2006 Edition of The Drinking Water Standards and Health Advisories
2006 Edition of The Drinking Water Standards and Health Advisories
2006 Edition of The Drinking Water Standards and Health Advisories
EPA 822-R-06-013
Office of Water
U.S. Environmental Protection Agency
Washington, DC
Summer 2006
Date of update: August, 2006
Recycled/Recyclable
Printed on paper that contains
at least 50% recycled fiber.
The Drinking Water Standards and Health Advisories Tables are revised periodically by EPA’s
Office of Water in order to update RfD and Cancer values so that they are consistent with the
most current Agency assessments of chemical contaminants that may occur in drinking water
and to introduce new Health Advisories. The following information should be kept in mind
when using the 2006 Edition of the Tables:
Reference dose (RfD) values are updated to reflect the values in the Integrated Risk
Information System (IRIS) and the Office of Pesticide Programs (OPP) Reregistration
Eligibility Decisions (RED) Documents. The Drinking Water Equivalent Level (DWEL)
has been adjusted accordingly. Thus, both the RfD and DWEL in the Tables differ from
the values in the Health Advisory document when the IRIS or OPP RfD is more recent
than the Health Advisory document value. RfD values from IRIS that differ from the
values in the Health Advisory documents are presented in BOLD type. Values derived
from the REDs are given in BOLD italics. For unregulated chemicals with a recent IRIS
or OPP RfD, the lifetime Health Advisory is calculated from the DWEL using the
relative source contribution value published in the Health Advisory document. For
regulated chemicals, no lifetime value is provided in the Tables when the revised lifetime
value would differ from the Maximum Contaminant Level Goal (MCLG).
The cancer group designation or cancer classification and 10-4 cancer risk values reflect
those presently in IRIS or in the OPP RED. New IRIS cancer designations and 10-4
cancer risk values are presented in BOLD type and those derived from the REDs are in
BOLD italics.
The IRIS Toxicological Reviews can be accessed at: http://www.epa.gov/IRIS. The OPP
REDs can be accessed at: http://cfpub.epa.gov/oppref/rereg/status.cfm?show=rereg
In some cases there is a Health Advisory value for a contaminant but there is no reference
to a Health Advisory document. These Health Advisory values can be found in the
Drinking Water Criteria Document for the contaminant.
With a few exceptions, the RfDs, Health Advisory, and cancer risk values have been
rounded to one significant figure following the convention adopted by IRIS.
The Drinking Water Standards and Health Advisories Tables may be reached from the Water
Science home page at: http://www.epa.gov/waterscience. The Tables are accessed under the
Health Advisories heading.
(i)
DEFINITIONS
The following definitions for terms used in the Tables are not all-encompassing, and should not
be construed to be “official” definitions. They are intended to assist the user in understanding
terms found on the following pages.
The letter abbreviations provided parenthetically above are now used in the Tables in place of
the prior alpha numeric identifiers for chemicals that have been evaluated under the new
guidelines (the 2005 guidelines or the 1996 and 1999 draft guidelines).
Group Category
A Human carcinogen
B Probable human carcinogen:
B1 indicates limited human evidence
B2 indicates sufficient evidence in animals and inadequate or no evidence in humans
C Possible human carcinogen
D Not classifiable as to human carcinogenicity
E Evidence of noncarcinogenicity for humans
(ii)
10-4 Cancer Risk: The concentration of a chemical in drinking water corresponding to an excess
estimated lifetime cancer risk of 1 in 10,000.
HA: Health Advisory. An estimate of acceptable drinking water levels for a chemical substance
based on health effects information; a Health Advisory is not a legally enforceable Federal
standard, but serves as technical guidance to assist Federal, State, and local officials.
One-Day HA: The concentration of a chemical in drinking water that is not expected to
cause any adverse noncarcinogenic effects for up to one day of exposure. The One-Day
HA is normally designed to protect a 10-kg child consuming 1 liter of water per day.
Ten-Day HA: The concentration of a chemical in drinking water that is not expected to
cause any adverse noncarcinogenic effects for up to ten days of exposure. The Ten-Day
HA is also normally designed to protect a 10-kg child consuming 1 liter of water per day.
Lifetime HA: The concentration of a chemical in drinking water that is not expected to
cause any adverse noncarcinogenic effects for a lifetime of exposure. The Lifetime HA
is based on exposure of a 70-kg adult consuming 2 liters of water per day. The Lifetime
HA for Group C carcinogens includes an adjustment for possible carcinogenicity.
