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    Drug Study

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    Tintin Honra
    This document summarizes information about the drug Isoxsuprine HCl, also known as Duvadilan. It is classified as a 2-amino-1-phenylethanol derivative peripheral vasodilator. It works by beta-sympathomimetic, alpha-sympathomimetic, and direct smooth muscle relaxation effects. It is used to treat premature labor and cerebral and peripheral vascular diseases. Common side effects include dizziness, palpitations, and nausea. It is contraindicated in cases of hypotension, prolonged premature rupture of membranes, or recent arterial hemorrhage.

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    Drug Study

    Uploaded by

    Tintin Honra
    19 views3 pages
    This document summarizes information about the drug Isoxsuprine HCl, also known as Duvadilan. It is classified as a 2-amino-1-phenylethanol derivative peripheral vasodilator. It works by beta-sympathomimetic, alpha-sympathomimetic, and direct smooth muscle relaxation effects. It is used to treat premature labor and cerebral and peripheral vascular diseases. Common side effects include dizziness, palpitations, and nausea. It is contraindicated in cases of hypotension, prolonged premature rupture of membranes, or recent arterial hemorrhage.

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    This document summarizes information about the drug Isoxsuprine HCl, also known as Duvadilan. It is classified as a 2-amino-1-phenylethanol derivative peripheral vasodilator. It works by beta-sympathomimetic, alpha-sympathomimetic, and direct smooth muscle relaxation effects. It is used to treat premature labor and cerebral and peripheral vascular diseases. Common side effects include dizziness, palpitations, and nausea. It is contraindicated in cases of hypotension, prolonged premature rupture of membranes, or recent arterial hemorrhage.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    19 views3 pages

    Drug Study

    Uploaded by

    Tintin Honra
    This document summarizes information about the drug Isoxsuprine HCl, also known as Duvadilan. It is classified as a 2-amino-1-phenylethanol derivative peripheral vasodilator. It works by beta-sympathomimetic, alpha-sympathomimetic, and direct smooth muscle relaxation effects. It is used to treat premature labor and cerebral and peripheral vascular diseases. Common side effects include dizziness, palpitations, and nausea. It is contraindicated in cases of hypotension, prolonged premature rupture of membranes, or recent arterial hemorrhage.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
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    Drug Study

    Generic Name: Isoxsuprine HCl.

    Brand Name: Duvadilan

    Classification:
    C04AA01 - isoxsuprine ; Belongs to the class of 2-amino-1-phenylethanol derivative agents. Used as peripheral vasodilators.

    Mode of Action:
     Beta-Sympathomimetic Effect: By virtue of this effect, isoxsuprine has relaxant action on the muscular tissue of the uterus.

     Alpha-Sympathomimetic Effect: Isoxsuprine antagonizes the effects of α-receptor stimulation. Some uterine contraction, which
    can otherwise occur because of α-receptor stimulation, gets inhibited due to this effect of isoxsuprine.

     Direct Relaxant Action on the Smooth Muscle Fibers: Isoxsuprine induces a direct relaxant action on the smooth muscle fibers
    and so enhances those effects resulting from its action on the sympathetic receptors.

    Suggested Dose:
     For use as a vasodilator, isoxsuprine HCl is given orally in doses of 10-20 mg 3 or 4 times daily.
     Arrest Premature Labor: Initially 200-500 mcg/min by IV infusion, adjusted according to the patient's response, until control is
    achieved. Once labor has been arrested IM injections of 10 mg are given every 3-8 hrs. Prophylaxis may be continued orally
    with 30-90 mg daily.

    Indication:
    Treatment of premature labor, cerebral and peripheral vascular disease. Dosage/Direction for Use

    Contraindication:
     Preexisting Hypotension: If the blood pressure is already low eg, <100 mmHg systolic, it must be borne in mind that the
    administration of isoxsuprine will, in most instances, bring about a further reduction in the blood pressure.

     Prolonged Premature Rupture of Membranes: If fetal membranes are ruptured/dilatation is >4 cm, chances of success are less.
    In the cases of prolonged premature rupture of membranes, the possible benefits to be gained from delaying emptying of the
    uterus must be weighed against the possibility that undue prolongation of the pregnancy may actually increase the maternal
    and fetal hazards.

     Isoxsuprine should not be used in presence of hemorrhage.

     Isoxsuprine is contraindicated after recent arterial hemorrhage.

    Side Effects:
     Dizziness
     Palpitations
    Adverse Effects: Isoxsuprine may cause transient nausea, vomiting, flushing, tachycardia, rashes, gastrointestinal disturbances and
    maternal pulmonary edema. In few cases, mainly in hypertensive patients, parenteral administration of Duvadilan may lead to
    transitory fall in blood pressure. A change over to oral administration or reduction in dosage will usually avoid this effect.

    Drug Interaction:
    Incompatibilities: None known.

    Nursing Responsibilities:

    Bibliography:

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