Sc. Part I (Semester II)
Credit Based Semester and Grading System (CBCS) with effect from the
academic year 2021-22

1
 M.Sc. Chemistry Part I Syllabus

Wef Academic year 2021-22

Semester I

Course Course Title Credits Lectures

Code /Week
PSCHE101 Physical Chemistry-I 4 4
PSCHE102 Inorganic Chemistry-I 4 4
PSCHE103 Organic Chemistry-I 4 4
PSCHE104 Analytical Chemistry-I 4 4
PSCHEPR101 Physical Chemistry Practical-I 4 4
PSCHEPR102 Inorganic Chemistry Practical-I 4 4
PSCHEPR103 Organic Chemistry Practical-I 4 4
PSCHEPR104 Analytical Chemistry Practical-I 4 4

Semester II

Course Course Title Credits Lectures

Code /Week
PSCHE201 Physical Chemistry-II 4 4
PSCHE202 Inorganic Chemistry-II 4 4
PSCHE203 Organic Chemistry-II 4 4
PSCHE204 Analytical Chemistry-II 4 4
PSCHEPR201 Physical Chemistry Practical-II 4 4
PSCHEPR202 Inorganic Chemistry Practical-II 4 4
PSCHEPR203 Organic Chemistry Practical-II 4 4
PSCHEPR204 Analytical Chemistry Practical-II 4 4

2
 Semester II – Theory
Physical Chemistry II (Credits: 04 Lectures/Week: 04)
PSCHE201

Thermodynamics, Quantum Chemistry, Kinetics, Solid State Chemistry &

Phase Equilibria

15L
Unit I Chemical Thermodynamics-II

1.1 Fugacity of real gases: Determination of fugacity of real gases

using graphical method and from equation of state. Equilibrium
constant for real gases in terms of fugacity. Gibbs energy of mixing,
entropy and enthalpy of mixing. [4L]

1.2 Real Solutions: Chemical potential in non ideal solutions excess

functions of non ideal solutions calculation of partial molar volume
and partial molar enthalpy, Gibbs Duhem Margules equation. [4L]

1.3 Thermodynamics of Surfaces: Pressure difference across curved

surface (Laplace equation), vapour pressure of droplets (Kelvin
equation), Gibbs adsorption isotherm, BET isotherm (derivations
expected). [5L]

1.4 Bioenergetics: standard free energy change in biochemical

reactions, exergonic, endergonic. Hydrolysis of ATP, synthesis of
ATP from ADP. [2L]

15L
Unit II Quantum Chemistry-II

2.1 Rigid rotor: particle in a ring, particle on a sphere, spherical

coordinates, Schrödinger wave equation in spherical coordinates,
separation of variables, solution of phi and theta equations,
spherical harmonics, quantisation of energy. (4L)

2.2 Hydrogen atom: Solution of Schrödinger equation for H-atom,

radial eigenfunctions, total wave functions for 1s, 2s, 2p & 3d
orbitals, quantum numbers & their significance, atomic orbitals in
their real forms. (4L)

2.3 Graphical representation of orbitals: radial & angular plots,

radial and angular probability distributions. (2L)

2.4 Multielectron systems: Application of Schrödinger equation for

multielectron system- limitations & introduction to approximation
methods. (1L)

2.5 Hückel Molecular Orbital Theory: Derivation & application to

conjugated systems like ethylene, 1,3-butadiene, benzene. (4L)

3
 15L
Unit III Chemical Kinetics & Molecular Reaction Dynamics

3.1 Elementary Reactions in Solution: Solvent Effects on reaction

rates, Reactions between ions- influence of solvent Dielectric
constant, influence of ionic strength, Linear free energy
relationships Enzyme action [4L]

3.2 Kinetics of reactions catalyzed by enzymes: Michaelis-Menten

analysis, Lineweaver-Burk and Eadie Analyses. [2L]

3.3 Inhibition of Enzyme action: Competitive, Noncompetitive and

Uncompetitive Inhibition. Effect of pH, Enzyme activation by metal
ions, Regulatory enzymes. [4L]

3.4 Kinetics of reactions in the Solid State:- Factors affecting

reactions in solids; Rate laws for reactions in solid: The
parabolic rate law, The first order rate Law, the contracting
sphere rate law, Contracting area rate law, some examples of
kinetic studies. [5L]

15L
Unit IV Solid State Chemistry & Phase Equilibria

4.1 Solid State Chemistry [6L]

a. Recapitulation: Structures and Defects in solids.

b. Types of Defects and Stoichiometry: Zero dimensional
(point), One dimensional (line), Two dimensional (Planar),
Thermodynamics of formation of defects (Mathematical
derivation to find concentration of defects and numerical
problems based on it.