MCLG: Maximum Contaminant Level Goal. A non-enforceable health goal which is set at a
level at which no known or anticipated adverse effect on the health of persons occurs and which
allows an adequate margin of safety.
MCL: Maximum Contaminant Level. The highest level of a contaminant that is allowed in
drinking water. MCLs are set as close to the MCLG as feasible using the best available
analytical and treatment technologies and taking cost into consideration. MCLs are enforceable
standards.
RfD: Reference Dose. An estimate (with uncertainty spanning perhaps an order of magnitude) of
a daily oral exposure to the human population (including sensitive subgroups) that is likely to be
without an appreciable risk of deleterious effects during a lifetime.
(iii)
TT: Treatment Technique. A required process intended to reduce the level of a contaminant in
drinking water.
ABBREVIATIONS
D Draft
F Final
NA Not Applicable
NOAEL No-Observed-Adverse-Effect Level
OPP Office of Pesticide Programs
P Proposed
Reg Regulation
TT Treatment Technique
(iv)
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ORGANICS
1
Chemicals evaluated under the 2005 Cancer Guidelines or the 1996 or 1999 drafts are demoted by an abbreviation for their weight-of-the-evidence descriptor (see page iii). If the agency
has not completed a new assessment for the chemical, the 1986 Guidelines Group designation (see page iii) is given in the Cancer Descriptor column.
2
.When acrylamide is used in drinking water systems, the combination (or product) of dose and monomer level shall not exceed that equivalent to a polyacrylamide polymer containing 0.05%
monomer dosed at 1 mg/L.
3
The MCL value for any combination of two or more of these three chemicals should not exceed 0.007 mg/L because of a similar mode of action.
4
Administrative stay of the effective date.
5
PAH = Polycyclic aromatic hydrocarbon.
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1
1998 Final Rule for Disinfectants and Disinfection By-products: The total for trihalomethanes (THM) is 0.08 mg/L.
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1
Under review.
2
1998 Final Rule for Disinfectants and Disinfection By-products: The total for trihalomethanes is 0.08 mg/L.
3
1998 Final Rule for Disinfectants and Disinfection By-products: The total for five haloacetic acids is 0.06 mg/L.
4
The values for m-dichlorobenzene are based on data for o-dichlorobenzene.
Drinking Water Standards and Health Advisories
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Status mg/L at
CASRN Status MCLG MCL HA One-day Ten-day RfD DWEL Life-time 10-4 Cancer Cancer
Chemicals Number Reg. (mg/L) (mg/L) Document (mg/L) (mg/L) (mg/kg/day) (mg/L) (mg/L) Risk Descriptor
1
Technical grade.
2
When epichlorohydrin is used in drinking water systems, the combination (or product) of dose and monomer level shall not exceed that equivalent to an epichlorohydrin-based polymer
containing 0.01% monomer dosed at 20 mg/L.
3
1,2-dibromoethane.
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Status mg/L at
Status MCLG MCL HA One-day Ten-day RfD DWEL Life-time 10-4 Cancer Cancer
Chemicals CAS Number Reg. (mg/L) (mg/L) Standards (mg/L) (mg/L) (mg/kg/day) (mg/L) (mg/L) Risk Descriptor
1
Carcinogenicity based on inhalation exposure.
2
Regulatory Determination Health Effects Support Document for Hexachlorobutadiene
(http://www.epa.gov/safewater/ccl/pdfs/reg_determine1/support_cc1_hexachlorobutadiene_healtheffects.pdf).
3
HMX = octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine.
4
Lindane = γ − hexachlorocyclohexane.
5
MCPA = 4(chloro-2-methoxyphenoxy)acetic acid.
