Summary of Antidiabetic Drugs PDF
Summary of Antidiabetic Drugs PDF
Summary of Antidiabetic Drugs PDF
METFORMIN WOF:
1ST LINE AGENT OF T2DM 1. Diarrhea
USED IN PCOS 2. Lactic acidosis ( inc. risk if dehydrated
PHENFORMIN or with congested liver/kidney)
Notes:
“Euglycemic” = NO HYPOGLYCEMIA
MOA: acts on PPAR-GAMMA peroxisomal
THIALOZIDINEDIONES proliferator acting receptor (insulin sens.)
ROSIGLITAZONE WOF:
1. Hepatotoxicity
(Avandia) 2. Cardiotoxicity
PIOGLITAZONE
(Prialta, PPAR)
Incretin- produced in
ACTING ON INCRETIN SYSTEM response to oral glucose
DPP-IV load
GLP-1 Inactive For T1DM and T2DM
CANAGLIFLOZIN WOF:
1. Euglycemic Diabetic Ketoacidosis
DAPAGLIFLOZIN 2. UTI and AKI
(Forsiga)
XIGDUO: Dapagliflozin + Metformin
EMPAGLIFLOZIN GLYAXMBI: Empagliflozin + Linagliptin
AMYLIN ANALOG
WOF:
PRAMLINTIDE 1. Hypoglycemia
2. Nausea and vomiting
3. Weight loss