4.2 Phase Equilibria [9L]

a. Recapitulation: Introduction and definition of terms

involved in phase rule; thermodynamic derivation of Gibbs
Phase Rule.
b. Two component system:
i. Solid-Gas system: hydrate formation, amino
compound formation
ii. Solid-Liquid system: formation of compounds with
congruent and incongruent melting points with
suitable examples.
c. Three Component system:
i. Type I: Formation of one pair of partially miscible
liquids
ii. Type-II: Formation of two pairs of partially miscible
liquids
iii. Type-III: Formation of three pairs of partially
miscible liquids

4
Standard References:
Unit I
1. Peter Atkins and Julio de Paula, Atkin’s Physical Chemistry, 7th Edn., Oxford
University Press, 2002.
2. Puri, B.R.; Sharma, L.R.; Pathania, M.S.; Principles of Physical Chemistry, Vishal
Publishing Company, 2008.
3. K. L. Kapoor, ‘A textbook of Physical Chemistry’ Vol 2, 6th Edition Mc Graw Hill
education
4. K. L. Kapoor, ‘A textbook of Physical Chemistry’ Vol 3, 6th Edition Mc Graw Hill
education
Unit II
5. R.K. Prasad, Quantum Chemistry, 4th Revised Edn., New Age International Publishers,
2010 (Reprint 2018)
6. Donald A. McQuarrie, Quantum Chemistry, 2 Edition, University Science Books Mill
nd

Valley, California
7. Ira R. Levine, Physical Chemistry, 5th Edn., Tata McGraw-Hill New Delhi, 2002.
Unit III
8. K.J. Laidler and J.H. Meiser, Physical Chemistry, 2nd Ed., CBS Publishers and
Distributors, New Delhi, 1999.
9. Principles of Chemical Kinetics, 2nd Ed., James E. House, ELSEVIER, 2007
Unit IV
10. Solid State Chemistry [An Introduction], 3rd Ed., Lesley E. Smart & Elaine A.
Moore, Taylor & Francis, 2010.
11. Principles of the Solid State, H.V. Keer, New Age International Publishers, 2011.
12. Advanced Physical Chemistry by Gurtu and Gurtu
13. Puri, B.R.; Sharma, L.R.; Pathania, M.S.; Principles of Physical Chemistry, Vishal
Publishing Company, 2008.
14. K. L. Kapoor, ‘A textbook of Physical Chemistry’ Vol 3, 6th Edition Mc Graw Hill
education
Additional References:
15. Peter Atkins and Julio de Paula, Atkin’s Physical Chemistry, 7th Edn., Oxford
University Press, 2002.
16. Robert J. Silby and Robert A. Alberty, Physical Chemistry, 3 Edn., John Wiley and
rd

Sons (Asia) Pte. Ltd., 2002.

17. K.J. Laidler and J.H. Meiser, Physical Chemistry, 2nd Ed., CBS Publishers and
Distributors, New Delhi, 1999.
18. McQuarrie, Donald A, and John D. Simon. Physical Chemistry: A Molecular
Approach., 1997. Sausalito, Calif.: University Science Books
19. G.W. Castellan, Physical Chemistry, 3 Edn., Narosa Publishing House, New Delhi,
rd

1983.
20. S. Glasstone, Text Book of Physical Chemistry, 2 Edn., McMillan and Co. Ltd.,
nd

London, 1962
21. B.K. Sen, Quantum Chemistry including Spectroscopy, Kalyani Publishers, 2003.
22. A.K. Chandra, Introductory Quantum Chemistry, Tata McGraw – Hill, 1994.
23. S. Glasstone, Thermodynamics for Chemists, Affiliated East-West Press, New Delhi,
1964.
24. W.G. Davis, Introduction to Chemical Thermodynamics – A Non – Calculus
Approach, Saunders, Philadelphia, 19772.

5
25. Peter A. Rock, Chemical Thermodynamics, University Science Books, Oxford
University Press, 1983.
26. Thomas Engel and Philip Reid, Physical Chemistry, 3 Edn., Pearson Education
rd

Limited 2013.
27. D.N. Bajpai, Advanced Physical Chemistry, S. Chand 1 Edn., 1992.
st

28. The Physics and ‘Chemistry of Solids, Stephen Elliott, Willey India, 2010
29. Solid State Chemistry, D.K. Chakrabarty, New Age International Publishers, 1996.
30. Principles of physical Chemistry , Marrown and Prutton 5th edition
31. Essentials of Physical Chemistry , Arun Bahl, B. S Bahl, G. D.Tulli , S Chand and Co.
Ltd , 2012 Edition.
32. Introduction of Solids L.V Azaroff , Tata McGraw Hill .
33. A Text book of physical Chemistry ; Applications of thermodynamics vol III, Mac
Millan Publishers India Ltd ,2011
34. New directions in solid state Chemistry, C.N.R. Rao and J Gopalkrishnan , Cambridge
University Press.