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Status mg/L at
CASRN Status MCLG MCL HA One-day Ten-day RfD DWEL Life-time 10-4 Cancer
Chemicals Number Reg. (mg/L) (mg/L) Document (mg/L) (mg/L) (mg/kg/day) (mg/L) (mg/L) Risk Cancer
Descriptor
Metolachlor 51218-45-2 - - - F ‘88 2 2 0.1 3.5 0.7 - C
Metribuzin 21087-64-9 - - - F ‘88 5 5 0.01 0.35 0.07 - D
Monochloroacetic acid 79-11-8 F 0.03 0.061 - 0.2 0.2 0.01 0.35 0.07 - I
Monochlorobenzene 108-90-7 F 0.1 0.1 F ‘87 4 4 0.02 0.7 0.1 - D
Naphthalene 91-20-3 - - - F ‘90 0.5 0.5 0.02 0.7 0.1 - I
Nitrocellulose2 9004-70-0 - - - F ‘88 - - - - - - -
Nitroguanidine 556-88-7 - - - F ‘90 10 10 0.1 3.5 0.7 - D
Nitrophenol p- 100-02-7 - - - F ‘92 0.8 0.8 0.008 0.3 0.06 - D
Oxamyl (Vydate) 23135-22-0 F 0.2 0.2 F ‘05 0.01 0.01 0.001 0.035 - N
Paraquat 1910-42-5 - - - F ‘88 0.1 0.1 0.0045 0.2 0.03 - C
Pentachlorophenol 87-86-5 F zero 0.001 F ‘87 1 0.3 0.03 1 - 0.03 B2
Phenanthrene (PAH) 85-01-8 - - - - - - - - - - D
Phenol 108-95-2 - - - D ‘92 6 6 0.3 11 2 - D
Picloram 1918-02-1 F 0.5 0.5 F ‘88 20 20 0.02 0.7 - - D
Polychlorinated biphenyls 1336-36-3 F zero 0.0005 D ‘93 - - - - - 0.01 B2
(PCBs)
Prometon 1610-18-0 - - - F ‘88 0.2 0.2 0.015 0.5 0.1 - D
Pronamide 23950-58-5 - - - F ‘88 0.8 0.8 0.08 3 - 0.2 B2
Propachlor 1918-16-7 - - - F ‘88 0.5 0.5 0.05 2 - 0.1 L
Propazine 139-40-2 - - - F ‘88 - - 0.02 0.7 0.1 - N
Propham 122-42-9 - - - F ‘88 5 5 0.02 0.6 0.1 - D
Pyrene (PAH) 129-00-0 - - - - - - 0.03 - - - D
RDX3 121-82-4 - - - F ‘88 0.1 0.1 0.003 0.1 0.002 0.03 C
Simazine 122-34-9 F 0.004 0.004 F ‘88 - - 0.02 0.7 - - N
Styrene 100-42-5 F 0.1 0.1 F ‘87 20 2 0.2 7 0.1 - C
2,4,5-T (Trichlorophenoxy- 93-76-5 - - - F ‘88 0.8 0.8 0.01 0.35 0.07 - D
acetic acid)
1
1998 Final Rule for Disinfectants and Disinfection By-products: the total for five haloacetic acids is 0.06mg/L.
2
The Health Advisory Document for nitrocellulose does not include HA values and describes this compounds as relatively nontoxic.
3
RDX = hexahydro -1,3,5-trinitro-1,3,5-triazine.
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Status
CASRN Status MCLG MCL HA One-day Ten-day RfD DWEL Life-time mg/L at 10-4 Cancer
Chemicals Number Reg. (mg/L) (mg/L) Document (mg/L) (mg/L) (mg/kg/day) (mg/L) (mg/L) Cancer Risk Descriptor
2,3,7,8-TCDD (Dioxin) 1746-01-6 F zero 3E-08 F ’87 1E-06 1E-07 1E-09 4E-08 - 2E-08 B2
Tebuthiuron 34014-18-1 - - - F ‘88 3 3 0.07 2 0.5 - D
Terbacil 5902-51-2 - - - F ‘88 0.3 0.3 0.01 0.4 0.09 - E
Terbufos 13071-79-9 - - - F ‘88 0.005 0.005 0.00005 0.002 0.0004 - D
Tetrachloroethane (1,1,1,2-) 630-20-6 - - - F ‘89 2 2 0.03 1 0.07 0.1 C
Tetrachloroethane (1,1,2,2-) 79-34-5 - - - F ‘89 0.04 0.04 0.00005 0.002 0.0003 0.02 C
Tetrachloroethylene1 127-18-4 F zero 0.005 F ‘87 2 2 0.01 0.5 0.01 - -
Trichlorofluoromethane 75-69-4 - - - F ‘89 7 7 0.3 10 2 - D
Toluene 108-88-3 F 1 1 D ‘93 20 2 0.08 3 - - I
Toxaphene 8001-35-2 F zero 0.003 F ‘96 0.004 0.004 0.0004 0.01 - 0.003 B2
2,4,5-TP (Silvex) 93-72-1 F 0.05 0.05 F ‘88 0.2 0.2 0.008 0.3 0.05 - D
Trichloroacetic acid 76-03-9 F 0.02 0.062 - 3 3 0.03 1 0.02 - S
