The document discusses the nucleophilic aromatic substitution reaction of chlorobenzene with sodium hydroxide. A mixture of regioisomers is observed, which can be explained by an elimination-addition mechanism involving generation of a benzyne intermediate. Formation of the benzyne is the rate determining step, with the rate increasing in the order F < Cl < Br < I. This mechanism is supported by trapping experiments that show reaction of the benzyne with dienophiles. The document also provides examples to exercise understanding of the reaction mechanism.
The document discusses the nucleophilic aromatic substitution reaction of chlorobenzene with sodium hydroxide. A mixture of regioisomers is observed, which can be explained by an elimination-addition mechanism involving generation of a benzyne intermediate. Formation of the benzyne is the rate determining step, with the rate increasing in the order F < Cl < Br < I. This mechanism is supported by trapping experiments that show reaction of the benzyne with dienophiles. The document also provides examples to exercise understanding of the reaction mechanism.
The document discusses the nucleophilic aromatic substitution reaction of chlorobenzene with sodium hydroxide. A mixture of regioisomers is observed, which can be explained by an elimination-addition mechanism involving generation of a benzyne intermediate. Formation of the benzyne is the rate determining step, with the rate increasing in the order F < Cl < Br < I. This mechanism is supported by trapping experiments that show reaction of the benzyne with dienophiles. The document also provides examples to exercise understanding of the reaction mechanism.
The document discusses the nucleophilic aromatic substitution reaction of chlorobenzene with sodium hydroxide. A mixture of regioisomers is observed, which can be explained by an elimination-addition mechanism involving generation of a benzyne intermediate. Formation of the benzyne is the rate determining step, with the rate increasing in the order F < Cl < Br < I. This mechanism is supported by trapping experiments that show reaction of the benzyne with dienophiles. The document also provides examples to exercise understanding of the reaction mechanism.