6
 Semester II – Practical
Course: Physical Chemistry Practical II (Credits: 04, Practicals/Week: 01)
PSCHEPR201
Non-instrumental

1. Polar plots of atomic orbitals such as 1s, 2pz and 3dz2 orbitals
by using angular part of hydrogen atom wave functions.
2. To study the influence of ionic strength on the base catalysed
hydrolysis of ethyl acetate.
3. To study the phase diagram of three component system water
– chloroform /toluene - acetic acid.
4. To determine the rate constant of decomposition reaction of
diacetone alcohol by dialtometric method

Instrumental

1. To determine the formula of silver ammonia complex by

potentiometric method.
2. To determine CMC of sodium Lauryl Sulphate from
measurement of conductivities at different concentrations.
3. To determine Hammette constant of m- and p- amino benzoic
acid/nitro benzoic acid by pH measurement.
4. To determine the Michaelis – Menten’s constant value (Km)
of the enzyme Beta Amylase spectrophotometrically.

REFERENCES:
1. Practical Physical Chemistry, B. Viswanathan and P.S.
Raghavan, Viva Books Private Limited, 2005.
2. Practical Physical Chemistry, A.M. James and F.E.
Prichard, 3 Edn., Longman Group Ltd., 1974.
rd

3. Experimental Physical Chemistry, V.D. Athawale and P.

Mathur, New Age International Publishers, 2001

7
 Semester II – Theory
Inorganic Chemistry II (Credits: 04 Lectures/Week: 04)
PSCHE202

Chemical Reaction Mechanisms in Inorganic Chemistry, Nanomaterials &

Nanotechnology, Organometallic & Bioinorganic Chemistry

15L
Unit I Inorganic Reaction Mechanism:
1.1 Rate of reactions, factors affecting the rate of reactions, techniques
for determination of rate of reaction (Direct chemical analysis,
spectrophotometric method, electrochemical and flow methods).

1.2 Ligand Substitution Reactions of:

a. Octahedral complexes without breaking of metal-ligand

bond (Use of isotopic labelling method)
b. Square planar complexes, trans-effect, its theories and
applications; trans effect v/s trans influence in square planar
complexes; mechanism and factors affecting these
substitution reactions.

1.3 Redox reactions: inner and outer sphere mechanisms,

complimentary and non- complimentary reactions.

1.4 Stereochemistry of substitution reactions of octahedral complexes.

(Isomerization and racemization reactions and applications.)

15L
Unit II Organometallic Chemistry of Transition Metals

2.1 Eighteen and sixteen electron rule and electron counting with
examples.

2.2 Ligand Substitution Reactions(CO, Phosphine, CS, NO)

2.3 Preparation, reactions & properties of:

a. Metal carbonyls
b. Metal alkyls
c. Metal carbenes & carbynes
d. Metal complexes with alkenes & alkynes
e. Allyl complexes of transition metals
f. Group-subgroup relationships.
2.4 Homogeneous & heterogeneous catalysis

2.5 Structure and bonding on the basis of VBT and MOT in the
following organometallic compounds:

8
 a. Zeise’s salt
b. Bis(triphenylphosphine)diphenylacetylene platinum (0)
c. [Pt(PPh3)2(HC≡CPh2]
d. Diallylnickel (II)
e. Ferrocene
f. Bis(arene)chromium (0)

15L
Unit III Introduction to Nanomaterials & Nanotechnology:

3.1 Introduction to Nanomaterials and Nanotechnology: Definitions,

Historical development, Classification, Types of nanomaterials
(2L)

3.2 Fundamentals: Size effect (grain boundaries, surface area),

Properties of nanomaterials: Optical and mechanical properties with
applications (in brief). (3L)

3.3 Special Nanostructures: Carbon nanostructures (Fullerenes, CNT,

Graphene), Quantum dots, porous silica, Core-shell structures and
Nanocomposites. (3L)

3.4 Synthesis of nanomaterials: Top down & Bottom-up approach (7L)

a. Chemical methods: Role of surfactant, Reduction, Colloidal

method, Sol-gel methods, Hydrothermal, Microwave,
Langmuir-Blodgett Method
b. Physical methods: CVD, Laser Ablation, Arc discharge and
Electrochemical methods.

15L
Unit IV Bioinorganic Chemistry

4.1 Biological oxygen carriers; hemoglobin, hemerythrene and

hemocyanine- structure of metal active center and differences in
mechanism of oxygen binding, Differences between hemoglobin
and myoglobin: Cooperativity of oxygen binding in hemoglobin
and Hill equation, pH dependence of oxygen affinity in hemoglobin
and myoglobin and its implications.