Trichlorobenzene (1,2,4-) 120-82-1 F 0.07 0.07 F ‘89 0.1 0.1 0.01 0.35 0.07 - D
Trichlorobenzene (1,3,5-) 108-70-3 - - - F ‘89 0.6 0.6 0.006 0.2 0.04 - D
Trichloroethane (1,1,1-) 71-55-6 F 0.2 0.2 F ‘87 100 40 0.035 1 0.2 - D
Trichloroethane (1,1,2-) 79-00-5 F 0.003 0.005 F ‘89 0.6 0.4 0.004 0.1 0.003 0.06 C
Trichloroethylene 1 79-01-6 F zero 0.005 F ‘87 - - 0.007 0.2 - 0.3 B2
Trichlorophenol (2,4,6-) 88-06-2 - - - D ‘94 0.03 0.03 0.0003 0.01 - 0.3 B2
Trichloropropane (1,2,3-) 96-18-4 - - - F ‘89 0.6 0.6 0.006 0.2 0.04 - -
Trifluralin 1582-09-8 - - - F ‘90 0.08 0.08 0.02 0.7 0.01 0.4 C
Trimethylbenzene (1,2,4-) 95-63-6 - - - D ‘87 - - - - - - D
Trimethylbenzene (1,3,5-) 108-67-8 - - - D ‘87 10 - - - - - D
Trinitroglycerol 55-63-0 - - - F ‘87 0.005 0.005 - - 0.005 0.2 -
Trinitrotoluene (2,4,6-) 118-96-7 - - - F ‘89 0.02 0.02 0.0005 0.02 0.002 0.1 C
Vinyl chloride 75-01-4 F zero 0.002 F ‘87 3 3 0.003 0.1 - 0.002 H
Xylenes 1330-20-7 F 10 10 D ‘93 40 40 0.2 7 - - I
1
Under review.
2
1998 Final Rule for Disinfectants and Disinfection By-products: The total for five haloacetic acids is 0.06 mg/L.
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Status
CASRN Status MCLG MCL HA One-day Ten-day RfD DWEL Life-time mg/L at 10-4 Cancer
Chemicals Number Reg. (mg/L) (mg/L) Document (mg/L) (mg/L) (mg/kg/day) (mg/L) (mg/L) Cancer Risk Descriptor
INORGANICS
1
MFL = million fibers per liter.
2
Carcinogenicity based on inhalation exposure.
3
Monochloramine; measured as free chlorine.
4
1998 Final Rule for Disinfectants and Disinfection By-products: MRDLG=Maximum Residual Disinfection Level Goal; and MRDL=Maximum Residual Disinfection Level.
5
IRIS value for chromium VI.
6
Copper action level 1.3 mg/L; lead action level 0.015 mg/L.
7
This RfD is for hydrogen cyanide.
8
Based on dental fluorosis in children, a cosmetic effect. MCLG based on skeletal fluorosis.
9
Dietary manganese. The lifetime health advisory includes a 3 fold modifying factor to account for increased bioavailability from drinking water.
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Status Life-
CASRN Status MCLG MCL HA One-day Ten-day RfD DWEL time mg/L at 10-4 Cancer
Chemicals Number Reg. (mg/L) (mg/L) Document (mg/L) (mg/L) (mg/kg/day) (mg/L) (mg/L) Cancer Risk Descriptor
RADIONUCLIDES
1
These values are calculated for a 4-kg infant and are protective for all age groups.
2
Based on a cosmetic effect.
3
AMCL = Alternative Maximum Contaminant Level
4
Soluble uranium salts. Radionuclide Rule.
Secondary Drinking Water Regulations
Summer 2006 Page 10
1
Final for systems using surface water; also being considered for regulation under groundwater disinfection rule.
Drinking Water Advisory Table
Taste Threshold: Concentration at which the majority of consumers do not notice an adverse taste in drinking water; it is
recognized that some sensitive individuals may detect a chemical at levels below this threshold.
Odor Threshold: Concentration at which the majority of consumers do not notice an adverse odor in drinking water; it is recognized
that some sensitive individuals may detect a chemical at levels below this threshold.