4.2 Activation of oxygen in biological system with examples of mono-

oxygenases, and oxidases- structure of the metal center and
mechanism of oxygen activation by these enzymes.

4.3 Copper containing enzymes- superoxide dismutase, tyrosinase and

laccase: catalytic reactions and the structures of the metal binding
site.

4.4 Nitrogen fixation-nitrogenases, hydrogenases

9
 4.5 Metal ion transport and storage: Ionophores, transferrin, ferritin and
metallothionins

4.6 Medicinal applications of cis-platin and related compounds

Standard References:
Unit I
1. F. Basalo and R. G. Pearson, Mechanism of Inorganic Reactions, 2nd Ed., Wiley, 1967.
2. Selected topics in Inorganic Chemistry, Wahid U Malik, G.D Tuli, R.D Madan.
S.Chand and company.12th edition.
3. Fundamental concepts of Inorganic Chemistry. Vol 5. Asim K. Das. CBS Publishers
and distributors Pvt Ltd.
Unit II
4. Organometallic Chemistry of Transition metals, Robert Crabtree, john Wiley & Sons
publications,4th edition.
5. Basic Organometallic Chemistry, B.D. Gupta & A. Elias, Universities Press,2nd
Edition
6. R.C Mehrotra and A.Singh, Organometallic Chemistry- A unified Approach, 2nded,
New Age International Pvt Ltd, 2000.
Unit III
7. Kulkarni, S. K. Nanotechnology: Principles and Practices, Capitol Publishing
Company (2007)
8. Goyal,R.K. Nanomaterials and Nanocomposites: Synthesis, Properties,
Characterization Techniques and Applications, CRC press, Taylor & Francis (2018)
9. Rao, C.N.R., Müller & Cheetham, A.K., Eds. The Chemistry of Nanomaterials:
Synthesis, Properties and Applications, Wiley-VCH Verlag GmbH & Co. KGaA,
Weinheim (2004).
Unit IV
10. I. Bertini, H.B.Gray, S. J. Lippard and J.S. Valentine, Bioinorganic Chemistry, First
South Indian Edition, Viva Books, New Delhi, 1998.
11. S. J. Lippard and J. M. Berg, Principles of Bioinorganic Chemistry, University Science
Publications, Mill Valley, Caligronic, 1994.
Additional References:
12. P. Atkins, T. Overton, J. Rourke, M. Weller and F. Armstrong, Inorganic Chemistry,
5th Ed., Oxford University Press, 2010.
13. D. Banerjea, Coordination Chemistry, Tata McGraw Hill, 1993.
14. M. L. Tobe and J. Burgess, Inorganic Reaction Mechanism, Longman, 1999.
15. S. Asperger, Chemical kinetics and Inorganic Reaction Mechanism, 2nd Ed., Kluwer
Academic/ Plenum Publishers, 2002
16. Gurdeep Raj, Advanced Inorganic Chemistry-Vol.II, 12th Edition, Goel publishing
house, 2012.
17. B. R. Puri, L. R. Sharma and K. C. Kalia, Principles of Inorganic Chemistry, Milestone
Publishers, 2013-2014.
18. R. Gopalan and V. Ramlingam, Concise Coordination chemistry, Vikas Publishing
house Pvt Ltd., 2001.

10
19. Robert B. Jordan, Reaction Mechanisms of Inorganic and Organometallic Systems, 3rd
Ed., Oxford University Press 2008.
20. D. Banerjea, Coordination chemistry. Tata McGrew Hill, New Delhi,1993.
21. B.Doughlas, D.H McDaniel and J.J Alexander. Concepts and Models of Inorganic
Chemistry, 2nd edition, John Wiley and Sons. 1983.
22. Organometallic Chemistry by G.S Sodhi. Ane Books Pvt Ltd.
23. R. W. Hay, Bioinorganic Chemistry, Ellis Harwood, England, 1984.
24. J. A. Cowan, Inorganic Biochemistry-An introduction, VCH Publication, 1993.
25. G.N. Mukherjee and A. Das, Elements of Bioinorganic Chemistry, Dhuri & Sons,
Calcutta, 1988.
26. J.Chem. Educ. (Special issue), Nov, 1985.
27. E.Frienden, J.Chem. Educ., 1985, 62.
28. Robert R.Crechton, Biological Inorganic Chemistry – An Introduction, Elsevier
29. J. R. Frausto da Silva and R. J. P. Williams The Biological Chemistry of the Elements,
Clarendon Press, Oxford, 1991.
30. JM. D. Yudkin and R. E. Offord A Guidebook to Biochemistry, Cambridge University
Press, 1980.

11
 Semester II – Practical
Course: Inorganic Chemistry Practical II (Credits: 04, Practicals/Week: 01)
PSCHEPR202
Ores and Alloys
1. Analysis of Devarda’s alloy
2. Analysis of Cu – Ni alloy
3. Analysis of Tin Solder alloy
4. Analysis of Limestone.

Instrumental

1. Estimation of Copper using Iodometric method

Potentiometrically.
2. Estimation of Fe+3 solution using Ce(IV) ions
Potentiometrically

REFERENCES:
1. Advanced experiments in Inorganic Chemistry., G. N.
Mukherjee., 1 Edn., 2010., U.N.Dhur & Sons Pvt Ltd
st

2. The Synthesis and Characterization of Inorganic Compounds

by William L. Jolly
3. Inorganic Chemistry Practical Under UGC Syllabus for M.Sc.
in all India Universities By: Dr Deepak Pant

12
 Semester II – Theory
Organic Chemistry II (Credits: 04 Lectures/Week: 04)
PSCHE203

Physical Organic Chemistry, Nucleophilic Substitution, Aromaticity,

Stereochemistry & Reagents in organic synthesis

15L
Unit I Enols & Enolates

1.1 Acid & Base catalysed enolisation, enols & enolates from aldehydes,
ketones, esters, acids, amides; kinetic & thermodynamically stable
enols [2L]
1.2 Regioselectivity in formation of enolates- thermodynamic & kinetic
control, factors governing regioselectivity [3L]
1.3 Reactions of enols & enolates: [5L]
a. O-alkylation versus C-alkylation of enolates
b. Alkylation of enolates from nitriles, nitroalkanes, carboxylic
acids, esters, aldehydes & ketones
c. Regioselective formation of dianion and alkylation of
dianion
d. Acid and base catalysed halogenation, iodoform reaction
e. Nitrosation of enols
f. Conjugate addition of enolates to α,β-unsaturated carbonyls
(Michael reaction)
1.4 Acid and base catalysed aldol condensation, mixed aldol
condensation with aromatic aldehydes, chemoselectivity in mixed
reactions of aliphatic aldehydes and ketones, intramolecular aldol
& Robinson’s annulation [2L]
1.5 Nucleophilic reactions at carbonyl carbon- Mannich reaction,
Claisen condensation, Knoevenagel reaction [3L]

15L
Unit II Name Reactions & Rearrangements
Mechanism, stereochemistry (if applicable) and applications of the
following:
2.1 Reactions: Baylis-Hilman reaction, McMurry Coupling, Corey-
Fuchs reaction, Nef reaction, Passerini reaction

2.2 Concerted rearrangements: Hofmann, Curtius, Lossen, Schmidt,

Wolff, Boulton- Katritzky

2.3 Cationic rearrangements: Tiffeneau-Demjanov, Pummerer,

Dienone-phenol, Rupe, Wagner-Meerwein.

13
 2.4 Anionic rearrangements: Brook, Neber, Von Richter, Wittig,
Gabriel–Colman, Payne

15L
Unit III Molecular Orbital Theory & Photochemistry

Applications of Molecular Orbital Theory in Organic Chemistry:

3.1.1 MOT: Formation of MOs by LCAO, concept of nodal planes and

energies of π-MOs; Construction of MO of conjugated systems-
ethene, butadiene, hextriene, allyl cation, anion & radical; MO of
formaldehyde involving electronegativity perturbation. (2L)

3.1.2 Salem-Klopman equation: Explanation of terms in the equation,

frontier molecular orbitals (HOMO & LUMO) and their
significance, Pearson’s principle and Hard-soft electrophiles and
nucleophiles- examples and identification of hard and soft reactive
sites. (3L)

3.1.3 Application of FMO concepts to: (a) significance of HOMO-

LUMO band gap in absorption spectra of polyenes, effect of
conjugation on FMOs of alkenes (b) SN2 reaction, (c) dimerization
of ethylene to cyclobutane, (d) Diels-Alder cycloaddition (4L)

Photochemistry: (6L)

3.2.1 Introduction to Photochemistry: General Principles, electronic

states and transitions, selection rules, fate of excited molecules
(Jablonski diagram)

3.2.2 Photochemistry of alkenes: cis-trans isomerization, dimeriztation,

oxidative coupling

3.2.3 Photochemistry of carbonyl compounds: π → π* & n → π*

transitions, Norrish type I & II reactions, photoreduction &
photosensitization.

15L
Unit IV Organic Spectroscopy:
4.1 Uv Spectroscopy (2L): Principles of absorption spectroscopy,
chromophore, auxochrome; factors affecting position and intensity
of uv bands- conjugation, steric factor, pH and solvent polarity
Woodward-fieser rules for dienes & enones

4.2 Infrared Spectroscopy (3L): Fundamental, overtone and

combination bands, vibrational coupling, factors affecting
vibrational frequency (atomic weight, conjugation, ring size,
solvent and hydrogen bonding). Characteristic vibrational
frequencies for different functional groups. Detailed study of

14
 vibrational frequencies of carbonyl compounds, aldehydes, ketones,
esters, amides, acids, acid halides, anhydrides, lactones, lactams and
conjugated carbonyl compounds.

4.3 NMR Spectroscopy (7L):

4.3.1 Proton Magnetic resonance: Principle, Chemical shift,

Factors affecting chemical shift (Electronegativity, H-
bonding, Anisotropy effects). Chemical and magnetic
equivalence, Chemical shift values and correlation for protons
bonded to carbon and other nuclei; Spin-spin coupling,
Coupling constant (J), Factors affecting J, geminal, vicinal and
long range coupling (allylic and aromatic), Karplus equation
13
4.3.2 C NMR spectroscopy: Theory and comparison with proton
NMR, proton coupled and decoupled spectra, off-resonance
decoupling. Factors influencing carbon shifts, correlation of
chemical shifts of aliphatic, olefin, alkyne, aromatic and
carbonyl carbons.

4.4 Mass Spectrometry (3L): Molecular ion peak, base peak, isotopic
abundance, metastable ions. Nitrogen rule, Determination of
molecular formula of organic compounds based on isotopic
abundance and HRMS. Fragmentation pattern in various classes of
organic compounds (including compounds containing hetero
atoms), McLafferty rearrangement, Retro-Diels-Alder reaction,
ortho effect.

Standard References:
Unit I
1. Organic Chemistry, J. Clayden, N. Greeves, S. Warren and P. Wothers, Oxford
University Press
2. Advanced Organic Chemistry, F.A. Carey and R.J. Sundberg, Part A and B, Plenum
Press.
Unit II
3. Name Reactions- A collection of Detailed Mechanisms and Synthetic Applications, Jie
Jack Li, Fourth Edition, Springer Publisher.
4. Name Reactions and Reagents in Organic Synthesis, Bradford P. Mundy, M.G.
Ellerd, and F.G. Favaloro, John Wiley & Sons.
5. Organc Reaction Mechanisms, V.K. Ahluwalia, R.K. Parasher, Alpha Science
International, 2011.
Unit III
6. Molecular Orbitals and Organic Chemical Reactions, Ian Fleming, Reference Edition
2010, Wiley & Sons Ltd.
7. Advanced Organic Chemistry, F.A. Carey and R.J. Sundberg, Part A, Plenum Press.
8. Principles of Organic Synthesis, R.O.C. Norman and J.M Coxon, Third edition,
Blackie Academic & Professional Publishers.
Unit IV

15
 9. Introduction to Spectroscopy, Donald L. Pavia, Gary M. Lampman, George S. Kriz,
Thomson Brooks.
10. Organic Spectroscopy- Principles and applications, Jag Mohan, Narosa Publication
11. Spectrometric Identification of Organic Compounds, R. Silverstein, G.C. Bassler and
T.C. Morrill, John Wiley and Sons.

Additional References:

12. March’s Advanced Organic Chemistry: Reactions, Mechanisms and Structure,

Michael B. Smith, Jerry March, Wiley.
13. Organic Chemistry, R.T. Morrison, R.N. Boyd and S.K. Bhattacharjee, Pearson
Publication (7th Edition)
14. Advanced Organic Chemistry: Reactions and mechanism, B. Miller and R. Prasad,
Pearson Education.
15. Advanced Organic Chemistry: Reaction mechanisms, R. Bruckner, Academic Press.
16. Understanding Organic Reaction Mechanisms, Adams Jacobs, Cambridge University
Press.
17. Writing Reaction Mechanism in organic chemistry, A. Miller, P.H. Solomons,
Academic Press.
18. Advanced Organic Chemistry: Reactions and mechanism, L.G. Wade, Jr., Maya
Shankar Singh, Pearson Education.
19. Mechanism in Organic Chemistry, Peter Sykes, 6th Edition
20. Organic Spectroscopy, William Kemp, W.H. Freeman & Company.
21. Organic Spectroscopy, V.R. Dani, Tata McGraw Hill Publishing Co.
22. Spectroscopy of Organic Compounds, P.S. Kalsi, New Age International Ltd.

16
 Semester II – Practical
Course: Organic Chemistry Practical II (Credits: 04, Practicals/Week: 01)
PSCHEPR203
Separation of Binary Mixture:

1. Separation of binary mixture using physical and chemical

methods.
2. Characterization of one of the components with the help
of chemical analysis and confirmation of the structure
with the help of derivative preparation and its physical
constant.
3. Purification and determination of mass and physical
constant of the second component. The following types
are expected:
a) Water soluble/water insoluble solid and water insoluble
solid,
b) Non-volatile liquid and Non-volatile liquid (chemical
separation)
c) Water-insoluble solid and Non-volatile liquid.

Minimum three mixtures from each type and a total of ten mixtures
are expected.

REFERENCES:
1. Organic Analytical Chemistry: Theory and Practice, Jag Mohan,
Alpha Science, 2003
2. Advanced Practical Organic Chemistry – N. K. Vishnoi, Third
Addition, Vikas Publishing House PVT Ltd
3. Vogel's Textbook of Practical Organic Chemistry, Fifth
edition,2008, B.S.Furniss, A. J. Hannaford, P. W. G. Smith, A. R.
Tatchell, Pearson Education
4. Laboratory Manual of Organic Chemistry, Fifth edition, R K
Bansal, New Age Publishers.
5. Comprehensive Practical Organic Chemistry: Preparation and
Quantitative Analysis- V. K. Ahluwalia and Renu Aggarwal,
Universities Press India Ltd., 2000

17
 Semester II – Theory
Analytical Chemistry II (Credits: 04 Lectures/Week: 04)
PSCHE204

Chromatography, Thermal methods, automation in chemical analysis,

Surface Analytical & Electroanalytical methods

15L
Unit I Chromatography [15L]

1.1 Basic concepts in chromatography: Classification of

chromatographic methods, theories of separation in
chromatography; Optimization of chromatographic conditions.
[3L]

1.2 Gas Chromatography: Instrumentation of GC with special

reference to sample injection systems – split/splitless, column types,
solid/ liquid stationary phases, column switching techniques,
temperature programming, detectors in GC- Thermionic, thermal
conductivity detector, Flame ionisation detector, mass
spectrometric detector, Applications. [5 L]

1.3 High Performance Liquid Chromatography (HPLC): Normal

phase and reversed phase with special reference to types of
commercially available columns (Use of C8 and C18 columns).
Detectors in HPLC: uv detector- Diode array type and fluorescence
detector, mass detector, Applications of HPLC. Chiral and ion
chromatography. [7 L]

15L
Unit II Thermal Methods, Hyphenation & Automation in Chemical Analysis

2.1 Thermal Methods [7L]

2.1.1 Recapitulation of types of thermal methods, comparison between

TGA, DTA and DSC.

2.1.2 Applications of DSC - Heat of reaction, Specific heat, Safety

screening, polymers, liquid crystals, Percentage crystallinity,
oxidative stability, Drug analysis, Magnetic transition. e.g.
Analysis of Polyethylene for its crystallinity.

2.1.3 Enthapimetric methods

2.1.4 Thermometric titration

2.1.5 Evolved Gas Analysis

2.2 Hyphenated Techniques [3L]

18
 Introduction, need for hyphenation, possible hyphenation,
interfacing devices and applications of the following: GC-MS,
GC-IR, MS-MS, LC-MS

2.3 Automation in Chemical Analysis [4L]

Need for automation, objectives of automation, an overview of

automated instruments and instrumentation, process control
analysis, flow injection analysis, discrete automated systems,
automatic analysis based on multi-layered films, gas monitoring
equipment, Automatic titrators

15L
Unit III Surface Analytical Techniques [15L]

3.1 Introduction: Principle, Types, Surface Sensitivity & Specificity,

Electron scattering, distinction of surface species [3L]

3.2 Photoelectron Spectroscopy: Principle, Instrumentation and

Applications of X-ray photoelectron Spectroscopy (XPS,ESCA) &
Auger spectroscopy [3L]

3.3 Electron Microscopy: Principle, Instrumentation and

Applications of Scanning Electron Microscopy (SEM) and
Transmission Electron Microscopy (TEM) [4L]

3.4 Scanning Probe Microscopy: Principle, Instrumentation and

Applications of Scanning Tunneling Microscopy (STM) and
Atomic force Microscopy (AFM) [3L]

3.5 Ion Spectroscopy: Principle, Instrumentation and Applications of

Ion Spectroscopy (ISS & SIMS) [2L]

15L
Unit IV Electroanalytical Methods
4.1 Ion Selective Potentiometry: Ion selective electrodes and their
applications (solid state, precipitate, liquid –liquid, enzyme and gas
sensing electrodes), ion selective field effect transistors,
biocatalytic membrane electrodes and enzyme based biosensors.
[6L]

4.2 Polarography: Ilkovic equation, derivation starting with Cottrell

equation, effect of complex formation on the polarographic waves.
[4L]

4.3 Electrogravimetry: Introduction, principle, instrumentation,

factors affecting the nature of the deposit, applications. [3L]

4.4 Coulometry: Introduction, principle, instrumentation, coulometry

at controlled potential and controlled current. [2L]

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Standard References:
Unit I
1. Fundamentals of Analytical Chemistry, By Douglas A. Skoog, Donald M. West,
F. James Holler, Stanley R. Crouch, 9 Edition, 2004.
th

2. HPLC Practical and Industrial Applications, 2 nd Ed., Joel K. Swadesh, CRC

Press
Unit II
3. Instrumental Analysis, 5 th Edition, Skoog, Holler and Nieman.
4. Handbook of Thermal Analsis- Hatakeyama & Liu, Wiley.
5. Hyphenated techniques in Speciation Analysis- Royal Society of Chemistry
(2003) Joanna Scpunar and Ryszard Lobinski.
Unit III
6. Modern techniques of surface science by D.P. Woodruff, T.A. Delchar,
Cambridge Univ. Press, 1994.
Unit IV
7. Electrochemical Methods Fundamentals and Applications, Allen J Bard and Larry R
Faulkner, John Wiley and Sons, (1980)
8. Instrumental Methods of Analysis Willard, Merrit, Dean and Settle, 7th edition, CBS
publishers.
9. Principles of Instrumental Analysis – Skoog, Holler, Nieman, 5th Edition, Harcourt
College Publishers, 1998. Chapters - 23, 24, 25.

Additional References:

10. Physical Principles of Electron Microscopy, An Introduction to TEM, SEM, and

AEM Authors: Ray F. Egerton, ISBN: 978-0- 387-25800- 3 (Print)
11. Introduction to Scanning Tunneling Microscopy by C. J. Chen, Oxford University
Press, NewYork, 1993
12. Transmission Electron Microscopy: A text book for Material Science, David B
Williams and C., Barry Carter, Springer
13. Modern Spectroscopy, by J.M. Hollas, 3rd Edition (1996), John Wiley, New York
14. Analytical Chemistry Principles – John H Kennnedy, 2nd edition, Saunders College
Publishing (1990)
15. Modern Analytical Chemistry David Harvey; McGraw Hill Higher education
publishers, (2000).

20
 Semester II – Practical
Course: Analytical Chemistry Practical II (Credits: 04, Practicals/Week: 01)
PSCHEPR204
1. To determine percentage purity of sodium carbonate in washing
soda pH metrically.
2. To determine the amount of Ti(III) and Fe(II) in a mixture by
titration with Ce(IV) potentiometrically.
3. To determine the percentage purity of a sample (glycine/sodium
benzoate/primary amine) by titration with perchloric acid in a non
aqueous medium using glass calomel system potentiometrically.
4. To determine the amount of nitrite present in the given water sample
colorimetrically.
5. To determine the amount of Fe(II) and Fe(III) in a mixture using
1,10-phenanthroline spectrophotometrically.
6. Simultaneous determination of Cr(VI) and Mn(VII) in a mixture
spectrophotometrically.
7. To determine the percentage composition of HCl and H2SO4 on
weight basis in a mixture of two by conductometric titration with
NaOH and BaCl2.
8. To determine the amount of potassium in the given sample of
fertilizers using a flame photometer by standard addition method.

REFERENCES:
1. Quantitative Inorganic Analysis including Elementary Instrumental
Analysis by A. I. Vogels, 3 Ed. ELBS (1964)
rd

2. Vogel's textbook of quantitative chemical analysis, Sixth Ed.

Mendham, Denny, Barnes, Thomas, Pearson education
3. Standard methods of chemical analysis, F. J. Welcher
4. Standard Instrumental methods of Chemical Analysis, F. J. Welcher
5. W.W.Scott."Standard methods of Chemical Analysis",Vol.I, Van
Nostrand Company,Inc.,1939.
6. E.B.Sandell and H.Onishi,"Spectrophotometric Determination of
Traces of Metals",Part- II,4th Ed.,A Wiley Interscience
Publication,New York,1978.

21
 Evaluation Scheme

A. Evaluation scheme for Theory courses

I. Semester End Examination (SEE)- 60 Marks
II. Internal Continuous Assessment (CA) – 40 Marks
a. Knowledge and Application based: Online objective test of 20 Marks
b. Skill based (20 marks): Learner will be assessed on relevant skills
pertaining to the course content of a particular paper which could involve
but not limited to
a. Oral Presentations on relevant topics
b. Review writing/Worksheets etc.

B. Evaluation scheme for Practical courses

I. Semester End Examination (SEE)- 50 Marks per course

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